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Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
mice, then, olfactory behavioral tests were conducted. It was reported that minocycline treatment could prevent neuronal apoptosis and olfactory impairment, indicating that suppression of microglial activity is protective of olfactory deafferentation and functional deficits after olfactory ablation [63]. Neuroinflammation models (inducible olfactory inflammation and bacteria-infected model):... Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 2 431-437 (7 pages)
of febrile disease on the pharmacokinetics of veterinary drugs. Annal Vet Res 1990, 21 (Suppl 1), 11S-28S. 29. Wang C, Zhao M, Liu YR, Luan X, Guan YY, Lu Q, Yu DH, Bai F, Chen HZ, Fang C. Suppression of colorectal cancer subcutaneous xenograft and experimental lung metastasis using nanoparticle-mediated drug delivery to tumor neovasculature. Biomaterials 2014, 35, 1215-1226. 30. Zhang P,... A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet... -
Analgesic efficacy of oral firocoxib in ovariohysterectomized cats
Prangtip Phuwapattanachart, Naris Thengchaisri 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 7 175-182 (8 pages)
a significant reduction of renal blood flow due to the suppression of vasoactive prostaglandin synthesis. Two cats in the firocoxib-3 group with azotemia responded well to fluid therapy and the animals recovered without other complications. Firocoxib has been shown to be highly effective and acceptable to control pain and inflammation due to osteoarthritis in canines. It also has been used... The postoperative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 h post-operation. The average CPSS (mean ± SEM) over 2 to 48 h post-operation in firocoxib-3 (0.4... -
A novel M2e-multiple antigenic peptide providing heterologous protection in mice
Feng Wen, Ji-Hong Ma, Hai Yu, Fu-Ru Yang, Meng Huang, Yan-Jun Zhou, Ze-Jun Li, Xiu-Hui Wang, Guo-Xin Li, Yi-Feng Jiang, Wu Tong, 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 9 71-78 (8 pages)
vaccine were then infected with 10 6 EID50 of SwGD96 and SwHLJ1 and 10LD50 of PR8 through nasal inoculation. High titer of HI and neutralizing antibody induced by the vaccine provided effective suppression of replication of homologous SwHLJ1 virus (H3N2) and pathological changes in the lung, with a protection rate of 100%. Reassortant H3N2 vaccine also provided cross protection, determined... Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in which novel strains loom. Here, we developed and evaluated a novel M2e-multiple antigenic peptide (M2e-MAP) as a supplemental antigen for inactivated H3N2 vaccine to provide cross-protection against two main subtypes of SwIVs, H1N1 and H3N2. The novel tetra-branched MAP was constructed by... -
Hepatitis E virus as an emerging zoonotic pathogen
Woo-Jung Park, Byung-Joo Park, Hee-Seop Ahn, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Han-Sang Yoo, In-Soo 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 1 1-11 (11 pages)
a T-cellspecific immunosuppressant, enhanced HEV infection, whereas steroids did not influence HEV infection in liver cells. These findings suggest that suppression of the T-cellmediated immune response is an important reason that increases the development of chronic hepatitis E in solid organ recipients. HEV treatment Reduction of immunosuppressive therapy is clinically recommended to... Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence... -
Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model
Hye Kyung Baek, Hyeji Shim, Hyunmook Lim, Minju Shim, Chul-Kyu Kim, Sang-Kyu Park, Yong Seok Lee, Ki-Duk Song, Sung-Jo Kim, Sun 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 1 389-396 (8 pages)
in the AA groups was more suppressed than in the Veh groups. This suppression was more evident between ND/Veh and ND/AA than between HF/Veh and HF/AA (*p 0.05, **** p 0.001). (C) Real time PCR. C/EBP- was more significantly suppressed in the HF/AA group than in the HF/Veh group. Levels of other transcription factors did not differ between the Veh and AA group (***p 0.005). Scale bar = 200... Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the... -
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue, Ki Nam Lee, Jae-Hwang Jeong, Sang-Hwa Lee, Young Ho Lee, Seong-woon Jeong, Sang Yoon Nam, Young Won Yun, Beom Jun L 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 3 189-195 (7 pages)
associated with their suppression of adipocyte differentiation and adipogenesis. Mesentery, renal, and epididymal fat mass in the abdomen of mice were significantly decreased by CLA treatment. The specific mechanism by which CLA exerts these effects remains unknown, but several hypotheses have been offered, including the inhibition of arachidonic acid formation and modulation of desaturase... This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p ＜ 0.01). All... -
Comparative study on the aflatoxin B1 degradation ability of rumen fluid from Holstein steers and Korean native goats
Santi Devi Upadhaya, Ha Guyn Sung, Chan Hee Lee, Se Young Lee, Sun Woo Kim, Kyung Jin Cho, Jong K. Ha* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 5 29-34 (6 pages)
by immunity suppression by AFB1 observed in turkeys, chickens, pigs, mice, guinea pigs, and rabbits [22]. Symptoms of acute aflatoxicosis in mammals include inappetence, lethargy, ataxia, rough hair coat, and enlarged pale fatty livers. In contrast, chronic aflatoxicosis exhibits symptoms including reduced feed efficiency and milk production, icterus, and decreased appetite [18]. Reduced... The aflatoxin B1 degrading abilities of two different ruminants were compared in this study. One set of experiments evaluated the aflatoxin B1 degradation ability of different rumen fluid donors (steers vs. goats) as well as the rumen fluid filtration method (cheese cloth filtered vs. 0.45 Ռm Millipore) in a 2 × 2 factorial arrangement. Additional studies examined aflatoxin B1 degradation by collecting rumen fluid at different times (0, 3, 6, 9 and 12 h) after feeding. Cannulated... -
Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits
Ayman Goudah, Samar M. Mouneir, Jae-Han Shim, A. M. Abd El-Aty 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 2호 10 151-155 (5 pages)
of appetite as well as the synthesis and secretion of acute phase hepatic proteins [27]. Significant concentrations of proinflammatory cytokines, such as tumor necrosis factor-α, interleukins and interferons, are produced during APR, which leads to the direct suppression of the microsomal cytochrome P450 (CYP)-dependent activity in the liver [1,4,30]. This might in turn alter the pharmacokinetic... This study examined the effect of experimentally induced fever on the pharmacokinetics of cefepime (75 mg/kg BW) administered intramuscularly to six rabbits. The study was carried out in two consecutive phases separated by a two-week washout period. An infection was induced by an intravenous inoculation of 5 × 108 colony-forming units of Escherichia coli 24 h before the pharmacokinetic investigation. A quantitative microbiological assay was employed to measure the plasma cefepime concentrations... -
A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog
Young Mi Lee, Byeong Teck Kang, Dong in Jung, Chul Park, Ha Jung Kim, Ju Won Kim, Chae Young Lim, Eun Hee Park, Hee Myung Park 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 4호 18 363-366 (4 pages)
a high-dose dexamethasone suppression test (HDDST), endogenous ACTH concentrations, abdominal ultrasound, or a combination of these methods. The purpose of this case report was to present that mitotane administration was effective and acceptable in dogs with cortisol-secreting adrenocortical tumors and periodical ACTH stimulation test was important to monitor responsiveness to mitotane therapy in... Hyperadrenocorticism, a disorder characterized by excessive production of cortisol by the adrenal cortex, is wellrecognized in dogs. A 10-year-old, intact male, Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking, clinical signs, physical examination, and results of routine laboratory testing (complete blood count, serum biochemical analysis, and urinalysis). In addition, adrenocorticotropic hormone (ACTH)...