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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
Mohammed Mohsen Safhi, Tarique Anwer, Gyas Khan, Rahimullah Siddiqui, Sivagurunathan Moni Sivakumar, Mohammad Firoz Alam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 3 493-501 (9 pages)
MF, Westendorp RG, van der Laarse A, Smelt AH. Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial. Am J Med. 2002;112:275- 280. 36. Feingold KR, Grunfeld C. Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. J Clin Invest. 1987;80:184-190. 37. Ali F, Naqvi... The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines and histological studies in type 2 diabetes mellitus (DM). Type 2 DM was induced by injecting nicotinamide (120 mg/kg, i.p.) 15 min before STZ (60 mg/kg) injection. Canagliflozin (5 and 10 mg/ kg) and omega-3 fatty acid (300 mg/kg) were given for 28 days after confirmation of... -
Reduction of Food Intake by Fenofibrate is Associated with Cholecystokinin Release in Long-Evans Tokushima Rats
Mi-KyoungPark, YingHan, , MiSunKim, , EunhuiSeo, SoojeongKang, So-YoungPark, HyeongjongKoh, DukKyuKim, Hye-JeongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 5 181-186 (6 pages)
of fenofi- brate, bezafibrate or clofibrate (Sigma-Aldrich, St. Louis, MO) for 24 hours. Measurement of PPAR α and CCK expression Total proteins were isolated from Caco-2 cells and the small intestine of rats using radioimmunoprecipitation as- say buffer containing Protease Inhibitor Cocktail and Pho- sphatase Inhibitor Cocktails (Sigma-Aldrich). Protein con- centration was determined in... Fenofibrate is a selective peroxisome proliferator-activated receptor Ձ (PPARՁ) activator and is prescribed to treat hyperlipidemia. The mechanism through which PPARՁ agonists reduce food intake, body weight, and adiposity remains unclear. One explanation for the reduction of food intake is that fenofibrate promotes fatty acid oxidation and increases the production of ketone bodies upon a standard experimental dose of the drug (100∼300 mg/kg/day). We observed that low-dose... -
Activation of PPARα Attenuates IFNγ and IL-1β-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway
Jin-KooLee, Eun-MinSeo, Sang-SooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Seon-MiKim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 11 185-189 (5 pages)
ng/ml) dose-dependently inhibited the IFN γ and IL-1 β-induced cell proliferation. However, bezafibrate and fenofibrate did not affect increased mRNA and protein levels of IL-6 in IFN γ and IL-1 β-stimulated astrocytes. Taken together, these results clearly suggest that activation of PPAR α attenuates the IFN γ and IL-1 β-induced cell proliferation through IL-6 independent pathway. Key... astrocytes. Alone or combination treatment with cytokines, such as IL-1Ղ (10 ng/ml), IFNՃ (10 ng/ml), and TNF-Ձ (10 ng/ml) cause a significant increase of cell proliferation in a time-dependent manner. Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 ՌM) reduced the IFNՃ and IL-1Ղ-induced cell proliferation in a dose-dependent manner. To address the involvement of IL-6 on the IFNՃ and IL-1Ղ-induced cell proliferation, released...