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전체 선택해제
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본문검색 결과만 보기
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Effect of Cation Binding Agents on Sludge Solubilization Potential of Bacteria
Kumar. S. Gopi, Merrylin. J., Kaliappan. S., Kumar. S. Adish, Yeom. Ick-Tae, Banu. J. Rajesh 한국생물공학회 Biotechnology and bioprocess engineering 7 Pages
한국생물공학회 Biotechnology and bioprocess engineering 2012, Vol.17 No.2 346-352 (7 pages)
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Studies on the Binding Affinity of Aminoglycoside Antibiotics to the HIV-l Rev Responsive Element for Designing Potential Antiviral Agents
Kwon. Young-Joo 한국미생물생명공학회 Journal of microbiology and biotechnology 9 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2006, Vol.16 No.1 109-117 (9 pages)
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Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats
Himangshu Baruah, Dulal Chandra Roy, Rohini Kumar Roy, Hirendra Nath Khonikor 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 2 97-101 (5 pages)
..PAGE:1 . . . . . . . . . . ........... ....... J. Vet. Sci. (2004),.5(2), 97101 Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats Himangshu Baruah*, Dulal Chandra Roy, Rohini Kumar Roy, Hirendra Nath Khonikor Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Guwahati 781022, Assam, India Ofloxacin was... male goats intravenously (5 mg/kg) to determine its kinetic behavior, tissue residue, in vitro plasma protein binding and to compute a rational dosage regimen. The concentration of ofloxacin in plasma and tissue samples collected at prescheduled time were estimated by using HPLC. The pharmacokinetic parameters were determined by non-compartmental model and plasma protein binding was estimated by equilibrium dialysis technique. The therapeutic concentration (≥0.5 ?g/ml) was maintained up to 36 h... -
Unchanged Protein Level of Ryanodine Receptor but Reduced [3H] Ryanodine Binding of Cardiac Sarcoplasmic Reticulum from Diabetic Cardiomyopathy Rats
EunHeeLee, YoungJuSeo, Young-HoonKim, HaeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 5 397-405 (9 pages)
2 h. Antibody binding was detected using ECL (enhanced chemiluminescence) horsera dish peroxidase developing agents from Amersham lntertional (Little Chalfont， UK)， and membranes were exposed to a sheet of autoradiography film. The developed bands were quantitated by the scanned image using ImageQuant software， with data reported as integrated density units. The density associated with... The levels of protein and mRNA of the ryanodine receptor in diabetic rats were comparable to these of the control. However, the binding capacity of ryanodine was significantly decreased in diabetic rat hearts. Furthermore, the reduction in the binding capacity of ryanodine receptor was completely restored by insulin. This result suggests that there were no transcriptional and translational changes but functional changes, such as conformational changes of the Ca2 release channel, which... -
Changes in Phosphate Transporter Activity Evaluated by Phosphonoformic Acid Binding in Cadmium-Exposed Renal Brush-Border Membranes
JinMoChung, DoWhanAhn, KyoungRyongKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 8 513-519 (7 pages)
et a1， 1996) and p1acenta1 microvillus (Boadi et a1， 1992) membranes， and as indirect1y suggested by an increase in lipid peroxides in Cd-treated rena1 cell membranes (Oner et a1， 1996)， Cd binding to the rena1 BBM cou1d impair the Na + -Pi cotransporter activity possib1y by a1tering the membrane fuidity. In fact， it has been shown that severa1 agents that affect the membrane + fuidi... by BBMV was determined by 32P-labeled inorganic phosphate uptake, and the number of Na- Pi cotransporters in the BBM was assessed by Pi-protectable 14C-labeled phosphonoformic acid ([14C]PFA) binding. The exposure of BBMV to Cd decreased the Na-Pi cotransport activity in proportion to the Cd concentration in the preincubation medium, but it showed no apparent effect on the Pi-protectable PFA binding. These results indicate that an interaction of renal BBM with free Cd induces a... -
Effects of Dopamine and Haloperidol on Morphine-induced CREB and AP-1 DNA Binding Activities in Differentiated SH-SY5Y Human Neuroblastoma Cells
Soo-kyungKimGee-younKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 3 671-676 (6 pages)
increasing the transcriptional activity. CREB and AP-l DNA binding activities right be directy related to ro rphine-induced gene expression， and rorphine tole rance cou1d be prevented by haloperidol. Further rore， the specific binding sites on these transcription factors could be plausible targets of the developrent of phracological agents that prevent or reverse the actions of rorphine... a significant increase or decrease of the CREB and AP-1 DNA binding activities, respectively. In the case of acute morphine treatment, the CREB and AP-1 DNA binding activities were shown to decrease in a time-dependent manner (30, 60, 90, and 120 min). Taken these together, in differentiated SH-SY5Y cells, morphine tolerance seems to involve simultaneous changes of the CREB and AP-1 DNA binding activities. Our data also suggest the possible involvement of haloperidol in prevention or reversal of... -
β1/β2 비선택적 Radioligand (-)-[3H]-DHA를 사용한 Rat 좌심실 β-adrenoceptor에 대한 심장순환계 약물의 Binding
권광일(Kwang-Il Kwon), 이선경(Sun-Kyung Lee), 유성은(Sung-Eun Yoo) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 1991, 제 27권 제 2호 4 119-124 (6 pages)
as cardiotonic agents. In this study, these PDE inhibitors hardly inhibited the ( - )-['H]- DHA binding to P.. adrenoceptors in rat left ven- tricle. Thus it is suggested that cAMP increasing effect of these agents are due to the PDE inhibi- tion, not by the P.. adrenoceptor stimulation. In conclusion, it was shown that(±) proprano- lol, labetalol and... 및 PDE 억제약물(imazodan, KR-30045, KR-30075 등)에 대한 β-adrenoceptor binding 실험을 β1/β2 비선택적 radioligand인 (-)-[3H]-DHA를 사용하여 실시하였다. Saturation 실험에서 β_1 및 β_2 수용체를 모두 갖고 있는 rat 좌심실의 β 수용체에 대한 (-)-[3H]-DHA의 KD 값은 1.5 ± 0.43 nM, B_{max}는 22.0 ± 0.9 fmol/mg protein이었다. ( ± )propranolol, labetalol 및 (-)NE는 단일상으로 (-)-[3H]-DHA의 결합을 억제하였으며 Ki 값은 각각 17.0 ± 0.43 nM, 57.3 ± 1.30 nM, 1.57 ± 0.95μM로 나타났다. 실험에 사용한... -
Race- and Isolate-specific Molecular Marker Development through Genome- Realignment Enables Detection of Korean Plasmodiophora brassicae Isolates, Causal agents of Clubroot Disease
Ji-Yun Jeong, Arif Hasan Khan Robin, Sathishkumar Natarajan, Rawnak Laila, Hoy-Taek Kim, Jong-In Park, Ill-Sup Nou 한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 6호 6 506-513 (8 pages)
at the primer binding site. Race- and isolate-specific markers and their potential applications. In this study, we developed 12 SCAR mark- ers that identify particular Korean isolates of the clubroot pathogen P. brassicae. Eleven of these markers were spe- cific to four single isolates. Importantly, two Yeoncheon isolate-specific markers perfectly amplified only Yeon- cheon isolate of Korea.... Clubroot is one of the most economically important diseases of the Brassicaceae family. Clubroot disease is caused by the obligate parasite Plasmodiophora brassicae, which is difficult to study because it is nonculturable in the laboratory and its races are genetically variable worldwide. In Korea, there are at least five races that belongs to four pathotype groups. A recent study conducted in Korea attempted to develop molecular markers based on ribosomal DNA polymorphism to detect P. brassicae...