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R-type Calcium Channel Isoform in Rat Dorsal Root Ganglion Neurons
ZhiFang, JaeHongHwang, JoongSooKim, SungJunJung, SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 7 45-49 (5 pages)
1.2, 1.3 and 1.4) channels [4]; α1A encodes P/Q-type (Cav2.1) channels [5]; α1B encodes N-type (Cav2.2) channels [6]; α1E encodes R-type (Cav2.3) channels [7]. Six isoforms of the R-type Cav2.3 Ca 2+ channel (Ca v2.3a∼ Cav2.3f) have been reported in various mammalian species [8-12]. R-type Ca 2+ channels are also present in DRG neu- rons [2], and have been suggested to play a critical... few medium-sized neurons (n=2/14) and not in large-sized neurons, indicating the prominence of Cav2.3e in nociceptive DRG neurons. Moreover, Cav2.3e was preferentially expressed in tyrosine-kinase A (trkA)-positive, iso</SUB>lectin B4 (IB4)-negative and transient receptor potential vanilloid 1 (TRPV1)-positive neurons. These results suggest that Cav2.3e may be the main R-type Ca2+ channel isoform in nociceptive DRG neurons and thereby a potential target for pain treatment, not only in the... -
Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons
HaiYingLi, ByungKyLee, JoongSooKim, SungJunJung, SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 5 315-322 (8 pages)
CaV2.3 calcium channel currents by eugenol. J Dent Res 87: 137141, 2008 Cook SP, McCleskey EW. Desensitization, recovery and Ca(2＋)- dependent modulation of ATP-gated P2X receptors in nociceptors. Neuropharmacology 36: 1303 1308, 1997 Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387: 505508, 1997 Cook... Eugenol is widely used in dentistry to relieve pain. We have recently demonstrated voltage-gated Na＋ and Ca2＋ channels as molecular targets for its analgesic effects, and hypothesized that eugenol acts on P2X3, another pain receptor expressed in trigeminal ganglion (TG), and tested the effects of eugenol by whole-cell patch clamp and Ca2＋ imaging techniques. In the present study, we investigated whether eugenol would modulate 5'-triphosphate (ATP)-induced currents in rat TG neurons and... -
Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca2＋ Channels in Neonatal Rat Ventricular Cardiomyocytes
OlegV.Yarishkin, EunMiHwang, DonggyuKim, JaeChealYoo, SangSooKang, DeokRyoungKim, Jae-Hee-JungShin, Hye-JooChung, Ho-SangJeong, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 5 437-442 (6 pages)
in rat hearts, Cav1.2, Cav2.3, Cav3.1, and Cav3.2. The level of Cav3.1 and Cav3.2, the phen otypes of the T-type Ca 2＋ channel, is not changed significantly during development and become undetectable at five weeks postpartum. Cav2.3, an R-type Ca 2＋ channel, gradually declines after four weeks, when it reaches its peak expression. Of the four channel types, the phenotype of LCC, Cav1.2 is... A non-steroidal anti-inflammatory drug (NSAID) has many adverse effects including cardiovascular (CV) risk. Diclofenac among the nonselective NSAIDs has the highest CV risk such as congestive heart failure, which resulted commonly from the impaired cardiac pumping due to a disrupted excitation- contraction (E-C) coupling. We investigated the effects of diclofenac on the L-type calcium channels which are essential to the E-C coupling at the level of single ventricular myocytes isolated from...