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Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks
Min Young Kim, Hyun Woo Kim, Jin Hong Park, Jun Sung Kim, Hwa Jin, Seo Hyun Moon, Kook Jong Eu, Hyun Sun Cho, Gami Kang, Yoon Sh 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 14 379-385 (7 pages)
if the test material treatment resulted in an agent-specific mutation profile. Our study revealed that the most common type of mutations in treated male and female mice was transversion with few transitions. Such dominat transversion may be responsible for mixture-induced genotoxicity in our study. In fact, Masumura et al. [23] found that long term treatment of 2-amino-3,8-dimethylimidazo[4,5-f]... Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibuthyl phthalate (DBP) on ozone were investigated after 32- and 52-wk exposures using hprt mutation assay. Male and female B6C3F1 mice exposed to ozone (0.5 ppm), NNK (1.0 mg/kg), DBP (5,000 ppm), and two or three combinations of these toxicants 6 h per day for 32- and 52-wk showed increases in the frequencies of TG rlymphocytes compared to the control groups. Additive interactions were... -
Theobroxide Treatment Inhibits Wild Fire Disease Occurrence in Nicotiana benthamiana by the Overexpression of Defense-related Genes
한국식물병리학회 The Plant Pathology Journal 6 Pages
한국식물병리학회 The Plant Pathology Journal 2013, 29권 1호 14 110-115 (6 pages)
of resistance. Among the genes, the theobroxide treatment increased the expression of patho- genesis-related protein 1a (PR1a), pathogenesis-related protein 1b (PR1b), glutathione S-transferase (GST), allen oxide cyclase (AOC), and lipoxyganase (LOX). All these data strongly indicate that theobroxide treatment inhibits disease development by faster induction of defense responses, which can be... symptoms, and growth of the bacterial cells was significantly retarded. Semiquantitative RT-PCRs using the primers of 18 defenserelated genes were performed to investigate the molecular mechanisms of resistance. Among the genes, the theobroxide treatment increased the expression of pathogenesis- related protein 1a (PR1a), pathogenesis-related protein 1b (PR1b), glutathione S-transferase (GST), allen oxide cyclase (AOC), and lipoxyganase (LOX). All these data strongly indicate that theobroxide... -
Influence of category−heifers, primiparous and multiparous lactating cows−in a large-scale resynchronization fixed-time artificial insemination program
Márcio de Oliveira Marques, Fábio Morotti, Camila Bizarro da Silva, Mario Ribeiro Júnior, Rubens C&am 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 15 367-371 (5 pages)
1 to 5 [1] were used for the FTAI program. The herds were kept in an extensive system that allowed for continuous grazing of Brachiaria spp. and were given ad libitum access to mineralized salt and water. Hormonal treatment On a random day of the estrous cycle (Day 0), heifers (n = 903), primiparous lactating cows (n = 338) and multiparous lactating cows (n = 1,223) underwent a conventional... large scale resynchronization ovulation program. Nelore heifers (n = 903), primiparous lactating cows (n = 338) and multiparous lactating cows (n = 1,223) were synchronized using a conventional protocol of estradiol/P4-based fixed-time artificial insemination (FTAI). Thirty days after ultrasonography, females who failed the first FTAI were resynchronized with the same hormonal protocol prior to a second FTAI. The pregnancy status of each cohort was evaluated by ultrasonography 30 days after each... -
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain
MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)
longer effect than GBT or EA alone, and this analgesic effect was mediated by spinal opioi- dergic and/or a2-adrenergic receptors. These results suggest that combination treatment with GBT and EA could be used as an alternative method for reducing paclitaxel-induced neuropathic pain. ACKNOWLEDGEMENTS This work was supported by a grant from Kyung Hee Uni- versity in 2016 (KHU-20160548) and by a... receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced cold and mechanical allodynia, which were assessed by the acetone drop test and von Frey filament assay, respectively. Significant signs of allodynia were observed after four paclitaxel injections (a cumulative dose of 8... -
Effect of subcutaneous treatment with human umbilical cord blood-derived multipotent stem cells on peripheral neuropathic pain in rats
MinJuLee, TaeGyoonYoon, MoonkyuKang, HyunJeongKim, KyungSunKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 2 153-160 (8 pages)
a new treatment strategy for treatment of neuropathic pain is necessary and transplantation of stem cells, a novel therapeutic modality developed for intractable neurological diseases, is a potential alternative. Compared to stem cells of embryonic, bone marrow, and adipose origin, human umbilical cord blood-derived multipotent Original Article Effect of subcutaneous treatment with human... In this study, we aim to determine the in vivo effect of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) on neuropathic pain, using three, principal peripheral neuropathic pain models. Four weeks after hUCBMSC transplantation, we observed significant antinociceptive effect in hUCB-MSC– transplanted rats compared to that in the vehicle-treated control. Spinal cord cells positive for c-fos, CGRP, p-ERK, p-p 38, MMP-9 and MMP 2 were significantly decreased in only CCI... -
NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices
SeJoonChoi, KiJungKim, HyeongSeokCho, SeongYunKim, Dong-SeokYim, Young-JinCho, SangJuneHahn, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 2 303-308 (6 pages)
malized to the baseline mean amplitude. The representative traces of PSs shows ACSF (a), PTX treatment (b), and ethanol treatments (c). (B) The bar graph shows the average changes of PSs durin g treatment of PTX only and PTX with ethanol. #p <0.05 when PSs amplitudes changes by PTX treatment compared to the normal ACSF, *p<0.05 when PSs amplitudes changes by coapplication o f PTX with ethanol... The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs striatal function. Ethanol caused a decrease in population spike amplitudes in a dose dependent manner (50∼200 mM). Pretreatment with picrotoxin, a γ-amino butyric acid (GABA)A receptor antagonist, increased the population spikes but ethanol (100 mM) was still effective in... -
Combination of Electroconvulsive Therapy and Clozapine in Treatment-Resistant Schizophrenia
Jung Hyun Kim, Tak Youn, Jun Gwon Choi, Seong Hoon Jeong, Hee Yeon Jung, Yong Sik Kim, In Won Chung 대한신경정신의학회 Psychiatry Investigation 7 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 13 829-835 (7 pages)
in Asian patients with treatment-resistant schizophrenia has the same effect over racial diferences. 8,36-38 An acute course of ECT is benefcial for relieving psychiat- ric symptoms, 39 but the relapse rate is relatively high afer the end of ECT, mainly reported in mood disorders. 40,41 Confict- ing results of ECT for the treatment of schizophrenia 39 and scarce evidence regarding adjunctive... during five years of pre-determined period were recruited from Electronic Medical Record. Clinical effects of acute ECT on psychotic symptoms were investigated. We also tried to identify predictive variables requiring maintenance treatment of ECT. Results_Fourteen patients received ECT and clozapine and sixteen were treated with clozapine alone. In the ECT group, which could be refined as clozapine-resistance, PANSS total score was significantly reduced by 19.0±9.9 points, corresponding to a... -
Effect of Bacillus mesonae H20-5 Treatment on Rhizospheric Bacterial Community of Tomato Plants under Salinity Stress
Shin Ae Lee, Hyeon Su Kim, Mee Kyung Sang, Jaekyeong Song, Hang-Yeon Weon 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 15 662-671 (10 pages)
sequencing of the bacterial 16S rRNA gene. Although the abundance of H20-5 rapidly decreased in the bulk and rhizosphere soils, a shift in the bacterial community was observed following H20-5 treatment. The variation in bacterial communities due to H20-5 treatment was higher in the rhizosphere than in the bulk soils. Additionally, the bacterial species richness and diversity were greater in... soils, a shift in the bacterial community was observed following H20-5 treatment. The variation in bacterial communities due to H20-5 treatment was higher in the rhizosphere than in the bulk soils. Additionally, the bacterial species richness and diversity were greater in the H20-5 treated rhizosphere than in the control. The composition and structure of the bacterial communities varied with soil salinity levels, and those in the H20-5 treated rhizosphere soil were clustered. The members of... -
Suppression of Green and Blue Mold in Postharvest Mandarin Fruit by Treatment of Pantoea agglomerans 59-4
한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2010, 26권 4호 8 353-359 (7 pages)
days after inoculation. Twenty fruits with four wounds per fruit were used at each treatment. There were three replicates per treatment. Population dynamics of Pa 59-4 on mandarin fruit surface. Population dynamics of Pa 59-4 were evaluated on wounded and unwounded mandarin fruits. The fruits were treated with 2 × 10 8 cfu/ml of Pa 59-4 as described above. The treated fruits were incubated at 20... In order to control postharvest spoilage of satsuma mandarin fruits, rhizobacteria were isolated from soil samples. The Pantoea agglomerans strain 59-4 (Pa 59-4) which suppresses the decay of mandarin fruit by green and blue mold, was tested for the control efficacy and its mode of action was investigated. Pa 59-4 inhibited infection by green and blue mold on wounded mandarins, which were artificially inoculated with a spore suspension of Penicillium digitatum and P. italicum with control... -
Effects of a Case-Based Sepsis Education Program for General Ward Nurses on Knowledge, Accuracy of Sepsis Assessment, and Self-efficacy
Kim Bohyun, Jeong Younhee 한국기초간호학회 Journal of Korean Biological Nursing Science 11 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2020, Volume 22, No 4 4 260-270 (11 pages)
to the control, intervention I, or inter- vention II groups by matching unit characteristics. Study participants were recruited using bulletin boards and the Internet. To prevent con- tamination of treatment, interventions were provided per units. Pretests including knowledge of sepsis, accuracy of sepsis assessment, and self- efficacy on sepsis management were done prior to the educational pro-... case-based education program with and without smartphone applications to the nurses and tested the effects of the program on knowledge, the accuracy of sepsis assessment, and self-efficacy as outcome variables. A total of 60 nurses in general units participated. To test differences in knowledge, the accuracy of sepsis assessment, and self-efficacy regarding sepsis between the groups over time, a mixed-design ANCOVA was used for parametric analysis, and generalized estimating equations (GEE) were...


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