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Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 2 431-437 (7 pages)
C. Suppression of colorectal cancer subcutaneous xenograft and experimental lung metastasis using nanoparticle-mediated drug delivery to tumor neovasculature. Biomaterials 2014, 35, 1215-1226. 30. Zhang P, Hao H, Li J, Ahmad I, Cheng G, Chen D, Tao Y, Huang L, Wang Y, Dai M. The epidemiologic and pharmacodynamic cutoff values of tilmicosin against Haemophilus parasuis. Front Microbiol 2016,... A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet... -
Effect of superovulation on uterine and serum biochemical parameters and its potential association with transferable embryos in Holstein dairy cows
Hasina Santatriniaina Rasolomboahanginjatovo, Younès Chorfi*, Raynald Dupras, Louis Mills, Réjean Lefebvre 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 14 273-281 (9 pages)
of establishing pregnancy after transfer, maintaining normal development and resuming pregnancy with the delivery of healthy offspring. Multiple variables constrain SOV success in dairy cattle and reduce the predictability of the number of TE [35]. Variability in ovarian response has been shown to be related to factors such as gonadotrophin preparation, batch and total dose, duration and... The objective of this study was to determine the effects of superovulation (SOV) on serum and uterine biochemical parameters, uterine bacteriology and cytology and number of transferable embryos (TE). Dairy cows were placed on a Presynch/CIDR Synch protocol. The SOV group was superovulated, induced in estrus, and inseminated, whereas the control group was induced in estrus and inseminated without SOV. Uterine bacteriology and cytology and uterine and serum biochemical parameters were measured at... -
Comparison of a small volume of hypertonic saline solution and dextran 40 on hemodynamic alternations in conscious calves
Kazuyuki Suzuki, Tomoko Suzuki, Mitsuyoshi Miyahara, Shigehiro Iwabuchi, Ryuji Asano 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 2호 4 111-116 (6 pages)
shock. Vet Clin North Am Small Anim Pract 1998, 28, 623-644. 12.Meadow WL, Rudinsky BF. Effects of dextran infusion on cardiac output, oxygen delivery, and oxygen utilization in piglets during the first month of life. Crit Care Med, 1990, 18, 980-984. 13.National Research Council. Guide for the Care and Use of Laboratory Animals. pp. 1-70, National Academy Press, Washington DC, 1996. 14.Naylor JM.... The hemodynamic effects of rapid intravenous (IV) administration of 10% dextran 40 in saline solution (D40) and 7.2% hypertonic saline solution (HSS) in calves were compared. Calves received isotonic saline solution (ISS), HSS or D40 (3 calves/group) and were monitored of blood pressure, and cardiac output (CO) for 180 min. HSS and D40 infusions induced a significant increase in relative plasma volume reaching 134.9 ± 2.8 and 125.0 ± 1.9%, respectively at the end of fluid infusion. In the HSS... -
Original Article : Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats
Jin Joo Hue , Hu Jang Lee , Sang Yong Jon , Sang Yoon Nam , Young Won Yun , Jong Soo Kim , Beom Jun Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 4호 8 245-252 (8 pages)
imaging and drug delivery. Adv Drug Deliv Rev 2008, 60, 1252-1265. 25. Rana S, Gallo A, Srivastava RS, Misra RDK. On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics. Acta Biomater 2007, 3, 233-242. 26. Riggio C, Calatayud MP, Hoskins C, Pinkernelle J, Sanz B, Torres TE, Ibarra MR, Wang L, Keilhoff G, Goya... -
Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 6 525-538 (14 pages)
W, Luo Z, Yang L. Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic en- vironment in aging mice. Aging Cell. 2018;17:e12741. 60. Yang QH, Liang Y, Xu Q, Zhang Y, Xiao L, Si LY. Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with... Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several... -
Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats
MinJiKim, YoungHongPark, KuiYeYang, JinSookJu, YongChulBae, SeongKyuHan, DongKukAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 8 65-74 (10 pages)
up-regulated expression of NKCC1 mRNA was observed in the superficial, but not deep spinal dorsal horn [36]. Moreover, an intracolonic capsaicin injection was shown to induce NKCC1 membrane delivery and phosphorylation in the dorsal spinal cord [37]. Therefore, up-regulated NKCC1 activity under inflammatory conditions leads to changes in the anion gradient in postsynaptic neurons, which can... Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing 230-280 g. Subcutaneous injection of interleukin 1 beta (IL-1β) (1 ng/10 μL) was used to produce mechanical allodynia and thermal hyperalgesia. Intracisternal administration of bicuculline, a gamma aminobutyric acid A (GABAA) receptor antagonist, produced mechanical... -
A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents
PuneetKaurRhawa, KavinderSingh, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 1 279-288 (10 pages)
colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. Eur J Pharmacol. 2013;718:145-153. 86. Huang Z, Jiang Y, Yang Y, Shao J, Sun X, Chen J, Dong L, Zhang J. 3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppre ssion and Treg induction. Mol Immunol. 2013;53:335-344. 87. Daniel C, Sartory NA, Zahn N, Schmidt R,... Ulcerative colitis and Crohn’s disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain, development of various animal models provides new insights to unveil the onset and the progression of IBD. Various chemical-induced colitis models are widely used on laboratory scale. Furthermore, these... -
Overexpression of AMPKα1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats
EunhuiSeo, Eun-JinPark, YeonsooJoe, SoojeongKang, Mi-SunKim, Sook-HeeHong, Mi-KyoungPark, DukKyuKim, HyongjongKoh, Hye-JeongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 7 449-454 (6 pages)
gene transfer Tissue was analyzed on 7th day after Ad.AMPK α1 in- fection to assess its delivery and activity in rats. We checked for AMPKα protein activity in the liver of infected rats with a non-radioactive AM PK activity assay (Fig. 1A). AMPK activity levels were considerably increased by days 7 after Ad.AMPKα1 infection. We also assessed phosphor- ylation of AMPKα and ACC, a substrate... 5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (Ձ) and two regulatory (Ղ and Ճ) subunits. Two isoforms are known for catalytic subunit (Ձ1, Ձ2) and are encoded by different genes. To assess the metabolic effects of AMPKՁ1, we examined the effects of overexpression of adenoviral-mediated AMPKՁ1 in hyperlipidemic type 2 diabetic rats. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an established animal... -
Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain
Hwi-SeokJung, Hong-BinJeon, Ik-SungJeon, Bum-JunLee, Hyun-WooYoo, Dong-KukAhn, Dong-HoYoun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 8 379-383 (5 pages)
in the spinal cord, intrathecal delivery of 8-bromo-cGMP, a cGMP analog, at a low concentration interestingly inhibited nociceptive behaviors in formalin tests, whereas that at a higher concentration increased the behaviors (Tegeder et al., 2002), contemplating that different NO levels by different manipu lation tools can produce oppo- site processing of nociception (Sousa and Prado, 2001;... Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. In the spinal cord, it has been demonstrated that NO acts as pronociceptive or antinociceptive mediators, apparently in a concentration-dependent manner. However, the central role of NO in the trigeminal nucleus remains uncertain in support of processing the orofacial... -
Maternal Social Separation of Adolescent Rats Induces Hyperactivity and Anxiolytic Behavior
HyongRyolKwak, JaeWonLee, Kwang-JunKwon, ChangDonKang, IlYoungCheong, WanjooChun, Sung-SooKim, HeeJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 2 79-84 (6 pages)
The day of delivery was designated as postnatal day (PND) 0. All experiments were conducted in accordance with National Institutes of Health guidelines on animal care and experiments. Every effort was made to minimize the num- ber of animals used and to reduce their suffering. Maternal social separation On PND 14, ten male pups were separated from their dam and siblings and housed singly in a... Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were separated on postnatal day 14 from their dam and litters (maternal social separation, MSS) showed hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS...