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Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing
Hyeon-Joong Kim, Joon Young Kim, Byung-Hwan Lee, Sun-Hye Choi, Hyewon Rhim, Hyoung-Chun Kim, Seoung-Yob Ahn, Soon-Wuk Jeong, Min 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 16 387-397 (11 pages)
C 18:2, LPA C16:0, LPA C18:1, and ginseng proteins [11]. Gintonin consists of about 9.5% LPAs and induces [Ca 2+]i transients through plasma membrane LPA receptor signal transduction with high affinity [11]. In addition, gintonin regulates various Ca 2+-dependent ion channels and receptors [6,25]. Other studies have shown that gintonin-induced ..PAGE:2 388 Hyeon-Joong Kim et al. Journal of... Ginseng gintonin is an exogenous ligand of lysophosphatidic acid (LPA) receptors. Accumulating evidence shows LPA helps in rapid recovery of corneal damage. The aim of this study was to evaluate the therapeutic efficacy of gintonin in a rabbit model of corneal damage. We investigated the signal transduction pathway of gintonin in human corneal epithelium (HCE) cells to elucidate the underlying molecular mechanism. We next evaluated the therapeutic effects of gintonin, using a rabbit model of... -
The effect of conglutinin on production of reactive oxygen species in bovine granulocytes
Marta Dec*, Andrzej Wernicki, Andrzej Puchalski, Renata Urban-Chmiel, Adam Wa?ko 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 5 33-38 (6 pages)
the selective affinity of this lectin to high mannose oligosaccharides in the α-chain of iC3b [11]. It has been suggested that absorption of conglutinin by the activated complement component iC3b or directly by microorganisms is the cause of low conglutinin serum levels during acute infections like pneumonia or metritis [8]. Other study showed that conglutinin has antibacterial properties... Conglutinin is a high molecular-weight lectin originally detected in bovine serum. It belongs to the family of collectins that bind sugar residues in a Ca-dependent manner and are effector molecules in innate immunity. Conglutinin appears to play an important role in immune defense mechanisms, showing antiviral and antibacterial activities when tested in vivo and in vitro. The present study evaluated the effect of conglutinin on the respiratory bursts in bovine peripheral phagocytes. Using... -
The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens
Feng Wang, Xiaowei Wang, Hongbo Chen, Jianzhu Liu, Ziqiang Cheng* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 3호 6 235-241 (7 pages)
and 160 g, respectively while negative control birds had an average weight of 440 g. The affinity of ALV-J for lymphoid tissues results in severe morphological alterations of the spleen, thymus, and bursa followed by suppression of the host immune system. These changes appears to be a unifying aspect of ALV-J acute pathogenicity. In the spleen, an increasing relative weight during the first... The critical time of avian leukosis virus subgroup J (ALV-J)-mediated immunosuppression was determined by body weight, relative immune organ weight, histopathology, and presence of group specific antigen and antibodies in specific pathogen-free (SPF) chickens. CD4 and CD8 cell activity in the spleen, total and differential leukocyte counts in blood, and viral RNA levels in spleen were measured. Significant growth suppression was observed in the two ALV-J-infected groups. A strong immune response... -
Two-dimensional gel electrophoresis and immunoblot analysis of Neospora caninum tachyzoites
Eung-Goo Lee, Jae-Hoon Kim, Yong-Seung Shin, Gee-Wook Shin, Yong-Hwan Kim, Gon-Sup Kim, Dae-Yong Kim, Tae-Sung Jung, Myung-Deuk 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 8 139-145 (7 pages)
band. Among them, spot 61 was suspected as a major antigenic spot in 2-DE antigen profiles. Dense granule associated in 33 kDa protein (NCDG1) was subcloned and identified [28]. On the other hand, affinity purified anti-Nc-p33 antibodies were uniquely recognized against 33 kDa band by immunoblot performed under both reducing and non- reducing conditions [18]. Spot 59 was assumed corresponding to... Identification of expressed protein profiles and antigenic determination are some of the most challenging aspects of proteomics. Two-dimensional gel electrophoresis (2-DE) combined with immunoblot analysis were employed to study the N. caninum proteome. Protein sample preparation was carried out by first conducting sonication, followed by adding lysis buffer containing 7M urea plus 2M thiourea to the purified tachyzoites in order to complete disruption. A total of 335 differentially expressed... -
Genetic and biological characteristics of recent Korean isolates of avian influenza virus subtype H9N2
Madhav Prasad Acharya , Hyuk Joon Kwon , Il Hwan Kim , Youn Jeong Lee , Jae Hong Kim 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 4호 1 223-230 (8 pages)
in the receptor binding specificity. The presence or absence of 158N-glycan in the vicinity of receptor binding sites on HA is associ- ated with decreases or increases receptor-binding affinity, respectively. Fig. 2. Comparison of the deduced amino acid sequences at the neuraminidase (NA) stalk region among avian influenza virus (AIV) H9N2 strains. Deletion is indicated by dashes. Deletion of 2... -
Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
Dong Ho Bak, Mi Ji Choi, Soon Re Kim, Byung Chul Lee, Jae Min Kim, Eun Su Jeon, Wonil Oh, Ee Seok Lim, Byung Cheol Park, Moo Joong Kim, Ju 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 9 555-566 (12 pages)
on cellular growth and forms complexes with specific binding proteins (BPs) [41]. There are six insulin-like growth factor binding proteins (IGFBP-1~-6), which bind to IGF-1 and -2 with very high affinity [41]. Because their affinity to IGFBP is 2- to 50-fold greater than that of IGF-IR, these IGFBPs can modulate the distribution of IGF among the proteins in interstitial fluids [41]. In this... Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair... -
The activation of α2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality
Sung-SuKim, Soo-HyunPark, Jae-RyungLee, Jun-SubJung, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 5 495-507 (13 pages)
in experimental sepsis. Crit Care. 2009;13:R11. 17. Asano T, Dohi S, Ohta S, Shimonaka H, Iida H. Antinociception by epidural and systemic alpha(2)-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg. 2000; 90:400-407. 18. Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R, ..PAGE:12 506 https://doi.org/10.4196/kjpp.2017.21.5.495 Korean J... The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 µg/27 µl) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine (5 µg/5 µl) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with... -
Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats
MinJiKim, YoungHongPark, KuiYeYang, JinSookJu, YongChulBae, SeongKyuHan, DongKukAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 8 65-74 (10 pages)
ions. Both NKCCs and KCCs are chloride ion transporters in neurons and modulate the intracellular chloride ion concentrations. Generally, bumetanide has an approximately 500-fold greater affinity for NKCC1 than for KCC2 [34,35]. Our data indicate that intracisternal administration of a high dose of bumetanide (200 μg), but not low doses of bumetanide, decreases air-puff thresholds in naive... Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing 230-280 g. Subcutaneous injection of interleukin 1 beta (IL-1β) (1 ng/10 μL) was used to produce mechanical allodynia and thermal hyperalgesia. Intracisternal administration of bicuculline, a gamma aminobutyric acid A (GABAA) receptor antagonist, produced mechanical... -
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat
JeongHoonLee, JeongMiHa, ChaeHunLeem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 10 373-382 (10 pages)
W, Lechleiter JD. Chemical calcium indicators. Methods. 2008;46:143-151. 27. Hyrc KL, Bownik JM, Goldberg MP. Ionic selectivity of low- affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC. Cell Calcium. 2000;27:75-86. 28. Dong Z, Saikumar P, Griess GA, Weinberg JM, Venkatachalam MA. Intracellular Ca 2+ thresholds that determine survival or death of energy-deprived cells. Am... of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which can also generate great interference, mainly from nicotinamide adenine dinucleotide (NADH) autofluorescence. Specifically, this limitation causes serious problems for the quantitative measurement of mitochondrial [Ca2+], as no available ratiometric dyes are excited in the visible range. Thus, NADH interference cannot be avoided during quantitative measurement of [Ca2+] because the...