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Human Microbiome 연구개발 동향분석
박정민, 이지혜, 홍석인, Park. Jung-Min, Lee. Ji-Hye, Hong. Seok-In 한국식품과학회 식품과학과 산업 12 Pages
한국식품과학회 식품과학과 산업 2014, Vol.47 No.2 80-91 (12 pages)
방법을 도입하여 연구트렌드를 분석함으로써 연구테마 및 아이템을 발굴하는데 시사점을 제공 할 수 있다. 미국 NIH에서는 인체 미생물체의 메타지노믹스 연구를 시작하는 등 선진국을 중심으로 제2의 휴먼지놈프로젝트라고 불리는 장내미생물 균총에 대한 연구결과가 속속 제시되고 있다. 이런 측면에서 human microbiome 연구동향을 분석하여 식품 관련연구에 활용하기 위해 특허와 논문의 서지정보를 활용하여 정량적인 분석을 시도하였다. 분석대상은 1992년 이후로 2011년 말까지 전세계에 출원된 human microbiome 관련 특허와... -
Diversity of the Gastric Bacterial Microbiome in Thoroughbred Racehorses Having Gastric Ulcer
Hee Jin Dong, Hung wui Ho, Hye shin Hwang, Woo hyun Kim, Yong baek Kim, Janet Han, In hyung Lee, Seong beom Cho 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 85 182-183 (2 pages)
the combination treatment of cAT-MSC-IFN-β and low-dose cisplatin induced high levels of cell apoptosis. Conclusions: Cell therapy using AT-MSCs demonstrated an anti-tumor effect on canine and human melanomas, suggesting a possible therapeutic option for this type of cancer. These findings may provide valuable information warranting further explorations of the application of the combined... -
Anti-tumor Effects of Canine and Human Adipose Tissue-derived Mesenchymal Stem Cells in a Xenograft Mouse Model for Melanoma
Jin ok Ahn, Ye rin Coh, Hee woo Lee, Il seob Shin, Sung keun Kang, Hwa young Youn 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 84 182-182 (1 pages)
the combination treatment of cAT-MSC-IFN-β and low-dose cisplatin induced high levels of cell apoptosis. Conclusions: Cell therapy using AT-MSCs demonstrated an anti-tumor effect on canine and human melanomas, suggesting a possible therapeutic option for this type of cancer. These findings may provide valuable information warranting further explorations of the application of the combined... -
Gut microbiome responses of pigs to a high dose of deoxynivalenol (DON) in feed
Ho Seong Cho, Sung Hyun Moon, Yeonsu Oh, Won Il Kim, Byoung Joo Seo 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 39 198-199 (2 pages)
ed withthe CTL group. The intestinal microbiome of the DON group did not present a variable and abundant pattern compared with that of the CTL group. The fecal microbiome of the CTL group showed 2,981 OTUs, which consisted of 18 families including Rhodospirillaceae. However, the DON group had 321 OTUs and three families, which were Pasteurellaceae, Clostridiaceae and Lactibacillaceae.... -
Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium
AranSon, DongMinShin, JeongHeeHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 8 51-58 (8 pages)
X. The oral microbiome diversity and its relation to human diseases. Folia Microbiol (Praha). 2014. [Epub ahead of print] 30. Volz T, Nega M, Buschmann J, Kaesler S, Guenova E, Peschel A, Rocken M, Gotz F, Biedermann T. Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclu- sively in the presence of TLR... however, the exact mechanism of calcium signaling induced by bacterial toxins when gingival epithelial cells are exposed to pathogens is unclear. Here, we investigate calcium signaling induced by bacteria and expression of inflammatory cytokines in human gingival epithelial cells. We found that peptidoglycan, a constituent of gram- positive bacteria and an agonist of toll-like receptor 2, increases intracellular calcium in a concentra-tion-dependent manner. Peptidoglycan-induced calcium signali... -
Induced Systemic Resistance and the Rhizosphere Microbiome
한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2013, 29권 2호 3 136-143 (8 pages)
the human gut microbiome, the microbiome as- sociated with the plant root is staggeringly complex (Berendsen et al., 2012). Around 3000 culturable soil fungi have been described (Gams, 2007), but this number will undoubtedly increase with the application of molecular techniques (Anderson and Cairney, 2004). In sugar beet rhizosphere soil over 33,000 bacterial and archaeal opera- tional taxonomic... of species. This so-called microbiome controls plant health through several mechanisms including the suppression of infectious diseases, which is especially prominent in disease suppressive soils. The mechanisms implicated in disease suppression include competition for nutrients, antibiosis, and induced systemic resistance (ISR). For many biological control agents ISR has been recognized as the mechanism that at least partly explains disease suppression. Implications of ISR on recruitment and... -
Toward The Fecal Microbiome Project
운노 타쯔야, Unno. Tatsuya 한국미생물학회 미생물학회지 4 Pages
한국미생물학회 미생물학회지 2013, Vol.49 No.4 415-418 (4 pages)
위한 인간 미생물군집 프로젝트(human microbiome project, HMP)가 최근에 완료되었다. HMP는 세균에 의해 발생하는 여러 질병들의 특성들을 밝혀내었고, 특히 장에 서식하는 세균들에 대해 많은 연구가 수행되었다. 비록 인간의 장내 세균들에 대한 연구는 잘 수행되어왔지만, 다른 가축의 장내 세균에 대한 연구는 거의 이루어지지 않았다. 본 연구에서는 가축의 분변 미생물 다양성에 관해 조사하였고, 분변미생물 생태연구의 중요성을 제시 할 것이다. 한국에서의 분변 미생물 군집 프로젝트(fecal microbiome project) 시작을 본... -
Porcine intestinal lymphoid tissues synthesize estradiol
Chan Jin Park, Heehyen Kim, Jooyoung Jin, Radwa Barakat, Po-Ching Lin, Jeong Moon Choi, CheMyong Jay Ko 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 1 477-482 (6 pages)
V. The gut microbiome in autoimmunity: sex matters. Clin Immunol 2015, 159, 154-162. 11. Harada N, Sasano H, Murakami H, Ohkuma T, Nagura H, Takagi Y. Localized expression of aromatase in human vascular tissues. Circ Res 1999, 84, 1285-1291. 12. Hata S, Miki Y, Saito R, Ishida K, Watanabe M, Sasano H. Aromatase in human liver and its diseases. Cancer Med 2013, 2, 305-315. 13. Jung C, Hugot... Estradiol (17-estradiol) is synthesized primarily in the gonads of both sexes and regulates the development and function of reproductive organs. Recently, we reported that intestinal lymphocyte homeostasis is regulated by estradiol synthesized de novo in the endothelial cells of the high endothelial venules (HEVs) of mesenteric lymph nodes and Peyer’s patches in mice. This observation prompted us to hypothesize that HEVs of intestinal lymphoid tissues are sites of estradiol synthesis...