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Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis
AranSon, MinSeukKim, HaeJo, HaeMiByun, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 5 31-36 (6 pages)
..PAGE:1 31 Korean J Physiol Pharmacol Vol 16: 31－36, February, 2012 http://dx.doi.org/10.4196/kjpp.2012.16.1.31 ABBREVIATIONS: RANKL, receptor activator of NF-κB ligand; TRAF6, tumor necrosis factor receptor-associated factor 6; IP3, inositol 1,4,5-trisphosphate; BMMs, bone marrow-derived monocyte/ macrophage precursor cells; PLC, phospholipase C. Received October 27, 2011, Revised December... The receptor activator of NF-ՊB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-ՊB and other signal transduction pathways essential for osteoclastogenesis, such as Ca2＋ signaling. However, the intra</SUP>cellular levels of inositol 1,4,5-trisphosphate (IP3) and IP3-mediated cellular function of RANKL during osteoclastogenesis are not known. In the present study, we determined the levels of...