자료유형
전체 선택해제
총 14건 검색
본문검색 결과만 보기
-
Pathology of non-thermal irreversible electroporation (N-TIRE)-induced ablation of the canine brain
John H. Rossmeisl Jr., Paulo A. Garcia, John L. Roberston, Thomas L. Ellis, Rafael V. Davalos 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 4호 9 433-440 (8 pages)
of the brain (Fig. 5A). Remnant neurons within the treated regions were shrunken with hypereosinophilic and angular cytoplasm as well as nuclear pyknosis or chromatolysis (Fig. 5B). Multifocal aggregates of inflammatory cells including neutrophils, lymphocytes, macrophages, and gitter cells were also found within the treated regions (Figs. 5B and C). Free glial nuclei in various states of... This study describes the neuropathologic features of normal canine brain ablated with non-thermal irreversible electroporation (N-TIRE). The parietal cerebral cortices of four dogs were treated with N-TIRE using a dose-escalation protocol with an additional dog receiving sham treatment. Animals were allowed to recover following N-TIRE ablation and the effects of treatment were monitored with clinical and magnetic resonance imaging examinations. Brains were subjected to histopathologic and... -
The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek's disease virus exposure
Yongbaek Kim, Thomas P. Brown and Mary J. Pantin-Jackwood 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 7 49-58 (10 pages)
An 8 week-old chicken from PBS treated/ infected group. Small aggregates of myeloid cells within the interstitium. Bar=100 m ..PAGE:7 ALV-J and cyclophosphamide 55 CY treatment. By flow cytometric analysis, the relative population of CD3-positive lymphocytes was higher in CY treated birds, indicating a decrease in CD3-negative lymphocytes, presumably the B-cell population. There was no significant... B cell specific immunosuppression throughout the experiment confirmed by decreased bursal weight, intact lymphocyte mitogenetic activity stimulated by Con A and increased relative subpopulation of CD3-positive cells as measured by flow cytometry. Chickens in this experiment had Mareks disease virus exposure prior to three weeks of age as determined by the presence of lymphocytic infiltration and antibody. Virus neutralizing antibody against ALV-J was first observed at 6 weeks post-infection in... -
Original Article : Comparison of teratogenecity induced by nano- and micro-sized particles of zinc oxide in cultured mouse embryos
A Young Jung , Ki Youn Jung , Chun Mei Lin , Jung Min Yon , Jong Geol Lee , Beom Jun Lee , Young Won Yun , Sang Yoon Nam 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2015, 제 55권 제 2호 9 133-139 (7 pages)
dissolution in distilled water. J Environ Monit 2011, 13, 1975-1982. 34. Zhu L, Chang DW, Dai L, Hong Y. DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett 2007, 7, 3592-3597. 35. Zhu X, Wang J, Zhang X, Chang Y, Chen Y. The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio). Nanotechnology 2009, 20, 195103. -
Case report : Metastatic lipid-rich mammary carcinoma in a dog
Myung Chul Kim , So Yeon Kim , Su Hyung Lee , Dae Yong Kim , Jung Hee Yoon , Wan Hee Kim , Jeong Ha Lee , Yongbaek Kim 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 4 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 4호 12 265-268 (4 pages)
in aggregates and clusters (Fig. 1A). The neoplastic cells were characterized by small to moderate amount of basophilic cytoplasm with variably-sized vacu- oles that peripheralized the nucleus (Fig. 1B). The nuclei were round to oval and had clumped to coarse chromatin, and single to multiple nucleoli with occasional macronucle- oli. Anisocytosis and anisokaryosis were moderate to marked. Bi- and... -
The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling
SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)
of adenylyl cyclase (AC), particularly the AC5 and AC6 iso- forms [46,47] that are present in the cardiomyocytes [48], and of the function of the Gs alpha subunit (G αs). Zn 2+ in- duces aggregates of pure tubu lin, implying the activation of G proteins by tubulin dimers [49]. This possible regu- lation of cAMP signaling by Zn 2+ will provide complex out- comes of cAMP and cAMP-protein kinase A... role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of Zn2+ activity has been presumed to parallel the degree of calcium’s participation in cellular processes. Whole body and cellular Zn2+ levels are largely regulated by metallothioneins (MTs), Zn2+ importers (ZIPs), and Zn2+ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion... -
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3
SuInLee, JieunYun, Ji-YoungBaek, Yun-JiJeong, Jin-AhKim, JongSoonKang, SunHongPark, SangKyumKim, Song-KyuPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 4 105-109 (5 pages)
4 days of incubation, the cellular aggregates were collected, trypsinized, and transferred into poly-d-ly- sine coated cell culture dishes . The cells were cultured in neurobasal medium containing N2 supplement for an addi- tional 5 days. Before treating the cells with Nogo-P4 and/or NEP1-40 peptides for 30 min, the differentiated cells were incubated for 16 h in the absence of N2 supplement.... NgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells using all trans-retinoic acid and the presence and/or function of cellular molecules, such as NgR1, NMDA receptors and STAT3, were examined. Neuronally differentiated P19 cells expressed the mRNA and protein of NgR1, which could stimulate the phosphorylation of STAT3 when activated... -
Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 6 107-114 (8 pages)
insoluble protein aggregates with β-pleated sheet struc- ture and thioflavin-S readily stains the intracellular neuro- fibrillary tangles in AD brain [21]. Thioflavin-S-positive in- clusions were not observed in T4- or T4-2EC- expressing cells (Fig. 4). However, T4C3 expressing cells showed thio- flavin-S-positive inclusions even in basal condition (Fig. 4). These data suggest that T4C3 is more... All tau species showed increased accumulation with 3-MA treatment whereas reduced with trehalose, indicating that tau undergoes autophagic degradation. However, T4C3 and T4-2EC showed abundant formation of oligomers than T4. Active GSK3Ղ in the presence of 3-MA resulted in significantly increased formation of insoluble tau aggregates. These results indicate that GSK3Ղ-mediated phosphorylation and compromised autophagic activity significantly contribute to tau aggregation. -
Inhibition of β-amyloid1-40 Peptide Aggregation and Neurotoxicity by Citrate
YongHoonPark, Young-JinKim, IlHongSon, HyunDukYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 2 273-279 (7 pages)
length Aβ peptide (Aβ1-40), which constitutes about 90% of the most abundant cleaved form of larger amyloid precursor protein (APP), and which has be en shown to have a toxic effect in the AD brain (Cao et al., 2007). In this study, we investigat ed the inhibitory effect of cit- rate on Aβ 1-40 aggregation and A β1-40 aggregates-induced cell damage and death in SH-SY5Y cell line. METHOD... hydrophilicity of AՂ1-40 molecules via hydrophilic/electrostatic interactions. We found that citrate significantly inhibited AՂ1-40 aggregation and significantly protected SH-SY5Y cell line against AՂ1-40 aggregates-induced neurotoxicity. In details, we examined the effects of citrate on AՂ1-40 aggregation and on AՂ1-40 aggregates-induced cytotoxicity, cell viability, and apoptosis. Th-T assays showed that citrate significantly inhibited AՂ1-40 aggregation in... -
A1 Receptor-mediated Protection against Amyloid Beta-induced Injury in Human Neuroglioma Cells
YongWoonCho, HyunJuJung, YongKeunKim, JaeSukWoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 1 37-43 (7 pages)
K + channels. DISCUSSION In the present study,a human astrocyte-derived glioma cell line,A172 cells,and Aβ25∼35 were used to produce an experimental model ofAβ-induced glial cell injury.Aβ25∼35 has been used in a number of studies and found to have many effects in common with full length Aβ1∼40/42 (Pike et al, 1995). The shortened fragment Aβ25∼35 contains the residues essential for... an experimental Aβ-induced glial cell injury model. Adenosine significantly prevented Aβ-induced apoptotic cell death. Studies using various nucleotide receptor agonists and antagonists suggested that the protection was mediated by A1 receptors. Adenosine attenuated Aβ-induced impairment in mitochondrial functional integrity as estimated by cellular ATP level and MTT reduction ability. In addition, adenosine prevented Aβ-induced mitochondrial permeability transition, release of cytochrome c... -
Barbiturates가 소의 신선한 대뇌피질 Synaptosomal Plasma Membrane Vesicles로 부터 추출하여 제제한 Phosphatidylethanolamine 인공세포막의 유동성에 미치는 영향
윤일(Il Yun), 김형일(Hyung-Il Kim), 황태호(Tae-Ho Hwang), 김종렬(Jong-Ryoul Kim), 김인세(In-Se Kim), 정용자(Yong-Za Chung), 신영희(Yong-Hee Shin), 정현옥(Hyun 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1990, 제 26권 제 2호 13 209-218 (10 pages)
or fluidize the hydrophobic regions of intact SPMV isolated from bovine brain. The barbiturates had little effects on the ratio of Py-3-Py in the unilamellar liposomes of SPMV total ..PAGE:7 lipids but the barbiturates decreased it in the unilamellar liposomes of SPMV phospholipids (un- published data: our laboratory). And the decrease in the fluorescence polarization, the... Barbiturates가 분자적 약리작용기전 탐구에 기초자료를 제공하기 위하여 소의 신선한 대뇌피질 synaptosomal plasma membrane vesicles로부터 분리제제한 phosphatidylethanolamine인공세포막(SPMVPE)의 유동성에 미치는 barbiturates의 영향을 형광 probe법으로 검색한 결과는 다음과 같다. 1. Pentobarbital, hexobarbital, amobarbital 및 phenobarbital이 기재한 순위로 SPMVPE내 Py-3-Py의 monomer 형광세기에 대한 excimer 형광세기의 비 (I /I)를 감소시켰다. 2. Pentobarbital, hexobarbital, amobarbital 및 phenobarbital이...