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Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice
MeeSookHong, JeongYoonSong, DongHwanYun, Jeong-JeCho, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 1 337-341 (5 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 13: 337 －341, October, 2009 DOI: 10.4196/kjpp.2009.13.5.337 337 ABBREVIATIONS: KO, knockout; LHA, lateral hypothalamic area; NADPH-d, nicotinamide adenine dinucleotide phosphate-diaphorase; NO, nitric oxide; NOS, nitric oxide synthase; PVN, paraventricular nucleus; STAT4, signal transducer and activator of transcription 4. Received May 25, 2009, Revised... Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central nervous system, IL12 also enhances the production of nitric oxide (NO), which regulates food intake. In this study, the expression of neuronal NO synthase (Nos1), which is also related to food intake, was investigated in the hypothalamic areas of Stat4 knockout (KO) mice using nicotinamide... -
Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli
JonghoLee, RonaldB.Emeson 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 5 323-328 (6 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 10: 323－327, December, 2006 323 INTRODUCTION Based on its expression pattern and pharmacological stu- dies, calcitonin gene-related peptide (CGRP) has been implicated to be involved in nociception. CGRP is expressed in dorsal root ganglion and dorsal horns of spinal cords (Gibson et al, 1988; McNeill et al, 1988) and noxious ther- mal or mechanical... Despite the wealth of data concerning the roles of α-CGRP in nociceptive behaviors, α-CGRP-null mice showed no obvious phenotypic differences in nociceptive behaviors from wild type. The present studies specifically demonstrate that α-CGRP null mice showed no CGRP immunoreactivity from the spinal cord, implying that CGRPs in the mice spinal cord are mainly a-isoforms. However, the nociceptive behaviors of the null mice are not significantly different from the wild type mice in thermal...