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전체 선택해제
총 33건 검색
본문검색 결과만 보기
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Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer
Farruk M. Lutful Kabir, Patricia DeInnocentes, Payal Agarwal, Christopher P. Mill, David J. Riese 2nd, R. Curtis Bird 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 4 149-158 (10 pages)
to model human breast cancer in terms of causative mutations as well as for development of new treatment strategies for both species [2,7,18,20]. A more rapid and quantitative assay, based on quantitative reverse transcriptase polymerase ..PAGE:2 150 Farruk M. Lutful Kabir et al. Journal of Veterinary Science Table 1. Canine mammary tumor (CMT) and control cell lines Cells or cell line* Source... of amplicon size and DNA sequencing following amplification. Differential expression of ER1, PR, and c-erbB-2 in CMT cell lines clearly defined distinct human-like breast cancer phenotypes for a selection of CMT-derived cell lines. Expression profiles for EGFr family genes c-erbB-3 and c-erbB-4 in CMT models also provided an enriched classification of canine breast cancer identifying new extended phenotypes beyond the conventional luminal-basal characterization used in human breast cancer. -
Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures
YeonJooJung, EunChengSuh, KyungEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 8 423-429 (7 pages)
K, Ottersen OP, Runden-Pran E. Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation. Cell Tissue Res. 2011;345:329-341. 34. Bloom FE, Aghajanian GK. Fine structural and cytochemical analysis of the staining of synaptic junctions with... the CA3 area in organotypic hippocampal slice cultures. After OGD/reperfusion, neurons were found to be damaged; the organelles such as mitochondria, endoplasmic reticulum, dendrites, and synaptic terminals were swollen; and the PSD became thicker and irregular. Ethanolic phosphotungstic acid staining showed that the density of PSD was significantly decreased, and the thickness and length of the PSD were significantly increased in the OGD/reperfusion group compared to the control. The levels of... -
A Systematic Review and Meta-Analysis of Applicability of Web-Based Interventions for Individuals with Depression and Quality of Life Impairment
Danbi Yang, Ji-Won Hur, Yoo Bin Kwak, Sung-Won Choi 대한신경정신의학회 Psychiatry Investigation 8 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 3 759-766 (8 pages)
Assessment, Analysis and Interpretation of Patient-Reported Outcomes. West Sussex: John Wiley & Sons; 2013. 39. Frisch MB, Cornell J, Villanueva M, Retzlaf PJ. Clinical validation of the Quality of Life Inventory. a measure of life satisfaction for use in treatment planning and outcome assessment. Psychol Assess 1992;4: 92-101. 40. Zilcha-Mano S, Dinger U, McCarthy KS, Barrett MS, Barber JP.... on web-based intervention for individuals with depression were assessed eligible for this meta-analysis. Effect sizes were estimated for depression and quality of life. Results_The mean effect size of web-based treatment on depressive symptoms was 0.72. However, unlike the result showing medium to large effect size, the analysis on the quality of life did not yield adequate effects of web-based interventions. Conclusion_Our results suggest robust benefits of employing web-based treatments for... -
Combined Effect of CO2 and Temperature on Wheat Powdery Mildew Development
Slavica Matić, , Maria Alexandra Cucu, Angelo Garibaldi, Maria Lodovica Gullino 한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 4호 6 316-326 (11 pages)
growth and avenues for crop improvement by exploiting physio-morphological traits. Front. Plant Sci. 8:537. Paolacci, A. R., Tanzarella, O. A., Porceddu, E. and Ciaffi, M. 2009. Identification and validation of reference genes for quantitative RT-PCR normalization in wheat. BMC Mol. Biol. 10:11. Prior, S. A., Runion, G. B., Marble, S. C., Rogers, H. H., Gil- ..PAGE:11 Mati et al. 326 liam,... of CO2 conditions, and no typical powdery mildew symptoms were observed. Elevated CO2 did not stimulate powdery mildew development, but was detrimental for plant vitality. Similar abundance of three PR transcripts was found, and the level of their expression was different between six phytotron conditions. Real time PCR quantification of Bgt was in line with the disease index results, but this technique succeeded to detect the pathogen also in asymptomatic plants. Overall, future global warming... -
한글판 낙상 위험 주거환경 평가 (Home Falls and Accidents Screening Tool; HOME FAST)의 내용이해도 및 신뢰도 연구
주유미, 조선영 대한신경계작업치료학회 재활치료과학 16 Pages
대한신경계작업치료학회 재활치료과학 2019, 제 8권 4호 7 77-92 (16 pages)
, 59(3), 235-242. doi:10.1111/j.1440-1630.2012.01012.x ..PAGE:14 90 Therapeutic Science for Rehabilitation Vol. 8. No. 4. 2019. Abstract Validity and Reliability of Korean Version of Home Falls and Accidents Screening Tool (HOME FAST) Ju, Yumi, M.S. O.T., Cho, Sun-Young, M.S., O.T. Dept. of Occupational Therapy, Far-East University, Professor Objective : This study aims to obtain the validation... 목적 : 본 연구의 목적은 낙상 위험 주거환경 평가인 HOME FAST의 국내사용을 위해 체계적인 절차를통해 한국어로 번안하여 내용이해도 및 신뢰도를 검증하고자 하였다. 연구 방법 : 한글로 번역된 HOME FAST의 내용이해도를 알아보기 위해 작업치료사 총 21명에게 한글번역본의 이해도 평가하게 하였다. 이후 한글번역본을 역번역 하여 원문과 비교하고 문장구조 및 의미 유사성을평가하였다. 아울러 신뢰도 검증을 위해 지역사회에 거주하고 있는 낙상 고위험군 노인 75명을 대상으로평가를 진행하고 내적 일치도를 검증하였다. 그중... -
The Trend of Body Mass Index (BMI) Changes among Malaysian Children and the Prediction at 48 Months Old
Aslina Saad, Suzani Samuri, Bahbibi Rahmatullah, Mazlina Che Mustafa 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 20 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2021, Vol.15 No.2 9 187-206 (20 pages)
systematic review on the development and validation of a prediction model for overweight and obesity faced by children whose ages ranged from one to 13 years. Interestingly, Boseley (2019) proposed a predictor tool that parents could use to predict the risk of their children becoming obese and, therefore, recommended appropriate food and activities to reduce such a risk. Essentially, BMI is a... the decision tree algorithms of Rapid miner. The BMI of 48 months-old children can be reliably predicted by their BMI statuses at the ages of 21, 24, 27, 36, 42, and 45 months, parents’ incomes, and gender while the BMI at the age of 20 months and below are the negative predictors. The prediction model developed in this study may help practitioners to monitor such children’s BMI, especially in detecting the signs of severe overweight, obesity, and underweight among such children. Such a BMI... -
Synthesis and applications of graphene electrodes
Dolly Shin, Sukang Bae, Chao Yan, Junmo Kang, Jaechul Ryu, Jong-Hyun Ahn and Byung Hee Hong 한국탄소학회 Carbon Letters 16 Pages
한국탄소학회 Carbon Letters 2012, Vol.13 No.1 1 1-16 (16 pages)
its properties and to empirical validation of its conceptual theories (theories such as graphene band structure of two cones meeting together at a Dirac point, where the effective mass of electrons reaches zero). Most notably, its half integer quantum Hall effect and the ‘relativistic’ nature of its charge carriers were experi- mentally recorded and studied extensively [11]. The study that... -
Role of Cerebrospinal Fluid Biomarkers in Clinical Trials for Alzheimer’s Disease Modifying Therapies
Ju-HeeKang, Na-YoungRyoo, DongWunShin, JohnQTrojanowski, LeslieM.Shaw 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 1 447-456 (10 pages)
antibody responders [84]. Among the cur- rent key unknowns are the time frames for affecting CSF biomarker measurement and what degree the biomarker change might relate to the clin ical outcome. Therefore, we need to carefully consider the qualification and validation of AD biomarkers before using them as surrogate markers for clinical endpoints. Second, biomarkers can be used diagnostically... a tool to enrich patients for clinical trials with prospect of increasing statistical power and reducing costs in drug development. However, the standardization of technical aspects of analysis of these biomarkers is an essential prerequisite to the clinical uses. To accomplish this, global efforts are underway to standardize CSF biomarker measurements and a quality control program supported by the Alzheimer’s Association. The current review summarizes therapeutic targets of developing drugs in... -
Long-term Follow-up of Cutaneous Hypersensitivity in Rats with a Spinal Cord Contusion
Ji-InJung, JunesunKim, SeungKilHong, YoungWookYoon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 3 299-306 (8 pages)
to mild tactile and cold stimuli after experimental spinal cord injury in the rat. Neurorehabil Neural Repair 14: 287 300, 2000 Metz GA, Curt A, van de MH, Klusman I, Schwab ME, Dietz V. Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury. J Neurotrauma 17: 1 17, 2000 Ramer MS, Harper GP, Bradbury EJ. Progress in spinal cord research - a... response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.