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전체 선택해제
총 660건 검색
본문검색 결과만 보기
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In silico analysis of putative drug and vaccine targets of the metabolic pathways of Actinobacillus pleuropneumoniae using a subtractive/comparative genomics approach
Biruk T. Birhanu, Seung-Jin Lee, Na-Hye Park, Ju-Beom Song, Seung-Chun Park 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 5 188-199 (12 pages)
P, Bootsma HJ, de Vries SP, van der Gaast-de Jongh CE, Simonetti E, Langereis JD, Hermans PW, de Jonge MI, Zomer A. From microbial gene essentiality to novel antimicrobial drug targets. BMC Genomics 2014, 15, 958. 24. Morya VK, Dewaker V, Mecarty SD, Singh R. analysis metabolic pathways for identification of putative drug targets for Staphylococcus aureus. J Comput Sci Syst Biol 2010, 3... of drug resistance in this bacterium is increasing; thus, identifying new protein/gene targets for drug and vaccine development is critical. In this study, we used an in silico approach, utilizing several databases including the Kyoto Encyclopedia of Genes and Genomes (KEGG), the Database of Essential Genes (DEG), DrugBank, and Swiss-Prot to identify non-homologous essential genes and prioritize these proteins for their druggability. The results showed 20 metabolic pathways that were unique and... -
Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring
JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)
of a wide range of AEDs with ac- ceptable accuracy and precision included with newer AEDs such as ZSD and TPM developed. A simultaneous LC-MS assay would be faster and more reliable than multiple ana- lytical assays when quantification of multiple AED is need- ed for patients with AED polytherapy [30]. Additional methods included micellar electrokinetic capillary chroma- tography with diode... of AEDs in biological fluids is a necessity in order to explore pharmacokinetics, bioequivalence and TDM in various clinical situations. There are hundreds of published articles on the analysis of specific AEDs by a wide variety of analytical methods in biological samples have appears over the past decade. This review intends to provide an updated, concise overview on the modern method development for monitoring AEDs for pharmacokinetic studies, bioequivalence and therapeutic drug monitoring. -
Results of the Monitoring of Veterinary Drug and Chemical Residues in Domestic Meats in 2014
Hyo Jin Kim, Soo hee Kim, Byung Jae So, Jae Young Song, Sung Won Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 68 173-174 (2 pages)
hormones and pesticides (Surveillance testing). On the basis of QIA method for residue analysis, veterinary drug residues were analyzed using a bioassay for screening purposes and by HPLC and LC-MS/MS for confirmation and quantification. Results: The monitoring plan was conducted for 143 substances including 48 antibiotics, 59 synthetic antimicrobials, 2 hormones, 28 pesticides and 6 drugs... -
Isolation and multiple differentiation potential assessment of human periodontal ligament stem cells derived from deciduous tooth of dental patients
Byung cheol Kim, Sang Hwan Hyun 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 335 374-375 (2 pages)
1, Seung-Chun Park *1 1Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University Introduction: The emergence of antibacterial drug resistance initiates the search for new therapeutic agents in the past few decades using multiple approaches. In the present study, a computational comparative/subtractive genomic and proteomic... -
Target proteins for putative drug and vaccine in Salmonella Typhimurium using comparative genomics and proteomics approaches
Seung Jin Lee, Abraham Mechesso, Seung Chun Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 334 374-374 (1 pages)
1, Seung-Chun Park *1 1Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University Introduction: The emergence of antibacterial drug resistance initiates the search for new therapeutic agents in the past few decades using multiple approaches. In the present study, a computational comparative/subtractive genomic and proteomic... -
Analysis of pesticides in dead bees in Korea in 2016
Hyo-bi Kim Kum, Byun-kook Choi, Sun-jin Park, Su-young Lee, Dae Gyun Kim, Sung Won Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 174 305-306 (2 pages)
in sows. This shows that multiple swine influenza virus subtype was circulating in Korean pig farms. Therefore, the use of swine influenza virus vaccine is recommended in Korea. References [1] WHO Manual on Animal Influenza Diagnosis and Surveillance 2nd edition, 2002. [2] Seroprevalence of antibodies against swine influenza virus in pigs of different age. BullVet Inst Pulawy 49, 3-7, 2005.... -
Comparison of allele-specific PCR, created restriction-site PCR, and PCR with primer-introduced restriction analysis methods used for screening complex vertebral malformation carriers in Holstein cattle
Kozet Avanus, Ahmet Altınel 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 9 465-470 (6 pages)
to hydrogen peroxide, and SOD1 mutation can lead to multiple pathogenic mechanisms in ALS especially oxidative stress [5]. In previous study, many analyses of oxidative stress in ALS have been carried out to elucidate the relationship between degenerated motor neurons and elevated oxidative stress in ALS, and the results provide evidence supporting indications that oxidative stress affects... study was to compare sensitivity, specificity, positive and negative predictive values, accuracy, and rapidity of allele-specific polymerase chain reaction (AS-PCR), created restriction-site PCR (CRS-PCR), and PCR with primer-introduced restriction analysis (PCR-PIRA), three methods used in identification of CVM carriers in a Holstein cattle population. In order to screen for the G＞T mutation in the solute carrier family 35 member A3 (SLC35A3) gene, DNA sequencing as the gold standard method wa... -
Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer
Farruk M. Lutful Kabir, Patricia DeInnocentes, Payal Agarwal, Christopher P. Mill, David J. Riese 2nd, R. Curtis Bird 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 4 149-158 (10 pages)
and c- erb B/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer Farruk M. Lutful Kabir 1,†, Patricia DeInnocentes 1, Payal Agarwal 2, Christopher P. Mill 3,‡, David J. Riese 2nd 3, R. Curtis Bird 1,* Auburn University Research Initiative in Cancer (AURIC), 1 Department of Pathobiology, 2 Scott-Ritchey Research Center, College of Veterinary... Well characterized, stable, p16-defective canine mammary cancer (CMT) cell lines and normal canine mammary epithelial cells were used to investigate expression of the major breast cancer-specific hormone receptors estrogen receptor alpha (ER1) and progesterone receptor (PR) as well as luminal epithelial-specific proto-oncogenes encoding c-erbB-1 (epidermal growth factor receptor/EGFr), c-erbB-2/HER2, c-erbB-3, and c-erbB-4 receptors. The investigation developed and validated quantitative reverse... -
Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene
Yuqiang Cheng, Yingjie Sun, Hengan Wang, Shuduan Shi, Yaxian Yan, Jing Li, Chan Ding, Jianhe Sun 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 6 37-46 (10 pages)
on multiple alignments of humans, mice, chickens and geese with Oligo Primer Analysis Software (ver. 6.71; Molecular Biology Insights, USA). The sequences of TLR5, MyD88, OAS and Mx of humans, mice, chickens and geese were obtained from the GenBank (National Center for Biotechnology Information, USA). Degenerate primers (Table 1) and cDNA were used to amplify these genes. The PCR mixture... Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame (ORF) of duck TLR5 (dTLR5) cDNA is 2580 bp and encodes a polypeptide of 859 amino acids. We also cloned partial sequences of myeloid differentiation factor 88, 2’-5’-oligoadenylate synthetase (OAS), and myxovirus resistance (Mx) genes from duck. dTLR5 mRNA was highly expressed in the... -
Sporozoite proteome analysis of Cryptosporidium parvum by one-dimensional SDS-PAGE and liquid chromatography tandem mass spectrometry
AMAM Zonaed Siddiki* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 1 107-114 (8 pages)
in the MASCOT result page). Another important issue is that if one or more peptide(s) are common for multiple protein entities they can lead to false positive results by matching with other non-related peptides (peptides from additional proteins). Thus, although the peptides are truly present in the sample, its matched protein is actually absent. Further bioinformatic analysis using a... parvum was first fractionated using SDS-PAGE with subsequent LC-MS/MS analysis. A total of 135 protein hits were recorded from 20 gel slices (from same gel lane), with many hits occurring in more than one band. Excluding all non-Cryptosporidium entries and proteins with multiple hits, 33 separate C. parvum entries were identified during the study. The overall goal of this study was to reduce sample complexity by protein fractionation and increase the possibility of detecting proteins present in...