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Molecular Mechanism of Pancreatic Bicarbonate Secretion
MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 1 131-138 (8 pages)
N C I148T G178R E193K R297Q A1067T R1070Q G1244E S1255P G1349D NBD2NBD2 RDRD H949Y G970R CL4 CL3 CL2 CL1 NBD1NBD1 G551D G551S H620Q D648V A800G R117H ..PAGE:5 Molecular Mechanism of Pancre atic Bicarbonate Secretion 135 Regulatory HCO 3 - absorption by luminal mechanisms An interesting feature of HCO 3 - transport in HCO 3 - - secreting epithelia is the ex istence of regulatory HCO3 - absorptive... Thanks to recent progress in availability of molecular and functional techniques it became possible to search for the basic molecular and cellular processes that mediate and control HCO3 and fluid secretion by the pancreatic duct. The coordinated action of various transporters on the luminal and basolateral membranes of polarized epithelial cells mediates the transepithelial HCO3 transport, which involves HCO3 absorption in the resting state and HCO3 secretion in the...