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Effect of Heme Oxygenase Induction by NO Donor on the Aortic Contractility
Chang-KyunKim, UyDongSohn, Seok-YongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 12 87-92 (6 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 5: 87-92， Februar， 2001 Effect of Heme Oxygenase Induction by NO Donor on the Aortic Contractility 1 Chang-Kyun Kim， Uy Dong Sohn， and Seok-Yong Lee Department of Phannacy， College of Phannacy， Sungkyunkwan University， Suwon 440-746; 'College of Phannacy Chung-Ang University， Seoul 156-756， Korea Carbon monoxide (CO) binds to soluble... Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively expressed in endothelial and smooth muscle cells, and HO-1 can be greatly up-regulated by oxidative stress. Moreover, the substrate of HO, heme, is readily available for catalysis in vascular tissue. Although the activation of heme oxygenase pathway under various stress...