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Standard Error of Empirical Bayes Estimate in NONMEMⰒ VI
DongwooKang, Kyun-SeopBae, BrettE.Houk, RadojkaM.Savic, MatsO.Karlsson 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 3 97-106 (10 pages)
in NONMEM VI Dongwoo Kang 1 , Kyun-Seop Bae 2 , Brett E. Houk 1 , Radojka M. Savic 3 , and Mats O. Karlsson 3 1Pfizer Worldwide Biopharmaceutical Businesses - La Jolla, San Diego, CA 92111, USA, 2Asan Medical Center, University of Ulsan, Seoul 138-736, Korea, 3 Uppsala University, Uppsala 75105, Sweden The pharmacokinetics/pharmacodynamics analysis software NONMEM output provides model... The pharmacokinetics/pharmacodynamics analysis software NONMEMⰒ output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEMⰒ VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or... -
실제 임상 데이터를 이용한 NONMEM 7.2에 도입된 추정법 비교 연구
윤휘열, 채정우, 권광일, Yun. Hwi-Yeol, Chae. Jung-Woo, Kwon. Kwang-Il 한국임상약학회 한국임상약학회지 5 Pages
한국임상약학회 한국임상약학회지 2013, Vol.23 No.2 137-141 (5 pages)
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Pharmacokinetic/Pharmacodynamic 모델링의 개요: NONMEM$^{(R)}$ 소프트웨어를 이용한 Non-Linear Mixed Effects Modelling
윤영란, Yoon. Young-Ran 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 7 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 2006, Vol.14 No.2 99-105 (7 pages)
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Prospective validation of a novel dosing scheme for intravenous busulfan in adult patients undergoing hematopoietic stem cell transplantation
Sang-HeonCho, Jung-HeeLee, Hyeong-SeokLim, Kyoo-HyungLee, Dae-YoungKim, SangminChoe, Kyun-SeopBae, Je-HwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 3 245-251 (7 pages)
times for the given dosage history and demographic data, including sex, age, and body weight. These predictions were obtained by entering the structural model parameters into NONMEM 6.2.0 (GloboMax LLC, Ellicott City, MD, USA) with typical values of pharmacokinetic parameters and no residual errors. The predicted concentrations were compared with the corresponding measured concentrations by... established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a posteriori Bayesian estimators were estimated to calculate the predicted AUC (AUCPRED). The accuracy and precision of the AUCPRED values were assessed by calculating the mean prediction error (MPE) and root mean... -
Modeling of the Parathyroid Hormone Response after Calcium Intake in Healthy Subjects
JaeEunAhn, SangilJeon, JongtaeLee, SeunghoonHan, Dong-SeokYim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 4 217-223 (7 pages)
nonparametric 95% confidence intervals (2.5∼97.5 percentiles), and the median values were assessed using the runs with successful minimization. Software/ platform The analysis was performed using NONMEM 7.2.0 (ICON Development Solutions, MD) in the Pirana 2.6.1 platform [5]. R 2.15.1 (www.r-project.org) with R studio ver- sion 0.96.330 (http://www.rstudio.com/) was used for data formatting ... collected from 24 subjects from a clinical trial performed to evaluate the safety and calcium absorption of Geumjin Thermal Water in comparison with calcium carbonate tablets in healthy subjects. Indirect response models (NONMEM Ver. 7.2.0) were fitted to observed Ca2+ and PTH data, respectively, in a manner that absorbed but unobserved Ca2+ inhibits the secretion of PTH. Without notable changes in Ca2+ levels, PTH responses were modeled and used as a marker for the extent of calcium absorption. -
A Simple Dosing Scheme for Intravenous Busulfan Based on Retrospective Population Pharmacokinetic Analysis in Korean Patients
SangminChoe, GayeongKim, Hyeong-SeokLim, Sang-HeonCho, Jong-LyulGhim, JinAhJung, Un-JibKim, GyujeongNoh, Kyun-SeopBae, DonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 7 273-280 (8 pages)
Clinical Reseearch Center, Asan Medical Center (Seoul, Korea). Population pharmacokinetic analysis In total, 295 measurements from 60 patients were ana- lyzed by mixed-effect modeling using NONMEM (Version VI, GloboMax LLC, Ellicott City, MD, USA). The pharmaco- kinetic parameters were estimated with NONMEM sub- routines ADVAN1 TRANS2, using the First Order Condi- tional Estimation with inte... daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women.... -
The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects
SangilJeon, SeunghoonHan, JongtaeLee, TaegonHong, Dong-SeokYim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 4 249-253 (5 pages)
(NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption... (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h－1, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and... -
Nortriptyline 적정 용법을 위한 Population Pharmacokinetics 및 Bayesian Feedback법의 적용
신상구, 우종인, 장인진, 박찬웅, 김재진, 홍진표, 이경훈 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 1992, 제 31권 제 5호 6 884-894 (11 pages)
가정하여 소실속 도상수(ke) 의 분산(variance) 을 예측하는 모델(A) 과 청소율(C1) 의 분산을 예측하는 모델(타을 설정 후 NONMEM(Beal과 Sheiner 1991) 을 이용하여 nortriptyline의 약동학적 경수를 산출하였다. k=ka+nka ka ： 흡수속도상수 ka=ka+nke ke : 소실속도상수 Vd= [Intercept+a+(체중) ] + n Vd Vd ： 분포용적 Cpi^CpijCl + Eij) C l： 청소율 ke=CW d Cp ： 혈장농도 n ： 각 경수의 분산 E ：잔존오차 2... -
조혈모세포이식을 받은 한국 성인 백혈병환자에서 cyclosporine의 집단약동학 분석
김승희, 김경임, 윤휘열, 강원구, 윤성수, 신완균, 이혜숙, 오정미, Kim. Seung-Hee, Kim. Kyung-Im, Yun. Hwi-yeol, Kang. Won-Ku, Yoon. Sung-Soo, Shin. Wan-Gyoon, Lee. Hye- 한국임상약학회 한국임상약학회지 8 Pages
한국임상약학회 한국임상약학회지 2010, Vol.20 No.1 9-16 (8 pages)
대사를 유도하는 프레드니솔론의 투여량, 헤마토크리트, 사이클로스포린의 대사를 저해하는 약물의 병용여부 등을 검토하였다. 분석은 NONMEM$^{(R)}$ VI 프로그램을 이용하였으며, 변수를 추가하지 않은 기본 모형을 만든 후에 단계적인 요인의 추가와 제거를 통해 최종모형을 제작하였다. Results: 최종 상관 모형은 다음과 같다; CL/F (L/h) = $85.6{ imes}e^{(0.646;{ imes};HCT/28.9;+;0.0464;{ imes};Gender)}$. 사이클로스포린의 겉보기 클리어런스는 환자의 성별이 남자일 때 또는 헤마토크릿이 감소할수록 증가하였다. 그 외... -
Population Pharmacokinetic Analysis of the Oral Absorption Process of Tacrolimus in Healthy Volunteers
홍은경, 임동석, Hong. Eun-Kyung, Savic. Radojka M., Yim. Dong-Seok 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 10 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 2007, Vol.15 No.2 117-126 (10 pages)
혈장 내 타크로리무스의 농도 분석은 HPLC-MS-MS를 이용하였다. 약동학적 분석을 위해 NONMEM을 사용하였고, 영차 흡수, 일차 흡수, 트랜짓 분획 흡수 모델에 2분획적 모델을 적용하여 비교하였다. 결과: 트랜짓 분획 흡수 모델이 타크로리무스의 약동학적 흡수 과정을 가장 잘 설명하는 것으로 나타났다. 여기서 적용된 3 가지의 흡수 모델 중 트랜짓 분획 흡수 모델에서 OFV와 RMSE가 가장 감소하였고, 각 개인 피험자들의 흡수기를 나타낸 그래프와 산점도 그림에서도 트랜짓 분획 흡수 모델이 일차 흡수 모델보다 더 우수했다. 결론:...