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Toxic effects of methylmercury, arsanilic acid and danofloxacin on the differentiation of mouse embryonic stem cells into neural cells
Seok-Jin Kang, Sang-Hee Jeong, Eun-Joo Kim, Young-Il Park, Sung-Won Park, Hyo-Sook Shin, Seong-Wan Son, Hwan-Goo Kang* 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 7 61-71 (11 pages)
the definitive phase and evaluation of prediction models. Altern Lab Anim 2002, 30, 151-176. 14. Graff RD, Falconer MM, Brown DL, Reuhl KR. Altered sensitivity of posttranslationally modified microtubules to methylmercury in differentiating embryonal carcinoma- derived neurons. Toxicol Appl Pharmacol 1997, 144, 215-224. 15. Hogberg HT, Kinsner-Ovaskainen A, Coecke S, Hartung T, Bal-Price AK.... This study was performed to assess the neurotoxic effects of methylmercury, arsanilic acid and danofloxacin by quantification of neural-specific proteins in vitro. Quantitation of the protein markers during 14 days of differentiation indicated that the mouse ESCs were completely differentiated into neural cells by Day 8. The cells were treated with non-cytotoxic concentrations of three chemicals during differentiation. Low levels of exposure to methylmercury decreased the expression of GABAA-R... -
Role of Cerebrospinal Fluid Biomarkers in Clinical Trials for Alzheimer’s Disease Modifying Therapies
Ju-HeeKang, Na-YoungRyoo, DongWunShin, JohnQTrojanowski, LeslieM.Shaw 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 1 447-456 (10 pages)
we analyzed the overall clin- ical performance of CSF AD biomarkers (concentration of Aβ 1-42, t-tau and p-tau181) for the diagnosis of AD in pre- viously reported clinical studies, both mean sensitivity and specificity for Aβ1-42 and t-tau are over 80%, while those for p-tau181 are slightly lower than 80%. When A β1-42 and t-tau are combined (i.e., Aβ1-42/t-tau ratio or regression model... Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer’s disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD... -
Differential Effects of Nitric Oxide Synthase Inhibitors in Rats
Jun-HeeLee, ChangYellShin, BongSuKang, JiHoonJeong, KyeongBumChoi, YoungSilMin, JinHakKim, InHoiHuh, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 3 99-104 (6 pages)
L-NAME on basal and ACh-stimulated production of nitric oxide. L-NMMA selectively blocked basal but not ACh-stimulated production of NO. Based on these results， we also examined dif ferential sensitivity of basal and ACh-stimulated NO activity in the superoxide anion induced destruction of NO， PAF-induced relaxation and nerve conduction velocity. Two inhibitors of nitric oxide synthase... ACh, however, decreased the augmentation induced by L-NMMA, but not by L-NAME. Superoxide dismutase (SOD, 50 u/ml) potentiated an inhibitory effect of ACh on the PE (107 M)-induced contraction. It has been known that platelet activating factor itself induces iNOS. Platelet activating factor (PAF, 107 M) inhibited PE (107 M)-induced contraction. Pretreatment with L-NMMA (30 mM) or L-NAME (30 mM) significantly blocked the inhibitory action of PAF on PE-induced contraction.... -
Improvement of CF/ABS Composite Properties by Anodic Oxidation of Pitch based C-type Carbon Fiber
Xiao ping Yang, Cheng Zhong Wang, Yun Hun Yu, Seung Kon ryn 한국탄소학회 Carbon Letters 5 Pages
한국탄소학회 Carbon Letters 2002, Vol.3 No.2 2 80-84 (5 pages)
by sensitivity factor based on the transmission characteristics. The surface of carbon fiber and notch assault fractured surfaces of CF/ABS composites were observed by SEM (Cambridge S-250 Scanning Elec- tron Microscope) to examine the fractography of the com- posites and adhesion between carbon fiber and ABS resin. 3. Results and Discussion 3.1. Effects of anodic oxidation on surface functional... -
SM45C와 SCM4의 마찰용접 및 피로특성에 관한 연구
오세규, 김부안, 김선진, 남상훈, O. Se-Gyu, Kim. Bu-An, Kim. Seon-Jin, Nam. Sang-Hun 한국해양공학회 韓國海洋工學會誌 10 Pages
한국해양공학회 韓國海洋工學會誌 1988, Vol.2 No.2 112-121 (10 pages)