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Normal clinical electroretinography parameters for poodle, Labrador retriever, Thai ridgeback, and Thai Bangkaew
Metita Sussadee, Janjira Phavaphutanon, Kornchai Kornkaewrat, Aree Thayananuphat 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 9 67-74 (8 pages)
inherited progressive retinal atrophy (PRA) or characterizing retinopathy due to other causes. ERG is also tremendously useful when performed before cataract surgery as well as diagnosing specific blinding disorders in dogs such as sudden acquired retinal degeneration from optic neuritis or cortical blindness [21]. There are numerous factors that can distort the accuracy and reliability of... ridgeback, and Thai Bangkaew. Standard ERG findings were bilaterally recorded using a handheld multi-species ERG unit with an ERG-jet lens electrode for 28 dogs under preanesthesia with diazepam, anesthesia with propofol, and anesthesia maintenance with isoflurane. There were significant differences in the mean values of ERG amplitudes and implicit times among the four dog breeds (p＜ 0.05) except for the b-wave implicit time of the photopic 30 Hz flicker response with... -
Electroretinography recordings using a light emitting diode active corneal electrode in healthy beagle dogs
Yoshiki Itoh, Seiya Maehara, Norihiko Itoh*, Kazuto Yamashita, Yasuharu Izumisawa 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 1호 11 77-84 (8 pages)
cataract extraction [19] to experimentally evaluate retinal toxicity [10] and diagnose retinal disorders such as generalized progressive retinal atrophy (an inherited form of photoreceptor degeneration) and sudden acquired retinal degeneration associated with sudden visual loss due to acute photoreceptor death in dogs [18,19]. Establishment of normal ERG values is important for evaluating... Electroretinography (ERG) is a well-established diagnostic procedure for objectively evaluating retinal function. In this study, ERG in beagle dogs, which are a popular experimental animal, was performed to determine the normal range of ERG variables and assess differences between the left and right eyes. ERG findings including rod, combined rod-cone, single-flash cone, and 30-Hz flicker responses were recorded with an LED-electrode in 43 sedated beagle dogs. The subjects were divided into young... -
The normal electroretinogram in adult healthy Shih Tzu dogs using the HMsERG
June-sub Lee, Kyung-hee Kim, Ha-young Jang, Bora Lee, Joon Young Kim, Soon-wuk Jeong* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 9 233-238 (6 pages)
(min. to max.). most preferred and the most common dog breed in Korea. The breed has a predisposition for eye diseases which requires retinal evaluation for diagnosis, such as retinal detachment, progressive retinal atrophy and cataracts [13]. Various anesthetic protocols can affect the results of ERG examinations. According to previous studies, halothane and sevoflurane strongly depress the... Electroretinography (ERG) is a reliable diagnostic tool for the diagnosis of retinal disease. It measures electric potentials occurring in the retina in response to light stimulation. In this study, we examined the normal electroretinogram using the Handheld Multispecies ERG (HMsERG) in Shih Tzu dogs. ERG recordings were performed in twelve eyes of six healthy Shih Tzu dogs. Dogs were anesthetized with a combination of medetomidine and ketamine. Proparacaine eye drops were also applied as a... -
The determination of dark adaptation time using electroretinography in conscious Miniature Schnauzer dogs
Hyung-Ah Yu, Man-Bok Jeong, Shin-Ae Park, Won-Tae Kim, Se-Eun Kim, Je-Min Chae, Na-Young Yi, Kang-Moon Seo* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 4호 14 409-414 (6 pages)
retina of the eye when it is stimulated by light [40]. An important indication for ERG recordings in dogs is the early diagnosis of generalized progressive retinal atrophy (gPRA) [24]; which is an inherited form of photoreceptor degeneration, analogous to retinitis pigmentosa in humans [23]. The breed with the highest prevalence of gPRA in Korea is the Miniature Schnauzer [29]. The ERG is a... a contact lens electrode and a built-in light source (LED-electrode). The ERG recordings were performed on nine healthy Miniature Schnauzer dogs. The bilateral ERG's at seven different dark adaptation times at an intensity of 2.5 cdㆍs/m² was performed. Signal averaging (4 flashes of light stimuli) was adopted to reduce electrophysiologic noise. As the dark adaptation time increased, a significant increase in the mean a-wave amplitudes was observed in comparison to base-line levels up to 10... -
증례보고 : Ocular coherence tomography를 이용한 개의 망막변성증 평가
지동범, 유석종, 서강문, 정만복 , 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2013, 제 53권 제 2호 13 137-141 (5 pages)
그 변화 여부를 제시함으로써 망막질환의 임상적 진단, 치료 의 예후 평가 및 망막 연구에 유용하게 이용할 수 있을 것 이다. References 1. Aguirre G, Alligood J, O'Brien P, Buyukmihci N. Pathogenesis of progressive rod-cone degeneration in miniature poodles. Invest Ophthalmol Vis Sci 1982, 23, 610- 630. 2. Aguirre GD, Rubin LF. Progressive retinal atrophy in the miniature poodle: an electrophysiologic... -
Music-Centered Integrated Lesson Plan Based on IB PYP
Sung-Ji Kim, Euna Choi 한국음악교육학회 음악교육연구 20 Pages
한국음악교육학회 음악교육연구 2022, 제 51권 제 2호 1 1-20 (20 pages)
constructed to help students see the world and express themselves through the lens of music. The central ideas are selected based on the transdisciplinary theme “how to express ourselves”, taking into consideration the level of each grade level. The lines of inquiry are structured to help understand the central ideas, and the key concepts, related concepts, and skills extracted for learning.... The purpose of this study is to design music-centered integrated lessons based on the International Baccalaureate Primary Years Programme (IB PYP). For this purpose, first, the characteristics of IB PYP were examined, and the scope and sequence, and learning contents on music subject of IB PYP were compared with those of Korea National Curriculum. Second, based on this analysis, the music-centered integrated lessons based on transdisciplinary themes were designed in a spiral curriculum. The... -
MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
SeongmiLee, SeungTackOh, HaJinJeong, SokCheonPak, Hi-JoonPark, JongpilKim, Hyun-seokCho, SongheeJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 7 625-632 (8 pages)
as a progressive neurological incurable disorder with no preventative nor effective long-term treatment strategies [1]. The phenotypes of PD are characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN); dopamine depletion in the striatum; and motoric in- stabilities including bradykinesia, rigidity, and tremor [2]. In most cases, the etiology of PD is not... Familial Parkinson’s disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygous (hemi) or homozygous (homo) A53T α-synuclein (α-syn Tg) and their wildtype (WT) littermates by treatment with sub-toxic (10 mg/kg, i.p., daily for 5 days) or toxic (30 mg/kg, i.p., daily for 5... -
Advanced Glycation End Products and Diabetic Complications
VarunParkashSingh, AnjanaBali, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 1 1-14 (14 pages)
for the change in the color, opacity of the eye lens and formation of AGEs occurs at a higher rate in cataract lens [118]. AGEs in Diabetic nephropathy Diabetic nephropathy is defi ned as a progressive decline in glomerular filtration rate, accompanied by proteinuria and other end-organ complications such as retinopathy [119]. Diabetic nephropathy progresses to end-stage renal disease via a... During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with... -
Electrophysiological and Histologic Evaluation of the Time Course of Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa
SeolAJae, KunNoAhn, JiYoungKim, JeHoonSeo, HyongKyuKim, YongSookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 8 229-235 (7 pages)
Retinitis pigmentosa (RP) is a group of retinal dystro- phies characterized by photoreceptor abnormalities pro- gressing to denudation of the sensory receptor layers of the retina. This leads to a progressive and irreversible loss of vision - characterized initially by tunnel vision. As one of the most frequently seen retinal dystrophies, RP is the leading cause of blindness in adults with an... Among several animal models of retinitis pigmentosa (RP), the more recently developed rd10 mouse with later onset and slower rate of retinal degeneration than rd1 mouse is a more suitable model for testing therapeutic modalities. We therefore investigated the time course of retinal degeneration in rd10 mice before adopting this model in our interventional studies. Electroretinogram (ERG) recordings were carried out in postnatal weeks (PW) 3∼5 rd10 (n=23) and wild-type (wt) mice (n=26). We... -
Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice
JeongHoLee, ChulHoonKim, DongGooKim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 4 91-98 (8 pages)
expression, Cerebral cortex, Hypothalamus INTRODUCTION The tubby mouse, which arose from spontaneous muta- tion of the tub gene in the Jackson Laboratory, shows char- acteristic phenotypes includ ing progressive retinal and cochlear degeneration, and late-onset obesity with insulin resistance due to a loss-of-function mutation in tub (Coleman and Eicher, 1990; Ohlemiller et al., 1995; Stubdal ... The tubby mouse is characterized by progressive retinal and cochlear degeneration and late-onset obesity. These phenotypes are caused by a loss-of-function mutation in the tub gene and are shared with several human syndromes, suggesting the importance of tubby protein in central nervous system (CNS) functioning. Although evidence suggests that tubby may act as a transcription factor mediating G-protein coupled receptor (GPCR) signaling, any downstream gene regulated by tubby has yet to be...