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Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum
HoaiBacNguyen, ShinYoungLee, SooHyunPark, JunHyunHan, MooYeolLee, SoonChulMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 10 257-262 (6 pages)
..PAGE:1 257 Korean J Physiol Pharmacol Vol 19: 257 －262, May, 2015 http://dx.doi.org/10.4196/kjpp.2015.19.3.257 pISSN 1226-4512 eISSN 2093-3827 ABBREVIATIONS: HEPES, 4-(2-hydroxyethyl)-1-piperazineethane- sulfonic acid; PSS, physiological salt solution; TP receptor, throm- boxane receptor; S.E.M., standard error of means; ANOVA, analysis of variance; W/O, washout; NO, nitric oxide; Rho-kinase,... It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile...