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Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization
Hyang-AeLee, Sung-AeHyun, Sung-GurlPark, Ki-SukKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 15 119-127 (9 pages)
ISR, and AML were summarized and fitted with Hill function (each n=4). The IC50 values were 0.88±0.05 mM for NIC, 6.78±0.36 mM for AML, and >30 mM for ISR. ..PAGE:7 Effects of CCBs on cardiac repolarization Korean J Physiol Pharmacol 2016;20(1):119-127 www.kjpp.net 125 not obtain the IC50 value for ISR. For recording IKs, the KCNQ1/KCNE1-coexpressing cells were depolarized for 3 s to +60 ... both APD50 and APD90 already at 1 μM whereas NIC and AML shortened APD50 but not APD90 up to 30 μM. According to ion channel studies, NIC and AML concentration-dependently inhibited IKr and IKs while ISR had only partial inhibitory effects (<50% at 30 μM). Inhibition of INa was similarly observed in the three CCBs. Since the IKr and IKs mainly contribute to cardiac repolarization, their inhibition by NIC and AML could compensate for the AP shortening effects due to the block of ICa. -
Effects of cardiac biological activities on low-intensity physical training in doxorubicin-induced cardiotoxicity rat models
Yeong-Kye Ki, Gye-Yeop Kim, Eun-Jung Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 5 107-111 (5 pages)
the stable current and repolarization of my- ocardial cells as found in the altered diseased state, and could result from an unstable state consisting of heavy breathing after drug use. In the experimental group than in the control group performed the exercise is weight loss caused by doxorubicin dose was reduced. Dudka et al. [17] reported increases in oxidative stress and oxidative enzyme... Objective: In the present study, we investigated the protective effects of low-intensity treadmill training in doxorubicin-induced cardiotoxicity rat models. Design: Randomized controlled trial. Methods: In this study, we randomly divided them into four groups. The normal group included non-cardiotoxicity normal control (n=10), the control group included non-treadmill training after doxorubicin-induced cardiotoxicity (n=10), the experimental group I included low-intensity treadmill training (3... -
Poncirin Induced Fas-Dependent and Mitochondrial Independent Apoptotic Cell Death in AGS Human Gastric Cancer Cells
Venu Venkatarame Gowda Saralamma, Gyeong Eun Hong, Silvia Yumnam, Suchismita Raha, Ho Jeong Lee, Jeong Doo Heo, Sang Joon Lee, Gon Sup 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 142 212-213 (2 pages)
KenA, Jun X, Ronit V. O, Zheng I. Z, Collen E. C, Mitsuaki I, Tetsuchi F.Progesterone regulates cardiac repolarization through a nongenomic pathway: Anin vitro patch-clamp and computational modeling study, Circulation. 2007;116: 2913-2922. P-121 Poncirin Induced Fas-Dependent and Mitochondrial Independent Apoptotic Cell Death in AGS Human Gastric Cancer Cells Venu Venkatarame Gowda Saralamma... -
The Influence of Progesterone on Beating-rate of Differentiated Mouse Embryonic Stem Cells into Cardiomyocytes
Eui Bae Jeung, Young Kwon Choi 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 141 212-212 (1 pages)
KenA, Jun X, Ronit V. O, Zheng I. Z, Collen E. C, Mitsuaki I, Tetsuchi F.Progesterone regulates cardiac repolarization through a nongenomic pathway: Anin vitro patch-clamp and computational modeling study, Circulation. 2007;116: 2913-2922. P-121 Poncirin Induced Fas-Dependent and Mitochondrial Independent Apoptotic Cell Death in AGS Human Gastric Cancer Cells Venu Venkatarame Gowda Saralamma... -
EMT During the Differentiation of SF1-mESCs into Steroidogenic Cells
Eui Bae Jeung, Hee Young Kang 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 140 211-212 (2 pages)
KenA, Jun X, Ronit V. O, Zheng I. Z, Collen E. C, Mitsuaki I, Tetsuchi F.Progesterone regulates cardiac repolarization through a nongenomic pathway: Anin vitro patch-clamp and computational modeling study, Circulation. 2007;116: 2913-2922. P-121 Poncirin Induced Fas-Dependent and Mitochondrial Independent Apoptotic Cell Death in AGS Human Gastric Cancer Cells Venu Venkatarame Gowda Saralamma... -
Development of alternative toxicity models for nonclinical cardiotoxicity testing
Hyang Ae Lee, Ki Moo Lim Ki Suk Kim 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 18 95-95 (1 pages)
cardiac repolarization and TdP in man has been reduced but not eliminated. Despite all the efforts to establish and to validate preclinical models, none of the preclinical in vitro and in vivo methods have been proven to be fully predictive for QT prolongation and for torsadogenic potential because of interspecies differences. The fact that several drugs have been withdrawn from the market due... -
Comparison of electrophysiological properties of two types of pre-sympathetic neurons intermingled in the hypothalamic paraventricular nucleus
Yiming Shen, Seong Kyu Han, Pan Dong Ryu 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 2 483-491 (9 pages)
PVN neuron groups. In the regulation of action potential duration and decay time, the voltage-activated potassium channels (Kv3.13.2) have a critical role in modeling the action potential repolarization phase. Blockade of Kv3.13.2 channels with tetraethylammonium prolongs the decay time and decreases the firing rate in response to current inputs [13]. Multiple Ca 2+ channels are also largely... The hypothalamic paraventricular nucleus (PVN) contains two types of neurons projecting to either the rostral ventrolateral medulla (PVNRVLM) or the intermediolateral horn (IML) of the spinal cord (PVNIML). These two neuron groups are intermingled in the same subdivisions of the PVN and differentially regulate sympathetic outflow. However, electrophysiological evidence supporting such functional differences is largely lacking. Herein, we compared the electrophysiological properties of these... -
Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice
Yiming Shen, Janardhan P. Bhattarai, Soo Joung Park, Gyu Seung Lee, Pan Dong Ryu, Seong Kyu Han 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 3 172-178 (7 pages)
novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors. Mol Cells 2012, 34, 563-572. 35. Storm JF. Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells. J Physiol 1987, 385, 733-759. 36. Sugaya A, Yuzurihara M, Tsuda T, Yasuda K, Kajiwara K, Sugaya E. Proliferative... It has been reported that Korean red ginseng (KRG), a valuable and important traditional medicine, has varied effects on the central nervous system, suggesting its activities are complicated. The paraventricular nucleus (PVN) neurons of the hypothalamus has a critical role in stress responses and hormone secretions. Although the action mechanisms of KRG on various cells and systems have been reported, the direct membrane effects of KRG on PVN neurons have not been fully described. In this study,... -
Studies on sodium and potassium metabolism and subsequent influence on electrocardiogram in unilaterally adrenalectomized black Bengal goat (Capra hircus)
G. D.V. Pandiyan, P. R. Ghosh, B. C. Das, P. K. Das, S. Sanyal 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 4호 2 273-277 (5 pages)
(TAP) of cardiac cell. Elevated potassium concentration of ECF increases membrane permeability to potassium [16] thereby increasing the rate of repolarization and shortening of the duration of the TAP. These changes in TAP characteristics are responsible for the electrocardiographic manifestation of hyperkalemia. The earliest electrocardiographic changes in hyperkalemia are peaked or ‘tented’ T... Unilateral adrenalectomy was performed in six black Bengal goat (Capra hircus)to study electrocardiograph in connection with mineral metabolism with special reference to sodium and potassium and some other factors of physiological importance. The parameters were studied at every 12 hrs interval upto 120 hrs and 24 hrs interval from 120 to 240 hrs.Physiological parameters, like body weight and rectal temperature, changed non-significantly (p<0.05)after adrenalectomy.Among minerals, plasma sodium... -
Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs
Ji Sang Chae , Jin Ok Ahn , Ye Rin Coh , Chong Woo Park , Hwa Young Youn 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 3호 3 163-167 (5 pages)
by torsades de pointes [7, 13]. These effects are not mediated by 5-HT 4 receptor activation. Cisapride blocks human ether-a-go-go-related gene (HERG) K + channels that are responsible for the repolarization phase of cardiac action potential in human studies [2]. Although Fig. 2. QT intervals in 3 mg/kg mosapride administration group (A group), and 3 mg/kg mosapride with 5 mg/kg itraconazole...