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The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells
JungryulAhn, Myoung-HwanChoi, KwangsooKim, SolomonS.Senok, Dong-ilDanCho, Kyo-inKoo, YongsookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 10 555-563 (9 pages)
..PAGE:1 www.kjpp.net Korean J Physiol Pharmacol 2017;21(5):555-563 555 Korean J Physiol Pharmacol 2017;21(5):555-563 https://doi.org/10.4196/kjpp.2017.21.5.555 Author contributions: J.R.A., M.H.C., K.I.K., and Y.S.G. conceived and de- signed the experiments; J.R.A. and M.H.C. performed experiments; J.R.A., M.H.C., K.S.K, S.S.S, and D.Cho analyzed the data; J.R.A, K.I.K, Y.S.G. wrote the... Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted... -
Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice
KunNoAhn, JeongYeolAhn, Jae-hyungKim, KyoungrokCho, Kyo-inKoo, SolomonS.Senok, YongSookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 12 167-175 (9 pages)
..PAGE:1 167 Korean J Physiol Pharmacol Vol 19: 167 －175, March, 2015 http://dx.doi.org/10.4196/kjpp.2015.19.2.167 pISSN 1226-4512 eISSN 2093-3827 ABBREVIATIONS: ACSF, artificial cerebrospinal fluid; AMD, age-related macular degeneration; MEA, multielectrode array; OPL, outer plexiform layer; PSTH, post-stimulus time histogram; RGC, retinal ganglion cell; RP, retinitis pigmentosa; SD,... A retinal prosthesis is being developed for the restoration of vision in patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking retinal ganglion cell (RGC) responses. Retinal... -
Accurate Representation of Light-intensity Information by the Neural Activities of Independently Firing Retinal Ganglion Cells
SangBaekRyu, JangHeeYe, ChiHyunKim, YongSookGoo, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 13 221-227 (7 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 13: 221 －227, June, 2009 221 ABBREVIATIONS: RGC, retinal ganglion cell; MEA, multi-electrode array; PSTH, post-stimulus time histogram. Received May 23, 2009, Revised June 9, 2009, Accepted June 23, 2009 Corresponding to: Kyung Hwan Kim, Department of Biomedical Engineering, College of Health Science, Yonsei University, 234, Maeji-ri, Heungup-myun,... For successful restoration of visual function by a visual neural prosthesis such as retinal implant, electrical stimulation should evoke neural responses so that the information on visual input is properly represented. A stimulation strategy, which means a method for generating stimulation waveforms based on visual input, should be developed for this purpose. We proposed to use the decoding of visual input from retinal ganglion cell (RGC) responses for the evaluation of stimulus encoding... -
Functional Connectivity Map of Retinal Ganglion Cells for Retinal Prosthesis
JangHeeYe, SangBaekRyu, KyungHwanKim, YongSookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 4 307-314 (8 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 12: 307 －314, December, 2008 307 ABBREVIATIONS: RP, retinitis pigmentosa; AMD, age-related macular degeneration; RGC, retinal ganglion cell; MEA, multi- electrode array; ACSF, artificial cerebrospinal fluid; PSTH, post- stimulus time histogram; STA, spike-triggered average. Corresponding to: Yong Sook Goo, Department of Physiology, Chungbuk National... Retinal prostheses are being developed to restore vision for the blind with retinal diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Among the many issues for prosthesis development, stimulation encoding strategy is one of the most essential electrophysiological issues. The more we understand the retinal circuitry how it encodes and processes visual information, the greater it could help decide stimulation encoding strategy for retinal prosthesis. Therefore,...