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The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects
SangilJeon, SeunghoonHan, JongtaeLee, TaegonHong, Dong-SeokYim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 4 249-253 (5 pages)
on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h －1, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a... of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h－1, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract. -
Enhancement of Seed Dehiscence by Seed Treatment with Talaromyces flavus GG01 and GG04 in Ginseng (Panax ginseng)
한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 1호 1 1-8 (8 pages)
Ginseng Seed Dehiscence by T. favus growth inhibition (PMGI) was calculated using the for- mula: PMGI (%) = RC IR/RC × 100, where radicle of control (RC) represents the distance (measured in mm) from the point of inoculation to the colony margin on the control dishes and inhibition radicle (IR) the distance of fungal growth from the point of in- oculation to the colony margin on the treated... ginseng seed in four traditional stratification facilities. The isolates showed antagonistic activities against fungal plant pathogens, such as Cylindrocarpon destructans, Fusarium oxysporum, Rhizoctonia solani, Sclerotinia nivalis, Botrytis cinerea, and Phytophthora capsici. The dehiscence ratios of ginseng seed increased more than 33% by treatment of T. flavus GG01, GG02, GG04, GG12, and GG23 in comparison to control (28%). Among the treatments, the reformulating treatment of... -
Analysis of protein expression in Brucella abortus mutants with different growth rates by two-dimensional gel electrophoresis and LC-MS/MS peptide analysis
Woo Bin Park, Young Bin Im, Soojin Shim, Han Sang Yoo 대한수의학회 Journal of Veterinary Science 16 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 8 216-231 (16 pages)
B. abortus mutants. Materials and Methods Sample selection and preparation for 2-DE B. abortus mutants were prepared by transposon mutagenesis using wild-type and kanamycin resistance (rKan) genes and the EZ-Tn5 transposon system (Epicentre Biotechnologies, USA). The mutants were used in experiments to assess changes in ..PAGE:4 Analysis of protein expression in Brucella abortus mutants 219... Brucella abortus is a bacterium that causes brucellosis and is the causative agent of worldwide zoonoses. Pathogenesis of the B. abortus infection is complicated, and several researchers have attempted to elucidate the infection mechanism of B. abortus. While several proteins have been revealed as pathogenic factors by previous researchers, the underlying mechanism of B. abortus infection is unresolved. In this study, we identified proteins showing different expression levels in B. abortus... -
Protective efficacy of a high-growth reassortant swine H3N2 inactivated vaccine constructed by reverse genetic manipulation
Feng Wen, Ji-Hong Ma, Hai Yu*, Fu-Ru Yang, Meng Huang, Yan-Jun Zhou, Ze-Jun Li, Guang-Zhi Tong* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 3호 6 381-388 (8 pages)
Phylogenetic analysis of hemaggulutinin (HA) gene segment of H3N2 SwIV isolates from southern China. The HA donor of the seed virus in this study is indicated by a dark circle. may have occurred years before emergence in humans [26]. Owing to the short life span of pigs, the human influenza virus transmitted to pigs undertake less selection pressure than their counterparts in humans [21]. As... Novel reassortant H3N2 swine influenza viruses (SwIV) with the matrix gene from the 2009 H1N1 pandemic virus have been isolated in many countries as well as during outbreaks in multiple states in the United States, indicating that H3N2 SwIV might be a potential threat to public health. Since southern China is the world’s largest producer of pigs, efficient vaccines should be developed to prevent pigs from acquiring H3N2 subtype SwIV infections, and thus limit the possibility of SwIV infection... -
An overview of calf diarrhea - infectious etiology, diagnosis, and intervention
Yong-il Cho, Kyoung-Jin Yoon* 대한수의학회 Journal of Veterinary Science 17 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 1 1-17 (17 pages)
dystocia, especially in beef heifers. To prevent dystocia, the dam’s genetic inheritance (e.g., adequate pelvic size and calving ease) should be taken into consideration during heifer selection [9], and frequent monitoring of the calving cow is required for appropriate calving assistance [71]. Immunity The bovine placenta does not permit the passive transfer of antibody to the fetus. As... Calf diarrhea is a commonly reported disease in young animals, and still a major cause of productivity and economic loss to cattle producers worldwide. In the report of the 2007 National Animal Health Monitoring System for U.S. dairy, half of the deaths among unweaned calves was attributed to diarrhea. Multiple pathogens are known or postulated to cause or contribute to calf diarrhea development. Other factors including both the environment and management practices influence disease severity or... -
Whole-Genome Characterization of Alfalfa Mosaic Virus Obtained from Metagenomic Analysis of Vinca minor and Wisteria sinensis in Iran: with Implications for the Genetic Structure of the Virus
Zohreh Moradi, Mohsen Mehrvar 한국식물병리학회 The Plant Pathology Journal 13 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 11 619-631 (13 pages)
least two separate algorithms within the HYPHY software package (Supple- mentary Table 3). Positive selection on some codons in AMV coding regions confirmed a molecular adaptation by fixing beneficial genotypes and enhancing population diversification. This finding also presents additional sup- port for the wide spectrum of AMV infection. Our analyses distinguished six putative reassortment... isolate CaM and American isolate OH-2- 2017, with 97.96-98.07% nt identity. The P2 gene re- vealed more nucleotide diversity compared with other genes. Genes in the AMV genome were under dominant negative selection during evolution, and the P1 and coat protein (CP) proteins were subject to the strongest and weakest purifying selection, respectively. In the population genetic analysis based on the CP gene sequences, all 107 AMV isolates fell into two main clades (A, B) and isolates of clade A... -
Control Efficacy of Bacillus velezensis AFB2-2 against Potato Late Blight Caused by Phytophthora infestans in Organic Potato Cultivation
Min Jeong Kim, Chang Ki Shim, Jong-Ho Park 한국식물병리학회 The Plant Pathology Journal 16 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 8 580-595 (16 pages)
J. 2006. Selection of Brevibacillus brevis B23 and Bacillus stearothermophilus B42 as biological control agents against sclerotinia rot of lettuce. Res. Plant Dis. 12:254-259 (in Ko- rean). International Potato Center. 2004. Annual report. Late blight new development. International Potato Center, Lima, Peru. pp. 9-13. Jin, S.-R., Lee H.-M., Nam K.-W. and Park, K. 2018. Biological control of... Although late blight is an important disease in eco- friendly potato cultivation in Korea, it is highly depen- dent on the use of eco-friendly agricultural materials and the development of biological control technology is low. It is a necessary to develop an effective biocontrol agent to inactivate late blight in the field. AFB2-2 strain is a gram-positive with peritrichous flagella. It can uti- lize 20 types of carbon sources, like L-arabinose, and D- trehalose at 35°C. The optimal growth... -
Response of Barley Genotypes to Fusarium Head Blight under Natural Infection and Artificial Inoculation Conditions
Raja Khanal, Thin Meiw Choo, Allen G. Xue, Bernard Vigier, Marc E. Savard, Barbara Blackwell, Junmei Wang, Jianming Yang, Richard A. Martin 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 5호 5 455-464 (10 pages)
be used for indirect selection for low DON without resorting to the time-consuming, labor- intensive DON quantification. Geddes et al. (2008) con- cluded that indoor spray inoculation is most reproducible in comparison with point-inoculation and grain spawn. Em- pirical experiments are needed to determine if grain spawn inoculation or indoor spray inoculation produces similar results as those... (r = -0.23, P > 0.05) and FHB incidence (r = 0.19, P > 0.05) in the artificially inoculated nursery with grain spawn method. FHB severity, DON concentration, and yield were affected by year, genotype, and the genotype × year interaction. The effectiveness of green- house spray inoculation for indirect selection for low DON concentration requires further studies. Nine of the 48 genotypes were found to contain low DON under natural infection. Island barley had low DON and also had high yield. -
Different Phytohormonal Responses on Satsuma Mandarin (Citrus unshiu) Leaves Infected with Host-Compatible or Host-Incompatible Elsino? fawcettii
Kihye Shin, Dilli Prasad Paudyal, Seong Chan Lee, Jae Wook Hyun 한국식물병리학회 The Plant Pathology Journal 12 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 3호 6 268-279 (12 pages)
G. E. 2010. Reference gene selection for real-time quantita- tive polymerase chain reaction normalization in Swingle citrumelo under drought stress. Anal. Biochem. 402:197-199. Chung, K.-R. 2011. Elsinoe fawcettii and Elsinoe australis: the fungal pathogens causing citrus scab. Mol. Plant Pathol. 12:123-135. De Vleesschauwer, D., Yang, Y., Cruz, C. V. and Hofte, M. 2010. Abscisic acid-induced... Citrus scab, caused by the fungal pathogen Elsinoë fawcettii, is one of the most important fungal diseases affecting Citrus spp. Citrus scab affects young tissues, including the leaves, twigs, and fruits, and produces severe fruit blemishes that reduce the market value of fresh fruits. To study the molecular responses of sat- suma mandarin (C. unshiu) to E. fawcettii, plant hor- mone-related gene expression was analyzed in response to host-compatible (SM16-1) and host-incompatible... -
Necrotrophic Fungus Pyrenophora tritici-repentis Triggers Expression of Multiple Resistance Components in Resistant and Susceptible Wheat Cultivars
Ethan J. Andersen, Madhav P. Nepal, Shaukat Ali 한국식물병리학회 The Plant Pathology Journal 16 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 2호 2 99-114 (16 pages)
against Tan Spot 101 this study were published in BMC Research Note (Andersen et al., 2019b). Wheat cultivar selection and growth. Two cultivars of wheat were grown, TS resistant Salamouni and TS sus- ceptible Glenlea, selected due to their well-established in- sensitivity and sensitivity to Ptr ToxA, respectively. Seeds were germinated in petri dishes on damp filter paper and transferred to 3... Tan spot of wheat, caused by Pyrenophora tritici-re- pentis (Ptr), results in a yield loss through chlorosis and necrosis of healthy leaf tissue. The major objective of this study was to compare gene expression in resistant and susceptible wheat cultivars after infection with Ptr ToxA-producing race 2 and direct infiltration with Ptr ToxA proteins. Greenhouse experiments included ex- posure of the wheat cultivars to pathogen inoculum or direct infiltration of leaf tissue with Ptr-ToxA protein...