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2-2-Methylene bis (3, 4, 6-trichlorophenoxy acetic acid) (MTPA)의 체내흡수(體內吸收) 분포(分布) 및 배설(排泄)에 관(關)한 연구(硏究)
김종석(Kim, Chong-Suk), 박준형(Pock, Joon-Hyoung), 김유문(Kim, Yu-Moon), 강영호(Kang, Yung-Ho), 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1973, 제 9권 제 1호 3 39-46 (8 pages)
..PAGE:1 "1J ~~t!-] ~ 7J-;,] : .:<1] 9 il_ .:<1] 1 ~ Korean J. of Parmacology Volume 9, Number 1, 1973 2-2-Methylene bis (3, 4, 6-trichlorophenoxy acetic acid) =Abstract= (MTPA)E-1 pJ ::;,<; Studies on Absorption Distribution and Excretion of 2-2-Methylene bis (3, 4, 6-trichlorophenoxy acetic acid) (MTP A) in Rabbits Chong Suk Kim, M.D., Ph.D. Joon Hyoung:-Pock, M.S. and Yu Moon Kim, M.D.... -
CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells
Kyoung-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 13 331-336 (6 pages)
(TIF-2) bind to the C-terminal transactivation domain (C-TAD) of HIF-1α and function as transcriptional coactivators [6,7]. HIF-1α is also regulated at the translational level by the AKT-mTOR pathway. AKT phosphorylates mTOR, and the activated mTOR in turn phosphorylat es and inhibits S6K and 4E-BP1. Then, the translation-initiating factors aggregate to form the translational complex and... In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 con</SUB>sumption and supply. Hypoxia Inducible Factor (HIF)-1Ձ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-1Ձ-targeting... -
Genetic engineering of a temperate phage-based delivery system for CRISPR/Cas9 antimicrobials against Staphylococcus aureus
Bo-youn Moon, Joo Youn Park, Justin A. Thornton, Juw Won Park, Yong Ho Park, Kyung Ki Lee, Seong Hee Kim, Yeon Hee Kim, Dong Chan Moon, B 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 114 249-250 (2 pages)
..PAGE:1 Vol. 56, No. 3 October 249 and the samples were tested for the presence of virus. Results: No substitution in F gene of an APMV-6 isolate was observed even after 9 seri al passages in chickens. The amino acid sequences at the cleavage site in F gene of Ck9 was 113APEPR 117, indicating that the virus is not pathogenic in chickens. Three amino acids (aa) among 613 aa in HN gene (S66P,... -
Double-blind test에 의한 Moltase 의 효력평가(効力評價)
이동호(Lee, Tong-Ho), 이태희(Lee, Tae-Hee), 대한약리학회 대한약리학잡지 4 Pages
대한약리학회 대한약리학잡지 1970, 제 6권 제 1호 4 23-26 (4 pages)
..PAGE:1 1'Jl ~~;;,J ~:>-J-;;tl : ;,iJ 6 "1:1. ;,iJ 1 ~- Korean Journal of Pharmacology Volume 6, Nomber 1, 1970 Double-blind test o:tl 9-1 ~ Moltase 9-l 7J 1J ~fl: * =Abstract= Clinical Evaluation of Efficacy of Moltase by Double-blind Test Tong Ho Lee and Tae Hee Lee Depts. of Pharmacology & Internal Medicine, Chonnam Univ. Medical School Kwangju, Korea. (Director: profs. Y. I. Kim & B.... 소화불량(消化不良)을 호소(呼訴)하는 학생(學生) 및 환자(患者)에게 placebos 투여(投與) 및 double-blind test에 의하여 식욕부진(食慾不振), 구역, 구토, 트림, 공복통(空腹痛), 상복부통(上腹部痛), 상복부포만감(上腹部飽滿感), 복부팽만(腹部膨滿), 변비(便秘), 설사(泄瀉) 등의 증상(症狀) 및 위산도(胃酸度)에 대한 Moltase의 효력(効力)을 평가(評價)할 것을 시도(試圖)하여 1) 전반적(全般的)으로 Moltase투여(投與)가 placebos 투여(投與)보다 소화불량증상(消化不良症狀)을 소실(消失) 또는 경감(輕減)시키는... -
Differential gene expression pattern in brains of acrylamide-administered mice
Chang Hoon Han 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 2호 6 99-104 (6 pages)
..PAGE:1 大韓獸醫學會誌(2012) 第52卷 第2號 Korean J Vet Res(2012) 52(2) : 99~104 99 <원례보저> Differential gene expression pattern in brains of acrylamide-administered mice Chang-Hoon Han* Department of Toxicology & Biochemistry, College of veterinary Medicine, Jeju National University, Jeju 690-756, Korea (Received: May 7, 2012; Revised: May 14, 2012; Accepted: May 14, 2012) Abstract :The... -
Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
ChaKyungYoun, SeonJooPark., MeiHongLi, MinYoungLee, KunYeongLee, ManJinCha, OkHyeunKim, HoJinYou, InYoupChang, SangPilYoon, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 9 315-320 (6 pages)
..PAGE:1 315 Korean J Physiol Pharmacol Vol 17: 315 －320, August, 2013 http://dx.doi.org/10.4196/kjpp.2013.17.4.315 ABBREVIATIONS: iNOS, inducible nitric oxide synthase; IFN- γ, interferon-γ; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β. Received March 25, 2013, Revised May 22, 2013, Accepted July 5, 2013 Corresponding to: Young Jin Jeon, Department of Pharmacology, School of... Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-Ձ, IFN-Ճ, and IL-1Ղ). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-ՊB/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor... -
Catecholamines에 관(關)하여 -제5편(第五編) : 자궁(子宮) catecholamines에 관한 실험적(實驗的) 연구(硏究)-
이우주(Woo Choo Lee) 대한약리학회 대한약리학잡지 24 Pages
대한약리학회 대한약리학잡지 1983, 제 19권 제 1호 2 37-60 (24 pages)
..PAGE:1 ::ktlt~ll!I-'~~:~19~ ~1~ Korean J. of Pharmacology Volume 19, Number 1, 1983 Catecholamines oil lffl"6"}04 -ffilinlliii : r1I catecholamines cill ~~ 1(~1) Titf~- ~i!!:::k.113).' U'f4::k ~ll!I-'~~ * * tt =Abstract= Experimental Studies on Utarine Catecholamines Woo Choo Lee, M.D., Ph.D. Dapartment of Pharmacology, Yonsei University College of Medicine, Seoul, Korea Tii." ut"rn3... -
Catecholamines에 관(關)하여 -제4편(第四編) : 심실전동발생(心室顫動發生)에 있어서의 catecholamines의 의의(意義)-
이우주(Woo Choo Lee) 대한약리학회 대한약리학잡지 22 Pages
대한약리학회 대한약리학잡지 1983, 제 19권 제 1호 1 15-36 (22 pages)
..PAGE:1 *-~~11J!~~ : ~19~ ~ 1 ~ Korean J. of Pharmacology Volume 19, Number 1, 1983 =Abstract= Catecholamines oll !iffl "8"}°1 * Role of Catecholamines in Ventricular Fibrillation Woo Choo Lee, M.D., Ph.D. Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea Although it has been well known that ventricular fibrillation is the most important complication... -
두개내압상승(頭蓋內壓上昇)에 따른 혈압상승(血壓上昇)과 교감신경기능(交感神經機能)과의 관계(關係) -Clonidine, phenoxybenzamine 및 phentolamine의 영향(影響)-
정우섭(Woo Sup Chung) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 제 15권 제 1,2호 2 7-12 (6 pages)
..PAGE:1 :k$\t~:I!ll.~ifil.t : ~15~ ~1, 2t~ Korean J. of Pharmacology Volume 15, Number 1·2, 1979 -Clonidine, phenoxybenzamine g,) phentolamine 21 =Abstract= Sympathetic Activity in the Pressor Response in Raised Intrncranial Pressure -Experiments with clonidine, phenoxybcnzamine and phentolamine--- Woo Sup Chung Departments of Neurosurgery and Pharmacology, Cizonnam Univ. ;'v:[edical... 1. 두개내압상승(頭蓋內壓上昇)에 혈압상승(血壓上昇)이 중추(中樞)의 교감신경기능(交感神經機能)과의 관계(關係)가 있음을 확인(確認)하기 위하여, clonidine, phenoxybenzamine 및 phentolamine을 사용(使用)하여 이들 약물(藥物)이 두 개내압상승(頭蓋內壓上昇)에 따른 협압상승(血壓上昇)에 미치는 영향(影響)을 조사(調査)하였다. 2. 정맥내(靜脈內) clonidine은 측뇌실내(側腦室內) 주입시(注入時)와 같이 두개내압상승(頭蓋內壓上昇)에 따른 혈압상승(血壓上昇)을 억제(抑制)하였다. 3. Phenoxybenzamine 및 phentolamine의...