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Calbindin-D9k ablation dysregulate glucose homeostasis
Chang-hwan Ahn, Jae Hwan Lee, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 199 318-318 (1 pages)
insulin secretion. Prior to conduct this study, we confirmed Calbindin-D 9k (CaBP-9k) which responsible for regulation of th e distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, CaBP-9k KO mice showed more increased level of ER stressmarker protein than wild... -
The Role of Calbindin-D9k in Hypoxia-Induced Diabetes Mellitus like Model
Chang hwan Ahn, Jae Hwan Lee, Myeong ho Lee, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 234 322-322 (1 pages)
certain role in β cell insulin synthesis or secretion. Using Calbindin-D 9k knock out (CaBP-9k KO) mice, we demonstrate ablation of Calbindin-D 9k (CaBP-9k) induces reduction of insulin secretion and hyperglycemia. Furthermore, to find the role of CaBP-9k in pathophysiologic condition, we gave hypoxic condition to wild-type and CaBP-9k KO mice for 10days Results: Hypoxic condition induce s... -
Effects of simultaneous exposure to phthalates and 4-Vinylcyclohexene diepoxide on ovarian functions including folliculogenesis and steroidogenesis
Dinh Nam Tran, Duc Viet Ly, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 200 318-319 (2 pages)
insulin secretion. Prior to conduct this study, we confirmed Calbindin-D 9k (CaBP-9k) which responsible for regulation of th e distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, CaBP-9k KO mice showed more increased level of ER stressmarker protein than wild... -
Effects of steroid hormone on Calbindin-D9k expression in rat brainstem
Seon Young Park, Chang-hwan Ahn, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 198 318-318 (1 pages)
insulin secretion. Prior to conduct this study, we confirmed Calbindin-D 9k (CaBP-9k) which responsible for regulation of th e distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, CaBP-9k KO mice showed more increased level of ER stressmarker protein than wild... -
Effect of EDCs on calcium channels in cardiomyocytes derived from mES cell
Jae Hwan Lee, Jin Yong An, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 197 317-318 (2 pages)
insulin secretion. Prior to conduct this study, we confirmed Calbindin-D 9k (CaBP-9k) which responsible for regulation of th e distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, CaBP-9k KO mice showed more increased level of ER stressmarker protein than wild... -
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
the latter is associated with abnormal processing of stimuli in the OE and central olfactory system due to a defect in the neuronal network [24,46]. Olfactory dysfunction is a very common clinical condition with a high prevalence; Lee et al. [66] reported that 4.5% of adults (range, 2095 years) have self-awareness of olfactory dysfunction in Korea. The clinical implications of olfaction hav... Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
Seung Hoon Lee, Yongsun Kim, Daeun Rhew, Ahyoung Kim, Kwang Rae Jo, Yongseok Yoon, Kyeung Uk Choi, Taeseong Jung, Wan Hee Kim, O 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 15 377-386 (10 pages)
of the present study, proliferation rate under normal condition was not different between MSCs expressing HO-1 and normal MSCs. However, it was supposed that the number of cells expressing GFP in MSC-HO-1 group were less than that in MSC-GFP group in the implantation site but there was no difference of the degree of expression of GFP between groups. It is possible that the implanted site was... Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation of mesenchymal stromal cells (MSCs) overexpressing HO-1. Canine MSCs overexpressing HO-1 were generated by using a lentivirus packaging protocol. Eight beagle dogs with experimentally-induced SCI were divided into GFP-labeled MSC (MSC-GFP) and HO-1-overexpressing MSC... -
Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus
Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Jung Hoon Choi, Woosuk Kim, Hyo Young Jung, Moo-Ho Won, In Koo Hwang, Je Kyung Seong, 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 1 245-251 (7 pages)
twice per day is more effective than a single treatment. Thus, the inhibition of COX-2 can taper off until the next round of drug administration. Second, the point of initiation for the knockout condition and pharmacological inhibition condition was different. Reduction of COX-2 by knockout begins during development whereas suppression of COX-2 begins on the first day of drug administration.... Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor in adult neurogenesis has not been clearly demonstrated. Therefore, we performed the present study to compare the effects of pharmacological and genetic inhibition of COX-2 on adult hippocampal neurogenesis. Physiological saline or the same volume containing celecoxib was administered... -
Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma
Masaki Onoyama, Takeshi Tsuka, Tomohiro Imagawa, Tomohiro Osaki, Saburo Minami, Kazuo Azuma, Kazuhiko Kawashima, Hiroshi Ishi, T 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 13 117-123 (7 pages)
T1N0M0 T2N0M0 T2N0M0 (recurrent case) T2N0M0 T1N0M0 (recurrent case) T1N0M0 T1N0M0 T2N0M0 T2N0M0 T1N0M0 T1N0M0 T1N0M0 T1N0M0 T1N0M0 T1N0M0 BW: body weight, TNM: T, size of the primary tumor; N, condition of the regional lymph nodes; M, absence/presence of distant metastasis. Hospital of Tottori University (six dogs and four cats; Tottori, Japan), Takayama Pet Clinic (two dogs; Osaka, Japan),... Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed... -
Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry
Meejung Ahn, Heechul Kim, Jeong Tae Kim, Jeeyoung Lee, Jin Won Hyun, Jae Woo Park, Taekyun Shin 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 1 309-314 (6 pages)
caveolin-1. In the present study, we found that caveolin-1 was constitutively expressed in vascular endothelial cells in normal animals, and its expression was enhanced after irradiation. Under the condition of irradiation, it has been reported that endothelial apoptosis initiates the disruption of the acute blood-brain barrier following ionizing radiation [11], resulting in the leakage of plasma... We studied the expression of caveolin-1 in the spinal cords of rats using 60Co γ-ray irradiation (single dose of 8 Gray (Gy)) in order to determine the possible involvement of caveolin-1 in the tissues of the central nervous system after irradiation. Spinal cords sampled at days 1, 4, and 9 post-irradiation (PI) (n = 5 per each time point) were analyzed by Western blot and immunohistochemistry. Western blot analysis showed that the expression of caveolin-1 was significantly increased at day 1...