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A Study on Validation of Variable Aperture Channel Model: Migration Experiments of Conservative Tracer in Parallel and Wedge-Shaped Fracture
Keum. D.K., Hahn. P.S., Vandergraaf. T.T. 한국원자력학회 Journal of the Korean Nuclear Society 17 Pages
한국원자력학회 Journal of the Korean Nuclear Society 1998, Vol.30 No.3 245-261 (17 pages)
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Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension
TongZhou, HaiyangTang, YingHan, DustinFraidenburg, Young-WonKim, DongheeLee, JeongyoonChoi, HyoweonBang, Jae-HongKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 10 353-360 (8 pages)
a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014;289:32628-32638. 5. Chu Y, Goldman JG, Kelly L, He Y, Waliczek T, Kordower JH. Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease. Neurobiol Dis. 2014;69:1-14. 6. Huang H, Shah K, Bradbury NA, Li C, White C. Mcl-1 promotes lung cancer... Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we... -
Activation of K+ channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca2+ ionophore-induced cell death
MingZheYin, Seok-WooPark, , TaeWookKang, KyungSooKim, , , HaeYoungYoo6, JunhoLee, J.HunHah, , MyungHunSung, , SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 4 25-33 (9 pages)
of K + channel function in epithelial cell migration, proliferation, and repair. Am J Physiol Cell Physiol. 2014;306:C307-319. 14. Manzanares D, Gonzalez C, Ivonnet P, Chen RS, Valencia- Gattas M, Conner GE, Larsson HP, Salathe M. Functional apical large conductance, Ca 2+-activated, and voltage-dependent K + channels are required for maintenance of airway surface liquid volume. J Biol Chem.... K+ channel (SK4) in head and neck squamous cell carcinoma cells (HNSCCs) of dif-ferent cell lines; SNU-1076, OSC-19 and HN5. Treatment with 1 μM ionomycin induced cell death in all the three cell lines. Whole-cell patch clamp study suggested common expressions of Ca2+-activated Cl− channels (Ano-1) and Ca2+-activated nonselective cation channels (CAN). 1-EBIO, an activator of SK4, induced outward K+ current (ISK4) in SNU-1076 and OSC-19. In HN5, ISK4 was not observed or negligible. The... -
The Pathophysiologic Roles of TRPM7 Channel
HyunSooPark, ChansikHong, ByungJooKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 2 15-23 (9 pages)
Ca 2＋ influx through TRPM7 channel and then, increase of intracellular ROS levels: neuronal Ca 2＋ overload - cell death 46,78,79 Hypertension TRPM7 as a mechnotransducer 1) Cell membrane translocation of TRPM7 2) Altered cellular Mg 2＋ homeostasis: vascular remodeling (Inflammation, fibrosis, cell migration, contraction, cell growth) Downregulation of TRPM7 in spontaneous hypertensive rat:... channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2＋ and Ca2＋, and its channel activity is negatively regulated by free Mg2＋ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC)... -
The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell
Kyung-SunPark, MinHoHan, HeeKyungJang, Kyung-AKim, Eun-JongCha, Wun-JaeKim, YungHyunChoi, YangmiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 6 511-516 (6 pages)
remarkable decrease in protein expression of cyclins D1 and D3. Taken together, the TREK2 channel is present in bladder cancer cell lines and may, at least in part, contribute to cell cycle-dependent growth. Key Words: Bladder cancer, Cell cycle, Proliferation, Small interfering RNA, TREK2 INTRODUCTION K ＋ channels regulate membrane potential and may affect the oncogenic state of cells through... 253J. We confirmed that TREK2 was expressed in bladder cancer cell lines by Western blot and quantitative real-time PCR. Using the patch-clamp technique, the mechanosensitive TREK2 channel was recorded in the presence of symmetrical 150 mM KCl solutions. In 253J cells, the TREK2 channel was activated by polyunsaturated fatty acids, intracellular acidosis at －60 mV and mechanical stretch at −40 mV or 40 mV. Furthermore, small interfering RNA (siRNA)-mediated TREK2 knockdown resulted in a... -
Effects of Ethosuximide on the Pilocarpine Induced Seizure in Rat Model of Neuronal Migration Disorder
Byung-KonKim, In-SunChoi, Jin-HwaCho, Il-SungJang, Maan-GeeLeeByung-JuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 3 235-242 (8 pages)
CA1 pyra- midal neurons in an animal model of neuronal migration dis- orders: prenatal methylazoxymethanol treatment. Epilepsy Res 22: 145-156, 1995 Baraban SC, Wenzel HJ, Hochma n DW, Schwartzkroin PA. Char- acterization of heterotopic cell clusters in the hippocampus of rats exposed to methylaxzoxymethanol in utero. Epilepsy Res 39: 87-102, 2000 Barth PG. Disorders of cerebral migration. Can... Cortical malformation-associated epileptic seizures are resistant to conventional anticonvulsant drugs. Relatively little research has been conducted on the effects of antiepileptic drugs (AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of ethosuximide (ETX) in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed... -
Concentration distributions during flow of confined flowing polymer solutions at finite concentration: slit and grooved channel
Hernandez-Ortiz. Juan P., Ma. Hong-Bo, de Pablo. Juan J., Graham. Michael D. 한국유변학회 Korea-Australia rheology journal 10 Pages
한국유변학회 Korea-Australia rheology journal 2008, Vol.20 No.3 143-152 (10 pages)
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Immunomodulatory effects of oxygen water cultivated Glycine max sprout - Lentinula edodes - Crassostrea gigas compound in Balb/c mice
Jae Hun Ahn, Ji Yeon Park, Joo Hee Choi, Ah Ra Jang, Ha Nul Lee, Jong Hwan Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 257 349-350 (2 pages)
modified trans-well migration assay, hNSCs selectively migrated to JEG-3 choriocarcinoma cells. It was revealed that the tumor-tropic properties of hNSCs were attributed to chemoattractant factors (CXCR4, SCF, SDF-1a, VEGF) secreted by JEG-3 cells. In vitro MTT assay and in vivo mouse model, we confirmed the suppression of JEG-3 tumor growth and metastasis by hNSCs. Conclusions: The present... -
Zinc oxide nanoparticles induce oxidative injury via both cyclooxygenase-2 and lipoxygenase, intracellular zinc/calcium disturbance and Akt activation in primary glialcultures
Dongmin Choi, Myungbok Wie 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 256 349-349 (1 pages)
modified trans-well migration assay, hNSCs selectively migrated to JEG-3 choriocarcinoma cells. It was revealed that the tumor-tropic properties of hNSCs were attributed to chemoattractant factors (CXCR4, SCF, SDF-1a, VEGF) secreted by JEG-3 cells. In vitro MTT assay and in vivo mouse model, we confirmed the suppression of JEG-3 tumor growth and metastasis by hNSCs. Conclusions: The present... -
A growth of human choriocarcinoma was selectively inhibited by neural stem cells expressing cytosine deaminase and interferon-β
Gyu Sik Kim, Kyung Chul Choi 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 255 348-349 (2 pages)
trans-well migration assay, HB1.F3.CD and HB1.F3.CD.IFN-β cells selectively migrated to SNU-80 cells because of its tumor-tropic properties. Engineering NSCs were attributed to chemo attractant factors like uPAR, CXCR4, SCF and VEGFR2 secreted by SNU-80 cells. Also when co-cultured with HB1.F3.CD and HB1.F3.CD.IFN-β cells, SNU-80 cell viability was reduced in presence of 5-FC. Conclusions:...