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Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 6 525-538 (14 pages)
H, Liang XL, Liu Q, Wang HY, Cao B, Cao J, Liu S, Long YJ, Xie WY, Peng DZ. Epigenetic mechanism of maternal post-traumatic stress disorder in delayed rat offspring development: dysregulation of methylation and gene expression. Genet Mol Res. 2016;15:1-10. 52. Wang HT, Han F, Shi YX. Activity of the 5-HT1A receptor is in- volved in the alteration of glucocorticoid receptor in hippocampus and... Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several... -
The Plant-Stress Metabolites, Hexanoic Aacid and Melatonin, Are Potential “Vaccines” for Plant Health Promotion
Anne J. Anderson, Young Cheol Kim 한국식물병리학회 The Plant Pathology Journal 13 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 5호 1 415-427 (13 pages)
binding to the genes promoters, whereas repression of JA pathway marker genes is associated with methyla- tion of histone H3. DNA methylation also is required for transgenerational resistance. For rice, priming with methyl jasmonate (MeJA) changes DNA methylation and modifies the histones associated with the promoter of a defense gene (Laura et al., 2018). In tomato challenged by B. cinerea,... A plethora of compounds stimulate protective mecha- nisms in plants against microbial pathogens and abiotic stresses. Some defense activators are synthetic com- pounds and trigger responses only in certain protective pathways, such as activation of defenses under regula- tion by the plant regulator, salicylic acid (SA). This review discusses the potential of naturally occurring plant metabolites as primers for defense responses in the plant. The production of the metabolites, hexanoic acid and... -
Inhibitory Activity of Sedum middendorffianum-Derived 4-Hydroxybenzoic Acid and Vanillic Acid on the Type III Secretion System of Pseudomonas syringae pv. tomato DC3000
Ji Eun Kang, Byeong Jun Jeon, Min Young Park, Beom Seok Kim 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2020, 36권 6호 8 608-617 (10 pages)
col- umn chromatography was conducted with the concentrated silica fraction eluted with methanol. The sephadex fraction with T3SS inhibitory effect was concentrated in vacuo and dissolved in high-performance liquid chromatography (HPLC) grade methanol. Afterwards, preparative HPLC separation with Cosmosil 5C18-MS-II column (10 × 150 mm) was carried out at a rate of 3 ml/min with a linear gr... The type III secretion system (T3SS) is a key virulence determinant in the infection process of Pseudomonas syringae pv. tomato DC3000 (Pst DC3000). Pathogen constructs a type III apparatus to translocate effector proteins into host cells, which have various roles in pathogenesis. 4-Hydroxybenozic acid and vanillic acid were identified from root extract of Sedum middendorffianum to have inhibitory effect on promoter activity of hrpA gene encoding the structural protein of the T3SS apparatus. The... -
Antimicrobial Cyclic Peptides for Plant Disease Control
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2015, 31권 1호 1 1-11 (11 pages)
by non-ribosomal peptide synthe- tases (NRPSs), utilizing both coded and non-proteinogenic amino acids. NRPSs can also incorporate specific traits into the peptide chains such as epimerization, N-methylation, and heterocyclization, increasing the functional diversity of these molecules (Hur et al., 2012). So far, numbers of cyclic peptides with a variety of struc- tures have been reported to... Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural fungicides. Antimicrobial cyclic peptides are classified according to the types of bonds within the ring structure; homodetic, heterodetic, and complex cyclic peptides, which in turn reflect diverse physicochemical features. Most antimicrobial cyclic...