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Anti-stress effect of Cornus officinalis in immobilized rats
Weishun Tian, Rashedunnabi Aka, Anowarul Islam, Hae Dong Yang, Sang Cheon Lee, Jeong Ho Lee, Sang Ki Kim, Yu Jin Choi, So Yeon Im, Byung 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 241 341-342 (2 pages)
of calcium inflow prevented neuronal celldeath, autophagy activation and AMPK reduct ion inducedby human prion protein. Conclusions: These data demonstrated that calcium inflow mediated by prion protein is pivotal role inprion protein-induced neurotoxicity, autophagy flux activation and AMPK reduction in neuron cells and also suggest that calcium influx might play acritical role in... -
Validation in the Zebrafish Model for an Alternative Model of Drug Induced Intestinal Toxicity
Bo-kyeong Ryu, C Yoon Kim, Han-seul Oh, Ji Min Lee, Uk-jin Kim, Jin Kim, Cho Rok Jung, Jae Hak Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 240 341-341 (1 pages)
of calcium inflow prevented neuronal celldeath, autophagy activation and AMPK reduct ion inducedby human prion protein. Conclusions: These data demonstrated that calcium inflow mediated by prion protein is pivotal role inprion protein-induced neurotoxicity, autophagy flux activation and AMPK reduction in neuron cells and also suggest that calcium influx might play acritical role in... -
Calcium overload by prion protein induces neuronal apoptosis through AMPK
Jeong Min Hong, Mohammad Rasheduzzaman, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 239 341-341 (1 pages)
of calcium inflow prevented neuronal celldeath, autophagy activation and AMPK reduct ion inducedby human prion protein. Conclusions: These data demonstrated that calcium inflow mediated by prion protein is pivotal role inprion protein-induced neurotoxicity, autophagy flux activation and AMPK reduction in neuron cells and also suggest that calcium influx might play acritical role in... -
Activation of autophagy flux by Ophiopogonin B downregulates cellular FLICE–like inhibitory protein and enhances TRAIL-induced apoptosis
Mohammad Rasheduzzaman, Jeong Min Hong, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 238 340-341 (2 pages)
of calcium inflow prevented neuronal celldeath, autophagy activation and AMPK reduct ion inducedby human prion protein. Conclusions: These data demonstrated that calcium inflow mediated by prion protein is pivotal role inprion protein-induced neurotoxicity, autophagy flux activation and AMPK reduction in neuron cells and also suggest that calcium influx might play acritical role in... -
Expression and characterization of the flavoprotein domain of gp91phox
Chang-Hoon Han and Mun-Han Lee 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2000, 제 1권 제 1호 3 19-26 (8 pages)
a low rate of INT reduct- ion [10], but this rate is still approximately 100-200 fold higher than that seen in the present study, suggesting either a less efficient electron transfer in the expressed flavoprotein domain, or additional electron transfer mechanisms in the intact cytochrome. The low activity may make this preparation of limited utility for mechanistic studies, but the model system... Truncated forms of gp91(phox) were expressed in E. coli in which the N-terminal hydrophobic transmembrane region was replaced with a portion of the highly soluble bacterial protein thioredoxin (TRX). TRX-gp91(phox) (306-569), which contains the putative FAD and NADPH binding sites, showed NADPH-dependent NBT (nitroblue tetrazolium) reductase activity, whereas TRX-gp91(phox) (304-423) and TRX-gp91(phox) (424-569) were inactive. Activity saturated at about a 1:1 molar ratio of FAD to... -
Low Intensity Resistance Exercise Training with Blood Flow Restriction: Insight into Cardiovascular Function, and Skeletal Muscle Hypertrophy in Humans
Song-YoungPark, YiSubKwak, rewHarveson, JoshuaCWeavil, KookE.Seo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 1 191-196 (6 pages)
arterial BFR using high cuff pressure in dog gastrocnemius/plantaris muscles [83]. This study suggested that both complete arterial and venous BFR results in reduct ion of oxygen utilization in the local muscle [83],with a similar degree of potential skel- etal muscle hypertrophy. In addition, Iida et al. suggested that venous BFR caused by low occlusion pressure (100 mmHg) results in a... Attenuated functional exercise capacity in elderly and diseased populations is a common problem, and stems primarily from physical inactivity. Decreased function and exercise capacity can be restored by maintaining muscular strength and mass, which are key factors in an independent and healthy life. Resistance exercise has been used to prevent muscle loss and improve muscular strength and mass. However, the intensities necessary for traditional resistance training to increase muscular strength... -
Differential Gene Expression in GPR40-Overexpressing Pancreatic β-cells Treated with Linoleic Acid
In-SuKim, So-YoungYang, Joo-HuiHan, Sang-HyukJung, Hyun-SooPark, Chang-SeonMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 9 141-149 (9 pages)
a reduct ion in insulin secretion [34]. This seeming physiological antagonism between the sym- pathetic and parasympathetic nervous systems with regard to insulin secretion can be interpreted as an autoregulatory mechanism to maintain homeostasis against excessive acti- vation of GPR40. Our findings suggest seve ral areas for future study. Cross-talk effects may be induced by altered cellular... “G protein-coupled receptor 40” (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion. We examined the profiles of differential gene expression in GPR40-activated cells treated with linoleic acid, and finally predicted the integral pathways of the cellular mechanism of GPR40-mediated insulinotropic effects. After constructing a GPR40-overexpressing stable cell line (RIN-40) from the rat pancreatic β-cell line RIN-5f, we determined the... -
Pretreatment of Albino Rats with Methanolic Fruit Extract of Randia Dumetorum (L.) Protects against Alcohol Induced Liver Damage
ArshadAliNoorani, MohanK.Kale 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 7 125-130 (6 pages)
alcohol only. Increased levels of total glutathione could be the result of direct stimulation of antioxidant en- zyme synthesis and increased levels of other antioxidants in the liver or enhanced reduct ion of oxidized glutathione. The availability of sufficient amount of reduced glutathione may enhance the detoxification of active metabolites through the involvement of glutathione peroxidase... Alcohol abuse and its medical and social consequences are a major health problem in many areas of the world. The present study was conducted to evaluate the protective effect of methanolic fruit extract of Randia dumetorum (L.) on alcohol-induced liver damage in rats. Rats were divided into five different groups (n=6), group I served as a control, group II received ethanol (3 ml/100 g/day p.o.), group III served as standard group and received silymarin (50 mg/kg p.o.), group IV and V served as... -
A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K＋ Channels in Rabbit Ventricular Myocytes
WonSunPark, YounKyoungSon, EunAKo, SeongWooChoi, NariKim, Tae-HoonChoi, HyunJooYoun, Su-HyunJo, DaHyeHong, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 1 119-125 (7 pages)
EC 50 of 56.1±5.5μg/ml for the heart rate. This suggests that AIP1 activates IK in the sino-atrial (SA) node, which induces the reduct ion of APD in the SA node, resulting in the increased heart rate. AIP1 shortened APD in ventricular cardiomyocytes We also tested the effects of AIP1 on APs using rabbit ventricular cardiomyocytes. APs were elicited every 5s us- ing the current clamp mode fo... We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K＋ current (IK) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC50 value of 56.1±5.5Ռg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating IK without significantly altering the resting membrane... -
Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior
ChuljungKwak, Sue-HyunLee, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 4 357-360 (4 pages)
levels of mice, whereas a reduction in cage size had no effect on anxiety level. In the other behavioral tests, we found that depression-like behavior was not affected by social isolation or by a reduct ion in cage dimensions. Thus, it seems that the "downsizing" of a cage where mice are housed is not such a significant modification; it does not affect the animals’ emotional behavior as muc... It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data from various behavioral experiments testing animals' cognitive as well as emotional functions. For example, laboratory mice which had restricted environment showed different synaptic potentiation properties with wild mice (Zhao MG et al., 2009). While performing behavioral experiments, however, it is...