자료유형
발행기관
- 대한생리학회-대한약리학회(119)
- 대한수의학회(88)
- 대한신경정신의학회(19)
- 대한약리학회(14)
- 한국식물병리학회(11)
- 대한생리학회(8)
- 환태평양유아교육연구학회(5)
- 공주교육대학교 초등교육연구원(2)
- 대한치과교정학회(2)
- 물리치료재활과학회(2)
- 생화학분자생물학회(2)
- 한국생약학회(2)
- 경인교육대학교 교육연구원(1)
- 고령자치매작업치료학회(1)
- 대한한방내과학회(1)
- 한국노인간호학회(1)
- 한국보건기초의학회(1)
- 한국불교상담학회(1)
- 한국생명과학회(1)
- 한국음악교육학회(1)
- 한국음악치료학회(1)
- 한국초등체육학회(1)
- 한방비만학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(119)
- JOURNAL OF VETERINARY SCIENCE(54)
- 대한수의학회 학술대회발표집(19)
- 신경정신의학(19)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(15)
- 대한약리학잡지(14)
- THE PLANT PATHOLOGY JOURNAL (10)
- 대한생리학회지(8)
- ASIA-PACIFIC JOURNAL OF RESEARCH IN EARLY CHILDHOOD EDUCATION(5)
- 교육논총(3)
- BMB REPORTS(2)
- PHYSICAL THERAPY REHABILITATION SCIENCE(2)
- THE KOREAN JOURNAL OF ORTHODONTICS(2)
- 생약학회지(2)
- 고령자-치매작업치료학회지(1)
- 노인간호학회지(1)
- 대한한방내과학회지(1)
- 대한한방비만학회지(1)
- 불교상담학연구(1)
- 생명과학회지(1)
- 식물병연구(1)
- 음악교육연구(1)
- 한국보건기초의학회지(1)
- 한국음악치료학회지(1)
- 한국초등체육학회지(1)
전체 선택해제
총 285건 검색
본문검색 결과만 보기
-
Biological Activity of Recombinant Human Granulocyte Colony-Stimulating Factor and Isolation of the Somatic Cell Transfected EGFP-hG-CSF Gene
박종주, 민관식, Park. Jong-Ju, Min. Kwan-Sik 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2008, Vol.18 No.7 912-917 (6 pages)
유전자재조합 hG-CSF의 생리활성을 분석하기 위하여 편상의 암세포로부터 분리되어진 cDNA를 이용하여 hG-CSF 유전자를 분리하여 동물세포(CHO cell lines)를 이용하여 재조합 단백질을 생산하였다. 재조합 단백질의 체내 생리활성을 분석하기 위하여0일과 2일에 피하주사 후 5일에 혈액을 채취하여 백혈구 수를 분석하였다. 투여 전과 비교하여 5일째에 백혈구 수는 현저하게 증가하였다. 또한, pEGFP-mUII-hG-CSF벡터를 소 태아로부터 분리되어진 체세포에 형질전환을 시켜서, EGFP signal을 나타내는 세포를 confocal를 이용하여... -
Platelet-Activating Factor Enhances Interleukin-1 Activity by Alveolar Macrophages Inhibition by PAF Specific Receptor Antagonists
JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 10 201-208 (8 pages)
J Biol Chem 264: 13591-13598， 1989 Chung. Platc1ct-activating factor in infaration ad pulmonary disordcrs. Clinical Science 83: 127 -138， 1992 Cuss FM， Dixon CMS， Bame‘ PJ. Inhaled platelet activating factor in man: effects on pulmonarγ function and bronchial hyperrespnsiveness. Lancet 2: 189 -191， 1986 ..PAGE:7 PAF Enhan∞s IL-1 Activity 207 Dayer JM， Go1dring SR， Robinson DR，... by rat alveolar macrophages(AM) was examined using thymocyte proliferation assay in the supernate of sample obtained after 24 hr culture. When AM were cultured with PAF alone, no change in IL-1 activity was observed. However, the combined addition of PAF and muramyl dipeptide(MDP) or lipopolysaccharide(LPS) to AM cultures markedly enhanced IL-1 activity by 2-3 fold compared with AM cultures with the stimulant alone in a concentration dependent fashion. The peack effect was found at 108 M... -
Evaluation of immunocontraceptive vaccine composed of gonadotropin-releasing hormone conjugated with granulocyte-macrophage colony-stimulating factor in male rats
Byung-joo Park , Yong-hyun Kim , Hee-seop Ahn , Sang-hoon Han , Hyeon-jeong Go , Joong-bok Lee , Seung-yong Park , Chang 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 4 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 3호 2 155-158 (4 pages)
6. Dela Cruz JS, Trinh KR, Morrison SL, Penichet ML. Recombinant anti-human HER2/neu IgG3-(GM-CSF) fusion protein retains antigen specificity and cytokine function and demonstrates antitumor activity. J Immunol 2000, 165, 5112-5121. 7. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC. Vaccination with irradiated tumor cells engineered to... -
Antiapoptotic effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant in H9c2 rat cardiomyocytes
Chung. Hee Kyoung, Ko. Eun Mi, Kim. Sung Woo, Byun. Sung-June, Chung. Hak-Jae, Kwon. Moosik, Lee. Hwi-Cheul, Yang. Byoung-Chul, Han. Deu 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2012, Vol.45 No.12 742-747 (6 pages)
-
Enhanced biological effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant, on HL60 cells
Chung. Hee-Kyoung, Kim. Sung-Woo, Byun. Sung-June, Ko. Eun-Mi, Chung. Hak-Jae, Woo. Jae-Seok, Yoo. Jae-Gyu, Lee. Hwi-Cheul, Yang. Byoung 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2011, Vol.44 No.10 686-691 (6 pages)
-
SP, CGRP Changes in Dogs with Nerve Growth Factor Gene Therapy
Joo yeon Kang, Dae Young Yoo, Jung Hoon Choi, Hwa Young Youn, In Koo Hwang, Jin Young Chung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 160 222-222 (1 pages)
in the neuronal plasticity of nervous system. For this reason, there are many trials of gene therapy with NGF to improve symptoms of neurodegenerative disorders. However, NGF can cause pain from stimulating dorsal root ganglia nociceptive neurons. Su bstance P (SP) and calcitonin gene-related peptide (CGRP) are nociception- related proteins, which are associated with various type of pain. In... -
Improvement of pregnancy rate by intrauterine administration of dexamethasone and recombinant human leukemia inhibitory factor at the time of embryo transfer in cattle
Sangho Roh, Se-Woong Kim, Yeon-Gil Jung, Jong-Im Park 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 17 569-576 (8 pages)
by stimulating endogenous proteolytic activity or by enhancing the plasminogen activator of embryos through its proliferative effects [30]. The combination of Dex and rhLIF (Dex+rhLIF) increased the hatching rate of blastocysts cultured without PGF2 Although there were no significant differences among treatment groups, the negative effects of PGF2 on the hatching process were more highly... Bovine embryos (day 5) were cultured to day 10 with or without 100 ng/mL PGF2α in medium supplemented with control; 100 nM Dex; 1,000 U/mL recombinant human leukemia inhibitory factor (rhLIF); or Dex+rhLIF. Although the rates to development to the blastocyst were not significantly different among groups, the hatching rate after additional culture with Dex +/or rhLIF was significantly higher in all supplemented groups than the control (p ＜ 0.05). In the presence of PGF2α, the hatching rate was... -
The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
Guang Fang Zhou, Qing Tao Liu, Bin Zhou, Ya Feng Qiu, Xiao Dong Liu, Zhi Yong Ma, Xiu Li Feng, Rui Bing Cao, Pu Yan Chen 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 10 325-331 (7 pages)
T cells (Lat) 1.7337011 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Nfatc2) 1.551862 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (Nfatc4) 1.6950588 ELP 1.8279516 Cytokine-cytokine receptor interaction Bone morphogenetic protein receptor, type 1A (Bmpr1a) +2.445114 Colony stimulating factor 1 receptor (Csf1r) +2.035464 Ectodysplasin A2... The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that... -
Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells
Mohamed Mohamed Soliman*, Yakut Abdel-Fattah El-Senosi, Maysara Mahmoud Salem, Omniya Mahmoud Abdel Hamid, Kimura Kazuhiro 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 4 197-201 (5 pages)
biosynthesis and adipogenesis. Keywords: acylation stimulating protein, adipogenesis, 3T3L-1 cells Introduction Protease inhibitors (PI) are a class of medications used to treat viral infections such as HIV (AIDS) and hepatitis C virus [2]. PI prevents viral replication by inhibiting the activity of protease, an enzyme used by the viruses to cleave nascent proteins for final assembly of new... Treatment of AIDS (HIV) and hepatitis C virus needs protease inhibitors (PI) to prevent viral replication. Uses of PI in therapy are usually associated with a decrease in body weight and dyslipidemia. Acylation stimulating protein (ASP) is a protein synthesized in adipocytes to increase triglycerides biosynthesis, for that the relation of PI and ASP to adipogenesis is tested in this work. ASP expression was increased during 3T3-L1 differentiation and reached a peak at day 8 with cell maturation.... -
In vitro and in vivo gene therapy with CMV vector-mediated presumed dog β-nerve growth factor in pyridoxine-induced neuropathy dogs
Jin-Young Chung, Jung-Hoon Choi, Il-Seob Shin, Eun-Wha Choi, Cheol-Yong Hwang, Sang-Koo Lee, Hwa-Young Youn* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 4호 5 367-374 (8 pages)
are many neurotrophic factors for gene therapies, such as nerve growth factor (NGF), and the brain-derived neurotrophic factor, neurotrophin-3 [11]. Nerve growth factor is one of the growth factors now being recognized as essential to the survival and maturation of sensory and sympathetic neurons, along with other neurotrophins [16]. NGF consists of three subunits, α, β, and γ, and forms... Due to the therapeutic potential of gene therapy for neuronal injury, many studies of neurotrophic factors, vectors, and animal models have been performed. The presumed dog β-nerve growth factor (pdβ-NGF) was generated and cloned and its expression was confirmed in CHO cells. The recombinant pdβ-NGF protein reacted with a human β-NGF antibody and showed bioactivity in PC12 cells. The pdβb-NGF was shown to have similar bioactivity to the dog β-NGF. The recombinant pdβ-NGF plasmid was...