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Effects of Hesperidin Are Not Associated with Changes in Basal Synaptic Transmission, Theta-burst LTP, and Membrane Excitability in CA1 Neuron
Baek. Jin-Hee, Kim. Jae-Ick, Kaang. Bong-Kiun 한국통합생물학회 Animal cells and systems 6 Pages
한국통합생물학회 Animal cells and systems 2009, Vol.13 No.4 357-362 (6 pages)
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The Downregulation of Somatic A-Type K+ Channels Requires the Activation of Synaptic NMDA Receptors in Young Hippocampal Neurons of Rats
Moon-SeokKang, Yoon-SilYang, Seon-HeeKim, Joo-MinPark, Su-YongEun, Sung-CherlJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 7 135-141 (7 pages)
the altera tion of IE in CNS neurons [1,25,26]. This plastic correlation between synaptic and so- matic alteration involves pote ntial and concurrent changes of membrane factors such as voltage-gated ion channels to regulate membrane potential of neurons. It has been dem- onstrated that the enhancement of IE after synaptic LTP induction is clearly mediated through the reduction of the somatic... significant reduction of the somatic IA peak. Additionally, the gating property of IA channels was also sensitive to the activation of synaptic NMDA receptors, showing the hyperpolarizing shift in inactivation kinetics. These results suggest that synaptic LTP possibly potentiates somatic excitability via downregulating IA channels in expression and gating kinetics. The consequential changes of somatic excitability following the activity-dependent modulation of synaptic responses may be a series... -
Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord
SungWonHur, JooMinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 12 553-558 (6 pages)
Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord Sung Won Hur 1 , and Joo Min Park 2 1Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, 2Department of Physiology, Jeju National University College of Medicine, Jeju 690-756, Korea Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity,... undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spino-thalamic tract (STT) neurons that are the main nociceptive neurons projecting from the spinal cord to the thalamus. Optical technique using fluorescent dye has made it possible to identify the STT neurons in the spinal cord. Evoked fast mono-synaptic, excitatory postsynaptic currents (eEPSCs) were measured in the STT neurons. Time-based tetanic stimulation... -
The Effect of LidocaineㆍHCl on the Fluidity of Native and Model Membrane Lipid Bilayers
Jun-SeopPark, Tae-SangJung, Yang-HoNoh, Woo-SungKim, Won-IckPark, Young-SooKim, In-KyoChung, UyDongSohn, Soo-KyungBae, Moon-KyoungBae, Hye 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 7 413-422 (10 pages)
on a method previously established for synaptic plasma membrane [30,31] and SPMV [15-17]. Incorporated Py-3-Py in the SPMV was excited by radia- tionless energy transfer (RET) from tryptophan (excitation at 286 nm) and the excimer to monomer fluorescence in- tensity ratio (I'/I) of Py-3-Py was calculated from the ratio 480 nm to 379 nm signal. Taking into account that the Forster radius (the... synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex, and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. LidocaineㆍHCl increased the bulk lateral and rotational mobility of... -
The Effect of Methanol on the Structural Parameters of Neuronal Membrane Lipid Bilayers
Hyung-JinJoo, Shin-HoAhn, Hang-RaeLee, Sung-WooJung, Chang-WonChoi, Min-SeokKim, Moon-KyoungBae, In-KyoChung, Soo-KyoungBae, Hye-OckJang, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 5 255-264 (10 pages)
of the SPMVs outer monolayer membrane interface Ethanol in vitro had a greater fluidizing effect in the out- er monolayer as compared to the inner monolayer. Thus, ethanol exhibits a specific rather than nonspecific fluidizing action within transbilayer of synaptic plasma membranes [30], cultured mouse myeloma cell line Sp2/0-Ag14 [26], cul- tured Mar 18.5 hybridoma cells [25] and synaptosomal... 6 of aliphatic chains in phospholipids of the outer monolayers. Furthermore, the methanol increased annular lipid fluidity and also caused membrane proteins to cluster. The important finding is that was far greater increase by methanol in annular lipid fluidity than increase in lateral and rotational mobilities by the methanol. Methanol alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data... -
Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex
Sung-WonPark, Hyun-JongJang, Kwang-HyunCho, , Myung-JunKim, ShinHeeYoon, Duck-JooRhie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 10 65-70 (6 pages)
the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex Sung-Won Park 1 , Hyun-Jong Jang 1 , Kwang-Hyun Cho 1,2 , Myung-Jun Kim 1 , Shin Hee Yoon 1 , and Duck-Joo Rhie 1,2 1Department of Physiology, College of Medicine, 2Catholic Neuroscience Center, The Catholic University of Korea, Seoul 137-701, Korea Synaptic long-term potentiation (LTP) and long-term depression (LTD) have... Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP and LTD during the critical period of the rat visual cortex (postnatal 3∼5 weeks). However, in adult rats, the increase in 5-HT level in the brain by the administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reinstates ocular dominance plasticity... -
Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons
Jong-JuLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 9 461-467 (7 pages)
a membrane permeable cyclic-GMP analogue (Fig. 3 and 4). Thus, the effect of NO on GABAergic pre- synaptic nerve terminals in th e A1 seems to be mediated primarily by a cGMP-dependent signaling. NO produces its biological effect through distinct signal transduction pathways (Stamler et al., 1997; Ahern et al., 2002). NO activates soluble guanylyl cyclase to produce cyclic guanosine... of NO on spontaneous GABAergic synaptic transmission in mechanically isolated rat auditory cortical neurons preserving functional presynaptic nerve terminals. GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) in the A1 were completely blocked by bicuculline. The NO donor, S-nitroso-N-acetylpenicillamine (SNAP), reduced the GABAergic sIPSC frequency without affecting the mean current amplitude. The SNAP- induced inhibition of sIPSC frequency was mimicked by 8-bromoguanosine cyclic... -
NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices
SeJoonChoi, KiJungKim, HyeongSeokCho, SeongYunKim, Dong-SeokYim, Young-JinCho, SangJuneHahn, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 2 303-308 (6 pages)
DM, Lambert NA, Teyler TJ, Prager R, Ong J, Kerr DI. The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. Neurosci Lett 119: 272- 276, 1990 Jiang ZG, North RA. Membrane properties and synaptic responses of rat striatal neurones in vitro. J Physiol 443: 533-553, 1991 Jog MS, Kubota Y, Connolly CI, Hillegaart V, Graybiel AM. Buil- ding neural representations ... The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs striatal function. Ethanol caused a decrease in population spike amplitudes in a dose dependent manner (50∼200 mM). Pretreatment with picrotoxin, a γ-amino butyric acid (GABA)A receptor antagonist, increased the population spikes but ethanol (100 mM) was still effective in... -
Peripheral Nerve Injury Alters Excitatory and Inhibitory Synaptic Transmission in Rat Spinal Cord Substantia Gelatinosa
Dong-HoYoun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 2 143-148 (6 pages)
synapse will result in neurotran- smitter release, namely “release probability ”. In the central nervous system, the change in the release probability is the main mechanism underlying short-term synaptic plasticity, an activity-dependen t decrease (depression) or increase (facilitation) of synaptic transmission occurring within several hundreds of milliseconds (Zucker & Regehr, 2002). In t... Following peripheral nerve injury, excessive nociceptive inputs result in diverse physiological alterations in the spinal cord substantia gelatinosa (SG), lamina II of the dorsal horn. Here, I report the alterations of excitatory or inhibitory transmission in the SG of a rat model for neuropathic pain ("spared nerve injury"). Results from whole-cell recordings of SG neurons show that the number of distinct primary afferent fibers, identified by graded intensity of stimulation, is... -
Inhibitory Modulation of 5-Hydroxytryptamine on Corticostriatal Synaptic Transmission in Rat Brain Slice
SeJoonChoi, WonSoonChung, Ki-JungKim, Ki-WugSung, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 1 295-301 (7 pages)
or kainate-receptors. Neuroscience 14: 417－426, 1985 Jiang ZG, North RA. Membrane properties and synaptic responses of rat striatal neurones in vitro. J Physiol 443: 533－553, 1991 Jiang ZG, North RA. Pre- and postsynaptic inhibition by opioids in rat striatum. J Neurosci 12: 356－361, 1992 Jog MS, Kubota Y, Connolly CI, Hillegaart V, Graybiel AM. Build- ing neural representations of habits.... serotonergic (5-hydroxytryptamine, 5-HT) input from raphe nuclei. In the present study, the effects of 5-HT to modulate synaptic transmission were studied in the rat corticostriatal brain slice using in vitro extracellular recording technique. Synaptic responses were evoked by stimulation of cortical glutamatergic inputs on the corpus callosum and recorded in the dorsal striatum. 5-HT reversibly inhibited coticostriatal glutamatergic synaptic transmission in a dose-dependent fashion (5, 10, 50,...