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Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock
Yayeh. Taddessee, Jung. Kun-Ho, Jeong. Hye-Yoon, Park. Ji-Hoon, Song. Yong-Bum, Kwak. Yi-Seong, Kang. Heun-Soo, Cho. Jae-Youl, Oh. Jae-W 고려인삼학회 Journal of ginseng research 7 Pages
고려인삼학회 Journal of ginseng research 2012, Vol.36 No.3 263-269 (7 pages)
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Interleukin-$32{gamma}$ Transgenic Mice Resist LPS-Mediated Septic Shock
Kim. Sun Jong, Lee. Siyoung, Kwak. Areum, Kim. Eunsom, Jo. Seunghyun, Bae. Suyoung, Lee. Youngmin, Ryoo. Soyoon, Choi. Jida, Kim. Soohyun 한국미생물생명공학회 Journal of microbiology and biotechnology 10 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2014, Vol.24 No.8 1133-1142 (10 pages)
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A Tubulin Inhibitor, N-(5-Benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide, Induces Anti-inflammatory Innate Immune Responses to Attenuate LPS-mediated Septic Shock
Park. Hyun Jung, Lee. Sung Won, Park. Hwangseo, Park. Se-Ho, Hong. Seokmann 대한화학회 Bulletin of the Korean Chemical Society 6 Pages
대한화학회 Bulletin of the Korean Chemical Society 2014, Vol.35 No.11 3307-3312 (6 pages)
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Autophagy flux plays a pivotal role in LPS-mediated inflammation via TLR4 and NF-κB activation in primary human keratinocytes
Ji Hong Moon, Ju Hee Lee, You Jin Lee, Jae Won Seol, Nazim Uddin, Rasheduzzaman, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 252 330-331 (2 pages)
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Solanum lycopersicum (tomato) ethanol extract elicits anti-inflammatory effects via the nuclear factor kappa B pathway and rescues mice from septic shock
Evelyn Saba , Mi-ju Oh , Dongmi Kwak , Seong-soo Roh , Hyuk-woo Kwon , Sung-dae Kim , Man Hee Rhee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 2호 4 97-104 (8 pages)
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Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages
MeiHongLi, GuganKothan, SeungJooCho, PhamThiThuHuong, YongHaiNan, KunYeongLee, SongYubShin, SungSuYea, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 1 353-358 (6 pages)
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-ՊB/Rel in RAW 264.7 cells. Immunohisto-chemical staining of iNOS and Western blot analysis showed magnolol to inhibit iNOS gene expression. Reporter gene assay and electrophoretic mobility shift assay showed that magnolol inhibited NF-ՊB/Rel transcriptional activation and DNA binding, respectively.... -
Roles of ERK and NF-κB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
Seung-HunKang, Ji-HyukLee, Kyung-HaChoi, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 7 171-176 (6 pages)
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate whether HSP22 affects IL-8 expression in vascular smooth muscle cells (VSMCs), and which cellular factors are involved in the HSP-mediated IL-8 induction in that cell type in terms of mitogen activated protein kinase (MAPK) and transcription element. Exposure of aortic smooth muscle cells (AoSMCs) to HSP22 not only... -
Preventive Effect of Serotonergic Drugs on LPS-Induced Acute Anorexia in Rats
So-YoungPark, Keon-HoKim, Dong-KukAhn, Tae-ImPark, Jong-YeonKim, Yong-WoonKim, DongChulLee, Suck-KangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 3 149-154 (6 pages)
(LPS)-induced anorexia in rats. LPS (500μg/kg body weight) and all serotonergic drugs, except for 8-OH-DPAT (subcutaneous), were injected intraperitoneally into Sprague-Dawley rats. Without the LPS injection, 8-OH-DPAT (1A agonist), metergoline (1/2 antagonist), and mianserin (2A/2C antagonist) exerted no effects on food intake at any of the doses tested, but ketanserin (2A antagonist) caused an increase of food intake at 4 mg/kg. RS-102221 (2C antagonist) reduced food intake at 2 and 4 mg/kg.... -
p38 MAPK and NF-κB are Required for LPS-Induced RANTES Production in Immortalized Murine Microglia (BV-2)
Sae-ByeolJangKweon-HaengLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 1 339-346 (8 pages)
in LPS-stimulated RANTES production, we used specific inhibitors for p38 MAPK and Erk, SB 203580 and PD 98059, respectively. LPS-induced RANTES production was reduced approximately 80% at 25μM of SB 203580 treatment. But PD 98059 did not affect RANTES production. Pyrrolidine-dithiocarbamate (PDTC), NF-κB inhibitor, reduced RANTES secretion. These results suggest that LPS-induced RANTES production in microglial cells (BV-2) is mainly mediated by the coordination of p38 MAPK and NF-κB cascade. -
화분(Trichosanthes Kirilowii ext.)추출물이 LPS를 처리한 육계 병아리의 염증반응에 미치는 영향
홍영표, 최일, 이은, Hong. Yeung-Pyo, Choi. Il, Lee. Eun 한국자원식물학회 韓國資源植物學會誌 8 Pages
한국자원식물학회 韓國資源植物學會誌 2012, Vol.25 No.4 482-489 (8 pages)
첨가군들보다 높은 수치를 나타내었다. LPS 처리 후, 간장 및 비장내의 IFN-${gamma}$ mRNA량은 모든 처리군들이 LPS 처리 후, 2h 및 3h째까지 증가하였으나, 4h에서 하락하여, 9h째에서는 LPS 처리 전 수준으로 하락했다. 그러나 각 처리군별 경시적 변동치는 최고치를 나타낸 LPS 처리 후 2h 및 3h에서, 천화분 추출물 첨가량이 증가함에 따라 하락하였다. LPS 처리 후, 간장 및 비장 내의 iNOS mRNA량은 전 처리군이 3h째에서 가장 높은 수치를 나타내었으며, 9h째에서 LPS 처리 전 수준으로 회복되었다. 처리군별 2h째, 3h째 및... -
씀바귀 추출물이 LPS투여 흰쥐 및 Raw 264.7세포에서 전염증성 cytokines 생성에 미치는 영향
이은, Lee. Eun 한국자원식물학회 韓國資源植物學會誌 9 Pages
한국자원식물학회 韓國資源植物學會誌 2011, Vol.24 No.5 604-612 (9 pages)
씀바귀추출물이 LPS shock 염증반응에서 항염증효과에 미치는 영향을 검토하기 위하여 생체 및 세포배양실험에서 전염증성 cytokine들의 생성과 혈액 내 생물학적 수치를 조사했다. 그 결과 LPS 염증유도 rat에서 씀바귀 추출물은 혈액 내 전염증성 cytokines 들, 즉 IL-$1{eta}$, IL-6 및 TNF-${alpha}$의 생산을 저해하고, 한편으로는 IL-10의 생산을 촉진하였다. 간장 IL-$1{eta}$ 및 IL-6의 농도는 씀바귀추출물 처리군이 대조군보다 유의하게 낮은 값을 나타내었으나, TNF-${alpha}$ 및 IL-10의 농도는 모든 처리군 간에 유의한... -
마황이 LPS투여 흰쥐의 면역조절능에 미치는 영향
이은, Lee. Eun 한국자원식물학회 韓國資源植物學會誌 7 Pages
한국자원식물학회 韓國資源植物學會誌 2009, Vol.22 No.5 431-437 (7 pages)
in vivo 및 in vitro에서 마황의 항염증효과를 검토하기 위하여 마황추출물을 급여한 흰쥐에게 LPS shock로 급성기 염증반응을 유발시킨 후, 혈액 및 간장의 전염증성 cytokines들의 농도를 경시적으로 조사하였으며, 한편으로는 Raw 264.7 cell에 LPS shock를 가한 후, 마황추출물이 각종 전염증성 cytokines들의 생산량에 미치는 영향을 조사했다. in vivo 실험에서, 각 처리군 별 plasma IL-$1{eta}$, IL-6, TNF-$alpha$ 및 IL-10 농도의 경시적 변동은 전 처리군 모두가 LPS 처리 후, 2h째 급격하게 증가하여, 5h째에 최고치를... -
S. abortus 유래 LPS와 E. coli 유래 LPS에 의한 패혈증성 쇽 유도 작용 비교
조재열, 유은숙, Cho. Jae-Youl, Yoo. Eun-Sook 대한약학회 약학회지 7 Pages
대한약학회 약학회지 2007, Vol.51 No.1 44-50 (7 pages)
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LPS로 자극한 RAW264.7 세포에서 강활 추출물의 염증성세포활성물질의 억제효과
박희제, 배기상, 김도윤, 서상완, 박경배, 김병진, 송제문, 이경용, 나철, 신병철, 박성주, 송호준, 황성연, Park. Hee-Je, Bae. Gi-Sang, Kim. Do-Yun, Seo. Sang-Wan, Park. Kyung-Bae, Kim. Byun 대한본초학회 大韓本草學會誌 8 Pages
대한본초학회 大韓本草學會誌 2008, Vol.23 No.3 127-134 (8 pages)
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Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-α, IFN-γ and LPS
YoungJinKang, SunYoungKang, YoungSooLee, MinKyuPark, HyeJungKim, HanGeukSeo, JaeHeunLee, HyeSookYun-Choi, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 6 273-280 (8 pages)
(LPS). Results indicated that YS 49 concentration-dependently reduced iNOS mRNA and protein expression, as evidenced by Northern and Western blot analysis, respectively. The underlying mechanism by which YS 49 suppressed iNOS expression was not to affect iNOS mRNA stability but to inhibit activation and translocation of NF-κB by preventing the degradation of its inhibitory protein IκBα. As expected, YS 49 prevented NO-induced apoptotic cell death by sodium nitroprusside. Taken together, it is... -
Activation of autophagic flux induced by Epigallocatechin gallate (EGCG) mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors
Ji Hong Moon, Sung Wook Kim, Ju Hee Lee, Jae Won Seol, Nazim Uddin, Rasheduzzaman, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 254 331-332 (2 pages)


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