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Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows
Felix Diaz González*, Rodrigo Muiño, Víctor Pereira, Rómulo Campos, José Luis Benedito 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 3호 8 251-255 (5 pages)
cows, respectively, while subclinical ketosis (BHB ＞ 1.2 mmol/L) was detected in 41% and 28% of the early lactation and lactation cows, respectively. TG concentrations were low in all cows suffering subclinical ketosis and in 61% of the cows with high lipomobilization. During early lactation, 30% of cows suffered hepatic lipidosis as detected by levels of AST. Compromised hepatic function was observed in early lactation cows as shown by lower concentrations of glucose, total protein, and urea. -
Modulatory Effect of Fenugreek Saponins on the Activities of Intestinal and Hepatic Disaccharidase and Glycogen and Liver Function of Diabetic Rats
Hamden. Khaled, Jaouadi. Bassem, Salami. Tahia, Carreau. Serge, Bejar. Samir, Elfeki. Abdelfattah 한국생물공학회 Biotechnology and bioprocess engineering 9 Pages
한국생물공학회 Biotechnology and bioprocess engineering 2010, Vol.15 No.5 745-753 (9 pages)
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De novo Expression of Hepatic UCP3 Is Time-Dependently Related with Metabolic Function in Fenofibrate-Treated High Fat Diet Rats
박미경, 강아영, 서은희, 조연수, 강수정, 홍숙희, 김덕규, 이혜정, Park. Mi-Kyoung, Kang. Ah-Young, Seo. Eun-Hui, Joe. Yeon-Soo, Kang. Soo-Jeong, Hong. Sook-Hee, Kim. Du 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2009, Vol.19 No.1 15-20 (6 pages)
Uncoupling protein 3 (UCP3)는 골격근에서 주로 발현되는 미토콘드리아 단백질이다. 생체의 대사기능에 관여할 것으로 알려져 있지만, 아직 그 역할에 대하여 깊이 연구되어 있지 않다. 최근에 고지혈증 치료제인 페노파이브레이트를 처치한 쥐의 간에서는 UCP3가 새로이 발현 유도된다는 것이 알려졌으며, 본 연구자들은 새로이 발현되는 UCP3가 비만쥐의 지방조직올 감소시키며, 인슐린 감수성을 증가시킨다는 보고를 하였다. 본 연구에서는 이러한 새로이 발현되는 UCP3의 시간에 따른 발현 양상과 대사 기능의 연관 관계를... -
Effects of Dietary Perilla Oil and Corn Oil on Hepatic Mixed-Function Oxidase System and Antioxidant Enzyme Activities in 2-acetylaminofluorene-treated Rat
Kwak. Chung-Shil, Kim. Hye-Gyeong, Choi. Hay-Mie 생화학분자생물학회 Journal of biochemistry and molecular biology 7 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 1995, Vol.28 No.5 420-426 (7 pages)
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Fluoxetine-induced abnormalities of cardiac function
Mun Young Lee, Gi Beum Kim, Hyung Sub Kang, Jin Shang Kim, Shang Jin Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 264 336-337 (2 pages)
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Oxidative stress and hepatic injury induced in mice fed a Sarcocystis hirsuta cyst extract
Maryam Sasani, Reza Nabavi, Mohammadreza Hajinezhad, Parisa Hasanein 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 4 500-504 (5 pages)
as hepatic and brain malondialdehyde (MDA) levels along with concomitant decreases in catalase (CAT) and superoxide dismutase (SOD) activities of mice receiving fresh and frozen S. hirsuta extracts. Gavage feeding of heat-treated S. hirsuta cyst extract had no effects on liver enzymes or brain MDA content, but the liver MDA level did increase. Mice in the heat-treated cyst group showed reduced CAT and SOD activities as well as increased hepatic MDA levels compared to those in the control group.... -
Effect of phosphorus deficiency on erythrocytic morphology and function in cows
Ziwei Zhang, Mingyu Bi, Jie Yang, Haidong Yao, Zhonghua Liu, Shiwen Xu 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 10 333-340 (8 pages)
The aim of this study was to evaluate the influence of phosphorus (P) deficiency on the morphological and functional characteristics of erythrocytes in cows. Forty Holstein-Friesian dairy cows in mid-lactation were randomly divided into two groups of 20 each and were fed either a low-P diet (0.03% P/kg dry matter [DM]) or a control diet (0.36% P/kg DM). Red blood cell (RBC) indices results showed RBC and mean corpuscular hemoglobin decreased while mean corpuscular volume increased significantly... -
Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
Jin-Ok Ahn, Qiang Li, Young-Heun Lee, Sei-Myoung Han, Cheol-Yong Hwang, Hwa-Young Youn, Jin-Young Chung 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 3호 23 431-433 (3 pages)
Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p ＜ 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level... -
Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis
Eui-Hwa Nam, Seol-Hee Park, Ji-Young Jung, Seung-Hee Han, Hwa-Young Youn, Jun-Seok Chae, Cheol-Yong Hwang* 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 2호 10 187-191 (5 pages)
topical spray containing 0.0584% hydrocortisone aceponate (HCA) on canine atopic dermatitis (CAD) and to evaluate the skin barrier function during the treatment of CAD. Twenty-one dogs that fulfilled the diagnostic criteria for CAD were included in this study. The HCA spray was applied once a day to the lesions of all dogs for 7 or 14 days. Clinical assessment was performed before (day 0) and after treatment (day 14), and clinical responses were correlated with changes in skin barrier function.... -
p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells
MohanShrestha, Pil-HoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 6 487-498 (12 pages)
both hepatic (HepG2) and breast (MCF-7) cancer cells without significant effect on mRNA expression. Enhanced p53 expressionby leptin was mediated via modulation of ubiquitination, in particular ubiquitin specific protease 2 (USP2)-dependent manner. Furthermore, gene silencing of p53 by small interfering RNA (siRNA) suppressed leptin-induced growth of hepatic and breast cancer cells, indicating the role of p53 signaling in tumor growth by leptin. In addition, we also showed that knockdown of p53... -
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
KyungEunKim, HwajinKim, RokWonHeo, HyunJooShin, Chin-okYi, DongHoonLee, HyunJoonKim, SangSooKang, GyeongJaeCho, WanSungChoi, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 8 451-460 (10 pages)
to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO) mice were fed a high-fat diet (HFD) or normal diet (ND) for 12 weeks. Metabolic parameters and markers of hepatic steatosis and inflammation in liver were compared in WT and KO mice. SIRT1 deletion enhanced HFD-induced changes on body and liver weight gain, and increased glucose and insulin... -
Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
JongHeePark, HunjooHa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 12 269-274 (6 pages)
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study... -
Alterations in Membrane Transport Function and Cell Viability Induced by ATP Depletion in Primary Cultured Rabbit Renal Proximal Tubular Cells
SungJuLee, ChaeHwaKwon, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 3 15-22 (8 pages)
in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide (KCN)/0.1 mM iodoacetic acid (IAA), and membrane transport function and cell viability were evaluated by measuring Na＋-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in Na＋-dependent phosphate uptake and cell viability in a time-dependent manner. ATP depletion inhibited Na＋-dependent phosphate uptake in cells, when treated with... -
Alteration of Substrate Specificity by Common Variants, E158K/E308G and V257M, in Human Hepatic Drug-metabolizing Enzyme, Flavin-containing Monooxygenase 3
Jung-KyuLee, Ju-HeeKang, Young-NamCha, Woon-GyeChung, , Chang-ShinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 6 157-162 (6 pages)
significant correlation between the activities of ranitidine N-oxidation catalyzed by hepatic flavin-containing monooxygenase (FMO) and the presence of mutations in exon 4 (E158K) and exon 7 (E308G) of the FMO3 gene in Korean volunteers. However, caffeine N-1 demethylation (which is also partially catalyzed by FMO) was not significantly correlated with these FMO3 mutations. In this study, we examined another common mutation (V257M) in exon 6 of FMO3 gene. The V257M variant, which is caused by a... -
Ethanol Prevents from Acetaminophen Inducible Hepatic Necrosis by Inhibiting its Metabolic Activation in Mice
Sun-MeeLee, Tai-SoonCho, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 15 261-269 (9 pages)
the mice treated with acetaminophen alone, along with the hepatic necrosis, the hepatic microsomal aminopyrine N-demethylase activity was decreased. However, co-administration of ethanol prevented this acetaminophen dependent inhibition on the microsomal mixed function oxidase activity. Pharmacokinetic studies indicated that the concentration of un-metabolized drug in the blood was increased in the ethanol treated mice. Furthermore, upon co-administration of ethanol, although the biliary levels... -
Thiobenzamide S-oxidation in Perfused Rat Liver Ex Vivo Determination of Hepatic Flavin-Containing Monooxygenase Activity
Woon-GyeChung, Hyung-KeunRoh, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 15 591-595 (5 pages)
perfusates with either β- glucuronidase or arylsulfatase did not increase the TBSO level and thus, TBSO does not appear to undergo conjugation either to glucuronide or sulfate esters. Thus, measuring the rate of TB S-oxidation in the isolated perfused liver with 1 mM TB for 50 min provides a useful tool for evaluation of the hepatic FMO activity in the absence of hepatic necrosis and without the interferences caused by further conjugation or back reduction of the TBSO to the parent TB. -
Electroencephalogram Power Spectra in Thioacetamide-induced Hepatic Encephalopathy
김지희(Chi Hui Kim), 최원진(Won Jin Choi), 박정숙(Jung Sook Park), 이향이(Hyang Yi Lee), 하정희(Jeoung Hee Ha), 이만기(Maan Gee Lee) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 1 293-300 (8 pages)
During the development of hepatic encephalopathy after thioacetamide (TAA) injection to rat, EEG was recorded at two different states: without or with tactile stimulation of tail at regular intervals. Calculations based on the spectral and band analysis were used. The changes in the power spectra and bands were examined in 3 different behavioral stages: normal, mild ataxia and severe ataxia. In normal rats, the stimulation produced the increase in the power of the theta (3.5 ~ 8 Hz) and the... -
Ischemic Preconditioning Ameliorates Hepatic Injury from Cold Ischemia/Reperfusion
PARK. Sang-Won, LEE. Sun-Mee 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 6 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2005, Vol.13 No.3 127-132 (6 pages)
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Piperine이 간 Microsomal Mixed Function Oxidase System에 미치는 영향
신국현, 우원식, Shin. Kuk-Ryun, Woo. Won-Sick 생화학분자생물학회 한국생화학회지 7 Pages
생화학분자생물학회 한국생화학회지 1985, Vol.18 No.1 9-15 (7 pages)
간 microsome의 mixed function oxidase(MFO)에 미치는 효과를 검토하였다. Piperine을 100 mg/kg씩 7일간 마우스에 경구투여 한 결과 hexobarbital수면시간을 대조군에 비하여 72% 단축시켰으며 aminopyrine N-demethylase활성 (112.7%), hexobarbital hydroxylase활성 (78.5%) 및 cytochrome p-450(154.2%) 함량을 현저히 증가시켰다. Piperine은 약효를 나타내는 량을 일회 복강내에 주사하였을 때에는 간 효소활성에 변동을 초래하지 않았으나 대량(100 mg/kg, i.p.) 부여하면 aminopyrine 및 hexobaribtal 대사의 억제를 일으켰다.... -
STB-HO, a novel mica fine particle, inhibits the teratoma-forming ability of human embryonic stem cells after in vivo transplantation
Soon Won Choi, Tae Hoon Shin, Ji Hee Shin, Byung Chul Lee, In sung Kang, Hafiz Uddin, Yoo jin Seo, Hyung Sik Kim, Kyung Sun Kang 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 306 501-502 (2 pages)
