주제분류
- 의약학(466)
- 자연과학(113)
- 교육학(69)
- 기타(43)
- 농수해양학(32)
- 사회과학(30)
- 사회복지학(17)
- 보건학(14)
- 심리학(12)
- 유아교육학(8)
- 예체능(7)
- 인문학(7)
- 공학(6)
- 특수교육학(6)
- 종교(2)
발행기관
- 대한생리학회-대한약리학회(312)
- 한국탄소학회(80)
- 대한생리학회(59)
- 대한신경정신의학회(56)
- 대한수의학회(32)
- 한국식물병리학회(31)
- 대한약리학회(29)
- 경인교육대학교 교육연구원(16)
- 한국성인교육학회(14)
- 대한신경계작업치료학회(11)
- 은행법학회(9)
- 한국경호경비학회(9)
- 이화여자대학교 교과교육연구소(8)
- 한국광고PR실학회(6)
- 한국교육학회(6)
- 한국사회복지실천연구학회(6)
- 한국열환경공학회(6)
- 한국음악치료학회(6)
- 한방비만학회(6)
- 환태평양유아교육연구학회(6)
- 대한전기학회(5)
- 한국전기화학회(5)
- 한국조형교육학회(5)
- 한국미술치료학회(4)
- 한국박물관학회(4)
- 국민연금연구원(3)
- 대한기계학회(3)
- 인문사회과학기술융합학회(3)
- 한국교육정치학회(3)
- 한국교육행정학회(3)
- 한국보육지원학회(3)
- 한국사회복지교육협의회(3)
- 한국웰니스학회(3)
- 한국음악교육학회(3)
- 한국장애인복지학회(3)
- 한국전기전자재료학회(3)
- 한국학습장애학회(3)
- 한국헬스커뮤니케이션학회(3)
- 물리치료재활과학회(2)
- 아시아장애사회학회(2)
- 한국교원교육학회(2)
- 한국교육사회학회(2)
- 한국국제이해교육학회(2)
- 한국기초간호학회(2)
- 한국동력기계공학회(2)
- 한국습지학회(2)
- 한국시각장애교육재활학회(2)
- 한국연소학회(2)
- 한국종교교육학회(2)
- 한국초등체육학회(2)
- 대한결핵및호흡기학회(1)
- 대한구순구개열학회(1)
- 대한설비공학회(1)
- 대한어린이교육협회(1)
- 대한위생학회(1)
- 대한전자공학회(1)
- 대한치과보존학회(1)
- 대한치과이식임플란트학회(1)
- 대한한의학회(1)
- 대한화학회(1)
- 부산대학교 교육발전연구소(1)
- 서강대학교 철학연구소(1)
- 아시아아동지원학회(1)
- 영남퇴계학연구원(1)
- 전력전자학회(1)
- 한국고고학회(1)
- 한국곤충학회(1)
- 한국공작기계학회(1)
- 한국교원대학교 뇌기반교육연구소(1)
- 한국교육치료학회(1)
- 한국농업기계학회(1)
- 한국동서정신과학회(1)
- 한국미생물생명공학회(1)
- 한국미술교과교육학회(1)
- 한국박물관교육학회(1)
- 한국반도체및디스플레이장비학회(1)
- 한국보건기초의학회(1)
- 한국분자세포생물학회(1)
- 한국식품영양과학회(1)
- 한국심리치료학회(1)
- 한국여가문화학회(1)
- 한국원자력학회(1)
- 한국자동차공학회(1)
- 한국재료학회(1)
- 한국창의력교육학회(1)
- 한국청각언어재활학회(1)
- 한국해양공학회(1)
- 한국환경과학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(312)
- CARBON LETTERS(80)
- 대한생리학회지(59)
- 신경정신의학(56)
- 대한약리학잡지(29)
- THE PLANT PATHOLOGY JOURNAL (26)
- JOURNAL OF VETERINARY SCIENCE(17)
- ANDRAGOGY TODAY(14)
- 대한수의학회 학술대회발표집(13)
- 재활치료과학(11)
- 교육논총(9)
- 시큐리티연구(9)
- 은행법연구(9)
- 교과교육학연구(8)
- THE JOURNAL OF EDUCATION(7)
- 광고PR실학연구(6)
- 대한한방비만학회지(6)
- 미래사회복지연구(6)
- 한국음악치료학회지(6)
- ASIA-PACIFIC JOURNAL OF RESEARCH IN EARLY CHILDHOOD EDUCATION(5)
- 식물병연구(5)
- 열환경공학(5)
- 조형교육(5)
- 교육학연구(4)
- 미술치료연구(4)
- 박물관학보(4)
- 전기학회논문지= THE TRANSACTIONS OF THE KOREAN INSTITUTE OF ELECTRICAL ENGINEERS(4)
- 전기화학회지(4)
- 교육정치학연구(3)
- 교육행정학연구(3)
- 예술인문사회융합멀티미디어논문지(3)
- 음악교육연구(3)
- 전기전자재료학회논문지(3)
- 학습장애연구(3)
- 한국보육지원학회지(3)
- 한국사회복지교육(3)
- 한국웰니스학회지(3)
- 한국장애인복지학(3)
- 헬스커뮤니케이션연구(3)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(2)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(2)
- PHYSICAL THERAPY REHABILITATION SCIENCE(2)
- 교육사회학연구(2)
- 국제이해교육연구(2)
- 대한기계학회논문집(2)
- 시각장애연구(2)
- 아시아장애사회학연구(2)
- 종교교육학연구(2)
- 한국교원교육연구(2)
- 한국교육학회 학술대회논문집(2)
- 한국동력기계공학회지(2)
- 한국습지학회지(2)
- 한국연소학회지(2)
- 한국초등체육학회지(2)
- AUDIOLOGY AND SPEECH RESEARCH(1)
- BRAIN, DIGITAL, & LEARNING(1)
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY(1)
- JOURNAL OF DENTAL IMPLANT RESEARCH(1)
- JOURNAL OF ELECTROCHEMICAL SCIENCE AND TECHNOLOGY(1)
- JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY(1)
- JOURNAL OF POWER ELECTRONICS : JPE(1)
- JOURNAL OF THE KOREAN NUCLEAR SOCIETY(1)
- KOREAN JOURNAL OF ENTOMOLOGY(1)
- MOLECULES AND CELLS(1)
- PACIFIC EARLY CHILDHOOD EDUCATION RESEARCH ASSOCIATION ANNUAL CONFERENCE(1)
- 결핵 및 호흡기 질환(1)
- 교육치료연구(1)
- 교육혁신연구(1)
- 국민연금연구원 연구보고서(1)
- 국민연금연구원 정책보고서(1)
- 국민연금연구원 조사보고서(1)
- 대한구순구개열학회지(1)
- 대한위생학회지(1)
- 대한치과보존학회지(1)
- 대한한의학회지(1)
- 동서정신과학(1)
- 바이오시스템공학(1)
- 박물관교육연구(1)
- 반도체및디스플레이장비학회지(1)
- 사향미술교육논총(1)
- 서강대학교 철학연구소 학술대회지(1)
- 설비공학논문집(1)
- 아시아아동지원연구(1)
- 어린이교육(1)
- 여가학연구(1)
- 전기학회논문지. THE TRANSACTIONS OF THE KOREAN INSTITUTE OF ELECTRICAL ENGINEERS. C/ C, 전기물성-응용부문(1)
- 전자공학회논문지. JOURNAL OF THE INSTITUTE OF ELECTRONICS ENGINEERS OF KOREA. SD, 반도체(1)
- 창의력교육연구(1)
- 퇴계학논집(1)
- 한국고고학보(1)
- 한국공작기계학회논문집(1)
- 한국미생물-생명공학회지(1)
- 한국보건기초의학회지(1)
- 한국식품영양과학회지(1)
- 한국심리치료학회지(1)
- 한국열환경공학회 학술대회지(1)
- 한국자동차공학회논문집(1)
- 한국재료학회지(1)
- 한국해양공학회지(1)
- 한국환경과학회지(1)
전체 선택해제
총 832건 검색
본문검색 결과만 보기
-
Quercetin Enhances Human ${alpha}$7 Nicotinic Acetylcholine Receptor-Mediated Ion Current through Interactions with $Ca^{2+}$ Binding Sites
Lee. Byung-Hwan, Choi. Sun-Hye, Shin. Tae-Joon, Pyo. Mi-Kyung, Hwang. Sung-Hee, Kim. Bo-Ra, Lee. Sang-Mok, Lee. Jun-Ho, Kim. Hyoung-Chun 한국분자세포생물학회 Molecules and cells 9 Pages
한국분자세포생물학회 Molecules and cells 2010, Vol.30 No.3 245-253 (9 pages)
-
Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 13 597-605 (9 pages)
2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was increased after the application of propafenone, suggesting that the inhibitory action of propafenone on Kv current is partially use-dependent. Pretreatment with Kv1.5, Kv2.1 or Kv7 inhibitor did not change the inhibitory effect of propafenone on the Kv current. Together, these results suggest that propafenone inhibits the vascular Kv channels in a dose- and... -
Effects of acidic pH on voltage-gated ion channels in rat trigeminal mesencephalic nucleus neurons
Jin-EonHan, Jin-HwaCho, In-SunChoi, Do-YeonKim, Il-SungJang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 9 215-223 (9 pages)
the current-voltage and conductance-voltage relationships, the midpoint voltages for the activation of HCN channels were not changed by acidic pH. On the other hand, voltage-dependent Ca2+ channels were significantly inhibited by an acidic pH. The application of an acidic pH solution significantly shifted the current-voltage and conductance-voltage relationships to the depolarization range. The modulation of several voltage-dependent ion channels by an acidic pH might affect the excitability of... -
Acepromazine inhibits hERG potassium ion channels expressed in human embryonic kidney 293 cells
YoungShinJoo, HongJoonLee, Jin-SungChoi, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 9 75-82 (8 pages)
The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were recorded with or without acepromazine, and the steady-state and peak tail currents were analyzed for the evaluating the drug effects. Acepromazine inhibited the hERG currents in a concentration-dependent manner with an IC50 value of 1.5 μM and Hill... -
Disappearance of Hypoxic Pulmonary Vasoconstriction and O2-Sen-sitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia
HaeYoungYoo, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 13 463-468 (6 pages)
almost abolished without structural remodeling of PA in 2d-H rats, and the lost HPV was not recovered by Kv inhibitor, 4-aminopyridine. Patch clamp study showed that the hypoxic inhibition of Kv current in PASMC was similar between 2d-H and control. In contrast, hypoxia and TXA2-activated INSC was not observed in PASMCs of 2d-H. From above results, it is suggested that the decreased INSC might be the primary functional cause of HPV disappearance in the relatively early period (2 d) of hypoxia. -
Resveratrol Inhibits GABAC Ց Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes
Byung-HwanLee, Sun-HyeChoi, Sung-HeeHwang, Hyeon-JoongKim, Joon-HeeLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 10 175-180 (6 pages)
and life-prolonging effects. However, relatively little is known about the effects of resveratrol on the regulation of ligand-gated ion channels. We have previously reported that resveratrol regulates subsets of homomeric ligand-gated ion channels such as those of 5-HT3A receptors. The Ճ-aminobutyric acidC (GABAC) receptor is mainly expressed in retinal bipolar cells and plays an important role in visual processing. In the present study, we examined the effects of resveratrol on the... -
Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents
Byung-HwanLee, Sung-HeeHwang, Sun-HyeChoi, Hyeon-JoongKim, Joon-HeeLee, Sang-MokLee, YunGyongAhn, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 3 127-132 (6 pages)
M4 with GABA inhibited the GABA-induced inward peak current (IGABA). Interestingly, pre-application of M4 inhibited IGABA more potently than CK in a dose- dependent and reversible manner. The half-inhibitory concentration (IC50) values of CK and M4 were 52.1±2.3 and 45.7±3.9 ՌM, respectively. Inhibition of IGABA by CK and M4 was voltage-independent and non- competitive. This study implies that ginsenoside metabolites may regulate GABAC receptor channel activity in the brain, including in... -
Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels
Hyang-AeLee, Ki-SukKim, Sung-AeHyun, Sung-GurlPark, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 6 327-332 (6 pages)
the major cardiac ion channels expressed in HEK293 cells and the native voltage-gated Ca2＋ channels in rat ventricular myocytes. According to the results, sertraline is a potent blocker of cardiac K＋ channels, such as hERG, IKs and IK1. The rank order of inhibitory potency was hERG ＞IK1＞IKs with IC50 values of 0.7, 10.5, and 15.2 ՌM, respectively. In addition to K＋ channels, sertraline also inhibited INa and ICa, and the IC50 values are 6.1 and 2.6 ՌM, respectively. Modification... -
TRPC-Mediated Current Is Not Involved in Endocannabinoid-Induced Short-Term Depression in Cerebellum
WonseokChang, JooMinPark, JunKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 9 139-144 (6 pages)
completely. However, an alternative TRP channel inhibitor, BTP2 did not affect endocannabinoid-induced short-term depression although it blocked mGluR1-evoked TRPC currents. Endocannabinoid signaling occurred normally even though the TRPC current was mostly blocked by BTP2. Our data imply that TRPC current does not play an important role in endocannabinoid signaling. We also suggest precaution in applying SKF96365 to inhibit TRP channels and propose BTP2 as an alternative TRPC inhibitor. -
Effects of Protopanaxatriol-Ginsenoside Metabolites on Rat N-Methyl-D-Aspartic Acid Receptor-Mediated Ion Currents
Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, Byung-HwanLee, JiyeonKang, Hyeon-JoongKim, R.SuzanneZukin, HyewhonRhim, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 5 113-118 (6 pages)
activity. In the present study, we investigated the effects of ginsenoside metabolites, such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT), on oocytes that heterologously express the rat NMDA receptor. NMDA receptor-mediated ion current (INMDA) was measured using the 2-electrode voltage clamp technique. In oocytes injected with cRNAs encoding NMDA receptor subunits, PPT, but not CK or PPD, reversibly inhibited INMDA in a concentration-dependent manner. The IC50 for PPT on... -
Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes
Byung-HwanLee, Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, JiyeonKang, Hyeon-JoongKim, Chan-WooPark, Soo-HanLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 2 195-201 (7 pages)
of ligand-gated ion channels. Previously, we reported that quercetin regulates subsets of nicotinic acetylcholine receptors such as Ձ3Ղ4, Ձ7 and Ձ9Ձ10. Presently, we investigated the effects of quercetin on muscle-type of nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding human fetal or adult muscle-type of nicotinic acetylcholine receptor subunits. Acetylcholine treatment elicited an inward peak current... -
Quercetin Inhibits α3β4 Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes
Byung-HwanLee, Sung-HeeHwang, Sun-HyeChoi, Tae-JoonShin, JiyeonKang, Sang-MokLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 3 17-22 (6 pages)
of homomeric ligand-gated ion channels such as glycine, 5-HT3A and Ձ7 nicotinic acetylcholine receptors. In the present study, we examined quercetin effects on heteromeric neuronal Ձ3Ղ4 nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding bovine neuronal Ձ3 and Ղ4 subunits. Treatment with acetylcholine elicited an inward peak current (IACh) in oocytes expressing Ձ3Ղ4 nicotinic acetylcholine... -
Diversity of Ion Channels in Human Bone Marrow Mesenchymal Stem Cells from Amyotrophic Lateral Sclerosis Patients
KyoungSunPark, MiRanChoi, KyoungHwaJung, SeungHyunKim, HyunYoungKim, KyungSukKim, Eun-JongCha, YangmiKim, YoungGyuChai 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 8 337-342 (6 pages)
lateral sclerosis (ALS) patients, focusing on functional ion channels. All hBM-MSCs contain several MSCs markers with no significant differences, whereas the distribution of functional ion channels was shown to be different between cells. Four types of K＋ currents, including noise-like Ca＋2-activated K＋ current (IKCa), a transient outward K＋ current (Ito), a delayed rectifier K＋ current (IKDR), and an inward-rectifier K＋ current (Kir) were heterogeneously present in these cells, and a... -
Voltage-dependent Ca2＋ Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach
YoungChulKim, HikaruSuzuki, Wen-XieXu, HikaruHashitani, WoongChoi, Hyo-YungYun, Seon-MeePark6, SeiJinYoun6, Sang-JeonLee, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 6 323-330 (8 pages)
times min−1, respectively, in the presence of 1</SUP>ՌM nifedipine. Single ICC-MY isolated by enzyme treatment also showed c-Kit immunohistochemical reactivity. These cells were also identified by generation of spontaneous inward current under K＋-rich pipette solution. The voltage clamp experiments revealed the amplitude of - 329 pA inward current at irregular frequency. With Cs＋-rich pipette solution at Vh=−80 mV, ICC-MY produced voltage-dependent inward currents (VDIC... -
Acidic pH-activated Cl? Current and Intracellular Ca2＋ Response in Human Keratinocytes
SuJungPark, WonWooChoi, OhSangKwon, JinHoChung, HeeChulEun, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 8 177-184 (8 pages)
The layers of keratinocytes form an acid mantle on the surface of the skin. Herein, we investigated the effects of acidic pH on the membrane current and [Ca2＋]c of human primary keratinocytes from foreskins and human keratinocyte cell line (HaCaT). Acidic extracellular pH (pHe≤5.5) activated outwardly rectifying Cl− current (ICl,pH) with slow kinetics of voltage-dependent activation. ICl,pH was potently inhibited by an anion channel blocker 4,4`-diisothiocyanostilbene-2,2`-disulphonic... -
Lysophosphatidylcholine Increases Ca2+ Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells
SeungsooJung, YounghoLee, SungsikHan, YoungwhanKim, TaiksangNam, DucksunAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 5 31-34 (4 pages)
of LPC on L-type Ca2+ current (ICa(L)) activity and to elucidate the mechanism of LPC-induced change of ICa(L) in rabbit portal vein smooth muscle cells using whole cell patch clamp. Extracellular application of LPC increased ICa(L) through whole test potentials, and this effect was readily reversed by washout. Steady state voltage dependency of activation or inactivation properties of ICa(L) was not significantly changed by LPC. Staurosporine (100 nM) or chelerythrine (3ՌM), which is a... -
Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes
HaifengZheng, JaeHongKo, JooHyunNam, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 4 19-24 (6 pages)
pipette solution revealed a voltage-independent K current that was blocked by clotrimazole (1 mM), an SK4 blocker. The expression of mRNAs for SK4 was confirmed in both Bal-17 and WEHI-231 cells. The density of clotrimazole-sensitive SK4 current was significantly larger in Bal-17 than WEHI-231 cells (11.4⁑3.1 Vs. 5.7⁑1.15 pA/pF). Also, the chronic stimulation of B cell receptors (BCR) by BCR-ligation (anti-IgM Ab, 3μg/ml, 8∼12 h) significantly upregulated the... -
Calcium Ion Dynamics after Dexamethasone Treatment in Organotypic Cultured Hippocampal Slice
Hee-JungChae, Tong-HoKang, Ji-HoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 8 363-370 (8 pages)
slice was treated with a glutamate receptor antagonist together with dexamethasone, the real time Ca2 dynamics were decreased. Furthermore, we confirmed by PI uptake study that glutamate receptor antagonist reduced the hippocampal tissue damage caused by dexamethasone treatment. Therefore, our new calcium ion dynamics system in organotypic cultured hippocampal slice after dexamethasone treatment could provide real time analysis method for investigation of brain injuries by stress. -
Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes
Kyung-BongYoon, Sung-WanAhn, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 6 101-110 (10 pages)
into a huge inward current of 12.9⁑0.5 pA/pF. From the inward current, two different inward INCXs were identified. One was 10 μM ryanodine-sensitive, constituting 14.2⁑2.3%. It was completely blocked by CdCl2 (0.1 mM and 0.5 mM) and by Na-depletion. The other was identified by 5 mM NiCl2 after suppression of ICaL and ryanodine receptor, constituting 14.8⁑1.6%. This latter was blocked by either 10 mM caffeine-induced SR Ca2-depletion or 1 mM tetracaine.... -
Molecular Aspects of Organic Ion Transporters in the Kidney
SeokHoChaHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 1 107-122 (16 pages)
organic anion transporter (OAT), organic cation transporter (OCT), and organic anion-transporting polypeptide (oatp). Additional findings also suggested ATP-dependent organic ion transporters such as MDR1/P-glycoprotein and the multidrug resistance-associated protein (MRP) as efflux pump. The substrate specificity of these transporters is multispecific. These transporters also play an important role as drug transporters. Studies on their functional properties and localization provide information... -
DAMGO, a μ-Opioid Agonist and Cholecystokinin-Octapeptide Have Dual Modulatory Effects on Capsaicin-Activated Current in Rat Dorsal Root Ganglion Neurons
Su-YongEun, JimokKim, JihyeLee, SungJunJung, JooMinPark, YunKyungPark, DongkwanKim, SangJeongKim, JiyeonKwak, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 10 71-78 (8 pages)
when applied cutaneously and intradermally. Activation of capsaicin-gated channel in C-type dorsal root ganglion (DRG) neurons produces nonselective cationic currents. Although electrophysiological and biochemical properties of capsaicin-activated current (ICAP) were studied, the regulatory mechanism and intracellular signaling pathway are still unclear. In the present study, we investigated the modulations of ICAP by DAMGO (μ-opioid agonist) and cholecystokinin octapeptide (CCK-8). In 18 out ... -
Effect of Capsaicin on Delayed Rectifier K+ Current in Adult Rat Dorsal Root Ganglion Neurons
JunghyunHahn, SungkwonChung, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 2 9-14 (6 pages)
the delayed rectifier K current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the amplitude of K current in dose dependent manner, and the concentration-dependence curve was well described by the Hill equation with KD value of 19.1μM. The blocking effect of capsaicin was reversible. Capsaicin (10 μM) shifted the steady- state inactivation curve in the hyperpolarizing direction by about 15 mV and increased the rate of inactivation. The voltage dependence... -
Increase of L-type Calcium Current by cGMP-dependent Protein Kinase Regulates in Rabbit Ventricular Myocytes
JinHan, NariKim, EuiyongKim, WonkyungHo, YungEEarm, HankyounKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 10 733-742 (10 pages)
Background: We have previously reported that not only cGMP but also 8-Br-cGMP or 8-pCPT-cGMP, specific and potent stimulators of cGMP-dependent protein kinase (cGMP-PK), increased basal L-type calcium current (ICa) in rabbit ventricular myocytes. Our findings in rabbit ventricular myocytes were entirely different from the earlier findings in different species, suggesting that the activation of cGMP-PK is involved in the facilitation of ICa by cGMP. However, there is no direct evidence that... -
Inhibitory Effect of Caffeine on Carbachol-Induced Nonselective Cationic Current in Guinea-Pig Gastric Myocytes
SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 10 353-359 (7 pages)
by carbachol (CCh) activates nonselective cation channel current (ICCh) which is facilitated by intracellular [Ca2] increase. Caffeine is widely used in experiments to mobilize Ca2 from intracellular stores. This study shows a strong inhibitory effect of caffeine on ICCh in guinea-pig gastric myocyte. In this study, the underlying mechanism of the inhibitory effect of caffeine was investigated. ICCh was completely suppressed by the addition of caffeine (10 mM) to the superfusing... -
Ca2+ Signalling in Endothelial Cells Role of Ion Channels
BerndNilius, FelixViana, MasahiroKamouchi, CristinaFasolato, JanEggermont, GuyDroogmans 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 1 133-145 (13 pages)
-
토끼 단일 심근세포에서 대사억제시 Inward Rectifier(IK1)의 변화 Effect of Metabolic Inhibition on Inward Rectifier K Current in Single Rabbit Ventricular Myocytes
정유정, 호원경, 엄융의, YuJeongChung, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 15 741-748 (8 pages)
outward current was reversed by glibenclamide (10 ㄍM), suggesting that it is caused by the activation of KATP. When DNP and glibenclamide were applied at the same time or glibenclamide was pretreated, DNP produced same degree of reduction in the magnitude of the inward current. These results show that metabolic inhibition induces not only the increase of KATP channel but also the decrease of IK1. Perfusing the cell with ATP-free pipette solution induced the changes very similar to those... -
동방결절에서 과분극에 의해 활성화되는 내향전류에 대한 Cyclic-GMP의 영향 Effects of Cyclic-GMP on Hyperpolarization-activated inward Current (If) in Sino-atrial Node Cells of Rabbit
유신, 호원경, 엄융의, ShinYoo, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 14 731-739 (9 pages)
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current (If), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp technique. When sodium nitroprusside (SNP, 80μM), which is known to activate guanylyl cyclase, was added, If amplitude was increased and its activation was accelerated. However, when If was prestimulated by isopreterenol (ISO, 1μM), SNP reversed the effect of ISO. In the absence of... -
Effects of Arachidonic Acid on the Calcium Channel Current (IBa) and on the Osmotic Stretch-induced Increase of IBa in Guinea-Pig Gastric Myocytes
WenXieXu, SungJoonKim, InsukSo, SukHyoSuh, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 10 435-443 (9 pages)
the whole-cell patch clamp technique to investigate the effects of arachidonic acid (AA) on barium inward current through the L-type calcium channels (IBa) and on osmotic stretch-induced increase of IBa in guinea-pig antral gastric myocytes. Under isosmotic condition, AA inhibited IBa in a dose-dependent manner to 91.1⁑1.4, 72.0⁑3.2, 46.0⁑1.8, and 20.3⁑2.3% at 1, 5, 10, 30 mM, respectively. The inhibitory effect of AA was not affected by 10 ㄍM indomethacin, a...
