자료유형
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- 대한생리학회-대한약리학회(156)
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- 대한약학회(2)
- 인문사회과학기술융합학회(2)
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간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(156)
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- JOURNAL OF VETERINARY SCIENCE(39)
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- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(11)
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- 정보과학회논문지. JOURNAL OF KIISE. 소프트웨어 및 응용(2)
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Parsing KEGG XML Files to Find Shared and Duplicate Compounds Contained in Metabolic Pathway Maps: A Graph-Theoretical Perspective
Kang. Sung-Hui, Jang. Myung-Ha, Whang. Ji-Young, Park. Hyun-Seok 한국유전체학회 Genomics & informatics 6 Pages
한국유전체학회 Genomics & informatics 2008, Vol.6 No.3 147-152 (6 pages)
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Enhanced Production of Astaxanthin by Metabolic Engineered Isoprenoid Pathway in Escherichia coli
이재형, 서용배, 김영태, Lee. Jae-Hyung, Seo. Yong-Bae, Kim. Young-Tae 한국생명과학회 생명과학회지 7 Pages
한국생명과학회 생명과학회지 2008, Vol.18 No.12 1764-1770 (7 pages)
이 연구의 목적은 생물공학적으로 이소프레노이드 생합성 유전자를 클로닝하여 이들을 형질전환시킨 대장균을 제조하여 이들을 숙주로 사용하여 아스타잔틴의 생산을 증가시키는 것이다. 본 연구진은 선행연구에서 Paracoccus haeundaensis로부터 아스타잔틴 생산에 관여하는 6개의 아스타잔틴 생합성 유전자군을 보고하였고, 이들 유전자들을 발현 벡타(pCR-XL-TOPO-Crt)에 재조합한 후 이 벡터를 대장균에 형질 전환시켜서 건조중량으로 400 ${mu}g$/g의 아스타잔틴을 생산하였다. 아스타잔틴의 생산성을 증가시키기 위해서... -
Real-Time PCR Analysis of Metabolic Pathway of PHB in Acidiphilium cryptum DX1-1
Xu. Ai-Ling, Xia. Jin-Lan, Liu. Ke-Ke, Li. Li, Yang. Yu, Nie. Zhen-Yuan, Qiu. Guan-Zhou 한국미생물생명공학회 Journal of microbiology and biotechnology 7 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2010, Vol.20 No.1 71-77 (7 pages)
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Investigation of the Central Carbon Metabolism of Sorangium cellulosum: Metabolic Network Reconstruction and Quantification of Pathway Fluxes
Bolten. Christoph J., Heinzle. Elmar, Muller. Rolf, Wittmann. Christoph 한국미생물생명공학회 Journal of microbiology and biotechnology 14 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2009, Vol.19 No.1 23-36 (14 pages)
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Estimation of Theoretical Yield for Ethanol Production from D-Xylose by Recombinant Saccharomyces cerevisiae Using Metabolic Pathway Synthesis Algorithm
Lee. Tae-Hee, Kim. Min-Young, Ryu. Yeon-Woo, Seo. Jin-Ho 한국미생물생명공학회 Journal of microbiology and biotechnology 5 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2001, Vol.11 No.3 384-388 (5 pages)
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Could Organic Solvents Be Used for the Alteration of Flux of Hydrophobic Intermediates through a Metabolic Pathway in Microorganismsulcorner
Zucchi. Gioia, Khan. Jeffrey-A., Vulfson. Evgeny-N. 한국미생물생명공학회 Journal of microbiology and biotechnology 4 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 1998, Vol.8 No.6 719-722 (4 pages)
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Effect of low intensity pulsed ultrasound in activating the mitogen-activated protein kinase signaling pathway and inhibition inflammation cytokine synthesis in chondrocytes
Eun-Jung Kim, Gye-Yeop Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 6 33-37 (5 pages)
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BDNF/ERK pathway in TMT-induced neurotoxicity
Su eun Lee, Mi young Yang, Ju hwan Kim, Jin wook Kim, So hi Kang, Woo seok Ahn, Sung Ho Kim, Jong Choon Kim, Tae kyun Shin, Heh In Im, Ho 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 267 481-481 (1 pages)
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In silico analysis of putative drug and vaccine targets of the metabolic pathways of Actinobacillus pleuropneumoniae using a subtractive/comparative genomics approach
Biruk T. Birhanu, Seung-Jin Lee, Na-Hye Park, Ju-Beom Song, Seung-Chun Park 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 5 188-199 (12 pages)
20 metabolic pathways that were unique and contained 273 non-homologous proteins, of which 122 were essential. Of the 122 essential proteins, there were 95 cytoplasmic proteins and 11 transmembrane proteins, which are potentially suitable for drug and vaccine targets, respectively. Among these, 25 had at least one hit in DrugBank, and three had similarity to metabolic proteins from Mycoplasma hyopneumoniae, another pathogen causing porcine respiratory disease complex; thus, they could serve as... -
Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse model
Hye Kyung Baek, Pan Soo Kim, Ji Ae Song, Dong-Hwa Choi, Do Eun Kim, Seung Il Oh, Sang-Kyu Park, Sung-Jo Kim, Ki-Duk Song, In Koo 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 1 119-127 (9 pages)
Recently, we reported that Artemisia annua (AA) has anti-adipogenic properties in vitro and in vivo. Reduction of adipogenesis by AA treatment may dampen systemic inflammation and protect neurons from cytokine-induced damage. Therefore, the present study was undertaken to assess whether AA increases neuronal maturation by reducing inflammatory responses, such as those mediated by cyclooxygenase 2 (COX-2). Mice were fed normal chow or a high-fat diet with or without chronic daily oral... -
Involvement of the Ca signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation
Yingxiao Fu, Jianhong Gu, Yi Wang, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 3 151-156 (6 pages)
The results confirmed that M-CSF + RANKL significantly increased [Ca]i and CaMKII phosphorylation in osteoclasts (p ＜ 0.01), and that these effects were subsequently decreased by OPG treatment. Exposure to specific inhibitors of the Ca signaling pathway revealed that these changes varied between the different OPG treatment groups. Findings from the present study indicated that the Ca signaling pathway is involved in both the regulation of osteoclastogenesis as well as inhibition of osteoclast... -
Intragastric gavage with denatonium benzoate acutely induces neuronal activation in the solitary tract nucleus via the vagal afferent pathway
Hyo Young Jung, Woosuk Kim, Dae Young Yoo, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Yeo Sung Yoon, Hye Young Kim, In Koo Hwan 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 4호 1 459-464 (6 pages)
Natural toxic substances have a bitter taste and their ingestion sends signals to the brain leading to aversive oral sensations. In the present study, we investigated chronological changes in c-Fos immunoreactivity in the nucleus tractus solitarius (NTS) to study the bitter taste reaction time of neurons in the NTS. Equal volumes (0.5 mL) of denatonium benzoate (DB), a bitter tastant, or its vehicle (distilled water) were administered to rats intragastrically. The rats were sacrificed at 0, 0.5,... -
Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows
Marion Piechotta*, Lars Holzhausen, Marcelo Gil Araujo, Maike Heppelmann, Anja Sipka, Chistiane Pfarrer, Hans-Joachim Schuberth, 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 3호 2 343-352 (10 pages)
Cows with different Insulin-like Growth Factor-I (IGF-I) concentrations showed comparable expression levels of hepatic growth hormone receptor (GHR). Suppressor of cytokine signaling 2 (SOCS2), could be responsible for additional inhibition of the GHR signal cascade. The aims were to monitor cows with high or low antepartal IGF-I concentrations (IGF-I or IGF-I), evaluate the interrelationships of endocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to... -
Effects of resveratrol on the insulin signaling pathway of obese mice
Hyun Ju Hong, Wonyoung Kang, Dong Geon Kim, Dae Ho Lee, Youngjae Lee, Chang-Hoon Han* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 2 179-185 (7 pages)
compared with the levels in the HF group. In addition, the phosphorylation levels of IRS-1 (Ser636/Ser639), PI-3K p85-subunit α/γ (Tyr467/Tyr199), PDK1 (Ser241), GSK-3α (S21) and GSK-3 (Ser9), which are involved in the insulin signaling pathway, were decreased in the HF group, whereas the levels were restored to normal in the HFR group. Overall, the results show that resveratrol restores the phosphorylation levels of proteins involved in the insulin signaling pathway, which were decreased by... -
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway
Sijun Deng, Hui Yuan, Jine Yi, Yin Lu, Qiang Wei, Chengzhi Guo, Jing Wu, Liyun Yuan, Zuping He 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 7 281-289 (9 pages)
proliferation of RAW264.7 cells in a dose-dependent manner, and caused obvious cell apoptosis and a loss of ΔΨm in RAW264.7 cells. Moreover, the ROS production in cells was elevated, and the levels of activated caspase-3 and caspase-9 were up-regulated in a dose-dependent manner. Notably, GA-induced cell apoptosis was markedly inhibited by caspase inhibitors. These results suggest that GA-induced RAW264.7 cell apoptosis may be mediated via a caspase-dependent mitochondrial signaling pathway. -
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
Jong Soo Han, Young Sil Min, Gil Hyung Kim, Sang-hyun Chae, Yoonjin Nam, Jaehwi Lee, Seok-Yong Lee, Uy Dong Sohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 11 577-584 (8 pages)
Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors. In the present study, we compared the contractility of bladder smooth muscle from normal rats and DM rats. Furthermore, we utilized pharmacological inhibitors to delineate the mechanisms underlying bladder muscle differences between normal and DM rats. DM was established in 14 days after... -
Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway
YongKim, HanGyungKim, SangYunHan, DeokJeong, WooSeokYang, Jung-IlKim, JiHyeKim, Young-SuYi, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 9 547-554 (8 pages)
kinase of the IRF-3 signaling pathway. IRF-3 phosphorylation is highly induced by wild-type AKT and poorly induced by an AKT mutant, AKT C310A, which is mutated at an inhibitory target site of HQ. We also showed that HQ inhibited IRF-3 phosphorylation by targeting all three AKT isoforms (AKT1, AKT2, and AKT3) in RAW264.7 cells and suppressed IRF-3-mediated luciferase activities induced by AKT in HEK293 cells. Taken together, these results strongly suggest that HQ inhibits the production of a... -
Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters
Eun-SolLee, Dong-SungLee, PrakashRajPeya, Youn-ChulKim, Dae-GilKang, Ho-SubLee, Byung-ChulOh, DaeHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 7 519-529 (11 pages)
aimed to evaluate the metabolic actions of SB, considering its physiologically relevant concentration. We evaluated the effect of SB on regulation of DPP-4 and its other metabolic actions, both in vitro (HepG2 cells and mouse mesangial cells) and in vivo (high fat diet [HFD]-induced obese mice). Ten-week HFD-induced obese C57BL/6J mice were subjected to SB treatment by adding SB to HFD which was maintained for an additional 16 weeks. In HepG2 cells, SB suppressed DPP-4 activity and expression at... -
Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries
RanyVorn, HaeYoungYoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 11 91-97 (7 pages)
effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or without other metabolic substrates including FFAs termed “nutrition full” (NF) solution, on mesenteric (MA) and deep femoral arteries (DFA) of rats. Arterial ring segments were mounted in a... -
Nafamostat mesilate promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway
SujeongChoi, Hyon-JoKwon, Hee-JungSong, SiWanChoi, HarshaNagar, ShuyuPiao, Saet-byelJung, ByeongHwaJeon, DongWoonKim, Cuk-SeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 12 539-545 (7 pages)
decreased arginase activity, which could increase the available arginine substrate for NO production. Moreover, we investigated whether NM increased NO bioavailability and decreased aortic relaxation response to an eNOS inhibitor in the aorta. These results suggest that NM increases NO generation via the Akt/eNOS signaling pathway, leading to endothelium-dependent vascular relaxation. Therefore, the vasorelaxing action of NM may contribute to the regulation of cardiovascular function. -
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
VuThiThu, HyoungKyuKim, LeThanhLong, ToThanhThuy, NguyenQuangHuy, SoonHaKim, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 10 305-314 (10 pages)
of tumor necrosis factor alpha (TNFα), TGFβ1, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of TNFα, TGFβ1, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential anti-inflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway. -
Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway
EunJeongKim, MinYoungLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 4 211-218 (8 pages)
e experiments demonstrated that silymarin inhibited LPS-induced morphological changes in the RAW264.7 mouse macrophage cell line. Our findings indicated that the most likely mechanism underlying this biological effect involved inhibition of the MAPK pathway and NF-κB activity. Inhibition of these activities by silymarin is a potentially useful strategy for the treatment of inflammation because of the critical roles played by MAPK and NF-κB in mediating inflammatory responses in macrophages. -
EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway
YiCai, LiZhao, YuanQin, Xiao-QianWu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 3 203-210 (8 pages)
(PE). Moreover, we showed that AMPK is activated in H9C2 cardiomyocytes by EGCG, and AMPK-dependent pathway participates in the inhibitory effects of EGCG on cardiac hypertrophy. Taken together, our findings provide the first evidence that the effect of EGCG against cardiac hypertrophy may be attributed to its activation on AMPK-dependent signaling pathway, suggesting the therapeutic potential of EGCG on the prevention of cardiac remodeling in patients with pressure overload hypertrophy. -
Signaling Pathway of Lysophosphatidic Acid-Induced Contraction in Feline Esophageal Smooth Muscle Cells
YunSungNam, JungSookSuh, HyunJuSong, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 5 139-147 (9 pages)
and MAPK on the LPA-induced contraction. In addition, RhoA inhibitor C3 exoenzyme and ROCK inhibitor Y27632 significantly, but not completely, reduced the contraction. The present study demonstrated that LPA-induced contraction seems to be mediated by LPA receptors (1/3), coupled to PTX-sensitive G protein, resulting in activation of PLC, PKC-Յ pathway, which subsequently mediates activation of ERK and JNK. The data also suggest that RhoA/ROCK are involved in the LPA-induced contraction.
