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전체 선택해제
총 156건 검색
본문검색 결과만 보기
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Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats
Hyun-Kyu Park, Woori Jo, Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Hyojin Lee, Hyejin Kim, Eun-Sil Yu, Woo-Chan Son 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 6 45-51 (7 pages)
multiple circulating microRNAs (miRNAs) have been reported to be potential biomarkers for DILI. To adapt and validate miRNAs for clinical use, we investigated the time-course changes in miR-122 expression levels in an acetaminophen-induced liver injury model in rats. In addition, miR-155 and miR-21 were evaluated as makers of inflammation and regeneration, respectively, to characterize liver status. Our results revealed that miR-122 is an early and sensitive biomarker of hepatocellular injury at... -
Effects of dietary acetaminophen and vitamin C supplement on serum cortisol and tumor necrosis factor-alpha concentrations in pigs vaccinated with foot-and-mouth disease vaccine
Chun-nam Cha , Beom-jun Lee , Eun-kee Park , Chang-yeol Yoo , Suk Kim , Hu-jang Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 4 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 3호 8 197-200 (4 pages)
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Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice
QiGuo, ZhiyangShen, HongxiaYu, GaofengLu, YongYu, XiaLiu, PengyuanZheng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 3 15-23 (9 pages)
Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase... -
Ethanol Prevents from Acetaminophen Inducible Hepatic Necrosis by Inhibiting its Metabolic Activation in Mice
Sun-MeeLee, Tai-SoonCho, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 15 261-269 (9 pages)
of acetaminophen metabolites (glucuronide, sulfate and cysteine conjugates) were decreased, the level of unmetabolized acetaminophen was increased. Our findings suggest that co-administration of an acute dose of ethanol reduces the degree of hepatocellular necrosis produced by a large dose of acetaminophen and this ethanol dependent protection is, in major part, afforded by suppression of the hepatic microsomal mixed function oxidase activity catalyzing the metabolic activation of acetaminophen. -
Hepatoprotective and antioxidant activity of Leea asiatica leaves against acetaminophen-induced hepatotoxicity in rats
Sen. Saikat, De. Biplab, Devanna. N., Chakraborty. Raja 후마니타스의학회 TANG : International journal of genuine traditional medicine 2 Pages
후마니타스의학회 TANG : International journal of genuine traditional medicine 2014, Vol.4 No.3 18-19 (2 pages)
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Ecotoxicological Risk Assessment for Acetaminophen in Kyongahn River
Kim. Pan-Gyi 한국환경보건학회 韓國環境保健學會誌 6 Pages
한국환경보건학회 韓國環境保健學會誌 2006, Vol.32 No.5 440-445 (6 pages)
본 연구를 수행하였다. 한강 수계이며 용인시와 광주시를 거쳐 팔당호로 흘러 들어가는 경안천(해실교, 수포교, 왕산교, 경안교, 지월교, 광동교, 팔당호)내 acetaminophen 잔류 농도와 분포를 조사하였다. 또한 Daphnia magna를 대상으로 48시간 급성독성평가를 실시하여 위해도를 평가하였다. 잔류의약품 검출을 위해 SPE 추출법을 선택 하였으며, liquid chromatography/mass spectrometry (LC/MS)를 이용하여 분석하였다. 경안천 내에서 acetaminophen 0.439 mg/l이 검출되었다. 독성평가를 실시한 결과, 48시간 $LC_{50}$은 16.9... -
The Effect of Glycyrrhizae Radix on the Metabolism of Acetaminophen
Kim. Seung-Hee, Oh. Jee-Young, Aeree moon. Aeree-Moon, Kim. Hyo-Jung, Lee. Song-Deuck 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 6 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 1993, Vol.1 No.2 160-165 (6 pages)
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Rubus coreanus Extract Attenuates Acetaminophen Induced Hepatotoxicity; Involvement of Cytochrome P450 3A4
Lee. Young-Ik, Whang. Kyung-Eun, Cho. Jin-Sook, Ahn. Byung-Min, Lee. Sang-Bum, Dong. Mi-Sook, Kim. Tae-Hyun 한국응용약물학회 Biomolecules & therapeutics 6 Pages
한국응용약물학회 Biomolecules & therapeutics 2009, Vol.17 No.4 455-460 (6 pages)
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Development of Controlled Release Oral Drug Delivery System by Membrane-Coating Method-II-Correlation Between Acetaminophen Concentrations in Plasma and Sativa Samples of Man-
심창구, 김미애, 이민화, 김신근, Shim. Chang-Koo, Kim. Mi-Ae, Lee. Min-Hwa, Kim. Shin-Keun 한국약제학회 藥劑學會誌 5 Pages
한국약제학회 藥劑學會誌 1990, Vol.20 No.1 29-33 (5 pages)
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Acetaminophen에 의해 유도된 흰주의 간손상에 미치는 Calcium channel Blocker의 효과 및 조직학적 소견
이은경, 정기화, 정춘식 한국식품위생안전성학회 한국식품위생안전성학회지 10 Pages
한국식품위생안전성학회 한국식품위생안전성학회지 1998, Vol.13 No.3 258-267 (10 pages)
해혈 및 진동 효과를 가진 APAP는 과량 복용시 CYP-450에 의해 독성 유발 물질인 NAPQI로 대사되어 간장과 세포막을 붕괴시켜 세포 내 calcium 유입을 증가시킴으로서 간세포의 괴사를 일으킨다. DIL은 CYP-450 작용을 억제하는 것으로 알려진 칼슘채널차단제이다. 따라서 본 연구에서는 APAP 300mg/kg을 경구 투여한 후 3, 6. 9 및 12시간에 DIL을 복상내로 투여하여 DIL이 APAP의 독성에 미치는 영향을 조사하였다. APAP 투여 12시간후 DIL 투여군에서 혈청과 간조직의 생화학 분석과 조직학적 관찰에서 간손상의 개선 효과가... -
Caffeine과 Acetaminophen으로 인한 간독성과 항산화성 비타민의 효과
노숙령, 옥현이, 이재관 한국식품영양과학회 한국식품영양과학회지 8 Pages
한국식품영양과학회 한국식품영양과학회지 1997, Vol.26 No.6 1173-1180 (8 pages)
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Hepatoprotective Effects of an Anthocyanin Fraction from Purple-Fleshed Sweet Potato Against Acetaminophen-Induced Liver Damage in Mice
Choi. Jae-Ho, Choi. Chul-Yung, Lee. Kyung-Jin, Hwang. Yong-Pil, Chung. Young-Chul, Jeong. Hye-Gwang 한국식품영양과학회 Journal of medicinal food 7 Pages
한국식품영양과학회 Journal of medicinal food 2009, Vol.12 No.2 320-326 (7 pages)
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Effect of Colored Potato Flakes Against Acetaminophen-induced Liver Damage in Rats
Ohba. Kiyoshi, Watanabe. Shoko, Han. Kyu-Ho, Hashimoto. Naoto, Noda. Takahiro, Shimada. Ken-Ichiro, Tanaka. Hisashi, Sekikawa. Mitsuo, F 한국식품과학회 Food science and biotechnology 7 Pages
한국식품과학회 Food science and biotechnology 2007, Vol.16 No.3 463-469 (7 pages)
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Lipid Metabolism in Rats Fed Acetaminophen with Coadministration of Adzuki Bean Extract
Han. Kyu-Ho, Ohba. Kiyoshi, Lee. Chi-Ho, Shimada. Ken-Ichiro, Sekikawa. Mitsuo, Fukushima. Michihiro 한국식품과학회 Food science and biotechnology 6 Pages
한국식품과학회 Food science and biotechnology 2007, Vol.16 No.4 584-589 (6 pages)
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오미자 Schizandrin C 유도체 DDB 복합물 DWP-04가 Acetaminophen 해독계에 미치는 영향
박희준, 이명선, 지상철, 이경태, 신영호, 최종원, Park. Hee-Juhn, Lee. Myeong-Seon, Chi. Sang-Cheol, Lee. Kyung-Tae, Shin. Young-Ho, Choi. Jong-Won 한국생약학회 생약학회지 7 Pages
한국생약학회 생약학회지 2005, Vol.36 No.2 81-87 (7 pages)
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Nephrotoxicity of Acetaminophen and Gentamicin in Combination in Rats
Yoon. Sang-Don, Lim. Chae-Woong, Rim. Byung-Moo 한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 6 Pages
한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 1998, Vol.14 No.2 151-156 (6 pages)
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Anti-oxidative Effect of a Protein from Cajanus indicus L against Acetaminophen-induced Hepato-nephro Toxicity
Ghosh. Ayantika, Sil. Parames C. 생화학분자생물학회 Journal of biochemistry and molecular biology 11 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2007, Vol.40 No.6 1039-1049 (11 pages)
