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Evidence for estrogen receptor expression during medullary bone formation and resorption in estrogen―treated male Japanese quails (Coturnix coturnix japonica)
Shinji Hiyama*, Toshie Sugiyama, Seiji Kusuhara, Takashi Uchida 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 3호 2 223-227 (5 pages)
of ER―a was already observed on day 0 and increased slightly during bone formation whereas ER―b was hardly detected throughout this process. After osteoclasts appeared on the medullary bone surface, this type of bone disappeared from the bone marrow cavity (days 7∼15). ER―a expression simultaneously decreased slightly and ER―b levels remained very low. These results suggest that estrogen activity mediated by ER―a not only affects medullary bone formation but also bone resorption. -
Effects of continuous force application for extrusive tipping movement on periapical root resorption in the rat mandibular first molar
Yoshiro Matsumoto, Siripen Sringkarnboriboon, Takashi Ono 대한치과교정학회 The Korean Journal of Orthodontics 7 Pages
대한치과교정학회 The Korean Journal of Orthodontics 2018, 제 48권 제 5호 8 339-345 (7 pages)
distoapical third of the distal roots. However, there was no significant difference in the amount of root resorption between the two experimental groups. The control group did not exhibit any active root resorption lacunae. Conclusions: Periapical root resorption was induced by continuous extrusive tipping force and occlusal interference in rat mandibular molars. These data suggest that we orthodontists had better take care not to induce occlusal interference during our orthodontic treatment. -
Surface analysis of failed implants
Su-Gwan Kim, Young-Jong Kim, Yong-Min Kim, Young-Kyun Kim 대한치과이식임플란트학회 Journal of Dental Implant Research 7 Pages
대한치과이식임플란트학회 Journal of Dental Implant Research 2004, 제 23권 1호 1 1-7 (7 pages)
Knowledge of the concept of osseointegration has enhanced the success of dental implants owing to improved understanding of the concept of bone stress and bone response. Longitudinal clinical studies report 10-year successrates of 81-85% for implants in the maxilla and 98-99% for implants in the anterior mandible1). In 1989, the main causes of implant failure were the selection of inappropriate patients and the accumulation of residue owing to the use of improper prosthetic restoration... -
Unilateral rostral mandibulectomy for gingival vascular hamartoma in two calves
Takeshi Tsuka, Yoshiharu Okamoto, Naoki Yamamoto, Keiji Hayashi, Takehito Morita, Yuji Sunden, Yusuke Murahata, Kazuo Azuma, Tomohiro Os 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 16 582-584 (3 pages)
A 2-month-old female Holstein calf and a 5-month-old female Japanese black calf presented with gingival vascular hamartoma located in the interdental space between the second and third mandibular incisors in the right and left mandibles, respectively. On radiographic or computed tomographic images, osteolytic changes appeared within the mandibular bones adjacent to the masses. The masses were removed along with affected mandibular bone by using unilateral rostral mandibulectomy. After surgery,... -
Differential regulation of senescence and in vitro differentiation by 17β-estradiol between mesenchymal stem cells derived from male and female mini-pigs
Won-Jae Lee, Seung-Chan Lee, Jeong-Hyun Lee, Gyu-Jin Rho, Sung-Lim Lee 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 2호 5 159-170 (12 pages)
The characterization and potential of mesenchymal stem cells (MSCs) are gender dependent and estrogen influences these properties. This study demonstrated that supplementation with 17β-estradiol (E2) increases the proliferation of bone marrow-MSCs derived from male and female mini-pigs (Mp- and Fp-BMSCs) in a concentration-dependent manner, with 10 M E2 suggested as the optimal dose of E2 that led to the greatest improvement in BMSCs proliferation. Supplementation of 10 M E2 resulted in... -
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
Bratislav Dejanovic, Ivana Stevanovic, Milica Ninkovic, Ivana Stojanovic, Irena Lavrnja, Tatjana Radicevic, Milos Pavlovic 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 7 53-61 (9 pages)
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ... -
Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model
Daeyoung Yoon, Byung-Jae Kang, Yongsun Kim, Seung Hoon Lee, Daeun Rhew, Wan Hee Kim, Oh-Kyeong Kweon 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 2 397-404 (8 pages)
Composite biological and synthetic grafts with progenitor cells offer an alternative approach to auto- or allografts for fracture repair. This study was conducted to evaluate osteogenesis of autologous serum-derived albumin (ASA) scaffolds seeded with canine adipose tissue-derived mesenchymal stem cells (Ad-MSCs) in a canine segmental bone defect model. ASA scaffold was prepared with canine serum using cross-linking and freeze-drying procedures. Beta-tricalcium phosphate (β-TCP) was mixed at... -
Regulation of matrix metalloproteinase-9 protein expression by 1α, 25-(OH)2D3 during osteoclast differentiation
Jian-Hong Gu, Xi-Shuai Tong, Guo-Hong Chen, Xue-Zhong Liu, Jian-Chun Bian*, Yan Yuan, Zong-Ping Liu* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 15 133-140 (8 pages)
1α,25-(OH)2D3 during culturing, and cell proliferation was measured using the methylthiazol tetrazolium method. Osteoclast formation was confirmed using tartrate-resistant acid phosphatase (TRAP) staining and assessing bone lacunar resorption. MMP-9 protein expression levels were measured with Western blotting. We showed that 1α,25-(OH)2D3 inhibited RAW264.7 cell proliferation induced by RANKL and M-CSF, increased the numbers of TRAP-positive osteoclasts and their nuclei, enhanced osteoclast... -
Inhibitory effects of osteoprotegerin on osteoclast formation and function under serum-free conditions
Ying-Xiao Fu, Jian-Hong Gu, Yi-Ran Zhang, Xi-Shuai Tong, Hong-Yan Zhao, Yan Yuan, Xue-Zhong Liu, Jian-Chun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 4호 5 405-412 (8 pages)
and a bone resorption assay. Furthermore, the expression osteoclast-related genes, such as TRAP and receptor activator for nuclear factor κB (RANK), that was influenced by OPG in RAW264.7 cells was examined using real-time polymerase chain reaction. In summary, findings from the present study suggested that M-CSF with RANKL can promote osteoclast differentiation and activation, and enhance the expression of TRAP and RANK mRNA in osteoclasts. In contrast, OPG inhibited these activities under... -
Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs
Byung-Jun Jang, Ye-Eun Byeon, Ji-Hey Lim, Hak-Hyun Ryu, Wan Hee Kim, Yoshihisa Koyama, Masanori Kikuchi, Kyung-Sun Kang*, Oh-Kye 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 4호 8 387-394 (8 pages)
This study was performed to evaluate the osteogenic effect of allogenic canine umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) mixed with beta-tricalcium phosphate (b-TCP) in orthotopic implantation. Seven hundred milligrams of b-TCP mixed with 1 × 10 UCB-MSCs diluted with 0.5 ml of saline (group CM) and mixed with the same volume of saline as control (group C) were implanted into a 1.5 cm diaphyseal defect and wrapped with PLGC membrane in the radius of Beagle dogs.... -
Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat
Samit Kumar Nandi, Biswanath Kundu*, Samir Kumar Ghosh, Dipak Kumar De, Debabrata Basu 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 2호 9 183-192 (10 pages)
fibro-collagenization and an adequate amount of marrow material, fat cells, and blood vessels. An oxytetracycline labeling study showed moderate activity of new bone formation with crossing-over of new bone trabeculae along with the presence of resorption cavities in group II, whereas in the control group, the process of new bone formation was active from both ends and the defect site appeared as a homogenous non-fluoroscent area. Angiograms of the animals in the control group showed uniform... -
Phacoemulsification and acryl foldable intraocular lens implantation in dogs: 32 cases
Na-Young Yi, Shin-Ae Park, Man-Bok Jeong, Won-Tae Kim, Se-Eun Kim, Je-Min Chae, Kang-Moon Seo 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 3호 12 281-285 (5 pages)
This study evaluated the surgical outcome and complications of phacoemulsification and the implantation of an acryl foldable intraocular lens (IOL) with a squared edge in dogs with cataracts. Thirty-two eyes from 26 dogs were examined. The mean follow up period was 75.9 days ranging from 23 to 226 days. The complications after phacoemulsification were posterior capsular opacity (PCO) around the IOL (n = 11), ocular hypertension (n = 4), focal posterior synechia (n = 4), hyphema (n = 3) and... -
An immunohistochemical study of chromogranin A and Sp-1 immunoreactive cells in the gastrointestinal tract of ovariectomized rats
Sae Kwang Ku, Hyeung Sik Lee, Jae Hyun Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 3호 3 191-196 (6 pages)
The changes on the regional distributions and frequencies of two types of chromogranin, chromogranin A (CGA) and bovine Sp-1 chromogranin (BCG)-immunoreactive (IR)cells in gastrointestinal (GI)tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied by immunohistochemical methods. The experimental animals were divided into two groups, one is non-ovariectomized group (Sham)and the other is ovariectomized group (OVX). Samples were collected from each part of GI tract at 10th... -
Changes of gastrointestinal argyrophil endocrine cells in the osteoporotic SD rats induced by ovariectomy
Sae-Kwang Ku, Hyeung-Sik Lee, Jae-Hyun Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 3호 1 183-188 (6 pages)
The regional distributions and frequencies of argyrophil endocrine cells in gastrointestinal (GI) tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied using Grimelius silver stain. The experimental animals were divided into two groups, one is non-ovariectomized group (Sham) and the other is ovariectomized group (OVX). Samples were collected from each part of GI tract (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) at 10th week after ovariectomy or... -
Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis
Seong-Soo Kang, Seok-Hwa Choi 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 1호 11 65-70 (6 pages)
This study demonstrates that prophylactic effect of plaster and cataplasm contained ketoprofen in adjuvant arthritis therapy by X-ray. Adjuvant arthritis was induced by a single injection of Freund's complete adjuvant. Mature female Sprague-Dawley rats were designated to 3 groups such as nontreated control, plaster-treated (PT) and cataplasm-treated (CT), each of which was composed of ten animals. The PT and the CT groups showed reduced primary paw swelling, but secondary paw swelling was not... -
Histomorphometric evaluation of the bone surrounding orthodontic miniscrews according to their adjacent root proximity
Hyun-Ju Oh, Jung-Yul Cha, Hyung-Seog Yu, Chung-Ju Hwang 대한치과교정학회 The Korean Journal of Orthodontics 9 Pages
대한치과교정학회 The Korean Journal of Orthodontics 2018, 제 48권 제 5호 2 283-291 (9 pages)
Objective: This study was conducted to perform histomorphometric evaluations of the bone surrounding orthodontic miniscrews according to their proximity to the adjacent tooth roots in the posterior mandible of beagle dogs. Methods: Four male beagle dogs were used for this study. Six orthodontic miniscrews were placed in the interradicular spaces in the posterior mandible of each dog (n = 24). The implanted miniscrews were classified into no loading, immediate loading, and delayed loading groups... -
EFFECTS OF SODIUM NITROPRUSSIDE ON THE FORMATION AND ACTIVATION OF THE OSTEOCLAST IN CULTURE
Young-Jae Yoo, Jung-Kun Kim, Kyung-Suk Cha 대한치과교정학회 The Korean Journal of Orthodontics 10 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 6 705-714 (10 pages)
in a significant decrease in dentin resorption by osteoclasts in terms of total resorption area and average individual area. We also examined the effect of SNP on formation of osteoclast-like cells that is TRAP-positive multinucleated cells from chicken and rat bone marrow cells in the presence or absence of 10-8M l,25[OH]2D3. The addition of 300 µM SNP inhibited the formation of TRAP-positive multinucleated cells. The present data suggest that SNP, possibly as a NO- donor, inhibits the... -
EFFECTS OF SEVERAL CYTOKINES ON THE FUNCTIONS OF FETAL RAT OSTEOBLAST-LIKE CELLS IN VITRO
Hee-Sung Han, Jung-Keun Kim, Young-Il Chang 대한치과교정학회 The Korean Journal of Orthodontics 8 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 4 689-696 (8 pages)
Effects of several cytokines(IL -1β, TNFα, and IFNγ) have been examined on fetal rat osteoblast-like cells. To investigate whether cytokines play direct causal roles in production of lysosomal enzyme, fetal rat osteoblast-like cells were treated with IL-1β, TNFα, and IFNγ, respectively or combined. And acid phosphatase was determined by biochemical method. Alkaline phosphatase was assayed to determine the effects of IL-1β, TNFα, and IFNγ on the... -
A comparative study of the angles between crown axis and root axis in mesiodistal direction by using orthopantomogram
Young-Joon Kim, Hyun-Sil Choi 대한치과교정학회 The Korean Journal of Orthodontics 10 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 6호 2 657-666 (10 pages)
Orthopantomogram is commonly used to evaluate root parallelism. “Good parallelism” between roots is widely accepted as one of the guidelines of a successful orthodontic treatment. In case there was a large angle between crown axis and root axis, and if we valued only the position of crown in establishing occlusal relationship without considering of the situation of root, the problem of root arrangement between adjacent teeth would be occurred. The estimate of root parallelism in mesiodistal... -
백서의 실험적 치아 이동시 교원질 발현에 관한 면역조직화학적 연구
김상철(Sang-Cheol Kim), 전인섭(In-Seop Jeon) 대한치과교정학회 The Korean Journal of Orthodontics 13 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 4호 12 455-467 (13 pages)
견인력에 의한 치아 이동시 전반적인 치주 조직의 변화를 관찰하고 특히 제1형 교원질의 발현 정도 및 분포의 변화를 알아보고자 Sprague-Dawley계 백서 21마리를 대상으로 대조군(3마리)과 실험군(18마리)으로 나누었으며， 실험군은 양 중절치 사이에 견인력(75g)을 가한 후 12시간, 1일, 4일, 7일, 14일, 28일째에 각각 3마리씩 희생시켜, 시간에 따른 제1형 교원질의 발현과 조직학적 변화를 면역조직화학적 및 조직 병리학적으로 관찰한 바 다음과 같은 결과를 얻었다. 견인력을 가한 후 28일째까지, 견인측의 치주인대 섬유는... -
Bisphosphonate와 Indomethacin이 백서 치조골의 골개조에 미치는 영향
조명숙(Myeong-Sook Cho), 김종철(Jong-Chul Kim) 대한치과교정학회 The Korean Journal of Orthodontics 12 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 2호 4 163-174 (12 pages)
본 실험은 서로 다른 기전으로 골흡수를 억제한다고 추정되는 약제인 bisphosphonate와 indomethacin을 백서에 투여한 후 교정력을 이용한 치아 이동시 약제가 골개조에 미치는 영향을 밝히고자 시행되었다. 동일한 조건에서 사육된 체중 260-300g의 웅성백서(Sprague-Dawley계)를 대조군, bisphosphonate 투여군 및 indomethacin 투여군으로 분류하고 각 군은 다시 장치를 장착한 실험측과 장치를 장착하지 않은 대조측으로 분류하였다. Bisphosphonate(6.3mg/kg, 2.52×10-2mol/L)와 indomethacin(9mg/kg, 2.52×10-2mol/L)은 교정장치... -
유성견 급속정중이개시 정중구개봉하부위의 조직학적 변화에 대한 연구
이두희(Doo-Hee Lee), 정규림(Kyu-Rhim Chung) 대한치과교정학회 The Korean Journal of Orthodontics 10 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 2호 3 153-162 (10 pages)
정중구개봉합의 급속확장은 상악골의 악궁의 폭을 증가시키고, 전방이동을 용이하게 하므로 전후방적인 악골의 부조화나 상악치열궁 협착 등을 치료하는데 널이 사용되고 있다. 이 연구는 정주구개봉합의 급속이개시 봉합부위에서 나타나는 골개조 판정 및 교원섬유의 변화를 관찰하고자 시행되었다. 생후 6-8개월된 유성견 4마리를 실험동물로 사용하여 인상을 채득한 후 주조된 급속정중이개장치에 Hyrax screw를 납착하여 장착시키고 1회에 90°씩, 1일 2회전시켜 10일간 지속하였다. X-ray상에서 봉합의 이개를 확인한 후... -
1,25-Dihydroxyvitamin D₃가 치주인대세포활성 및 실험적 치아이동에 미치는 영향에 관한 연구
김성우(Sung-Woo Kim), 박동권(Dong-Kwon Park), 김상철(Sang Cheol Kim) 대한치과교정학회 The Korean Journal of Orthodontics 13 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1997, 제 27권 제 2호 14 335-347 (13 pages)
교정치료시 치아이동은 치주인대세포를 매개로 골조직의 개조가 일어나는 과정으로서 골조직의 성장과 개조는 조골세포, 파골세포 및 그 전구헤포의 증식, 분화 및 활성에 영향을 미치는 여러가지 전신적 인자와 국소적 인자에 의하여 조절되고 있다. 1,25-Dihydroxyvitamin D3의 대사물로서 경조직에 있어서 칼슘과 인산의 이동에 중요한 역할을 담당하고 있는 것으로 알려져 있으나 치주인대에 대한 1,25-Dihydroxyvitamin D3의 생물학적 기능은 잘 알려져 있지 않다. 1,25-Dihydroxyvitamin D3가 치주인대세초의 활성에 미치는 영향을... -
Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins
SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 8 531-546 (16 pages)
Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24,and 36 h to induce TLR-4 activation. The... -
Effects of Watercress Containing Rutin and Rutin Alone on the Proliferation and Osteogenic Differentiation of Human Osteoblast-like MG-63 Cells
HanbitHyun, HeajinPark, JaehoonJeong, JihyeKim, HaesungKim, HyunIlOh, HyeSeongHwang, HaHyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 10 347-352 (6 pages)
Most known osteoporosis medicines are effective for bone resorption, and so there is an increasing demand for medicines that stimulate bone formation. Watercress (N. officinale R. Br.) is widely used as a salad green and herbal remedy. This study analyzed a watercress extract using ultra-performance liquid chromatography/mass spectrometry, and identified a rutin as one of its major constituents. Osteogenic-related assays were used to compare the effects of watercress containing rutin (WCR) and... -
Characterization and Immunopotentiating Effects of the Glycoprotein Isolated from Dioscorea Batatas
PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 5 101-106 (6 pages)
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA,... -
Carthamus tinctorius L. Increases BMP-2 Gene Expression during Bone Fracture Healing in Rats
Kwang-HeeLee, Oog-JinSohn, Jong-ChulAhn, Yong-WoonKim, So-YoungPark, Jong-YeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 5 143-148 (6 pages)
Carthamus tinctorius L.is known to improve fracture healing, and bone morphogenetic proteins (BMPs) are associated with the formation and healing process of bone. BMP-2 and BMP-7 are two of the most important BMPs during the bone healing process. Human osteosarcoma MG63 cells and rats were used to determine the effects of Carthamus tinctorius L. extract (CTE) on BMP-2 gene expression. BMP-2 gene expression by CTE treatment in human osteosarcoma MG63 cells was not different from the control group... -
Phytoestrogen-Induced Phosphorylation of MAP Kinase in Osteoblasts is Mediated by Membrane Estrogen Receptor
YounHeePark, HwanKiPark, HyoJinLee, SunMuPark, SangWonChoi, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 7 165-170 (6 pages)
We have previously demonstrated that phytoestrogens isolated from safflower seeds significantly attenuated bone loss in ovariectomized rats, and directly stimulated proliferation and differentiation of cultured osteoblastic cells. In an attempt to elucidate underlying cellular mechanisms, in the present study we investigated effects of 17β-estradiol (E2) and phytoestrogens such as matairesinol and acacetin, a type of lignan and flavonoid, respectively, on activation of mitogen activated...
