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Anticancer Activity of Novel Daphnane Diterpenoids from Daphne genkwa through Cell-Cycle Arrest and Suppression of Akt/STAT/Src Signalings in Human Lung Cancer Cells
Jo. Si-Kyoung, Hong. Ji-Young, Park. Hyen Joo, Lee. Sang Kook 한국응용약물학회 Biomolecules & therapeutics 7 Pages
한국응용약물학회 Biomolecules & therapeutics 2012, Vol.20 No.6 513-519 (7 pages)
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Growth Inhibitory Activity of Honokiol through Cell-cycle Arrest, Apoptosis and Suppression of Akt/mTOR Signaling in Human Hepatocellular Carcinoma Cells
Hong. Ji-Young, Park. Hyen Joo, Bae. KiHwan, Kang. Sam Sik, Lee. Sang Kook 한국생약학회 Natural product sciences 5 Pages
한국생약학회 Natural product sciences 2013, Vol.19 No.2 155-159 (5 pages)
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Evidence of an Epigenetic Modification in Cell-cycle Arrest Caused by the Use of Ultra-highly-diluted Gonolobus Condurango Extract
Bishayee. Kausik, Sikdar. Sourav, Khuda-Bukhsh. Anisur Rahman 대한약침학회 Journal of pharmacopuncture 7 Pages
대한약침학회 Journal of pharmacopuncture 2013, Vol.16 No.4 7-13 (7 pages)
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 8 205-213 (9 pages)
signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the... -
Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
HyoungChulChoi, KwangYounLee, DongHyupLee, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 7 309-313 (5 pages)
those of control rats (Wistar-Kyoto rats; WKY). We tested the hypothesis that induction of heme oxygenase (HO)-1 induced by aprotinin inhibits VSMC proliferation through cell cycle arrest in hypertensive rats. Aprotinin treatment inhibited VSMC proliferation in SHR more than in normotensive rats. These inhibitory effects were associated with cell cycle arrest in the G1 phase. Tin protoporphyrin IX (SnPPIX) reversed the anti-proliferative effect of aprotinin in VSMC from SHR. The level of cyclin... -
Ochnaflavone, a Natural Biflavonoid, Induces Cell Cycle Arrest and Apoptosis in HCT-15 Human Colon Cancer Cells
Kang. You-Jin, Min. Hye-Young, Hong. Ji-Young, Kim. Yeong-Shik, Kang. Sam-Sik, Lee. Sang-Kook 한국응용약물학회 Biomolecules & therapeutics 6 Pages
한국응용약물학회 Biomolecules & therapeutics 2009, Vol.17 No.3 282-287 (6 pages)
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G0/G1 Cell Cycle Arrest and Activation of Caspases in Honokiol-mediated Growth Inhibition of Human Gastric Cancer Cells
Kang. You-Jin, Chung. Hwa-Jin, Min. Hye-Young, Song. Ja-Young, Park. Hyen-Joo, Youn. Ui-Joung, Bae. Ki-Hwan, Kim. Yeong-Shik, Lee. Sang- 한국생약학회 Natural product sciences 6 Pages
한국생약학회 Natural product sciences 2012, Vol.18 No.1 16-21 (6 pages)
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Interfering Transbody-mediated Her2 Gene Silencing Induces Apoptosis by $G_0/G_1$ Cell Cycle Arrest in Her2-overexpressing SK-BR-3 Breast Cancer Cells
Kim. Ae-Yung, Choi. Dong-Ki, Sung. Eun-Sil, Yun. Jee-Sun, Kwon. Myung-Hee, Kim. Yong-Sung 한국생물공학회 Biotechnology and bioprocess engineering 7 Pages
한국생물공학회 Biotechnology and bioprocess engineering 2012, Vol.17 No.2 413-419 (7 pages)
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(E)-1-(3,4-Dihydroxyphenethyl)-3-Styrylurea Inhibits Proliferation of MCF-7 Cells through $G_1$ Cell Cycle Arrest and Mitochondria-Mediated Apoptosis
Yu. Ji-Yeon, Kim. Ji-Hae, Kim. Tae-Geum, Kim. Beom-Tae, Jang. Yong-Suk, Lee. Jeong-Chae 한국분자세포생물학회 Molecules and cells 8 Pages
한국분자세포생물학회 Molecules and cells 2010, Vol.30 No.4 303-310 (8 pages)
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Helicobacter pylori ${gamma}$-Glutamyltranspeptidase Induces Cell Cycle Arrest at the G1-S Phase Transition
Kim. Kyung-Mi, Lee. Seung-Gyu, Kim. Jung-Min, Kim. Do-Su, Song. Jea-Young, Kang. Hyung-Lyun, Lee. Woo-Kon, Cho. Myung-Je, Rhee. Kwang-Ho 한국미생물학회 The journal of microbiology 6 Pages
한국미생물학회 The journal of microbiology 2010, Vol.48 No.3 372-377 (6 pages)
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Cell Cycle Arrest and Cytochrome c-mediated Apoptotic Induction in A549 Human Lung Cancer Cells by MCS-C2, an Analog of Sangivamycin
Kang. Jeong-Hwa, Lee. Dong-Keun, Lee. Chul-Hoon 한국미생물생명공학회 Journal of microbiology and biotechnology 5 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2010, Vol.20 No.2 433-437 (5 pages)
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Downregulation of Cdk1 and CyclinB1 Expression Contributes to Oridonin-induced Cell Cycle Arrest at G2/M Phase and Growth Inhibition in SGC-7901 Gastric Cancer Cells
Gao. Shi-Yong, Li. Jun, Qu. Xiao-Ying, Zhu. Nan, Ji. Yu-Bin 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.15 6437-6441 (5 pages)
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8-60hIPP5m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21cip1/waf1 Pathways and Delayed Cyclin B1 Nuclear Translocation
Zeng. Qi-Yan, Zeng. Lin-Jie, Huang. Yu, Huang. Yong-Qi, Zhu. Qi-Fang, Liao. Zhi-Hong 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 7 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.9 4101-4107 (7 pages)
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Extract of Saccharina japonica Induces Apoptosis companied by Cell Cycle Arrest and Endoplasmic Reticulum Stress in SK-Hep1 Human Hepatocellular Carcinoma Cells
Jung. Hyun Il, Jo. Mi Jeong, Kim. Hyung-Rak, Choi. Yung Hyun, Kim. Gun-Do 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 7 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.7 2993-2999 (7 pages)
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Induction of Cytotoxicity and Apoptosis in Human Gastric Cancer Cell SGC-7901 by Isovaltrate Acetoxyhydrin Isolated from Patrinia heterophylla Bunge Involves a Mitochondrial Pathway and G2/M Phase Cell Cycle Arrest
Yang. Bo, Wang. Yi-Qi, Cheng. Ru-Bin, Chen. Jia-Li, Chen. Jin, Jia. Li-Tao, Zhang. Ru-Song 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.11 6481-6486 (6 pages)
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S-benzyl-cysteine-mediated Cell Cycle Arrest and Apoptosis Involving Activation of Mitochondrial-dependent Caspase Cascade through the p53 Pathway in Human Gastric Cancer SGC-7901 Cells
Sun. Hua-Jun, Meng. Lin-Yi, Shen. Yang, Zhu. Yi-Zhun, Liu. Hong-Rui 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.11 6379-6384 (6 pages)
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Exogenous Morphine Inhibits Human Gastric Cancer MGC-803 Cell Growth by Cell Cycle Arrest and Apoptosis Induction
Qin. Yi, Chen. Jing, Li. Li, Liao. Chun-Jie, Liang. Yu-Bing, Guan. En-Jian, Xie. Yu-Bo 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.4 1377-1382 (6 pages)
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Bracken-fern Extracts Induce Cell Cycle Arrest and Apoptosis in Certain Cancer Cell Lines
Roudsari. Motahhareh Tourchi, Bahrami. Ahmad Reza, Dehghani. Hesam, Iranshahi. Mehrdad, Matin. Maryam Moghadam, Mahmoudi. Mahmud 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 7 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.12 6047-6053 (7 pages)
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LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity
Gong. Chen, Liao. Hui, Wang. Jiang, Lin. Yang, Qi. Jun, Qin. Liang, Tian. Lin-Qiang, Guo. Feng-Jing 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.7 3103-3107 (5 pages)
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Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways
Hwang. Yu-Jin, Lee. Eun-Ju, Kim. Haeng-Ran, Hwang. Kyung-A 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2013, Vol.46 No.12 611-616 (6 pages)
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High-Dose $^{111}In$ Induces G1 Cell Cycle Arrest and Cell Death in Rat Bone Marrow Mesenchymal Stem Cells
Park. Bok-Nam, Shim. Woo-Young, Ahn. Young-Hwan, Lee. Jae-Ho, An. Young-Sil, Yoon. Joon-Kee 대한핵의학회 Nuclear medicine and molecular imaging : NMMI 8 Pages
대한핵의학회 Nuclear medicine and molecular imaging : NMMI 2012, Vol.46 No.2 81-88 (8 pages)
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Quercetin-mediated Cell Cycle Arrest and Apoptosis Involving Activation of a Caspase Cascade through the Mitochondrial Pathway in Human Breast Cancer MCF-7 Cells
Chou. Chu-Chung, Yang. Jai-Sing, Lu. Hsu-Feng, Ip. Siu-Wan, Lo. Chyi, Wu. Chih-Chung, Lin. Jing-Pin, Tang. Nou-Ying, Chung. Jing-Gung, Ch 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 11 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2010, Vol.33 No.8 1181-1191 (11 pages)
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Antiproliferative Effects of Quercetin through Cell Cycle Arrest and Apoptosis in Human Breast Cancer MDA-MB-453 Cells
Choi. Eun-Jeong, Bae. Su-Mi, Ahn. Woong-Shick 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2008, Vol.31 No.10 1281-1285 (5 pages)
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보두산(寶豆散)에 의한 SNU-1 세포의 Apoptosis 유도와 Cell cycle arrest
윤현정, 서교수, 최재우, 이현우, 허숙경, 박원환, 박선동, Yun. Hyun-Joung, Seo. Gyo-Soo, Choi. Jae-Woo, Lee. Hyun-Woo, Heo. Sook-Kyoung, Park. Won-Hwan, Park. Sun-D 대한본초학회 大韓本草學會誌 9 Pages
대한본초학회 大韓本草學會誌 2007, Vol.22 No.2 35-43 (9 pages)
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Mechanism Underlying Curcumin-induced Apoptosis and Cell Cycle Arrest on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line
Moon. Jung-Bon, Lee. Kee-Hyun, Kim. In-Ryoung, Kim. Gyoo-Cheon, Kwak. Hyun-Ho, Park. Bong-Soo 대한구강생물학회 International journal of oral biology : official journal of the Korean Academy of Oral Biology and t 11 Pages
대한구강생물학회 International journal of oral biology : official journal of the Korean Academy of Oral Biology and t 2014, Vol.39 No.1 23-33 (11 pages)
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A Natural Product, Chios Gum Mastic, Induces the Death of HL-60 Cells via Apoptosis and Cell Cycle Arrest
Koo. Byung-Chan, Kim. Duck-Han, Kim. In-Ryoung, Kim. Gyoo-Cheon, Kwak. Hyun-Ho, Park. Bong-Soo 대한구강생물학회 International journal of oral biology : official journal of the Korean Academy of Oral Biology and t 9 Pages
대한구강생물학회 International journal of oral biology : official journal of the Korean Academy of Oral Biology and t 2011, Vol.36 No.1 13-21 (9 pages)
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Ethanol Elicits Inhibitory Effect on the Growth and Proliferation of Tongue Carcinoma Cells by Inducing Cell Cycle Arrest
Thanh-DoLe, ThiAnhThuDo, RinaYu, HoonYoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 1 153-158 (6 pages)
apoptosis in YD-15 cells exposed to 2.5% or higher percent of ethanol. The cleaved PARP, a marker of caspase-3 mediated apoptosis, and the activation of caspase-3 and -7 were detected by caspase activity assay or Western blotting. Our results suggest that ethanol elicits inhibitory effect on the growth and proliferation of YD-15 tongue carcinoma cells by mediating cell cycle arrest at G2/M at low concentration range and ultimately induces apoptosis under the condition of high concentration. -
Silibinin Inhibits Proliferation, Induces Apoptosis and Causes Cell Cycle Arrest in Human Gastric Cancer MGC803 Cells Via STAT3 Pathway Inhibition
Wang. Yi-Xin, Cai. Hong, Jiang. Gang, Zhou. Tian-Bao, Wu. Hai 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 8 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.16 6791-6798 (8 pages)
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Inhibition of Cell-Cycle Progression in Human Promyelocytic Leukemia HL-60 Cells by MCS-C2, Novel Cyclin-Dependent Kinase Inhibitor
Kim. Min-Kyoung, Cho. Youl-Hee, Kim. Jung-Mogg, Chun. Moon-Woo, Lee. Seung-Ki, Lim. Yoong-Ho, Lee. Chul-Hoon 한국미생물생명공학회 Journal of microbiology and biotechnology 6 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2003, Vol.13 No.4 607-612 (6 pages)
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Cigarettesmoke impaired maturation of ovarian follicle and abnormal growth of uterus innerwall via changed expression of estrogen receptors and cell cycle arrest proteinp21 in female rats
Hae Miru Lee, Cho Won Kim, Kyung Chul Choi 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 353 384-385 (2 pages)
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Scutellarein Induced G2/M Cell Cycle Arrest and Apoptosis in Hep3B Hepatocellular Carcinoma Cells
Sang Eun Ha, Ho Jeong Lee, Suchismita Raha, Venu Venkatarame Gowda Saralamma, Seong Min Kim, Anjugam Paramanantham, Jeong Doo Heo, Sang 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 214 326-327 (2 pages)
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CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
XuejiaoLiu, YulongChong, HuizeLiu, YanHan, MingshanNiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 4 161-168 (8 pages)
is reversible. Our data demonstrated that S109 significantly inhibits proliferation and colony formation of renal cancer cells. Cell cycle assay showed that S109 induced G1-phase arrest, followed by the reduction of Cyclin D1 and increased expression of p53 and p21. We also found that S109 induces nuclear accumulation of tumor suppressor proteins, Foxo1 and p27. Most importantly, mutation of CRM1 at Cys528 position abolished the effects of S109. Taken together, our results indicate that CRM1 is... -
Induction of Cell Cycle Arrest in Prostate Cancer Cells by the Dietary Compound Isoliquiritigenin
Lee. Yeo-Myeong, Lim. Do-Young, Choi. Hyun-Ju, Jung. Jae-In, Chung. Won-Yoon, YoonPark. Jung-Han 한국식품영양과학회 Journal of medicinal food 7 Pages
한국식품영양과학회 Journal of medicinal food 2009, Vol.12 No.1 8-14 (7 pages)
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G1 Arrest of the Cell Cycle by Gomisin N, a Dibenzocyclooctadiene Lignan, Isolated from Schizandra chinensis Baill in Human Leukemia U937 Cells
박철, 황혜진, 최병태, 최태현, 김병우, 최영환, 최영현, Park. Cheol, Hwang. Hye-Jin, Choi. Byung-Tae, Choi. Tae-Hyun, Kim. Byung-Woo, Choi. Young-Whan, Choi. Yung- 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2010, Vol.20 No.7 977-982 (6 pages)
G1 arrest는 cyclin E, cyclin-dependent kinase (Cdk) 2 및 Cdk4의 발현 억제와 Cdk inhibitor인 p16 (INK4A) 및 p21 (WAF1/CIP1)의 발현 증가와 연관성이 있었으나, gomisin A는 세포주기 인자들의 발현에 유의적인 변화를 유발하지 않았다. 또한 gomisin N은 retinoblastoma 단백질군인 pRB 및 p130의 인산화를 억제하였으며, 전사조절인자인 E2F 단백질들의 발현을 억제하였다. 본 연구의 결과에서 gomisin N에 의한 U937 세포의 증식억제는 세포주기 조절인자들의 발현 변화를 통한 G1 arrest 유발에 의한 것임을 알 수 있었으며,... -
NADPH oxidase inhibitor diphenyleneiodonium induces p53 expression and cell cycle arrest in several cancer cell lines
조홍재, 김강미, 송주동, 박영철, Jo. Hong-Jae, Kim. Kang-Mi, Song. Ju-Dong, Park. Young-Chul 한국생명과학회 생명과학회지 5 Pages
한국생명과학회 생명과학회지 2007, Vol.17 No.6 778-782 (5 pages)
시간 의존적으로 암세포주의성장을 막았으며 G2/M phase에서 cell cycle arrest를 일으켰다. Cell cycle arrest의 가장 높은 값은 DPI 처리후 12 시간에서 관찰할 수 있었다. 한편 DPI는 아폽토시스 그리고 cell cycle arres 에 관여하는 유전자 발현에 관여하는 p53의 표현을 크게 증가시켰으며, 이는 DPI처리 후 6시간 후 부터 관찰할 수 있었다. 그러나 NADPH oxidase의 조합을 억제하는 catechol 계인 apocynin은 p53의 발현을 유도하지 못하였다. 이것은 DPI에 의해 유도되는 p53의 발현증가는 NADPH oxidase활성의 저해와 관련되어... -
Hsp90 Inhibitor Induces Cell Cycle Arrest and Apoptosis of Early Embryos and Primary Cells in Pigs
Son. Myeong-Ju, Park. Jin-Mo, Min. Sung-Hun, Hong. Joo-Hee, Park. Hum-Dai, Koo. Deog-Bon 한국동물번식학회 Reproductive & developmental biology 13 Pages
한국동물번식학회 Reproductive & developmental biology 2011, Vol.35 No.1 33-45 (13 pages)
