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전체 선택해제
총 203건 검색
본문검색 결과만 보기
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Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model
Joongsun Kim, Sunhoo Park, Byung-Suk Jeon, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Kyung-Jin Rhim, Soong In Lee, Seung-Sook L 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 1 435-444 (10 pages)
decreased the epithelial desquamation after irradiation. Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB. Furthermore, irradiation prolonged healing of biopsy wounds in the exposed area, whereas curcumin treatment stimulated wound healing. These results suggest that curcumin can improve epithelial cell survival and recovery in the skin and therefore be used to treat radiation burns. -
Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
B. H. Pavithra, N. Prakash*, K. Jayakumar 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 4호 3 293-297 (5 pages)
Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-I were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-II received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days,... -
Antipruritic effect of curcumin on histamine-induced itching in mice
Han Kyu Lee, Seok Bum Park, Su-youne Chang, Sung Jun Jung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 8 547-554 (8 pages)
acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves. -
Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism
ShuyingTian, RuixueGuo, SichenWei, YuKong, XinliangWei, WeiweiWang, XiaomengShi, HongyuJiang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 2 147-152 (6 pages)
curcumin group were pretreated with curcumin by gastric gavage (200 mg/kg) for 2 days before I/R. Small intestine tissues were prepared for Haematoxylin & Eosin (H&E) staining. Serum diamine oxidase (DAO) and tumor necrosis factor (TNF)-α levels were measured. Expression of intestinal TNF-α and tight junction protein (ZO-1) proteins was detected by Western blot and/or immunohistochemistry. Serum DAO level and serum and intestinal TNF-α leves were significantly increased after I/R, and... -
Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells
Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 6 291-297 (7 pages)
activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1... -
Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
YuJiCho, ChinOkYi, ByeongTakJeon, YiYeongJeong, GiMunKang, JungEunLee, GuSeobRoh, JongDeogLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 3 267-274 (8 pages)
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage... -
Involvement of ROS in Curcumin-induced Autophagic Cell Death
YounJuLee, Nam-YiKim, Young-AhSuh, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 1 1-8 (8 pages)
a crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation. Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in... -
Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species
Kyung-ChanKim, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 7 391-397 (7 pages)
pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline. In addition, E2F4 overexpression was observed to partially ameliorate curcumin-induced growth inhibition by cell viability assay. Taken together, we found curcumin-induced ROS down-regulation of E2F4 expression and modulation of E2F4 target genes which finally lead to the apoptotic cell death in HCT116 colon cancer cells, suggesting that E2F4 appears to be a novel determinant of curcumin-induced cytotoxicity. -
Curcumin Attenuates Glial Cell Activation But Cannot Suppress Hippocampal CA3 Neuronal Cell Death in i.c.v. Kanic Acid Injection Model
JaeyoungCho, Pil-JaeKong, WanjooChun, Yeo-OkMoon, Yee-TaePark, So-YoungLim, Sung-SooKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 3 307-310 (4 pages)
(ROS) play a pivotal role in the pathogenesis of excitotoxic death by KA. Curcumin has been known to possess anti-oxidative and anti-inflammatory activities. In this study, the effects of curcumin on KA induced hippocampal cell death, reactive gliosis and biochemical changes in reactive glia were investigated by immunohistochemical methods. Our data demonstrated that curcumin attenuated KA-induced astroglial and microglial activation although it did not protect KA-induced hippocampal cell death. -
Stress Changes the Spatial Arrangement of Neurons and Glial Cells of Medial Prefrontal Cortex and Sertraline and Curcumin Prevent It
Ali Noorafshan, Mohammad-Amin Abdollahifar, Saied Karbalay-Doust 대한신경정신의학회 Psychiatry Investigation 8 Pages
대한신경정신의학회 Psychiatry Investigation 2015, 제 12권 제 1호 11 73-80 (8 pages)
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Synergistic Effects of 5-Fluorouracil (FU) and Curcumin on Human Cervical Cancer Cells
안성호, 김동희, 강정훈, 이명선, Ahn. Seong-Ho, Kim. Dong-Heui, Kang. Jung-Hoon, Lee. Myeong-Seon 한국현미경학회 한국현미경학회지 7 Pages
한국현미경학회 한국현미경학회지 2010, Vol.40 No.4 229-235 (7 pages)
있는 자연식품의 섭취에 관심이 커지면서 커리의 주성분인 curcumin (CMN), 녹차의 주성분인 카테킨, 토마토의 주성분인 리코펜 등의 약리효과에 대한 연구가 활성화되고 있다. CMN은 동물실험 결과 항염증의 활성이 있고, 피부, 대장, 유방, 전립선 등에서 암으로의 진행을 억제한다는 보고가 있으나 인체 자궁암에서는 그 효과가 밝혀져 있지않다. 본 연구는 항암제 5FU와 CMN이 인체 자궁암세포 HeLa에 미치는 영향을 apoptosis의 유도로 평가하고, p53유전자 발현율과의 상관관계로 확인하고자 시행하였다. CMN은 HeLa 세포의 성장을... -
Protective Effect of Curcumin and Aqueous Extract of Onchengyeum on CCI4-induced Hepatotoxicity
SEUNG. Keum Ran, JUNG. Ki Hwa 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 8 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2005, Vol.13 No.4 232-239 (8 pages)
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Erratum to "Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells" [Biomol. Ther. 22 (2014) 355-362]
An. Dami, Kim. Kwangmi, Kim. Jeongyun 한국응용약물학회 Biomolecules & therapeutics 1 Pages
한국응용약물학회 Biomolecules & therapeutics 2014, Vol.22 No.5 475-475 (1 pages)
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Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells
An. Dami, Kim. Kwangmi, Kim. Jeongyun 한국응용약물학회 Biomolecules & therapeutics 8 Pages
한국응용약물학회 Biomolecules & therapeutics 2014, Vol.22 No.4 355-362 (8 pages)
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Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
Li. Xian, Lu. Yue, Jin. Ye, Son. Jong-Keun, Lee. Seung Ho, Chang. Hyeun Wook 한국응용약물학회 Biomolecules & therapeutics 8 Pages
한국응용약물학회 Biomolecules & therapeutics 2014, Vol.22 No.1 27-34 (8 pages)
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Effects of Curcumin on the Pharmacokinetics of Loratadine in Rats: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Curcumin
Li. Cheng, Choi. Byung-Chul, Kim. Dong-Ki, Choi. Jun-Shik 한국응용약물학회 Biomolecules & therapeutics 7 Pages
한국응용약물학회 Biomolecules & therapeutics 2011, Vol.19 No.3 364-370 (7 pages)
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Antinociceptive Profiles and Mechanisms of Orally Administered Curcumin in Various Pain Models
Park. Soo-Hyun, Sim. Yun-Beom, Kim. Seon-Mi, Kang. Yu-Jung, Lee. Jin-Koo, Suh. Hong-Won 한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 5 Pages
한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 2012, Vol.55 No.1 57-61 (5 pages)
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Curcumin이 인체대장암세포주인 SW480 cell에서 세포사멸에 미치는 영향
최옥숙, 김우경 한국영양학회 韓國營養學會誌 7 Pages
한국영양학회 韓國營養學會誌 2004, Vol.37 No.1 31-37 (7 pages)
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Curcumin의 신경병증성 통증 억제효과
김채은, 박은성, 전영훈, Kim. Chae-Eun, Park. Eun-Sung, Jeon. Young-Hoon 한국약용작물학회 韓國藥用作物學會誌 5 Pages
한국약용작물학회 韓國藥用作物學會誌 2008, Vol.16 No.3 183-187 (5 pages)
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울금의 가공적성 증진을 위한 Curcumin 추출 최적화 및 쓴맛 성분 완화
강성구, 현규환, Kang. Seong-Koo, Hyun. Kyu-Hwan 한국식품저장유통학회 한국식품저장유통학회지 5 Pages
한국식품저장유통학회 한국식품저장유통학회지 2007, Vol.14 No.6 722-726 (5 pages)
분리 결과를 보였다. Curcumin 성분은 메탄올추출물이 가장 높은 함유량을 보였으며, 모든 시료구에서 상온 추출보다는 가열 추출이 더 높은 함유량을 보였다. 또한 메탄올과 에탄올추출물의 curcumin 함량은 물 추출물에 비하여 상온에서 각각 14.8배, 14.2배 높았으며, 유기용매 가열추출은 2 가지 모두 상온보다 약 150 mg% 정도가 더 높게 나타났다. 또한 물과 메탄올추출물 모두 30분 이상에서는 크게 함량이 증가하지 않아 가열추출 시 60분 정도면 충분한 것으로 판단되었다. 가열처리에 따른 울금의 쓴맛성분의 변화는 물추출물의... -
울금 품종과 채취시기별 유기산, 무기질, 색도, Curcumin 및 쓴맛의 변화
강성구, Kang. Seong-Koo 한국식품저장유통학회 한국식품저장유통학회지 6 Pages
한국식품저장유통학회 한국식품저장유통학회지 2007, Vol.14 No.6 633-638 (6 pages)
가을울금과 봄울금의 채취시기에 따른 유기산, 무기질, 색도, curcumin 및 쓴맛성분 등의 함량은 다음과 같다. 주요 유기산 중에 oxalic acid와 lactic acid는 채취시기가 늦어질수록 점차 증가하였으나 malic acid, malonic acid는 감소하는 경향을 보였으며, 유기산 총함량은 채취시기가 늦어질수록 점차 증가하다가 다음해인 1월에는 다소 감소하는 경향을 보였다. 무기질은 채취시기가 늦을수록 함량이 증가하다가 이듬해에는 다소 감소하는 경향을 보였다. 색소는 채취시기가 늦어질수록 L, a, b 값 모두 약간 증가하는 경향을... -
Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid-Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase
Topcu-Tarladacalisir. Yeter, Akpolat. Meryem, Uz. Yesim Hulya, Kizilay. Gulnur, Sapmaz-Metin. Melike, Cerkezkayabekir. Aysegul, Omurlu 한국식품영양과학회 Journal of medicinal food 10 Pages
한국식품영양과학회 Journal of medicinal food 2013, Vol.16 No.4 296-305 (10 pages)
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Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation
Singh. Ashok K., Jiang. Yin, Gupta. Shveta, Younus. Mohamod, Ramzan. Mohamod 한국식품영양과학회 Journal of medicinal food 13 Pages
한국식품영양과학회 Journal of medicinal food 2013, Vol.16 No.10 899-911 (13 pages)
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Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain
Ataie. Amin, Sabetkasaei. Masoumeh, Haghparast. Abbas, Moghaddam. Akbar Hajizadeh, Ataee. Ramin, Moghaddam. Shiva Nasiraei 한국식품영양과학회 Journal of medicinal food 6 Pages
한국식품영양과학회 Journal of medicinal food 2010, Vol.13 No.4 821-826 (6 pages)
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Curcumin은 ovalbumin에 의해서 유도된 inducible nitric oxide synthase 억제
김지수, 안희진, 신화정, 구교정, 엄상훈, 이청호, 민인순, 윤형선, Kim. Ji-Soo, Ahn. Hee-Jin, Shin. Hwa-Jeong, Gu. Gyo-Jeong, Eum. Sang-Hoon, Lee. Chung-Ho, Min. In-Soon 한국식품과학회 한국식품과학회지 4 Pages
한국식품과학회 한국식품과학회지 2012, Vol.44 No.4 498-501 (4 pages)
curcumin이 계란 알러젠 중의 하나인 OVA에 의해서 유도된 NF-${kappa}B$ 활성화 및 iNOS 발현에 어떤 영향을 미치는지 알아보았다. Curcumin은 OVA에 의해서 유도된 NF-${kappa}B$ 활성화와 iNOS 발현을 억제시켰다. 이러한 결과는 curcumin이 계란 알러젠인 OVA에 의해서 유도된 NF-${kappa}B$의 활성화와 iNOS의 발현을 억제하여 염증반응이나 알러지와 같은 만성적인 질병들을 조절할 수 있다는 것을 보여주는 중요한 결과라 사료된다. 이러한 연구는 추후 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로... -
Toll-like receptor 2, 3, 4의 신호전달체계 조절을 통한 curcumin의 항암${cdot}$항염증 효과
강순아, 윤형선, Kang. Soon-Ah, Youn. Hyung-Sun 한국식품과학회 한국식품과학회지 6 Pages
한국식품과학회 한국식품과학회지 2007, Vol.39 No.2 175-180 (6 pages)
viral 자극제인 poly[I:C](TLR3 agonist)에 의해서 유도된 IRF3나 $NF-{kappa}B$ 활성화를 억제하였지만, TRIF에 의해서 유도된 IRF3 활성화는 억제시키지를 못하였다. 이러한 결과 또한 TLR3 자체가 curcumin의 분자학적인 타깃이라는 가능성을 제시해 준다고 할 수 있겠다. 이러한 결과를 종합해 볼때, curcumin의 분자학적인 타깃이 $IKK{eta}$ 이외에 모든 TLRs가 될 수 있다는 가능성을 제시해 준다고 할 수 있겠다. 이러한 결과는 curcumin이 그람음성균 뿐만이 아니라 바이러스나 박테리아 등 여러 병원균들로부터 유도되는... -
강황(Curcuma longa L.)으로부터 초임계 유체 추출한 curcumin의 생리활성
정승현, 장규섭, 고경희, Jung. Seung-Hyeon, Chang. Kyu-Seob, Ko. Kyung-Hee 한국식품과학회 한국식품과학회지 4 Pages
한국식품과학회 한국식품과학회지 2004, Vol.36 No.2 317-320 (4 pages)
Curcumin의 추출효율은 에탄을 추출방법이 가장 높았고, 항산화효과는 에탄올, 초임계, 열수 추출물 순으로 나타났다. Ames의 mutagenicity test를 실시한 결과 각각의 추출물은 돌연변이원이 없는 것으로 확인되었고, TA98에 직접변이원 2-NF 처리시 초임계 추출물의 저해율이 20.1%로 에탄올과 열수 추출물에 비하여 가장 높은 항돌연변이 효과를 나타냈다. 또한 간접 변이원 2-acetamidofluorene($10;{mu}L/plate$; Sigma Co.; 2-AF)에 대한 항돌연변이 효과를 알아본 결과 2-AF로 유도된 TA98은 초임계 추출물을 0.1 mL/plate로... -
A Mixture of Curcumin, Vitamin C, and E Prolongs the Antioxidant Effect to Beyond That of Each Component Alone in Vivo
Jeon. Hee-Young, Kim. Jeong-Kee, Lee. Ji-Eun, Shin. Hyun-Jung, Lee. Sang-Jun 한국식품과학회 Food science and biotechnology 5 Pages
한국식품과학회 Food science and biotechnology 2008, Vol.17 No.6 1151-1155 (5 pages)
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Fabrication of Electrospun Poly L-lactide and Curcumin Loaded Poly L-lactide Nanofibers for Drug Delivery
Thangaraju. Elakkiya, Natarajan. Thirupathur Srinivasan, Kumar. Ramadhar, Sehgal. Praveen Kumar, Rajiv. Sheeja 한국섬유공학회 Fibers and polymers 8 Pages
한국섬유공학회 Fibers and polymers 2012, Vol.13 No.7 823-830 (8 pages)
