자료유형
발행기관
- 대한수의학회(370)
- 대한생리학회-대한약리학회(236)
- 한국식물병리학회(235)
- 대한약리학회(31)
- 한국탄소학회(13)
- 대한생리학회(10)
- 대한신경정신의학회(10)
- 한국기초간호학회(7)
- 한국습지학회(7)
- 물리치료재활과학회(5)
- 한국청각언어재활학회(5)
- 한방비만학회(5)
- 한국경호경비학회(4)
- 대한약학회(3)
- 대한화장품학회(3)
- 한국생약학회(3)
- 한국환경생물학회(3)
- 한국교원대학교 뇌기반교육연구소(2)
- 한국보건기초의학회(2)
- 한국생명과학회(2)
- 한국수소및신에너지학회(2)
- 한국식품영양과학회(2)
- 한국웰니스학회(2)
- 한국헬스커뮤니케이션학회(2)
- 환태평양유아교육연구학회(2)
- 대한구강생물학회(1)
- 생화학분자생물학회(1)
- 아시아태평양암예방학회(1)
- 은행법학회(1)
- 인문사회과학기술융합학회(1)
- 한국교육치료학회(1)
- 한국마린엔지니어링학회(1)
- 한국미생물생명공학회(1)
- 한국발달지원학회(1)
- 한국식품과학회(1)
- 한국약용작물학회(1)
- 한국여가문화학회(1)
- 한국응용생명화학회(1)
- 한국응용약물학회(1)
- 한국전기전자학회(1)
- 한국현미경학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(236)
- THE PLANT PATHOLOGY JOURNAL (195)
- JOURNAL OF VETERINARY SCIENCE(189)
- 대한수의학회 학술대회발표집(119)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(62)
- 식물병연구(40)
- 대한약리학잡지(31)
- CARBON LETTERS(13)
- 대한생리학회지(10)
- 신경정신의학(9)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(7)
- 한국습지학회지(7)
- AUDIOLOGY AND SPEECH RESEARCH(5)
- PHYSICAL THERAPY REHABILITATION SCIENCE(5)
- 대한한방비만학회지(5)
- 시큐리티연구(4)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(3)
- 대한화장품학회지(3)
- 환경생물(3)
- ASIA-PACIFIC JOURNAL OF RESEARCH IN EARLY CHILDHOOD EDUCATION(2)
- BRAIN, DIGITAL, & LEARNING(2)
- NATURAL PRODUCT SCIENCES(2)
- 생명과학회지(2)
- 한국보건기초의학회지(2)
- 한국수소 및 신에너지학회 논문집(2)
- 한국식품영양과학회지(2)
- 한국웰니스학회지(2)
- 헬스커뮤니케이션연구(2)
- ASIAN PACIFIC JOURNAL OF CANCER PREVENTION : APJCP(1)
- BIOMOLECULES & THERAPEUTICS(1)
- BMB REPORTS(1)
- INTERNATIONAL JOURNAL OF ORAL BIOLOGY : OFFICIAL JOURNAL OF THE KOREAN ACADEMY OF ORAL BIOLOGY AND T(1)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(1)
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY(1)
- PSYCHIATRY INVESTIGATION(1)
- 교육치료연구(1)
- 발달지원연구(1)
- 생약학회지(1)
- 여가학연구(1)
- 예술인문사회융합멀티미디어논문지(1)
- 은행법연구(1)
- 전기전자학회논문지(1)
- 한국마린엔지니어링학회지(1)
- 한국식품과학회지(1)
- 한국약용작물학회지(1)
- 한국전자현미경학회지(1)
전체 선택해제
총 982건 검색
본문검색 결과만 보기
-
Protection of Hepatic Cell Damage and Antimicrobial Evaluation of Chitosan-Catechin Conjugate
Cho. Young-Sook, Lee. Dae-Sung, Kim. Young-Mog, Ahn. Chang-Bum, Kim. Do-Hyung, Jung. Won-Kyo, Je. Jae-Young 한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 7 Pages
한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 2013, Vol.56 No.6 701-707 (7 pages)
-
Protection of Amyloid ${eta}$ Protein (25-35)-induced Neuronal Cell Damage by Methanol Extract of New Stem of Phyllostachys nigra Munro var. henonis Stapf in Cultured Rat Cortical Neuron
Ban. Ju-Yeon, Cho. Soon-Ock, Kwon. Soon-Ho, Kim. Jin-Bae, Song. Nak-Sul, Bae. Ki-Whan, Song. Kyung-Sik, Seng. Yeon-Hee 한국약용작물학회 韓國藥用作物學會誌 8 Pages
한국약용작물학회 韓國藥用作物學會誌 2005, Vol.13 No.2 95-102 (8 pages)
-
Protection of NMDA-Induced Neuronal Cell Damage by Methanol Extract of Myristica Fragrans Seeds in Cultured Rat Cerebellar Granule Cells
Ban. Ju-Yeon, Cho. Soon-Ock, Kim. Ji-Ye, Bang. Kyong-Hwan, Seong. Nak-Sul, Song. Kyung-Sik, Bae. Ki-Whan, Seong. Yeon-Hee 한국생약학회 Natural product sciences 7 Pages
한국생약학회 Natural product sciences 2004, Vol.10 No.6 289-295 (7 pages)
-
Protection Effects of Allylmercaptan, Metabolite of Garlic on Endothelial Cell Injury Induced by Oxidized Low Density Lipoprotein
양승택, Yang. Seung-Taek 한국생명과학회 생명과학회지 8 Pages
한국생명과학회 생명과학회지 2010, Vol.20 No.11 1595-1602 (8 pages)
LDH와 GSH 함량을 조사하였다. 본 실험 결과 allylmercaptan을 일정 농도 별로 endothelial cell에 첨가하여 배양했을 때 LDH의 방출과 GSH의 감소를 현저하게 억제하였다. Peroxide를 형광분석법으로 24 well plate에서 직접 측정한 결과 allylmercaptan이 폐동맥 내피세포 내에서 ox-LDL 유도 peroxide의 방출을 억제하였다. 그리고 allylmercaptan은 과산화수소의 소거능도 있었다. 본 실험결과 allylmercaptan은 ox-LDL 유도 폐동맥 내피세포를 보호할 수 있었으므로 allylmercaptan은 동맥경화의 예방에 유용할 것으로 생각된다. -
Neuronal Cell Protection Activity of Macrolactin A Produced by Actinomadura sp.
Kim. Hyeon-Ho, Kim. Won-Gon, Ryoo. In-Ja, Kim. Chang-Jin, Suk. Jae-Eun, Han. Kyou-Hoon, Hwang. Se-Young, Yoo. Ick-Dong 한국미생물생명공학회 Journal of microbiology and biotechnology 6 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 1997, Vol.7 No.6 429-434 (6 pages)
-
Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection
Tan. Pei-Xin, Du. Sha-Sha, Ren. Chen, Yao. Qi-Wei, Yuan. Ya-Wei 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.10 5631-5635 (5 pages)
-
Protection of Prenylated Flavonoids from Mori Cortex Radicis (Moraceae) against Nitric Oxide-induced Cell Death in Neuroblastoma SH-SY5Y Cells
Lee. Hak Ju, Lyu. Da Hyun, Koo. Uk, Nam. Kung-Woo, Hong. Seong Su, Kim. Kem Ok, Kim. Kyeong Ho, Lee. Dongho, Mar. Woongchon 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2012, Vol.35 No.1 163-170 (8 pages)
-
Protection of LLC-PK1 Cells Against Hydrogen PeroxideInduced Cell Death by Modulation of Ceramide Level
Yoo. Jae Myung, Lee. Youn Sun, Choi. Heon Kyo, Lee. Yong Moon, Hong. Jin Tae, Yun. Yeo Pyo, Oh. Seik Wan, Yoo. Hwan Soo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2005, Vol.28 No.3 311-318 (8 pages)
-
Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
Hong. Su Hee, Heo. Jee-In, Kim. Jeong-Hyeon, Kwon. Sang-Oh, Yeo. Kyung-Mok, Bakowska-Barczak. Anna M., Kolodziejczyk. Paul, Ryu. Ok-Hyu 한국응용약물학회 Biomolecules & therapeutics 6 Pages
한국응용약물학회 Biomolecules & therapeutics 2013, Vol.21 No.4 284-289 (6 pages)
-
Protection against Foot-and-Mouth Disease in Mice Treated with Guanosineanalog and Its Mixtures
Joo Hyung Choi, Seo Yong Lee, Mi Kyeong Ko, Min Eun Park, Su Hwa You, Ji Eun Yoon, Kwiwan Jeong, Kwang Nyeong Lee, Jin Mo Ku, Myoung Heo 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 168 423-423 (1 pages)
-
Vibrio vulnificus VvhA Induces Mitochondrial Cell Death Via Lipid Raft-mediated ROS Production and NF-kB Activation in Intestinal Epithelial Cells
Young Hyun Jung, Sei Jung Lee, Hyun Jik Lee, Dah Ihm Kim, Jeong Yeon Kim, Ing Ing Chai, Gee Euhn Choi, Ho Jae Han 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 116 198-199 (2 pages)
-
Capsaicin protects spermatogenic cell death caused by scrotal hyperthermia through its antioxidative and anti-apoptotic activities
Seul Gi Park, Jung Min Yon, Chun mei Lin, Lee Wha Gwon, Jong Geol Lee, In Jeoung Baek, Beom Jun Lee, Young Won Yun, Sang Yoon Nam 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 341 377-378 (2 pages)
-
Clinical assessment after human adipose stem cell transplantation into dogs
Seok Hee Lee, Erif M.N. Setyawan, Yoo Bin Choi, Jeong Chan Ra, Sung Keun Kang, Byeong Chun Lee, Geon A Kim 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 15 452-461 (10 pages)
Adipose tissue-derived stem cell (ASCs) are an attractive source of stem cells with therapeutic applicability in various fields for regenerating damaged tissues because of their stemness characteristics. However, little has reported on evaluating adverse responses caused by human ASC therapy. Therefore, in the present study, a clinical assessment after human ASC transplantation into dogs was undertaken. A total of 12 healthy male dogs were selected and divided into four groups: saline infusion,... -
Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues
Yingjie Sun, Pin Zhang, Hang Zheng, Luna Dong, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chunchun Meng, Shengqing Yu, Chan 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 2 3-12 (10 pages)
T-cell internal antigen-1 (TIA-1) has roles in regulating alternative pre-mRNA splicing, mRNA translation, and stress granule (SG) formation in human cells. As an evolutionarily conserved response to environmental stress, SGs have been reported in various species. However, SG formation in chicken cells and the role of chicken TIA-1 (cTIA-1) in SG assembly has not been elucidated. In the present study, we cloned cTIA-1 and showed that it facilitates the assembly of canonical SGs in both human and... -
A novel M2e-multiple antigenic peptide providing heterologous protection in mice
Feng Wen, Ji-Hong Ma, Hai Yu, Fu-Ru Yang, Meng Huang, Yan-Jun Zhou, Ze-Jun Li, Xiu-Hui Wang, Guo-Xin Li, Yi-Feng Jiang, Wu Tong, 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 9 71-78 (8 pages)
supplemental antigen for inactivated H3N2 vaccine to provide cross-protection against two main subtypes of SwIVs, H1N1 and H3N2. The novel tetra-branched MAP was constructed by fusing four copies of M2e to one copy of foreign T helper cell epitopes. A high-yield reassortant H3N2 virus was generated by plasmid based reverse genetics. The efficacy of the novel H3N2 inactivated vaccines with or without M2e-MAP supplementation was evaluated in a mouse model. M2e-MAP conjugated vaccine induced strong... -
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
Bratislav Dejanovic, Ivana Stevanovic, Milica Ninkovic, Ivana Stojanovic, Irena Lavrnja, Tatjana Radicevic, Milos Pavlovic 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 7 53-61 (9 pages)
to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The... -
Immunization of BALB/c mice with Brucella abortus 2308ΔwbkA confers protection against wild-type infection
Zhi-qiang Li, Dan Gui, Zhi-hua Sun, Jun-bo Zhang, Wen-zhi Zhang, Hui Zhang, Fei Guo, Chuang-fu Chen 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 10 467-473 (7 pages)
Brucellosis is a zoonotic disease that causes animal and human diseases. Vaccination is a major measure for prevention of brucellosis, but it is currently not possible to distinguish vaccinated animals from those that have been naturally infected. Therefore, in this study, we constructed the Brucella (B.) abortus 2380 wbkA mutant (2308ΔwbkA) and evaluated its virulence. The survival of 2308ΔwbkA was attenuated in murine macrophage (RAW 264.7) and BALB/c mice, and it induced high protective... -
Rapamycin treatment during in vitro maturation of oocytes improves embryonic development after parthenogenesis and somatic cell nuclear transfer in pigs
Joohyeong Lee, Jong-Im Park, Jung Im Yun, Yongjin Lee, Hwanyul Yong, Seung Tae Lee, Choon-Keun Park, Sang-Hwan Hyun, Geun-Shik L 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 16 373-380 (8 pages)
This study was conducted to investigate the effects of rapamycin treatment during in vitro maturation (IVM) on oocyte maturation and embryonic development after parthenogenetic activation (PA) and somatic cell nuclear transfer (SCNT) in pigs. Morphologically good (MGCOCs) and poor oocytes (MPCOCs) were untreated or treated with 1 nM rapamycin during 0–22 h, 22–42 h, or 0–42 h of IVM. Rapamycin had no significant effects on nuclear maturation and blastocyst formation... -
Establishment and evaluation of a murine ανβ3-integrin- expressing cell line with increased susceptibility to Foot- and-mouth disease virus
Wei Zhang, Kaiqi Lian, Fan Yang, Yang Yang, Zhijian Zhu, Zixiang Zhu, Weijun Cao, Ruoqing Mao, Ye Jin, Jijun He, Jianhong Guo, X 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 3 265-272 (8 pages)
a stable CHO-677 cell line expressing the murine ανβ3 heterodimer (designated as “CHO-677-mανβ3” cells) was established using a highly efficient lentiviral-mediated gene transfer technique. Integrin subunits αν and β3 were detected at the gene and protein levels by polymerase chain reaction (PCR) and indirect immunofluorescent assay (IFA), respectively, in the CHO-677-mανβ3 cell line at the 20th passage, implying that these genes were successfully introduced into the CHO-677 cells... -
Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice
Haiyan Zhao, Yalan Wang, Zhitao Ma, Yongqiang Wang, Wen-hai Feng* 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 5 199-208 (10 pages)
to this construct were analyzed in mice. Intestinal mucosal PRRSV-specific sIgA antibody and higher levels of IFN-γ in spleen CD4 and CD8 T cells were induced by oral administration of Yeast-GP5. Additionally, Yeast-GP5 administered subcutaneously evoked vigorous cell-mediated immunity, and PRRSV-specific lymphocyte proliferation and IFN-γ secretion were detected in the splenocytes of mice. These results suggest that Yeast-GP5 has the potential for use as a vaccine for PRRSV in the future. -
Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine
Fang Yan*, Yujun Zhao, Yongting Hu, Jianyang Qiu, Wenxin Lei, Wenhui Ji, Xuying Li, Qian Wu, Xiumin Shi, Zhong Li 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 1호 8 53-60 (8 pages)
The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or pVAX1-16N alone) or multivalently (combination of the three different plasmids, pVAX1-16S1/M/N). A prime-boost immunization protocol against IBV was developed. Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once. Antibody... -
Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
Sun-Gil Do, Jun-Hong Park, Hajin Nam, Jin-Bong Kim, Jae-Yong Lee, Yang-Seok Oh, Jun-Gyo Suh* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 4호 2 339-344 (6 pages)
that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model. -
Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice
Arash Minai-Tehrani, Young-Chan Park, Soon-Kyung Hwang, Jung-Taek Kwon, Seung-Hee Chang, Sung-Jin Park, Kyeong-Nam Yu, Ji-Eun Ki 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 4호 2 309-317 (9 pages)
KD did not. Our results showed that naphthalene affected extracellular signal-regulated kinase (ERK) protein levels, ERK-related signaling, and induced Clara cell injury. However, Clara cell injury induced by naphthalene was considerably attenuated in mice exposed to Akt1 KD. Furthermore, a dual luciferase activity assay showed that aerosol delivery of Akt1 WT and naphthalene treatment enhanced cap-dependent protein translation, while reduced cap-dependent protein translation was observed after... -
Protection of chicken against very virulent IBDV provided by in ovo priming with DNA vaccine and boosting with killed vaccine and the adjuvant effects of plasmid-encoded chicken interleukin-2 and interferon-g
Jeong Ho Park, Haan Woo Sung, Byung Il Yoon, Hyuk Moo Kwon* 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 2호 6 131-140 (10 pages)
The aim of this study was to examine the efficacy of in ovo prime-boost vaccination against infectious bursal disease virus (IBDV) using a DNA vaccine to prime in ovo followed by a killed-vaccine boost post hatching. In addition, the adjuvant effects of plasmid-encoded chicken interleukin-2 and chicken interferon-g were tested in conjunction with the vaccine. A plasmid DNA vaccine (pcDNA-VP243) encoding the VP2, VP4, and VP3 proteins of the very virulent IBDV (vvIBDV) SH/92 strain was injected... -
Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity
Yun-Young Byon, Mi-Hyoung Kim, Eun-Sook Yoo, Kyu-Kye Hwang, Youngheun Jee, Taekyun Shin, Hong-Gu Joo* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 4호 4 359-366 (8 pages)
we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated... -
Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutinin- neuraminidase proteins
Youn-Jeong Lee, Haan-Woo Sung, Jun-Gu Choi, Eun-Kyoung Lee, Hachung Yoon, Jae-Hong Kim, Chang-Seon Song 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 11 301-308 (8 pages)
provided good protection against the clinical signs and mortality, showing a 0.00 PI value and 100% protection after a booster immunization. On the other hand, the combined rND F+HN glycoprotein derived from the velogenic strain induced complete protection (0.00 PI value and 100% protection) and significantly reduced the amount of virus shedding even after a single immunization. The rND F and rND HN glycoproteins derived from the velogenic strain had a slightly, but not significantly, greater... -
Metoclopramide protection of diazinon-induced toxicosis in chickens
M. H. I. Al-Zubaidy, F. K. Mohammad 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 3호 8 249-254 (6 pages)
The efficacy of metoclopramide for preventing organophosphate insecticide-induced (diazinon) toxicosis was evaluated in 7~14 days old chicks. Injection of metoclopramide at 25 mg/kg, s.c. 15 min before diazinon increased the oral 24 h median lethal dose of the insecticide in the chicks by 80%. Metoclopramide alone inhibited the in vitro and in vivo plasma and whole brain cholinesterase activities of the chicks. Metoclopramide pretreatment at 100 mg/kg, s.c. reduced the extent of cholinesterase... -
Modification of maturation condition improves oocyte maturation and in vitro development of somatic cell nuclear transfer pig embryos
Kilyoung Song, Eunsong Lee 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 12 81-87 (7 pages)
examined effects on the developmental competence of pig oocytes after somatic cell nuclear transfer (SCNT) or parthenogenetic activation (PA) of : 1) co-culturing of oocytes with follicular shell pieces (FSP) during in vitro maturation (IVM); 2) different durations of maturation; and 3) defined maturation medium supplemented with polyvinyl alcohol (PVA; control), pig follicular fluid (pFF), cysteamine (CYS), or β-mercaptoethanol (β-ME). The proportion of metaphase II oocytes was increased (p <... -
Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus
Abdul Rahman Omar, Chong Lee Kim, Mohd Hair Bejo, Aini Ideris 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 3호 6 241-247 (7 pages)
coli provided protection against a hvIBDV challenge in specificpathogen- free (SPF) chickens. Six out of seven chickens that were injected three times with crude VP2 protein developed significant antibody titer against IBDV. However, only four out of the seven chickens survived the hvIBDV challenge. Despite showing low antibody titer profiles, all chickens immunized with the heat-inactivated whole virus also survived the challenged with hvIBDV. However, all of these chickens had bursal atrophy... -
Immunization of mice with recombinant P27/30 protein confers protection against hard tick Haemaphysalis longicornis (Acari: Ixodidae) infestation
Myung-Jo You 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 1호 7 47-51 (5 pages)
by the statistically significant longer pre-feeding periods in adult ticks. Furthermore, significantly longer feeding periods were noted in both larval and adult ticks. On the other hand, only larval ticks exhibited low attachment rates (31.1%). Immunization of mice with rP27/30 protein confers protection against hard tick Haemaphysalis longicornis infestation. These results demonstrated that the rP27/30 protein might be a useful vaccine candidate antigen for biological control of ticks. -
Induction of castration by immunization of male dogs with recombinant gonadotropin-releasing hormone (GnRH)-canine distemper virus (CDV) T helper cell epitope p35
Mi-Jeong Jung, Young-Chan Moon, Ik-Hyun Cho, Jung-Yong Yeh, Sun-Eui Kim, Wha-Seok Chang, Seung-Young Park, Chang-Seon Song, Hwi- 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 1호 3 21-24 (4 pages)
much higher antibody than that of GnRH-rotavirus VP6 protein or GnRH alone. The degeneration of spermatogenesis was also verified in the male dogs immunized with the fusion protein of GnRH-CDV Th cell epitope p35. These results indicate that canine GnRH conjugated to CDV Th cell epitope p35 acted as a strong immunogen and the antibody to GnRH specifically neutralized GnRH in the testes. This study also implies a potential application of GnRH-based vaccines for immunocastration of male pets. -
Cilostazol attenuates kainic acid-induced hippocampal cell death
Young-SeopPark, ZhenJin, EunAeJeong, Chin-okYi, JongYoulLee, InSungPark, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 7 63-70 (8 pages)
neuroprotective agent. However, little is known about cilostazol’s effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and... -
Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan
DangVanCuong, HyoungKyuKim, JubertMarquez, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 10 213-220 (8 pages)
degranulation, and evaluated the role of calcium transients during mast cell activation. Our investigation focused on the role of the mitochondrial calcium uniporter (MCU) in BG-induced degranulation. Black mouse (C57) bone marrow-derived mast cells were stimulated with 0.5 μg/ml BG, 100 μg/ml peptidoglycan (PGN), or 10 μM A23187 (calcium ionophore), and dynamic changes in cytosolic and mitochondrial calcium and membrane potential were monitored. BG-induced mast cell degranulation occurred in... -
Effects of Free Anthraquinones Extract from the Rhubarb on Cell Proliferation and Accumulation of Extracellular Matrix in High Glucose Cultured-Mesangial Cells
JianyunWang, HuiFang, BingzhengDong, DongdongWang, YanLi, XiaoChen, LijuanChen, TongWei, QunliWei 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 2 485-489 (5 pages)
high glucose-cultured glomerular mesangial cells (MCs). The cell proliferation was determined by CCK-8 assay, the levels of TGF-β1, CTGF, ColIV and FN proteins in the supernatant of MCs were measured by ELISA assays, and the mRNA levels of these four genes were detected by RT-PCR. The results showed that the increased proliferation of MCs, the mRNA levels and protein expression of TGF-β1, CTGF, ColIV and FN induced by high glucose were inhibited after the treatment with the FARs extract. This... -
Low Non-NMDA Receptor Current Density as Possible Protection Mechanism from Neurotoxicity of Circulating Glutamate on Subfornical Organ Neurons in Rats
WoneeChong, SeongNamKim, SeongKyuHan, SoYeongLee, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 13 177-181 (5 pages)
CA1 neurons (2.44 pA/pF for AMPA, p＜0.05; 2.34 pA/pF for kainate, p＜0.05). However, the current density by NMDA in SFO neurons was not significantly different from that of hippocampal CA1 neurons (1.58 vs. 1.47 pA/pF, p＞0.05). These results demonstrate that glutamate-mediated action through non-NMDA glutamate receptors in SFO neurons is smaller than that of hippocampal CA1 neurons, suggesting a possible protection mechanism from excitotoxicity by circulating glutamate in SFO neurons. -
Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells
HeeJin, HyeEunYoon, Jae-SeonLee, Jae-KyungKim, SungHoMyung, Yun-SilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 6 119-124 (6 pages)
absence of apoptotic cell death. Exposure to an ELF-MF alone (1 mT or 2 mT) did not affect the percentages of G2/M-arrested cells, aneuploid cells, or the populations of cells in the subG1 phase. Moreover, when cells were exposed to a 1 mT or 2 mT ELF-MF in combination with IR (0.5 Gy) or H2O2 (0.05 mM), the ELF-MF did not further increase the percentages of G2/M-arrested cells or aneuploid cells. These results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when... -
Ginsenoside Rg2 Inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cell
Young-SukCho, ChanHyungKim, Tae-SunHa, SangJinLee, HeeYulAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 4 133-137 (5 pages)
expression, in a time-dependent manner within 1 hr. Ginsenoside Rg2 prevented the decrease of IՊBՁ expression stimulated with LPS. Moreover, ginsenoside Rg2 reduced LPS-mediated THP-1 monocyte adhesion to HUVEC, in a concentration-dependent manner. These data provide a novel mechanism where the ginsenoside Rg2 may provide direct vascular benefits with inhibition of leukocyte adhesion into vascular wall thereby providing protection against vascular inflammatory disease. -
Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats
JiSooChoi, JoongWooLeem, KyungHeeLee, Sung-SooKim, HaeyoungSuh-Kim, SeJungJung, UnJengKim, BaeHwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 6 405-411 (7 pages)
The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approach. The purpose of the present study was to investigate the functional recovery and therapeutic... -
Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1
JungEunKim, JinYoungSung, Chang-HoonWoo, YoungJinKang, KwangYounLee, HeeSunKim, WooHyungKwun, HyoungChulChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 3 203-210 (8 pages)
A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated protein kinase (AMPK) activation induced by heme oxygenase-1 (HO-1) is a mediator of the beneficial effects of cilostazol and whether cilostazol may prevent cell proliferation and reactive oxygen species (ROS) production by activating AMPK in VSMC. In the present study, we investigated VSMC with various concentrations of cilostazol. Treatment with cilostazol increased HO-1 expression and... -
Bark Constituents from Mushroom-detoxified Rhus verniciflua Suppress Kainic Acid-induced Neuronal Cell Death in Mouse Hippocampus
Jong-SeonByun, YoonHeeHan, Sung-JunHong, Sung-MiHwang, Yong-SooKwon, HeeJaeLee, Sung-SooKim, Myong-JoKim, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 5 279-283 (5 pages)
in significant apoptotic neuronal cell death in the CA3 region of mouse hippocampus. However, seven daily administrations of RVH-1 or RVH-2 prior to KA injection significantly attenuated KA-induced pyramidal neuronal cell death in the CA3 region. Furthermore, pretreatment with RVH-1 and RVH-2 also suppressed KA-induced microglial activation in the mouse hippocampus. The present study demonstrates that RVH-1 and RVH-2 isolated from Rhus verniciflua and detoxified using mushroom species possess...
