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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
Mohammed Mohsen Safhi, Tarique Anwer, Gyas Khan, Rahimullah Siddiqui, Sivagurunathan Moni Sivakumar, Mohammad Firoz Alam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 3 493-501 (9 pages)
in type 2 diabetes mellitus (DM). Type 2 DM was induced by injecting nicotinamide (120 mg/kg, i.p.) 15 min before STZ (60 mg/kg) injection. Canagliflozin (5 and 10 mg/ kg) and omega-3 fatty acid (300 mg/kg) were given for 28 days after confirmation of diabetes. Biochemical estimations revealed elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines in diabetic group. Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin,... -
Reduction of TNFα-induced Oxidative DNA Damage Product, 8-Hydroxy-2′-Deoxyguanosine, in L929 Cells Stably Transfected with Small Heat Shock Protein
Young-MeePark, Eun-MiChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 11 209-219 (11 pages)
small HSP has not been completely understood. In this study, we have attempted to determine whether TNFα induces oxidative DNA damage in TNFα-sensitive L929 cells. We chose to measure the level of 8-hydroxy-2′-deoxyguanosine (8 ohdG), which has been increasingly recognized as one of the most sensitive markers of oxidative DNA damage. Our results clearly demonstrated that the level of 8 ohdG increased in L929 cells in a TNFα dose-dependent manner. Subsequently, we asked whether small HSP has... -
KSLV-I 발사2호기 VEB 조합체 이송
최상현, 박종찬, 원유진, 이수진, 정의승, Choi. Sang-Hyeon, Park. Jong-Chan, Won. You-Jin, Lee. Soo-Jin, Chung. Eui-Seung 한국항공우주연구원 항공우주기술 10 Pages
한국항공우주연구원 항공우주기술 2011, Vol.10 No.1 20-29 (10 pages)
상단부 이송 항목 중 KARI가 직접 이송하는 VEB 조합체는 진동 및 충격에 민감한 전기 전자 부품과 유공압 부품을 다수 포함하고 있어, 이송에 특별한 주의가 요구된다. VEB 조합체 이송 요구 조건을 만족시키기 위해 환경제어장치가 구비된 이송 컨테이너를 제작하였다. 제작한 이송 컨테이너의 성능 검증 및 이송 조건(이송 속도, 이송 경로 등) 타당성 확인을 위해 엔지니어링모델을 이용한 4회의 이송 시험을 수행한 바 있다. 본 논문에서는 기존의 VEB 조합체 이송 이력과 발사2호기 VEB 조합체 이송 개요 및 결과 등을 정리하였다. -
욕창예방을 위한 드레싱제의 효과: 메타분석
박경희, 정재심, 홍은영, 임경춘 한국근거기반간호학회 근거와 간호 11 Pages
한국근거기반간호학회 근거와 간호 2020, 제 8권 제 1호 2 7-17 (11 pages)
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Effect of repetitive wrist extension with electromyography-triggered stimulation after stroke
Yo-seb Lee, Yu-ri Cha, Young Kim, Su-jin Hwang, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 3호 4 127-133 (7 pages)
pre- and post-treatment periods. Results: In the EMG-triggered NMES group, faster muscle reaction time was observed, and median frequency also showed improvement, from 68.2 to 75.3 Hz, after training (p<0.05). Muscle reaction time was significantly faster, and median frequency was significantly higher in the experimental group than in the experimental group after training. Conclusions: EMG-triggered NMES is beneficial for patients with hemiparetic stroke in recovery of upper extremity function. -
Predictive validity of the gait scale in the Performance Oriented Mobility Assessment for stroke survivors
Seung-heon An, Young-ju Jee, Dong-geon Lee, Sun-hae Song, Gyu-chang Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 8 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 1호 1 1-8 (8 pages)
FM-LE), and Trunk Impairment Scale (TIS). The validity of POMA-GS for falls prediction was analyzed. Results: In the POMA-GS, which predicts falls in stroke survivors, the cut-off value was 8.5 (sensitivity 72%; specificity 65%) and the area under the curve was 0.75 (95% confidence interval: 0.60-0.90, p<0.007). There was a significant difference in the OLST, SST, FM-LE, and TIS between the subjects with POMA-GS >8.5 and the subjects with POMA-GS ≤8.5. Conclusions: The POMA-GS could be a useful... -
A comparison of the aerobic cost and muscle use in aerobic dance to the energy costs and muscle use on treadmill, elliptical trainer and bicycle ergometry
Jerrold Petrofsky, M. Laymon, R. Mcgrew, D. Papa, R. Hahn, R. Kaethler, M. Johnson, B. Wernow, D. Poblete 물리치료재활과학회 Physical Therapy Rehabilitation Science 9 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 1호 3 12-20 (9 pages)
20 minutes at a speed of 2 meters per second (4.47 miles per hour). Compared to the bicycle, it was equivalent to cycling at 112 watts for 20 minutes (2.25 kpm), and for the elliptical trainer, dance was equivalent to 435 watts. Concerning muscle use, the dance routine was the most balanced for upper, core and lower body muscles. Although the elliptical trainer was close, it required muscle less muscle use. Conclusion: A good dance video can be more effective than standard exercise equipment. -
The effect of a water exercise on gait characteristics in the elderly post stroke patients
Hee-Sung Lim, Suk-Min Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2012, 제 1권 제 1호 4 17-21 (5 pages)
parameters in the elderly post stroke patients. Design: One group pretest-posttest design. Methods: Twenty elderly post stroke patients (age: 56.5±10.1 years, height: 168.6±5.8 cm, body mass: 69.3±6.9 kg, handicapped level: 2.5±0.8) participated in this study. Participants took part in gait training of 1 hour per day, three days per week, for three months. Participants’ gaits were analyzed to find the effect of 3 months water exercise by a 3-D motion analysis with 8 infrared camera and 1... -
The effect of coenzyme Q10 on endothelial function in a young population
Jerrold Petrofsky, M. Laymona, H. Lee, E. Hernandez, D. Dequine, L. Thorsen, R. Lovell, J. Andrade 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2012, 제 1권 제 1호 2 6-12 (7 pages)
reverse endothelial cell damage in the blood vessels. It is also a potent antioxidant. Design: One group pretest-posttest design. Methods: In the present study, endothelial function was evaluated using the response to occlusion and heat before and 2 weeks after administration of CoQ10, 300 mg/day. Thirty Eight subjects, who are physical therapy students, participated in a series of experiments to see if taking 300 mg of CoQ10 daily for 2 weeks would impact resting blood flow in the forearm skin... -
Ovary and vaginal epithelium dynamics during the estrous cycle in Dasyprocta prymnolopha Wagler, 1831
Artur N. Carreiro, Joã, o A. R. A. Diniz, Joyce G. Souza, Dé, bora V. F. Araú, jo, Rô, mulo F. F. Dias, Liliane M. S. Aze 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 14 446-451 (6 pages)
of both ovaries. Topographic parameters in an ultrasound window were established to locate the ovaries. The agouti estrous cycle lasted an average of 29.94 ± 6.77 days. During vaginal cytology examinations, all cell types were identified, and each phase of the estrous cycle was established by cell counts. No significant alterations were observed in the assessed ovarian morphometry measurements. In 75% of the animals examined, ovarian follicle presence was observed in the proestrus phase. -
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Comparative proteomic analysis of outer membrane protein 43 (omp43)-deficient Bartonella henselae
Jun-Gu Kang, Hee-Woo Lee, Sungjin Ko, Joon-Seok Chae 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 9 59-70 (12 pages)
12 proteins were associated with metabolism, 7 proteins associated with information storage and processing, and 3 proteins associated with cellular processing and signaling. By semi-quantitative reverse transcriptase polymerase chain reaction, increases in tldD, efp, ntrX, pdhA, purB, and ATPA mRNA expression and decreases in Rho and yfeA mRNA expression were confirmed in Δomp43. In conclusion, this is the first report showing that a loss of OMP43 expression in B. henselae leads to retarded... -
Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 2 431-437 (7 pages)
concentration, half-life of the absorption phase, half-life of the distribution phase, and half-life of the elimination phase were 34.86 ± 9.69 vs. 28.73 ± 6.18 μgㆍh/mL, 1.77 ± 0.33 vs. 1.67 ± 0.28 μg/mL, 2.27 ± 0.45 vs. 2.24 ± 0.44 h, 5.35 ± 1.40 vs. 4.61 ± 0.35 h, and 43.53 ± 8.17 vs. 42.05 ± 9.36 h, respectively. These results of this exploratory study suggest that there were no significant differences between the PK profiles of TIL in the healthy and H. parasuis-infected pigs. -
Effect of fermented soybean products intake on the overall immune safety and function in mice
Jae Hee Lee, Se Hee Paek, Hye Won Shin, Seung Yeon Lee, Byoung Seok Moon, Jung Eun Park, Gyeong Dong Lim, Chang Yul Kim, Yong He 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 4 25-32 (8 pages)
was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Th1)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-γ vs. IL-4 and IgG2a vs. IgG1 in stimulated splenic T and B cells, respectively. Resistance to Listeria monocytogenes infection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Th1 responses. -
Enhancing effects of serum-rich and cytokine-supplemented culture conditions on developing blastocysts and deriving porcine parthenogenetic embryonic stem cells
Soo-Kyung Jung, Hyun-Jung Kim, Chan-Lan Kim, Joo-Hyeong Lee, Jin-Young You, Eun-Song Lee, Jeong-Mook Lim, Seon Jong Yun, Jae-You 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 4호 9 519-528 (10 pages)
The present study was conducted to develop an effective method for establishment of porcine parthenogenetic embryonic stem cells (ppESCs) from parthenogenetically activated oocyte-derived blastocysts. The addition of 10% fetal bovine serum (FBS) to the medium on the 3rd day of oocyte culturing improved the development of blastocysts, attachment of inner cell masses (ICMs) onto feeder cells, and formation of primitive ppESC colonies. ICM attachment was further enhanced by basic fibroblast growth... -
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers
Claudia Concha, María Daniella Carretta, Pablo Alarcón, Ivan Conejeros, Diego Gallardo, Alejandra Isabel H 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 7 217-224 (8 pages)
and plasma lactic acid was recorded in these animals. Specifically, a decrease in PAF-induced ROS production was observed 8 h after oligofructose overload, and this was sustained until 48 h post oligofructose overload. A reduction in PAF-induced L-selectin shedding was observed at 16 h and 32 h post oligofructose overload. Overall, the results indicated that neutrophil PAF responses were altered in heifers with ruminal acidosis, suggesting a potential dysfunction of the innate immune response. -
Protective effects of recombinant Brucella abortus Omp28 against infection with a virulent strain of Brucella abortus 544 in mice
Jeong Ju Lim, Dong Hyeok Kim, Jin Ju Lee, Dae Geun Kim, Wongi Min, Hu Jang Lee, Man Hee Rhee, Suk Kim* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 3호 10 287-292 (6 pages)
2a in rOmp28- immunized mice and the ability of rOmp28 immunization to protect against B. abortus infection were evaluated in a mouse model. In the immunogenicity analysis, the mean titers of IgG1 and IgG2a produced by rOmp28-immunized mice were 20-fold higher than those of PBS-treated mice throughout the entire experimental period. Furthermore, spleen proliferation and bacterial burden in the spleen of rOmp28-immunized mice were approximately 1.5-fold lower than those of PBS-treated mice when... -
Detection of Escherichia coli O157 and Escherichia coli O157:H7 by the immunomagnetic separation technique and stx1 and stx2 genes by multiplex PCR in slaughtered cattle in Samsun Province, Turkey
G?khan Inat*, Belgin Siriken 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2010, 제 11권 제 4호 7 321-326 (6 pages)
while two E. coli O157:H7 isolates were obtained from rectal swabs and carcasses of the same animal. The stx1 and stx2 genes were both detected in 35 E. coli O157 isolates and one E. coli O157:H7 isolate, but the stx2 gene was only detected alone in two E. coli O157 isolates. Overall, 16 carcasses tested positive for E. coli O157 and one carcass tested positive for E. coli O157:H7 based on both carcass and rectal samples. Overall, the results of this study indicate that cattle carcasses pose a... -
Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium
So Yeong Lee, Kyong-Ah Yoon, Soo Hwa Jang, Erdene Ochir Ganbold, Dembereldorj Uuriintuya, Sang-Mo Shin, Pan Dong Ryu, Sang-Woo J 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 4호 4 299-304 (6 pages)
symmetric stretching ns(PO3) band intensity at ∼970 cm and the phosphodiester symmetric stretching ns(PO2) band intensity at ∼1,085 cm in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools. -
Detection and molecular characterization of infectious bronchitis virus isolated from recent outbreaks in broiler flocks in Thailand
Tawatchai Pohuang, Niwat Chansiripornchai*, Achara Tawatsin, Jiroj Sasipreeyajan 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 7 219-223 (5 pages)
identities less than 84% in common with IBVs published in the GenBank database. This group likely represents the strains indigenous to Thailand. The isolates in group II showed a close relationship with Chinese IBVs. They had nucleotide sequence identities of 97-98% and amino acid sequence identities 96-98% in common with Chinese IBVs (strain A2, SH and QXIBV). This finding indicated that the recent Thai IBVs evolved separately and at least two groups of viruses are circulating in Thailand. -
Pregnancy loss in dairy cows: the contributing factors, the effects on reproductive performance and the economic impact
Je-In Lee, Ill-Hwa Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 3호 13 283-288 (6 pages)
or 2 was decreased by 0.6 or 0.5 fold compared to the cows with a parity of 3 or higher. Following PL, the mean rate of endometritis was 23.2% and endometritis was more common (p < 0.05) when PL occurred during the third trimester than during the first and second trimesters. The mean culling rate was 46.4% and this did not differ with the period of PL. The overall mean intervals from PL to the first service and conception were 63.4 and 101.8 days, respectively. The mean interval from PL to first... -
Studies on mastitis, milk quality and health risks associated with consumption of milk from pastoral herds in Dodoma and Morogoro regions, Tanzania
Esron D. Karimuribo, Lughano J. Kusiluka, Robinson H. Mdegela, Angolwisye M. Kapaga, Calvin Sindato, Dominic M. Kambarage 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 3호 7 213-221 (9 pages)
(27.7%), microcci (5.8%) and streptococci (9.8%). The average TVC of milk in Dodoma rural district (1.0*107¡¾3.4*107)was significantly higher than that in Mvomero district (8.9*10 5 3.5*106) (p<0.001)and the proportion of TCC-positive samples in Dodoma (70.7%)were significantly higher (p<0.001) than that of Mvomero sample(20.8%). Whereas no tuberculin reactor animal was detected in the study animals, atypical mycobacteria were isolated from milk and one sample from Dodoma had Mycobacterium... -
Cardiocirculatory, biochemical and hemostatic evaluation of dogs with hyperadrenocorticism at diagnosis and after treatment
Frederico Aecio Carvalho Soares , Juliana Pereira Matheus , Guilherme Luiz Carvalho , Elisa Barp Neuwald , Alan Gomes Poppl 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 3호 5 161-166 (6 pages)
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Original Article : Effect of a mixture of Galla rhois and Cinnamomum cassia extracts on susceptibility to the colonization of Campylobacter jejuni in broiler chickens
Byung-wook Cho , Soo-mi Lee , Chun-nam Cha , Chang-yeol Yoo , Song-ee Son , Suk Kim , Hu-jang Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 1호 2 9-14 (6 pages)
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Short Communication : Fecal microbiota analysis of obese dogs with underlying diseases: a pilot study
Hyung Jin Park , Sang Eun Lee , Hyeun Bum Kim , Jae Hoon Kim , Kyoung Won Seo , Kun Ho Song 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 4 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2015, 제 55권 제 3호 9 205-208 (4 pages)
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Original Article : Prevalence of virulence and cytolethal distending toxin (CDT) genes in thermophilic Campylobacter spp. from dogs and humans in Gyeongnam and Busan, Korea
Hyun Ho Cho , Sang Hyun Kim , Won Gi Min , Bok Kyung Ku , Yong Hwan Kim 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 1호 7 39-48 (10 pages)
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Effects of continuous force application for extrusive tipping movement on periapical root resorption in the rat mandibular first molar
Yoshiro Matsumoto, Siripen Sringkarnboriboon, Takashi Ono 대한치과교정학회 The Korean Journal of Orthodontics 7 Pages
대한치과교정학회 The Korean Journal of Orthodontics 2018, 제 48권 제 5호 8 339-345 (7 pages)
for extrusive tipping movement and occlusal interference on periapical root resorption in the rat mandibular first molar. Methods: We constructed an appliance comprising a titanium screw implant with a cobalt– chromium post as the anchorage unit and a nickel–titanium closed coil spring (50 cN) as the active unit. Force was applied on the mandibular left first molar of rats for 8 (n = 10) and 15 days (n = 10; experimental groups), with the tooth in occlusion. Five rats were included... -
골격성 Ⅲ급 부정교합자의 편악수술과 양악수술시 술후동태에 대한 비교연구
최양숙(Yang-Sook Choi), 손우성(Woo-Sung Son) 대한치과교정학회 The Korean Journal of Orthodontics 17 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1997, 제 27권 제 2호 11 297-313 (17 pages)
0.76, 0.75, 변화율은 각각 57%, 58%, 59%였다. 하악절치의 수평적 변화와 하순의 LI, ILS의 수평적 변화사이의 상관계수는 양악수술군에서 0.93, 0.90, 편악수술군에서는 0.71, 0.89였고 변화율은 양악수술군에서 76%, 87%, 편악수술군에서 75%, 85%였다. 4. 편악수술군에서 악골의 전후방 부조화 상하악절치 경사도사이에 FMIA = 57.48 - 2.17 ANB, U1-SN = -75.02+2.17 SNB의 회귀방정식을 구할 수 있었으며 결정계수는 각각 0.63, 0.63이었다. 양악수술군에서는 SNB와 FMIA, SNB 및 ANB와 U1-SN사이에 회귀방정식을 구할 수 있었으나... -
한국인 젊은여성의 심미적인 안면 연조직 형태에 관한 두부 X-선 계측학적 연구
우제경(Je-Kyung WOO), 권오원(Oh-Won KWON), 성재현(Jae-Hyun SUNG) 대한치과교정학회 The Korean Journal of Orthodontics 14 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1997, 제 27권 제 2호 7 245-258 (14 pages)
상관관계, 교정 전공의가 평가한 정모와 측모의 심미성간의 상관관계, 교정 전공의가 평가한 측모 실루엣의 평균 점수가 5점 이상인 38명의 측모 계측항목과 측모 심미성간의 상관관계를 분석하여 다음과 같은 결론을 얻었다. 1. 측모 실루엣에서 교정 전공의와 미대생의 심미안간의 상관관계는 유의성있게 나타났다(r=0.67, P=0.0001). 2. 교정 전공의가 평가한 정모와 측모의 심미성간의 상관관계는 유의성있게 나타났다(r=0.26, P=0.0381). 3. 측모 실루엣과 상관관계가 유의성있게 나타난 항목은 Na-Pog, to N´, BNV to... -
성장장애 흰쥐에서 경옥고(瓊玉膏)와 경옥고가녹용(瓊玉膏加鹿茸)의 성장효과 비교 연구
차윤엽(Yun Yeop Cha) 한방비만학회 대한한방비만학회지 11 Pages
한방비만학회 대한한방비만학회지 2009, 제 9권 제 1호 7 59-69 (11 pages)
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고지방 식이로 비만이 유도된 C57BL/6 마우스에서 식이 기간에 따른 비만 관련 지표 변화에 대한 연구
송미영(Mi Young Song) 한방비만학회 대한한방비만학회지 8 Pages
한방비만학회 대한한방비만학회지 2016, 제 16권 제 1호 3 19-26 (8 pages)
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Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
Dong-GeunKang, HyunJaeLee, KunTaeKim, Sun-ChulHwang, ChoongJaeLee, JinSungPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 7 197-204 (8 pages)
joint of rat. The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo. These results suggest that oleanolic acid can regulate the activity, secretion and gene expression of MMP-3, by directly acting on articular chondrocytes. -
Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in rodents
JaeHoonWoo, Tae-WooHa, Jae-SeonKang, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 4 27-36 (10 pages)
(42 mg/kg) and sub-hypnotic (28 mg/kg) dosages. Especially, DCA increased the number of sleeping animals in the sub-hypnotic dosage. DCA (50 mg/kg, p.o.) itself modulated sleep architectures; DCA reduced the counts of sleep/wake cycles. At the same time, DCA increased total sleep time, but not non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. In the molecular experiments. DCA (0.001, 0.01 and 0.1 μg/ml) increased intracellular Cl- influx level in hypothalamic primary cultured... -
Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat
HoJongRa, HyunJaeLee, HoSeungJo, DaeCheolNam, YoungBokLee, ByeongHunKang, DongKyuMoon, DongHeeKim, ChoongJaeLee, Sun-ChulHwang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 3 19-26 (8 pages)
was also examined in vivo. The results were as follows: (1) betulin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) betulin inhibited the secretion and proteolytic activity of MMP-3; (3) betulin suppressed the production of MMP-3 protein in vivo. These results suggest that betulin can regulate the gene expression, secretion, and proteolytic activity of MMP-3, by directly acting on articular chondrocytes. -
Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats
ChengYuWang, XiangDanLiZhiHongHao, DongyuanXu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 7 613-619 (7 pages)
by the bcl-2/bax ratio and TUNEL assays), increased fibrosis, increased markers of oxidative stress (MDA and SOD) and inflammatory factors (TNF-α and IL-1β), and decreased phosphorylation of Akt and glycogen synthase kinase (GSK-3β). IGF-1 treatment, however, attenuated the metabolic abnormalities and myocardial apoptosis, interstitial fibrosis, oxidative stress and inflammation seen in diabetic rats, while also increasing the phosphorylation levels of Akt and GSK-3β. These findings suggest... -
Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo
DaeCheolNam, BoKunKim, , HyunJaeLee, Hyun-DaeShin, ChoongJaeLee, Sun-ChulHwang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 11 221-228 (8 pages)
The effect of prunetin on MMP-3 protein production was also examined in vivo. The results were as follows: (1) prunetin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5; (2) prunetin inhibited the secretion and proteolytic activity of MMP-3; (3) prunetin suppressed the production of MMP-3 protein in vivo. These results suggest that prunetin can regulate the gene expression, secretion, and proteolytic activity of MMP-3, by directly acting on articular chondrocytes. -
Effects of Antioxidants on the Gamma-Radiation Damage of the Cultured Vascular Smooth Mucle Cells of Rat Aorta
Jong-DooLee, Hyoung-ChulChoi, Young-JinKang, Myung-SeKim, Kwang-YounLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 5 189-195 (7 pages)
and G2/M phases, and the maximum effects were observed at 1500 or 2000 cGy. Submaximal concentrations of antioxidants, such as allopurinol, vitamin C, N-acetylcycteine (NAC), lipoic acid, dihydrolipoic acid and rebamipide tended to increase the cell viability suppressed by low dose of radiation (500 cGy), and enalapril and vitamin E increased it significantly. Allopurinol, vitamin E, NAC, lipoic acid, captopril and enalapril significantly increased G1 phase. Allopurinol and vitamin E tended to... -
Effects of PCB Congeners in Rodent Neuronal Cells in Culture
Sun-YoungKimJae-HoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 2 9-16 (8 pages)
phobol 12,13-dibutyrate ([3H]PDBu) binding assay, indicating that non-coplanar PCBs are more neuroactive than coplanar PCBs in neuronal cells. PKC isozymes were immunoblotted with the selected monoclonal antibodies. PKC-α, δ, and ε were activated with non-coplanar PCB exposure. Receptor for activated C kinase-1 (RACK-1), anchoring protein for activated PKC, was more induced with exposure to coplanar PCBs than non-coplanar PCBs. Reverse transcription PCR (RT-PCR) analysis showed induction of... -
Effects of Norepinephrine and Neuropeptide Y on the Contractility of Small Mesenteric Artery from 2K1C and DOCA-Salt Hypertensive Rats
SangChaeNam, SeongsuKang, WonjaeKim, JongunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 8 55-61 (7 pages)
2K1C and DOCA- salt hypertension were made in Sprague-Dawley rats. Four weeks after induction of hypertension, systolic blood pressure measured in conscious state was significantly higher in 2K1C (216⁑18 mmHg) and DOCA-salt (205⁑29 mmHg) groups than that in control (128⁑4 mmHg). The third branches (＜300 μm in outer diameter) of the mesenteric artery were isolated and cut into ring segments of 2∼3 mm in length. Each ring segment was mounted in tissue bath and connected to a... -
Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats
EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)
was 0.73⁑0.11. Single channel conductance calculated from the slope of the relationship between single channel current and pipette potential (20∼100 mV) was not significantly altered by propofol (control: 60.0⁑2.7 pS, 0.1 mM propofol: 58.7⁑3.5 pS). However, mean closed time was surely increased. Above results indicate that propofol blocks the KATP channels in the pancreatic beta cells in the range of its blood concentrations during anesthesia, suggesting a... -
Effect of Capsaicin on Delayed Rectifier K+ Current in Adult Rat Dorsal Root Ganglion Neurons
JunghyunHahn, SungkwonChung, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 2 9-14 (6 pages)
K currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential. In this study, whole cell configuration of patch clamp technique had been applied to record the blocking effect of capsaicin, a lipophilic alkaloid, on the delayed rectifier K current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the... -
Effects of Cl Channel Blockers on the Cardiac ATP-sensitive K+ Channel
Yong-GeunKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 8 305-313 (9 pages)
2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the KATP channel activity in a concentration-dependent manner with IC50 of 0.24 and 927μM, respectively. The inhibitory action of DIDS was irreversible whereas that of niflumic acid was reversible. Furthermore, DIDS-induced block was not recovered despite exposure to ATP (1 mM). In cell-attached and inside-out patches, DIDS blocked the pinacidil- or 2,4-dinitrophenol (DNP)-induced KATP channel openings. In contrast,... -
The Role of Intracellular Mg2+ in Regulation of Ca2+-activated K+ Channel in Pulmonary Arterial Smooth Muscle Cells of the Rabbit
SukHoLeeMyoungKyuPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 9 611-616 (6 pages)
by mainly enhancement of Po. However, at very high concentration of cytoplasmic Ca2+, such as pCa 5.5, Mg2+ decreased IK,Ca through the inhibition of unitary current. Moreover, Mg2+ could activate the channel even in the absence of Ca2+. Mg2+ might, therefore, partly contribute to the opening of IK,Ca channel in resting membrane potential. This phenomenon might explain why IK,Ca contributes to the resting membrane potential where membrane potential and concentration of free Ca2+ are very low. -
Protective Mechanism of Nitric Oxide and Mucus against Ischemia/ Reperfusion-Induced Gastric Mucosal Injury
HyeyoungKim, KwangsooNam, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 13 511-519 (9 pages)
This study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, and sodium nitroprusside, a nitric oxide donor, were injected intraperitoneally to the rats 30 min prior to ischemia/reperfusion which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1... -
Platelet-Activating Factor Enhances Interleukin-1 Activity by Alveolar Macrophages Inhibition by PAF Specific Receptor Antagonists
JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 10 201-208 (8 pages)
or lipopolysaccharide(LPS) to AM cultures markedly enhanced IL-1 activity by 2-3 fold compared with AM cultures with the stimulant alone in a concentration dependent fashion. The peack effect was found at 108 M PAF with MDP and 1014 M PAF with LPS. the effect of PAF was also tested in silica, toxic respirable dust, -added AM cultures as well as in the cultures containing bacterial compounds. Although silica did not stimulate the IL-1 activity, PAF could enhance IL-1 activity by 2...
