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전체 선택해제
총 135건 검색
본문검색 결과만 보기
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Similarity Relations of Resin Flow in Resin Transfer Molding Process
Um. Moon-Kwang, Byun. Joon-Hyung, Daniel. Isaac M. 한국복합재료학회 Advanced composite materials : the official journal of the Japan Society of Composite Materials and 18 Pages
한국복합재료학회 Advanced composite materials : the official journal of the Japan Society of Composite Materials and 2009, Vol.18 No.2 135-152 (18 pages)
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Study on Design of Air-water Two-phase Flow Centrifugal Pump Based on Similarity Law
Matsushita. Naoki, Furukawa. Akinori, Watanabe. Satoshi, Okuma. Kusuo 유체기계공업학회 International journal of fluid machinery and systems 9 Pages
유체기계공업학회 International journal of fluid machinery and systems 2009, Vol.2 No.2 127-135 (9 pages)
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Charting the proteome of Cryptosporidium parvum sporozoites using sequence similarity-based BLAST searching
A.M.A.M.Z. Siddiki*, Jonathan M. Wastling 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 5 203-210 (8 pages)
global proteome analysis of these opportunistic pathogens. The well-known approach for mass spectrometry (MS) based data analysis using the BLAST tool (MS BLAST) is a database search protocol for identifying unknown proteins by sequence similarity to homologous proteins using peptide sequences produced by mass spectrometry. We have used several complementary approaches to explore the global sporozoite proteome of C. parvum with available proteomic tools. To optimize the output of the MS data, a... -
Use of flow cytometry to develop and characterize a set of monoclonal antibodies specific for rabbit leukocyte differentiation molecules
William C. Davis*, Mary Jo Hamilton 대한수의학회 Journal of Veterinary Science 16 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 1호 8 51-66 (16 pages)
Flow cytometry was used to identify and characterize monoclonal antibodies (mAbs) that react with rabbit leukocyte differentiation molecules (LDM). Screening sets of mAbs, developed against LDM in other species, for reactivity with rabbit LDM yielded 11 mAbs that recognize conserved epitopes on rabbit LDM orthologues and multiple mAbs that recognize epitopes expressed on the major histocompatibility class I or class II molecules. Screening of mAbs submitted to the Animal Homologues Section of... -
Evidence for Genetic Similarity of Vegetative Compatibility Groupings in Sclerotinia homoeocarpa
한국식물병리학회 The Plant Pathology Journal 13 Pages
한국식물병리학회 The Plant Pathology Journal 2014, 30권 4호 6 384-396 (13 pages)
to a VCG have been shown to share significantly higher genetic similarity than those of different VCGs. In this study we sought to examine the relationship between VCG and genetic similarity of an important cool season turfgrass pathogen, Sclerotinia homoeocarpa. Twenty-two S. homoeocarpa isolates from the Midwest and Eastern US, which were previously characterized in several studies, were all evaluated for VCG using an improved nit mutant assay. These isolates were also genotyped using 19... -
Effectivesuppression of PRRSV replicating in monocyte- derived macrophages byCD8-depleted PBMC
Sang Ho Cha, Amanda L. Grimm, Joanna Rzepka, Dharani Ajithdoss, Grace Chung, William C, Davis, Jae Young Song, In soo Cho, Jienny Lee, Cha 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 255 474-475 (2 pages)
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What is the primo-vascular system ?
Chae Jeong Lim, Pan Dong Ryu 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 74 364-365 (2 pages)
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Development of a new prototype of Point Of Care testing (POC) for Differentiation of Foot-and-Mouth sensitive Disease Virus Serotype O
Min geun Sagong, Jin Ju Nah, So yoon Ryoo, Sung Hwan Wee, Tae sung Kim, Su mi Lee, Ki Sik Choung 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 212 308-309 (2 pages)
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Developing non-invasive early diseases detection system for bovine thermal diseases using infrared thermography
Jeong Byoung Chae, Tae Woo Kim, Il Sun Ryu, Yong Sun Jo, Yun Kyung Cho, Jun Gu Kang, Kuk Jin Lee, Joon Seok Chae 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 51 110-111 (2 pages)
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Molecular cloning, characterization and expression analysis of duck interleukin-23p19 in Riemerella anatipestifer infection
Rochelle Flores, Cherry Fernez, Fahmida Afrin, Paula Leona Cammayo, Woo Hyun Kim, Jipseol Jeong, Suk Kim, Hyun Lillehoj, Wongi Min 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 62 237-238 (2 pages)
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Ovary and vaginal epithelium dynamics during the estrous cycle in Dasyprocta prymnolopha Wagler, 1831
Artur N. Carreiro, Joã, o A. R. A. Diniz, Joyce G. Souza, Dé, bora V. F. Araú, jo, Rô, mulo F. F. Dias, Liliane M. S. Aze 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 14 446-451 (6 pages)
The objective of the present study was to monitor and characterize morphological alterations in ovaries of agouti (Dasyprocta prymnolopha), reared in captivity, by using abdominal ultrasonography. All animals underwent daily vaginal cytological examination to identify the current cycle phase. For each phase of the estrous cycle, ultrasound examinations were carried out to identify and describe the morphology of both ovaries. Topographic parameters in an ultrasound window were established to... -
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model
Sooyoung Choi, Daji Noh, Youngwhan Kim, Inseong Jeong, Hojung Choi, Youngwon Lee, Kija Lee 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 17 137-143 (7 pages)
This study describes magnetic resonance imaging (MRI) results and changes in lateral ventricular size over time in a canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence MRI were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping were performed at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of... -
Infections by pathogens with different transmission modes in feral cats from urban and rural areas of Korea
Jusun Hwang, Nicole Gottdenker, Dae-Hyun Oh, Hang Lee, Myung-Sun Chun 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 14 541-545 (5 pages)
In this study, we examine prevalences of three infectious pathogens with different transmission modes (Bartonella henselae, hemoplasma, and Toxoplasma gondii) in feral cats from urban and rural habitats. Infection status of the three pathogens in blood samples (n = 117) was determined through molecular or serological diagnostic methods. Overall prevalence of hemoplasma, Toxoplasma gondii, and Bartonella henselae was 47.9%, 50%, and 35.7%, respectively. Comparing the two habitats, only... -
Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 2 431-437 (7 pages)
A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet... -
Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer
Farruk M. Lutful Kabir, Patricia DeInnocentes, Payal Agarwal, Christopher P. Mill, David J. Riese 2nd, R. Curtis Bird 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 4 149-158 (10 pages)
Well characterized, stable, p16-defective canine mammary cancer (CMT) cell lines and normal canine mammary epithelial cells were used to investigate expression of the major breast cancer-specific hormone receptors estrogen receptor alpha (ER1) and progesterone receptor (PR) as well as luminal epithelial-specific proto-oncogenes encoding c-erbB-1 (epidermal growth factor receptor/EGFr), c-erbB-2/HER2, c-erbB-3, and c-erbB-4 receptors. The investigation developed and validated quantitative reverse... -
Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues
Bonn Lee, Hee Young Kang, Dong Oh Lee, Changhwan Ahn, Eui-Bae Jeung 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 2 445-451 (7 pages)
Claudins, which are known as transmembrane proteins play an essential role in tight junctions (TJs) to form physical barriers and regulate paracellular transportation. To understand equine diseases, it is helpful to measure the tissue-specific expression of TJs in horses. Major equine diseases such as colic and West Nile cause damage to TJs. In this study, the expression level and distribution of claudin-1, -2, -4, and -5 in eight tissues were assessed by Western blotting and... -
Downregulation of cellular prion protein inhibited the proliferation and invasion and induced apoptosis of Marek’s disease virus-transformed avian T cells
Xuerui Wan, Runxia Yang, Guilin Liu, Manling Zhu, Tianliang Zhang, Lei Liu, Run Wu* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 2호 6 171-178 (8 pages)
Cellular prion protein (PrP) is ubiquitously expressed in the cytomembrane of a considerable number of eukaryotic cells. Although several studies have investigated the functions of PrP in cell proliferation, cell apoptosis, and tumorigenesis of mammals, the correlated functions of chicken PrP (chPrP) remain unknown. In this study, stable chPrP-downregulated Marek’s disease (MD) virus-transformed avian T cells (MSB1-SiRNA-3) were established by introducing short interfering RNA (SiRNA) targeting... -
Relationship between chicken cellular immunity and endotoxin levels in dust from chicken housing environments
Katharine Roque, Kyung-Min Shin, Ji-Hoon Jo, Hyoung-Ah Kim, Yong Heo 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 6 173-177 (5 pages)
Hazardous biochemical agents in animal husbandry indoor environments are known to promote the occurrence of various illnesses among workers and animals. The relationship between endotoxin levels in dust collected from chicken farms and various immunological markers was investigated. Peripheral blood was obtained from 20 broiler chickens and 20 laying hens from four different chicken farms in Korea. Concentrations of total or respirable dust in the inside the chicken farm buildings were measured... -
Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry
Joon-Hyeok Jeon, Hae-Won Jung, Hyo-Mi Jang, Jong-Hyun Moon, Ki-Tae Park, Hee-Chun Lee, Ha-Young Lim, Jung-Hyang Sur, By 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 10 75-85 (11 pages)
The purpose of this study was to identify time-related changes in clinical, MRI, histopathologic, and immunohistochemical findings associated with ischemic stroke in dogs. Additionally, the association of cerebrospinal fluid (CSF) and tissue levels of interleukin (IL)-6 with clinical prognosis was assessed. Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO) in nine healthy experimental dogs. The dogs were divided into three groups... -
An overview of calf diarrhea - infectious etiology, diagnosis, and intervention
Yong-il Cho, Kyoung-Jin Yoon* 대한수의학회 Journal of Veterinary Science 17 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 1 1-17 (17 pages)
Calf diarrhea is a commonly reported disease in young animals, and still a major cause of productivity and economic loss to cattle producers worldwide. In the report of the 2007 National Animal Health Monitoring System for U.S. dairy, half of the deaths among unweaned calves was attributed to diarrhea. Multiple pathogens are known or postulated to cause or contribute to calf diarrhea development. Other factors including both the environment and management practices influence disease severity or... -
Isolation and characterization of equine amniotic membrane-derived mesenchymal stem cells
Min-Soo Seo, Sang-Bum Park, Hyung-Sik Kim, Jun-gu Kang, Joon-Seok Chae*, Kyung-Sun Kang* 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 6 151-159 (9 pages)
in low glucose Dulbecco's modified Eagle's medium. The proliferation of eAM-MSCs was measured based on the cumulative population doubling level (CPDL). Immunophenotyping of eAM-MSCs by flow cytometry showed that the major population was of mesenchymal origin. To confirm differentiation potential, a multi-lineage differentiation assay was conducted. We found that under appropriate conditions, eAM-MSCs are capable of multi-lineage differentiation. Our results indicated that eAM-MSCs may be a good... -
Sporozoite proteome analysis of Cryptosporidium parvum by one-dimensional SDS-PAGE and liquid chromatography tandem mass spectrometry
AMAM Zonaed Siddiki* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 1 107-114 (8 pages)
Despite the development of new technologies, new challenges still remain for large scale proteomic profiling when dealing with complex biological mixtures. Fractionation prior to liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis is usually the preferred method to reduce the complexity of any biological sample. In this study, a gel LC-MS/MS approach was used to explore the stage specific proteome of Cryptosporidium (C.) parvum. To accomplish this, the sporozoite protein of C.... -
Genetic analysis of ORF5 of recent Korean porcine reproductive and respiratory syndrome viruses (PRRSVs) in viremic sera collected from MLV-vaccinating or non-vaccinating farms
Hye Kwon Kim, Jeong Sun Yang, Hyoung Joon Moon, Seong Jun Park, Yuzi Luo, Chul Seung Lee, Dae Sub Song, Bo Kyu Kang, Soo Kyung A 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 2호 5 121-130 (10 pages)
PRRSVs, one subgroup had 87.2∼88.9% similarity with the Lelystad virus, showing a close relationship with the 27∼2003 strain of Spain. The maximum parsimony tree of type II PRRSV from 1997 to 2008 showed that they had evolved to four lineages, subgroups 1, 2, 3 and 4. Most of the recently collected type II PRRSVs belonged to subgroup 4 (48%). The region of three B-cell epitopes and two T-cell epitopes of ORF5 amino acids sequences was considerably different from the MLV in subgroups... -
In vivo morphological and antigenic characteristics of Photobacterium damselae subsp. piscicida
Tae S. Jung*, Kim D. Thompson, Donatella Volpatti, Marco Galeotti, A. Adams 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 2호 7 169-176 (8 pages)
The present study was conducted to examine the morphology and antigenicity of Photobacterium damselae subsp. piscicida by culturing the bacterium in vivo in the peritoneal cavity of sea bass (Dicentrarchus labrax) within dialysis bags with either a low molecular weight (LMW) cut-off of 25 kDa or a high molecular weight (HMW) cut-off of 300 kDa. Differences were observed in the growth rate between the bacteria cultured in vivo or in vitro. Bacteria cultured in vivo were smaller and produced a... -
Purification and characterization of two larval glycoproteins from the cattle tick, Boophilus annulatus
Amr E. El Hakim, Yasser E. Shahein, Amira M. K. Abouelella, Mohamed E. Selim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 2호 12 175-180 (6 pages)
The present study was conducted to identify new target immunogenic molecules from the larval stage of the cattle tick, Boophilus annulatus (Acari: Ixodidae). Two specific larval glycoproteins (GLPs) were isolated by two-step affinity chromatography. The larval immunogens were first purified with CNBr-Sepharose coupled to rabbit anti-larval immunoglobulins, and the glycoproteins were then purified with Con-A Sepharose. These glycoproteins have molecular weights of approximately 32 and 15 kDa with... -
Occurrence of canine brucellosis in Korea and polymorphism of Brucella canis isolates by infrequent restriction site-PCR
Dong Hwa Bae , Young Ju Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2009, 제 49권 제 2호 1 105-111 (7 pages)
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한반도 출토 흑요석의 원산지를 알아보기 위해 38개 유적에서 출토된 204점을 분석하였다. 구석기시대의 5개 유적과 신석기시대의 33개 유적의 출토품이 대상이다. 흑요석 분석은 유도결합 플라즈마 질량분석기(LA-ICP-MS)를 사용하였다. 분석결과는 스펙트럼 형상분석법(SSA)을 이용하여 흑요석 산지를 검토하였다. 본 연구에서는 선사시대의 유적에서 출토된 흑요석 204점을 분석하여, 98% 이상의 산지를 규명하였다. 기존 연구에서는 백두산 흑요석은 3종류만이 존재하는 것으로 보고되었다. 이번 연구에서는 새로운 백두산 계열인...
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장편영화 ‘디 아워스’(The Hours)의 오프닝 시퀀스(Opening Sequence)에 나타나는 화면과 음악의 관계
이상윤(SangYoon Lee) 한국음악교육공학회 음악교육공학 24 Pages
한국음악교육공학회 음악교육공학 2014, 제 21호 12 233-256 (24 pages)
본 논문은 장편영화 ‘디 아워스’의 오프닝 시퀀스에서 화면의 시제적인 흐름과 음악의 화성진행 간의 관계를 중심으로 비교분석하였다. 오프닝 시퀀스의 장면을 시제 흐름의 패턴으로 분석해보면 모두 네 개의 부분과 이에 따른 특정한 패턴으로 나누어지고 이러한 패턴은 반복으로 구성된다. 시제 흐름 패턴의 흐름은 화면 속의 인물 또는 카메라의 움직임, 유사한 행동과 사물 등에 의한 화면의 연계와 관계가 깊다. ‘디 아워스’의 오프닝 시퀀스 음악을 형식적으로 나누고 각 단락의 화성진행을 요약해보면 모두 네 가지... -
음악창작의 문화 비교를 위한 예비연구 - 한국과 미국을 중심으로 -
박은실, 강상미 한국음악교육학회 음악교육연구 22 Pages
한국음악교육학회 음악교육연구 2020, 제 49권 제 4호 3 53-74 (22 pages)
본 예비연구의 목적은 한국과 미국의 초등학교 고학년 학생들의 음악창작 결과를 분석하여 음악창작에 대한 문화를 비교하는 것이다. 32명의 한국학생들과 35명의 미국학생들을 대상으로 4주간 창작 지도를 하고 MuseScore2를 이용하여 8마디 가락을 창작하게 하였다. 합의적 평가기법(CAT)을 이용하여 평가한 결과, 두 나라 간 창의성에서 통계적으로 유의미한 차이가 없었다. 그러나 창의성에서 높은 점수와 낮은 점수를 받은 작품들을 추가적으로 분석한 결과, 창의성이 높은 그룹은 다양한 소리 선택, 발전과 대조, 구조화 등의... -
이차구개 형태분화의 내적 조절유전자 규명
이재국, 장은하, 임양희, 김기병, 고승오, 조의식, 신효근 대한구순구개열학회 대한구순구개열학회지 16 Pages
대한구순구개열학회 대한구순구개열학회지 2007, 제 10권 1호 1 1-16 (16 pages)
이차구개는 발생과정에서 구개선반의 형성과 성장, 거상과 융합의 과정을 통해 형성된다. 이와 같은 이차구개의 형성과정은 미세한 분자유전학적 신호전달기전에 의해 조절되는 것으로 알려져 있어서, 신호전달과정에 관여하는 유전인자의 발현이상이 되면 정상적인 이차구개가 형성되지 못하고 구개파열이라는 선천성 기형이 발생된다. 구개파열의 유발인자들에 대한 많은 연구에도 불구하고 현재까지 정상적인 이차구개의 형성을 조절하는 분자유전학적 기전에 대해서는 명확히 알려져 있지 않다. 따라서 본 연구에서는 이차구개의... -
Spatial reproducibility of complex fractionated atrial electrogram depending on the direction and configuration of bipolar electrodes: an in-silico modeling study
Jun-SeopSong, Young-SeonLee, MinkiHwang, Jung-KeeLee, ChangyongLi, BoyoungJoung, Moon-HyoungLee, EunBoShim, Hui-NamPak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 8 507-514 (8 pages)
Although 3D-complex fractionated atrial electrogram (CFAE) mapping is useful in radiofrequency catheter ablation for persistent atrial fibrillation (AF), the directions and configuration of the bipolar electrodes may affect the electrogram. This study aimed to compare the spatial reproducibility of CFAE by changing the catheter orientations and electrode distance in an in -silico left atrium (LA). We conducted this study by importing the heart CT image of a patient with AF into a 3D-homogeneous... -
High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells
Oak-KeeHong, Soon-JibYoo, Jang-WonSon, Mee-KyoungKim, KiHyunBaek, Ki-HoSong, Bong-YunCha, HanjoongJo, Hyuk-SangKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 5 169-175 (7 pages)
Here, we investigated whether hyperglycemia and/or free fatty acids (palmitate, PAL) aff ect the expression level of bone morphogenic protein 4 (BMP4), a proatherogenic marker, in endothelial cells and the potential role of BMP4 in diabetic vascular complications. To measure BMP4 expression, human umbilical vein endothelial cells (HUVECs) were exposed to high glucose concentrations and/ or PAL for 24 or 72 h, and the effects of these treatments on the expression levels of adhesion molecules and... -
The Pathophysiologic Roles of TRPM7 Channel
HyunSooPark, ChansikHong, ByungJooKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 2 15-23 (9 pages)
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2＋ and Ca2＋, and its channel activity is negatively regulated by free Mg2＋ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell... -
Binding Specificity of Philyra pisum Lectin to Pathogen-Associated Molecular Patterns, and Its Secondary Structure
ByungTaePark, ByungSunKim, HeajinPark, JaehoonJeong, HanbitHyun, HyeSeongHwang, HaHyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 11 547-552 (6 pages)
We recently reported a Philyra pisum lectin (PPL) that exerts mitogenic effects on human lym-phocytes, and its molecular characterization. The present study provides a more detailed charac-terization of PPL based on the results from a monosaccharide analysis indicating that PPL is a glycoprotein, and circular dichroism spectra revealing its estimated α-helix, β-sheet, β-turn, and random coil contents to be 14.0%, 39.6%, 15.8%, and 30.6%, respectively. These contents are quite similar to those... -
The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell
Kyung-SunPark, MinHoHan, HeeKyungJang, Kyung-AKim, Eun-JongCha, Wun-JaeKim, YungHyunChoi, YangmiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 6 511-516 (6 pages)
Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium channels have been linked with cell proliferation. Some two-pore domain K＋ channels (K2P), such as TASK3 and TREK1, have recently been shown to be overexpressed in cancer cells. Here we focused on the relationship between cell growth and the mechanosensitive K2P channel, TREK2, in the human bladder cancer cell... -
Gene Expression Profile in Microglia following Ischemia- Reperfusion Injury
JuHyeonOh, HyungSooHan, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 2 173-180 (8 pages)
Microglial activation is thought to play a role in the pathogenesis of many brain disorders. Therefore, understanding the response of microglia to noxious stimuli may provide insights into their role in disorders such as stroke and neurodegeneration. Many genes involved in this response have been identified individually, but not systematically. In this regards, the microarray system permitted to screen a large number of genes in biological or pathological processes. Therefore, we used microarray... -
Kinesin Superfamily KIF5 Proteins Bind to βIII Spectrin
Jae-EunPaik, NariKim, SungSuYea, WonHeeJang, Joon-YoungChung, Sang-KyoungLee, Yeong-HongPark, JinHan, Dae-HyunSeog 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 8 167-172 (6 pages)
The kinesin proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF5 is a heterotetrameric motor that conveys vesicles and plays an important role in neuronal function. Here, we used the yeast two-hybrid system to identify the neuronal protein(s) that interacts with the tail region of KIF5 and found a specific interaction with βIII spectrin. The amino acid residues between 1394 and 1774 of βIII spectrin were... -
Physiological, Pharmacological and Toxicological Implications of Heterodimeric Amino Acid Transporters
YoshikatsuKanaiHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 1 117-128 (12 pages)
The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT (related to b0, -amino acid transporter). Six members are associated with 4F2hc and one is linked... -
Alzheimer형 치매 의심 환자의 신경심리검사 소견
박종한, 이종학 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 4호 11 705-711 (7 pages)
목 적：Alzheimer형 치매의심(QDAT)과 비치매간에 신경심리 검사 성적을 비교함으로서 QDAT의 특 성을 밝히는 것이 본 연구의 목적이다. 대상과 방법：어느 농촌 지역에서 행해진 치매의 역학적 연구에서 QDAT로 진단된 노인들 14명, 그리고 이들과 연령, 성, 교육 수준을 통제한 비치매 대조군 14명이었다. 사용된 신경심리 검사는 한국판 Wechsler 지능검사의 이해 문제, 숫자 외우기, 산수 문제, 공통성 문제와 토막 짜기, Wechsler 기억 검사의 즉각적 회 상, 지연성 회상과 연상 학습, 그리고 언어 유창성 검사이었다. 결 과：이해... -
폐경기 여성에서 에스트로젠 사용이 인지기능에 미치는 영향
김성엽, 기백석, 남범우, 이상훈 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 1호 16 183-189 (7 pages)
비사용군 15명을 선택하여 K-BNT(Boston naming test, Korean version), SRT(Selective reminding test), 공통성 검사(similarity test)를 사용하여 인지기능의 차이를 알아보려고 하였다. 더불어 BDI(Beck depression inventory)를 이용하여 우울에 미치는 영향도 함 께 알아보려고 하였다. 결 과： 에스트로젠 사용군은 비사용군에 비해 공통성 검사, SRT(delayed recall) 그리고 BDI에서 유의한 차이가 있었다. 결 론： 에스트로젠 비사용군에 비해 사용군에서 기억력에만 한정된 인지기능의 호전뿐만 아니라 추상적 사고영역 등 다른... -
여성 경도 알쯔하이머형 치매군, 치매의심군 그리고 비치매 대조군간의 신경인지기능 비교
이은하, 안석균, 오병훈, 김기현, 이연희, 오희철, 김승민 대한신경정신의학회 신경정신의학 16 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 1호 15 167-182 (16 pages)
사(Similarity), 판단력검사(Judgment), Go-No-Go 검사, Vienna test system의 가설형성검사(Hypotheis formation test), 보속증검사(Perseveration test)를 이용하여 평가하였다. 진단을 독립변수로, 각종 신경인지기능검사의 결과를 종속변수로 설계하여 one-way ANOVA를 실시하였고, 유의한 차이를 보인 종 속변수에 대해서는 사후분석을 실시하였다. 경도 알쯔하이머형 치매군 5인, 치매 의심군 9인 및 비치매 대조군 14인을 대상으로 신경인지기능을 평 가한 결과, 언어적연상학습의 즉각회상 중에서 쉬운짝연상(경도 치매군,... -
역학적 연구에서 치매 의심의 문제 : 경도 치매와의 비교
박종한, 조성완, 이황회, 최상용 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 1993, 제 32권 제 4호 13 572-578 (7 pages)
