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In vitro and in vivo gene therapy with CMV vector-mediated presumed dog β-nerve growth factor in pyridoxine-induced neuropathy dogs
Jin-Young Chung, Jung-Hoon Choi, Il-Seob Shin, Eun-Wha Choi, Cheol-Yong Hwang, Sang-Koo Lee, Hwa-Young Youn* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 4호 5 367-374 (8 pages)
Due to the therapeutic potential of gene therapy for neuronal injury, many studies of neurotrophic factors, vectors, and animal models have been performed. The presumed dog β-nerve growth factor (pdβ-NGF) was generated and cloned and its expression was confirmed in CHO cells. The recombinant pdβ-NGF protein reacted with a human β-NGF antibody and showed bioactivity in PC12 cells. The pdβb-NGF was shown to have similar bioactivity to the dog β-NGF. The recombinant pdβ-NGF plasmid was... -
Pyridoxine induced neuropathy by subcutaneous administration in dogs
Jin-Young Chung, Jung-Hoon Choi, Cheol-Yong Hwang, Hwa-Young Youn* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 2호 2 127-132 (6 pages)
in the axons and myelin with vacuolation. The dorsal root ganglia of L4, and sciatic and tibial nerves showed degenerative changes and vacuolation. However, the lateral and ventral funiculi of L4 showed a normal histopathologic pattern. Although this subcutaneous administration method did not cause systemic toxicity and effectively induced sensory neuropathy, this study confirmed the possibility of producing a pyridoxine-induced sensory neuropathy model in dogs with short-term administration. -
Factors that Affect Remission of Chemotherapy-Induced Peripheral Neuropathy Symptoms: Short-Term Prospective Study
Jeong Gay Suk, Choi Jin Yi, Choi Heejung 한국기초간호학회 Journal of Korean Biological Nursing Science 9 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2022, Volume 24, No 2 2 86-94 (9 pages)
Purpose: Patients experiencing chemotherapy-induced peripheral neuropathy (CIPN) apply various palliative care as well as drugs in their daily life to alleviate symptoms. There is a need to identify the influence of these efforts and patients’ psychosocial status on the relief of CIPN symptoms. This short-term prospective study investigated how prescription drugs, non-pharmacological behaviors (exercise, massage, and heat therapy), and psychological states (social support, depression, and... -
Wide phenotypic variations in Charcot-Marie-Tooth 1A neuropathy with rare copy number variations on 17p12
Kanwal. Sumaira, Choi. Byung-Ok, Kim. Sang-Beom, Koo. Hea-Soo, Kim. Jee-Young, Hyun. Young-Se, Lee. Hye-Jin, Chung. Ki-Wha 한국통합생물학회 Animal cells and systems 9 Pages
한국통합생물학회 Animal cells and systems 2011, Vol.15 No.4 301-309 (9 pages)
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Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice
Moon. Eunjung, Lee. Sung Ok, Kang. Tong Ho, Kim. Hye Ju, Choi. Sang Zin, Son. Mi-Won, Kim. Sun Yeou 한국응용약물학회 Biomolecules & therapeutics 8 Pages
한국응용약물학회 Biomolecules & therapeutics 2014, Vol.22 No.5 445-452 (8 pages)
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Treatment of chemotherapy-related peripheral neuropathy with traditional Chinese medicine from the perspective of blood-arthralgia Zheng
Cao. Peng, Yang. Jie, Cai. Xueting, Wang. Xiaoning, Huo. Jiege 탕정한의학회 TANG : International journal of genuine traditional medicine 1 Pages
탕정한의학회 TANG : International journal of genuine traditional medicine 2012, Vol.2 No.4 30-30 (1 pages)
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The Kampo Medicine Goshajinkigan Prevents Neuropathy in Breast Cancer Patients Treated with Docetaxel
Abe. Hajime, Kawai. Yuki, Mori. Tsuyoshi, Tomida. Kaori, Kubota. Yoshihiro, Umeda. Tomoko, Tani. Tohru 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.11 6351-6356 (6 pages)
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Lumbar Plexopathy Caused by Metastatic Tumor, Which Was Mistaken for Postoperative Femoral Neuropathy
Lee. Ki-Hwa, Choe. Ji-Hyun, Lee. Sang-Eun, Park. Jae-Hong, Bang. Si-Ra, Kim. Yong-Han, Jeon. Sang-Yoon 대한통증학회 The Korean journal of pain 5 Pages
대한통증학회 The Korean journal of pain 2011, Vol.24 No.4 226-230 (5 pages)
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A Novel Botanical Drug for the Treatment of Diabetic Neuropathy
Choi. Sang-Zin, Son. Mi-Won 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 3 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2011, Vol.34 No.6 865-867 (3 pages)
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How to Overcome Retinal Neuropathy: The Fight against Angiogenesisrelated Blindness
Jo. Dong-Hyun, Kim. Jin-Hyoung, Kim. Jeong-Hun 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2010, Vol.33 No.10 1557-1565 (9 pages)
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Combination of Vitamin C and Rutin on Neuropathy and Lung Damage of Diabetes Mellitus Rats
Sohn. Uy-Dong, Je. Hyun-Dong, Shin. Chang-Yell, Park. Sun-Young, Yim. Sung-Hyuk, Kum. Chan, Huh. In-Hoi, Kim. Jin -Hak 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002, Vol.25 No.2 184-191 (8 pages)
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Clinical Features of Wrist Drop Caused by Compressive Radial Neuropathy and Its Anatomical Considerations
Han. Bo Ram, Cho. Yong Jun, Yang. Jin Seo, Kang. Suk Hyung, Choi. Hyuk Jai 대한신경외과학회 Journal of Korean neurosurgical society 4 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2014, Vol.55 No.3 148-151 (4 pages)
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Usefulness of Ultrasound for Detecting Suspected Peripheral Nerve Lesions in Diagnosis of Peripheral Neuropathy : Case Report and Brief Review of the Literature
Jung. Jae-Hyun, Kim. Kwang-Hai, Choi. Soon-Kyoo, Shim. Jae-Hyun 대한신경외과학회 Journal of Korean neurosurgical society 4 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2013, Vol.53 No.2 132-135 (4 pages)
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Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy
Han. Kyoung-Hee, Kim. Sung-Hoon, Jeong. In-Cheol, Lee. Young-Hee, Chang. Sei-Jin, Park. Bit-Na-Ri, Kim. Seok-Won 대한신경외과학회 Journal of Korean neurosurgical society 5 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2012, Vol.52 No.1 32-36 (5 pages)
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Clinical Outcomes of the Surgical Excision of the Ganglion Cyst Causing Compressive Neuropathy - A Review of Twelve Collected Cases -
정성택, 조성범, 문은선, 이재준, 김기형, 양현기, Jung. Sung-Taek, Cho. Seong-Beom, Moon. Eun-Sun, Lee. Jae-Joon, Kim. Ki-Hyeoung, Yang. Hyun-Kee 대한골관절종양학회 대한골관절종양학회지 8 Pages
대한골관절종양학회 대한골관절종양학회지 2006, Vol.12 No.1 63-70 (8 pages)
목적: 이 연구의 목적은 말단 신경을 침범하는 결절종을 가진 환자의 수술적 치료를 고찰하는 데 있다. 대상 및 방법: 1995년부터 2000년까지 결절종으로 인한 신경적 증상을 가지고 있었고 수술적으로 치료받았던 12예의 환자를 대상으로 하였다. 평균 나이는 44.3(15-71)세였다. 압박 받았던 신경은 경골 신경이 3예로 가장 많았고 견갑상 신경, 총 비골 신경, 요골 신경, 척골 신경이 각각 2예, 정중 신경이 1예였다. 동통은 6명의 환자에서 있었고, 감각 이상이나 운동력 저하가 각각 7예의 환자에서 보였고 4명의 환자에서는 이 두... -
Musculoskeletal diseases of heavy industrial workers
Hyun-jin Baek, Sun-hae Song, Dong-geon Lee, Seung-hyeon Pyo, Doo-chul Shin, Gyu-chang Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 2호 4 71-76 (6 pages)
Objective: The purpose of this study was to investigate the musculoskeletal diseases (MSDs) that occur in heavy industrial workers according to the occupational category, prevalence, environment, and number of physical therapy visits. Design: Retrospective cohort study. Methods: For this study, data was collected of workers who were engaged in heavy industry in Korea and who visited the company physicians and received physical therapy in 2016. Data was collected from 855 subjects and was... -
Effects of balance imagery of semi-tandem stance on a flat floor and balance beam for postural control
Jeong-Weon Lee, Su-jin Hwang 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 2호 5 87-93 (7 pages)
Objective: Balance is a preceding task for functional activities in daily activities as well as community-dwelling activities. To learn skilled and functional activities, it is also necessary to imagine an appropriate and effective movement representation used to plan and execute the functional activities. The purpose of this study was to evaluate the effects of balance imagery of semi-tandem stance on a flat floor and balance beam on balance abilities for elderly and young adults. Design:... -
The effects of low level laser radiation on bacterial growth
Wendy Chung, Jerrold S. Petrofsky, Michael Laymon, Jason Logoluso, Joon Park, Judy Lee, Ha-neul Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 4 20-26 (7 pages)
Objective: The low level lasers currently in the market vary in wavelength, dosage, and frequency. These devices are used with much different clinical pathology. Most notably, some studies claim that wounds heal faster with low level laser therapy due to the fact that bacteria commonly found in wounds are killed by laser light. Systemic and meta-analysis studies found the difficulty of comparison of numerous research studies because of differences in the intensities and frequencies of low level... -
Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway
Ziqiang Zhang, Yumei Liu, Xuemin Zhu, Lan Wei, Jiamin Zhu, Ke Shi, Guotao Wang, Li Pan 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 6 512-518 (7 pages)
Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may have to be sacrificed to obtain enough sciatic nerves to make a sciatic nerve preparation. Some studies have demonstrated that the role of sciatic nerve preparations in neural differentiation depends on the neurotrophins that Schwann cells secrete, and these factors are... -
Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
Ihsan Ali, Syed Zahid Ali Shah, Yi Jin, Zhong-Shu Li, Obaid Ullah, Nan-Zhu Fang 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 1 1-9 (9 pages)
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic development with the increase in protein requirements for cell survival and growth. The ER is a multifunctional cellular organelle responsible for protein folding, modification, and cellular homeostasis. ER stress is activated by a variety of factors including... -
Distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens in nervous and non-nervous organs of European seabass (Dicentrarchus labrax) during the course of an experimental challenge
Benjamin Lopez-Jimena, Esther Garcia-Rosado, Kim Dawn Thompson, Alexandra Adams, Carlos Infante, Juan Jose Borrego, Maria del Ca 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 4호 4 355-362 (8 pages)
The distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens was examined by immunohistochemistry in the nervous and non-nervous organs of juvenile European seabass (Dicentrarchus labrax) during the course of an intramuscular infection. Histological changes resulting from the infection were evaluated from 3 days to 2 months post-infection. The specific antibody response was also studied 2 months post-challenge. Viral proteins were present throughout the experimental period in... -
Evaluation of the Perkins handheld applanation tonometer in horses and cattle
Silvia Franco Andrade, Daniel Silva Kupper, Luiz Fernando Rodrigues de Pinho, Elizabeth Cunha Franco, Marcus Vin?cius Felix Fabr 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 2호 10 171-176 (6 pages)
The objective of this study was to evaluate and validate the accuracy of the Perkins handheld applanation tonometer for measuring intraocular pressure (IOP) in horses and cattle. Both eyes of 10 adult horses and cattle were evaluated in a postmortem study. The eyes from 10 clinically normal adult horses and cattle were also examined after bilateral auriculopalpebral nerve block and topical anesthesia for an in vivo study. IOP was measured postmortem using direct manometry (measured with an... -
Ultrasonographic examination of the carpal canal in dogs
Erkut Turan*, Yelda Ozsunar, Ismail Gokce Yildirim 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 12 77-80 (4 pages)
The aim of this study was to determine the course of the median nerve and its adjacent structures in the carpal canals of 8 healthy dogs by using high-frequency transducers. Before performing ultrasonography, the transverse and posteroanterior diameters as well as the perimeter of the carpus were measured at just proximal to the side of the carpal pad. The anatomical structures were then determined at two levels of the carpal canal, which were named the proximal and distal levels, on the... -
Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome
Jun-Ho La, Tae-Wan Kim, Tae-Sik Sung, Hyun-Ju Kim, Jeom-Yong Kim, Il-Suk Yang 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 6 319-324 (6 pages)
The involvement of mucosal mast cells (MMC) in the pathophysiology of irritable bowel syndrome (IBS) is still controversial. We aimed to re-evaluate the role of MMC in visceral hypersensitivity associated with IBS using a rat IBS model that develops the IBS symptom after a subsidence of acetic acid-induced colitis. No significant difference in the number of MMC was observed between normal rat colon and IBS rat colon. (61.7 ±2.9/mm 2 in normal vs. 88.7 ±13.3/mm 2 in IBS, p > 0.29). However, the... -
Original Article : Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
Kang Min Chung , Won Young Kang , Dong Geon Kim , Hyun Ju Hong , Young Jae Lee , Chang Hoon Han 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 1호 4 21-26 (6 pages)
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악기 연주가 유발할 수 있는 임상 질환의 소개 및 분류
문호진(HoJin MOON) 한국음악교육공학회 음악교육공학 19 Pages
한국음악교육공학회 음악교육공학 2012, 제 15호 7 111-129 (19 pages)
연주 활동은 일상의 신체 활동과는 다른 동작을 필요로 한다. 연주자는 오랜 시간 연주 자세를 유지하며 고난이도의 동작을 거듭한다. 실수없는 표현을 위한 정신적인 긴장과 더불어 지속적이며 반복적인 근골격계의 움직임으로 육체적인 피로가 누적된다. 연주자는 일반적으로 노출된 피로에 적응하고 회복하지만 회복 기회가 충분하지 않다면 증상은 통증과 운동 이상, 감각마비 또는 감염 등을 동반한 질환에 이르게 된다. 이에 본 연구는 국내 연주인들이 겪고 있는 질환의 유병율을 인식하는 데에서 출발하여 국내외 연주자 질환... -
소청룡탕 추출물의 당뇨병 질환에서 위장관 운동 기능 개선에 관한 연구
배진수, 김익성, 서병도, 김병주 한방비만학회 대한한방비만학회지 7 Pages
한방비만학회 대한한방비만학회지 2017, 제 17권 제 2호 1 61-67 (7 pages)
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Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells
Yong Soo Park, Seok Ho Myeong, In-Beom Kim, Ki-Wug Sung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 12 585-595 (11 pages)
Amitriptyline, a tricyclic antidepressant, is commonly used to treat depression and neuropathic pain, but its mechanism is still unclear. We tested the effect of amitriptyline on 5-hydroxytryptamine 3 (5-HT3) receptor currents and studied its blocking mechanism because the clinical applications of amitriptyline overlapped with 5-HT3 receptor therapeutic potentials. Using a whole-cell voltage clamp method, we recorded the currents of the 5-HT3 receptor when 5-HT was applied alone or co-applied... -
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
Jong Soo Han, Young Sil Min, Gil Hyung Kim, Sang-hyun Chae, Yoonjin Nam, Jaehwi Lee, Seok-Yong Lee, Uy Dong Sohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 11 577-584 (8 pages)
Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors. In the present study, we compared the contractility of bladder smooth muscle from normal rats and DM rats. Furthermore, we utilized pharmacological inhibitors to delineate the mechanisms underlying bladder muscle differences between normal and DM rats. DM was established in 14 days after... -
Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
Seon-Hui Jang, Soo-Joung Park, Chang-Jin Lee, Dong-Kuk Ahn, Seong-Kyu Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 7 539-546 (8 pages)
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action... -
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain
MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)
a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced cold and... -
RhGLP-1 (7-36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD
YiFang, XiaofangLiu, LiboZhao, ZhongnaWei, DaoliJiang, HuaShao, YannanZang, JiaXu, QianWang, YangLiu, YePeng, XiaoxingYin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 3 475-485 (11 pages)
The present study aimed to explore the neuroprotective effect and possible mechanisms of rhGLP-1 (7-36) against transient ischemia/reperfusion injuries induced by middle cerebral artery occlusion (MCAO) in type 2 diabetic rats. First, diabetic rats were established by a combination of a high-fat diet and low-dose streptozotocin (STZ) (30 mg/kg, intraperitoneally). Second, they were subjected to MCAO for 2 h, then treated with rhGLP-1 (7-36) (10, 20, 40 μg/kg i.p.) at the same time of... -
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM... -
Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms
AmritpalSinghAulakh, PuneetKaurRhawa, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 1 145-152 (8 pages)
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce... -
Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats
MinJiKim, YoungHongPark, KuiYeYang, JinSookJu, YongChulBae, SeongKyuHan, DongKukAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 8 65-74 (10 pages)
Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing 230-280 g. Subcutaneous injection of interleukin 1 beta (IL-1β) (1 ng/10 μL) was used to produce mechanical allodynia and thermal hyperalgesia. Intracisternal administration of bicuculline, a gamma aminobutyric acid A (GABAA) receptor antagonist, produced mechanical...


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