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Interaction between Cholecystokinin and Secretin in Isolated Rat Pancreatic Acini
Yoon, Shin-Hee, Hahn, Sang-June, Sim, Sang-Soo, Rhie, Duck-Joo, Song, In-Young, Baek, Hye-Jung, Kim, Myung-Suk, Jo, Yang-Hyeok 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 6 243-250 (8 pages)
(CCK) and secretin in amylase secretion from isolated rat pancreatic acini was investigated. Combined treatment of acini with secretin and CCK at low concentrations, which are known to be physiological, resulted in enzyme secretion larger than the arithmetic sum of their separate effects. Such a potentiating effect also occurred between secretin and A23187 (Ca ionophore), between forskolin (adenylate cyclase activator) and CCK, and between forskolin and A23187. Staurosporin (protein kinase C... -
Cholinergic Control of Pancreatic Secretion: The Effects of Atropine on Plasma Cholecystokinin and Secretin Release
Jo, Yang-Hyeok, Rhie, Duck-Joo, Chang, Young-Soon, Hahn, Sang-June, Sim, Sang-Soo, Kim, Myung-Suk, Kim, Chung-Chin 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 3 27-36 (10 pages)
Generally, it has been known that cholecystokinin (CCK) release into the plasma is under cholinergic control, but secretin release is not. Thus in anesthetized dogs we studied the effect of atropine (50 μg/kg followed by 50 μg/kg/hr) on pancreatic secretion and plasma concentrations of bioactive CCK and immunoreactive secretin in response to intraduodenal perfusion of sodium oleate (1, 3 and 9 mmol/hr). The volume, protein output and bicarbonate output of the secretion were increased by sodium... -
정맥 주입한 Catecholamine이 흰쥐의 기초상태시 위산, Gastrin 및 Secretin 분비에 미치는 영향
김명석(Kim, Myung-Suk), 심상수(Sim, Sang-Soo), 김미혜(Kim, Mie-Hye), 최현(Choi, Hyun) 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1988, 제 22권 제 2호 3 179-188 (10 pages)
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정상 한국 성인의 공복시 및 식후 혈장 Secretin 농도
심여림(Sim, Yeo-Rim), 조양혁(Jo, Yang-Hyeok), 심상수(Sim, Sang-Soo), 남상채(Nam, Sang-Chae), 김명석(Kim, Myung-Suk) 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1985, 제 19권 제 2호 6 161-172 (12 pages)
경향이었으며, 단지 식후 30분의 값에서만 유의하게 증가하였다. 식후 혈장 secretin농도의 증가폭은 햄버거에서의 증가 값이 쌀밥에서의 값보다 더 컸다. 나머지 8명은 자당 용액과 생리 식염수를 마셨다. 자당 용액의 섭취후 평균 혈장 secretin농도(10 ~ 14 pg/ml)는 공복시의 값보다 유의하게 증가하였으나 쌀밥의 값과 마찬가지로 일시적이었다. 그러나 생리 식염수를 섭취한 후에는 혈장 secretin농도에 이렇다할 변화가 없었다. 이상의 결과로 미루어 정상 한국 성인에서는 단백질 음식물은 물론 탄수화물 음식물의 섭취로도... -
단삼보혈탕(丹蔘補血湯)이 혈청(血淸) gastrin, secretin 및 중추신경계(中樞神經系)에 미치는 영향(影響)
여은경, 윤상협, 류봉하, 박동원, 류기원, Yeo. Eun-Kyung, Yun. Sang-Hyup, Rue. Bong-Ha, Park. Dong-Won, Rue. Gi-Won 대한한방내과학회 대한한방내과학회지 16 Pages
대한한방내과학회 대한한방내과학회지 1998, Vol.19 No.2 233-248 (16 pages)
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Intragastric gavage with denatonium benzoate acutely induces neuronal activation in the solitary tract nucleus via the vagal afferent pathway
Hyo Young Jung, Woosuk Kim, Dae Young Yoo, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Yeo Sung Yoon, Hye Young Kim, In Koo Hwan 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 4호 1 459-464 (6 pages)
Natural toxic substances have a bitter taste and their ingestion sends signals to the brain leading to aversive oral sensations. In the present study, we investigated chronological changes in c-Fos immunoreactivity in the nucleus tractus solitarius (NTS) to study the bitter taste reaction time of neurons in the NTS. Equal volumes (0.5 mL) of denatonium benzoate (DB), a bitter tastant, or its vehicle (distilled water) were administered to rats intragastrically. The rats were sacrificed at 0, 0.5,... -
An immunohistochemical study of the gastrointestinal endocrine cells in the ddY mice
Sae-kwang Ku, Hyeung-sik Lee, Jae-hyun Lee 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 1 87-95 (9 pages)
The distributions and frequencies of some endocrine cells in the gastrointestinal (GI) tract of ddY mice were studied with immunohistochemical method using 7 types of antisera against bovine chromogranin (BCG), serotonin, gastrin, cholecystokinin (CCK)-8, somatostatin, glucagon and human pancreatic polypeptide (HPP). All of 7 types of immunoreactive (IR) cells were identified. Most of IR cells in the intestinal portion were generally spherical or spindle in shape (open typed cell) while cells... -
An immunohistochemical Study on the Pancreatic Endocrine Cells of the C57BL/6 Mouse
Sae-Kwang Ku, Hyeung-Sik Lee and Jae-Hyun Lee 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 11 327-333 (7 pages)
The regional distribution and relative frequency of the pancreatic endocrine cells in the C57BL/6 mouse were studied by immunohistochemical method using four types of specific mammalian antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (PP). The pancreas of mouse could be divided into three portions; pancreatic islets, pancreatic duct and exocrine portions, and pancreatic islets were further subdivided into three regions (central, mantle and peripheral regions)... -
Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)
Seong-Mok Jeong 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 8 303-314 (12 pages)
The regional distribution and relative frequency of some endocrine cells in the pancreas of the carp, Cyprinus carpio Linnaeus, belonging to the family Cyprinidae in the order Cypriniformes, were observed using specific mammalian antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP) by peroxidase antiperoxidase (PAP) method. The pancreas was divided into four regions (principal and secondary islets, exocrine and pancreatic duct regions). In addition, the... -
Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in Large Intestines of C57BL/6 Mice
Tae-Su Ham 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 13 233-238 (6 pages)
The regional distributions and relative frequencies of some gastrointestinal endocrine cells in the three portions (cecum, colon and rectum) of the large intestinal tract of C57BL/6 mice were examined with immunohistochemical method using 7 types of specific antisera against chromogranin A (CGA), serotonin, somatostatin, human pancreatic polypeptide (HPP), glucagon, gastrin and cholecyctokinin (CCK)-8. In this study, all 3 types of immunoreactive (IR) cells were identified. Most of these IR... -
Immunohistochemical Study of the Pancreatic Endocrine Cells inthe BALB/c mice: An Unique Distributional Pattern of Glucagon
Sae-Kwang Ku, Hyeung-Sik Lee and Jae-Hyun Lee 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 4 167-173 (7 pages)
The regional distribution and relative frequency of insulin-, glucagon-, somatostatin- and pancreatic polypeptide (PP)-producing endocrine cells in the pancreas of BALB/c mouse were investigated by immunohistochemical method. The pancreas of mice was divided into two portions; pancreatic islets and exocrine portions, and pancreatic islets were further subdivided into two regions (central and peripheral regions) and the relative frequency and regional distribution of immunoreactive cells against... -
Comparative study of endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus (Siluridae) and Siniperca scherzeri (Centropomidae)
Jae-hyun Lee, Sae-kwang Ku, Ki-dae Park and Hyeung-sik Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 2호 1 75-80 (6 pages)
The regional distribution and relative frequency of some endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus Linne (Siluridae) and Siniperca scherzeri Steindachner (Centropomidae), which have similar feeding habits, were observed using specific antisera against insulin, glucagon, somatostatin and bovine pancreatic polypeptide (bovine PP) using the peroxidase antiperoxidase (PAP) method. Spherical to spindle shaped cells were demonstrated in the principal pancreatic... -
An immunohistochemical study on the pancreatic islets cells of the Mongolian gerbils, Meriones unguiculatus
Sae-kwang Ku, Hyeung-sik Lee, Ki-dae Park, Jae-hyun Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 1호 2 9-14 (6 pages)
In order to study the regional distribution and relative frequency of the immunoreactive endocrine cells in the pancreatic islets of the Mongolian gerbil, pancreatic sections of Meriones unguiculatus were immunostained using an immunohistochemical (PAP) method with four types of specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (PP). The pancreatic islets were subdivided into three portions (central region, mantle zone and peripheral region) according to... -
Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
MeiJinWu, KeunHongKee, JisunNa, SeokWonKim, YouinBae, DongHoonShin, SeokChoi, JaeYeoulJun, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 6 435-440 (6 pages)
This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the underlying mechanisms of PACAP action. Spontaneous pacemaker activity of colonic ICC and the effects of PACAP were studied using electrophysiological recordings. Exogenously applied PACAP induced hyperpolarization of the cell membrane and inhibited pacemaker frequency in a dose-dependent manner (from... -
Hypericum Perforatum Decreased Hippocampus TNF-α and Corticosterone Levels with No Effect on Kynurenine/Tryptophan Ratio in Bilateral Ovariectomized Rats
WesamMEl-Bakly, AmanyHHasanin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 6 233-239 (7 pages)
The present study was designed to investigate the effect Hypericum Perforatum (HP), on behavioral changes, corticosterone, TNF-α levels and tryptophan metabolism and disposition in bilateral ovariectomized rats compared to 17α-ethinylestradiol. Behavioral analysis by measuring immobility time in forced swimming test and open field test, serum and hippocampal corticosterone and TNF-α along with hippocampal kynurenine/tryptophan ratio were determined in mature ovariectomized rats treated orally... -
DA-6034 Induces [Ca2+]i Increase in Epithelial Cells
Yu-MiYang, SoonhongPark, HyeWonJi, Tae-imKim, EungKweonKim, KyungKooKang, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 1 89-94 (6 pages)
DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces Ca2+ signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in Ca2+... -
Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas
ZhengerJiang, Bich-NaShin, In-HyeKim, HyunJooLee, Jun-HwanYong, Min-JaeLee, Moo-HoWon, Yun-LyulLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 9 307-312 (6 pages)
It has been rereported that axons which display 5-hydroxytryptamine (5-HT) immunoreactivity are abundant in the pancreas and the majority of serotonergic axons terminate within intrapancreatic ganglia, islet and acini. This histological result strongly suggests that intrapancreatic serotonergic nerves could affect to the pancreatic endocrine and exocrine secretion. Thus, this study was aimed to investigate whether intrapancreatic serotonergic nerves could affect pancreatic exocrine secretion and... -
Role of Gap Junction in the Regulation of Renin Release and Intracellular Calcium in As 4.1 Cell Line
JeongHeeHan, Bing-ZheHong, YoungGeunKwak, KuichangYuan, WooHyunPark, SungZooKim, SuhnHeeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 5 107-112 (6 pages)
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of gap junction in renin secretion and its underlying mechanisms using As 4.1 cell line, a renin-expressing clonal cell line. Renin release was increased proportionately to incubation time. The specific gap junction inhibitor, 18-beta glycyrrhetinic acid (GA) increased renin release in dose-dependent and time-... -
Ca2+-activated K+ Currents of Pancreatic Duct Cells in Guinea-pig
Han-WookLee, JingchaoLi, Na-YounKoo, ZhengGenPiao, SungMinHwang, Jae-WoongHan, Han-SaemChoi, Jong-HeunLee, JoongSooKim, KyungpyoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 7 335-338 (4 pages)
There are numerous studies on transepithelial transports in duct cells including Cl and/or HCO3. However, studies on transepithelial K transport of normal duct cells in exocrine glands are scarce. In the present study, we examined the characteristics of K currents in single duct cells isolated from guinea pig pancreas, using a whole-cell patch clamp technique. Both Cl and K conductance were found with KCl rich pipette solutions. When the bath solution... -
Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas
HyungSeoPark, SeHoonKim, HyoungJinPark, MeeYoungLee, YoungHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 5 217-221 (5 pages)
to basal value. Moreover, secretin-induced fluid secretion was not affected by infusion of progesterone. Therefore, initial increase of secretion-induced amylase secretion by progesterone seems to be a non-specific action by washout effect of secretin. Estradiol-17β failed to change the secretin-induced fluid and amylase secretion. Both progesterone and estradiol-17β did not exert any influence on CCK-induced fluid and amylase secretion. Acetylcholine-induced exocrine secretion of isolated... -
Effects of γ-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas
YongDeukPark, HyungSeoPark, ZhengYunCui, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 8 169-174 (6 pages)
γ-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly that exert a stimulatory role in exocrine secretion. This study was undertaken to examine effects of GABA on an action of cholinergic neurons in exocrine secretion of the pancreas. Intrinsic neurons were excited by electrical field stimulation (EFS; 15 V, 2 msec, 8 Hz, 45 min)... -
Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats
Myung-JunKim, GyeongRyulRyu, Sae-YoungYi, DoSikMin, Duck-JooRhie, ShinHeeYoon, SangJuneHahn, Myung-SukKim, Yang-HyeokJo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 6 311-317 (7 pages)
Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also... -
Characterization of Intermediate Conductance K+ Channels in Submandibular Gland Acinar Cells
Sung-ManCho, ZhengGenPiao, YoonBaeKim, Joong-SooKim, KyungpyoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 5 305-309 (5 pages)
There are some evidences that K efflux evoked by muscarinic stimulation is not mainly mediated by large conductance K (BK) channels in salivary gland. In this experiment, we therefore characterised non BK channels in rat submandibular gland acinar cells and examined the possibility of agonist effect on this channel using a patch clamp technique. Two types of K channels were observed in these cells. BK channels were observed in 3 cells from total 6 cells and its average... -
Molecular Mechanism of Pancreatic Bicarbonate Secretion
MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 1 131-138 (8 pages)
Thanks to recent progress in availability of molecular and functional techniques it became possible to search for the basic molecular and cellular processes that mediate and control HCO3 and fluid secretion by the pancreatic duct. The coordinated action of various transporters on the luminal and basolateral membranes of polarized epithelial cells mediates the transepithelial HCO3 transport, which involves HCO3 absorption in the resting state and HCO3 secretion in the... -
Distribution, Content and Molecular Heterogeneity of Gastrin- Releasing Peptide in Rat Pancreas
HyungSeoParkHyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 7 427-432 (6 pages)
Although importance of intrapancreatic neurons containing gastrin-releasing peptide (GRP) in control of exocrine secretion has been raised, the nature of GRP in the pancreas is unclear. Thus, the present study was undertaken to see distribution, content and molecular heterogeneity of immunoreactive GRP in the rat pancreas. Content of immunoreactive GRP in the rat pancreas was 2.99 ⁑ 0.66 ng/g wet tissues determined by radioimmunoassay. Immunoreactive GRP was most abundantly expressed in... -
Further Characterization of Bombesin Like Immunoreactivities from the Skin of Korean Fire-bellied Toad, Bombina orientalis
HyeokYilKwon, HyungSeoPark, MooHoWon, YunLyulLee, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 12 637-644 (8 pages)
Previously, we have isolated authentic bombesin and another bombesin like peptide named bombesin like immunoreactivity (BLI)-K2 from the skin of Korean fire-bellied toad, Bombina orientalis. In the present study, we have newly purified three heterogeneous forms of BLI named BLI-K3, BLI-K4, and BLI-K5 from side fractions obtained in previous isolation of bombesin like peptide. The BLIs were separated into five peaks on a column of C18 preparative HPLC. Among them, three minor peaks containing... -
Mechanism of Vasoactive Intestinal Polypeptide-Induced Catecholamine Secretion from the Rat Adrenal Medulla
Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 6 443-454 (12 pages)
The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary CA secretion from the isolated perfused rat adrenal gland. The perfusion into an adrenal vein of VIP (3⁓106 M) for 5 min or the injection of acetylcholine (ACh, 5.32⁓103 M) resulted in great increases in CA secretion. Tachyphylaxis to... -
신경펩타이드 : 역사와 개관
Kwang-Soo Kim, Uriel Halbreich 대한신경정신의학회 신경정신의학 12 Pages
대한신경정신의학회 신경정신의학 1988, 제 27권 제 6호 1 943-954 (12 pages)
지난 수십년간 인간의 뇌의 기능에 대한 신경화학적 탐구가 활발히 진행되어 왔으며 1960 년대에 이르러서는 noradrenaline, dopamine, serotonin 및 acetylcholine과 같은 “고전적” 신 경전달물질의 개념이 확립되었으며 내적항정성의 유지 및 인간의 행동과 정신장애에 있어서의 이들의 역할에 관심의 촛점이 맞추어졌다. 그러나 오늘날에 있어서는 최소한 50개 이상의 신경전달물질 혹은 신경조절물질들이 알려져 있으며 이들의 대부분은 최근 20여년간에 밝혀 진 신경펩타이드들이다. 신경펩타이드들의 종류 그리고... -
이자효소 분비에 관여하는 세포 내 조절 단백에 대한 연구
정구용(Ku Yong Chung), 최재원(Jae Won Choi), 최홍순(Hong Soon Choi), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 2호 12 243-258 (16 pages)
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Camostat 투여 흰쥐 이자 외분비선의 분비자극물질에 대한 반응성
김철(Chul Kim), 김동구(Dong Goo Kim), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 2호 6 205-216 (12 pages)
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담즙분비와 Cyclic nucleotides간의 상호관계에 관한 연구
이향우(H.W. Lee), 김원준(W.J. Kim), 홍사석(S.S. Hong), 조석준(S.J. Cho), 홍사오(S.U. Hong), 임중기(C.K. Lim) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1982, 제 18권 제 1호 6 43-54 (12 pages)
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취외분비에 미치는 cyclic nucleotides의 역할
이향우(H.W Lee), 김원준(W.J. Kim), 홍사석(S.S. Hong) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1977, 제 13권 제 2호 5 41-48 (8 pages)
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고장수액의 위내 주입으로 인한 취외분비의 변동
조태순(T.S. Cho), 김원준(W.J. Kim), 홍사석(S.S. Hong) 대한약리학회 대한약리학잡지 5 Pages
대한약리학회 대한약리학잡지 1977, 제 13권 제 1호 5 29-33 (5 pages)
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Caerulein의 흰쥐 취외분비반응에 미치는 phenoxybenzamine의 영향
김혜영(H.Y. Kim), 노재열(J.Y Ro), 조태순(T.S. Cho), 홍사석(S.S. Hong) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 1976, 제 12권 제 2호 2 7-12 (6 pages)
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흰쥐의 담취액 분비에 미치는 수종 중추흥분 및 억제물질의 영향
박서경(Suh-Kyung Park) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1976, 제 12권 제 1호 2 15-22 (8 pages)
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Cholinergic Role on Insulin Action in Exocrine Secretion of the Isolated Rat Pancreas
Lee, Yun-Lyul, Park, Hyung-Seo, Kim, Myoung-Sub, Kwon, Hyeok-Yil, Park, Hyoung-Jin 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 4 219-230 (12 pages)
In order to investigate intra-pancreatic cholinergic roles on insulin action in exocrine secretion, the pancreas was isolated from rats and continuously perfused with modified Krebs-Henseleit solution. Intra-arterial infusion of insulin (100 nM) or cholecystokinin (CCK, 14 pM) alone resulted in stimulation of the volume flow and amylase output. Also insulin potentiated the action of CCK in the exocrine secretion. Tetrodotoxin and atropine completely abolished the potentiating action of insulin... -
Electrophysiological Responses of δ -Opioid Receptor Expressed on HEK293 Cells
Kim, Jin-Hyuk, Koh, Young-Ik, Chin, He-Min, Lee, Yong-Sung, Cho, Yeul-Hee, Kim, Kee-Soon 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 12 301-308 (8 pages)
To explore electrophysiological properties of the δ-Opioid receptors artificially expressed in the mammalian cell, effect of an opioid agonist DPDPE (1 μM) on the voltage-sensitive outward currents was examined in the HEK293 (human embryonic kidney) cells transfected with δ-Opioid receptor cDNA cloned from NG-108-15 (neuroblastoma X glioma hybrid) cDNA library. Also studied were effects of 8-bromo-cyclic AMP and naloxone on DPDPE-induced changes in the voltage sensitive outward current. The... -
Production and Characterization of Specific Antibodies to Bombesin
Kwon, Hyeok-Yil, Lee, Yun-Lyul, Park, Hyoung-Jin 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 9 91-98 (8 pages)
In order to produce a specific bombesin antiserum far very sensitive radioimmunoassay, synthetic [lys3]-bombesin conjugated to bovine serum albumin was subcutaneously injected into guinea pigs. The conjugation was performed using either carbodiimide or gIutaraldehyde as a coupling agent. The antisera were characterized by analysis of Scatchard and Sips plots. The antiserum LBE 2G/2 raised by repeat injection of the immunogen conjugated with carbodiimide showed the titer of 1 : 188,000, very low... -
흰쥐에서 배측 봉선핵의 전기자극이 췌장의 외분비기능에 미치는 영향
서상원(Suh, Sang-Won), 박형진(Park, Hyoung-Jin) 대한생리학회 대한생리학회지 9 Pages
대한생리학회 대한생리학회지 1990, 제 24권 제 2호 14 403-411 (9 pages)
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한국산 무당개구리 피부에 존재하는 Bombesin 유사면역 반응물질의 순수정제 및 생물학적 활성
권혁일(Kwon, Hyeok-Yil), 김일(Kim, Yil), 박형진(Park, Hyoung-Jin) 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1990, 제 24권 제 2호 11 363-376 (14 pages)
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흰쥐에서 내측 편도핵의 전기 자극에 의한 췌액 분비 증가 기전
윤신희(Yoon, Shin-Hee), 한상준(Hahn, Sang-June), 조양혁(Jo, Yang-Hyeok) 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 2호 15 401-408 (8 pages)
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내측 편도핵의 위산분비 촉진작용에서 미주신경의 역할
김명석(Kim, Myung-Suk), 조양혁(Jo, Yang-Hyeok), 윤신희(Yoon, Shin-Hee), 한상준(Hahn, Sang-June), 이덕주(Rhie, Duck-Joo), 김정진(Kim, Chung-Chin) 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 2호 14 393-400 (8 pages)
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방사면역측정을 위한 항 Gastrin 혈청의 생산 및 평가
박형진(Park, Hyoung-Jin), 권혁일(Kwon, Hyeok-Yil), 이윤렬(Lee, Yun-Lyul), 신원임(Shin, Won-Im), 서상원(Suh, Sang-Won), 오양석(Oh, Yang-Suk) 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 1호 9 89-98 (10 pages)
New Zealand white 계의 토끼에게 EDC를 사용하여 hemocyanin에 접합시킨 human G-17-I을 면역한 결과 gastrin의 방사면역측정에 적합한 항 gastrin 혈청을 얻는데 성공하였다. 본 실험에서 얻은 항 gastrin 혈청의 역가는 1:25,000이며 human G-17-I과 human big gastrin에 매우 친화력이 높은 반면 다른 위장관 peptide 들과는 교차반응성이 아주 낮았다. 본 항 gastrin 혈청의 effective affinity constant는 1.77 X 1011/M이었다. 또한 총 결합부위(total binding sites)는 255 nM, 이질성지수(heterogeneity index)는 0.84 그리고...
