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Cadaver Study for Spinal Fusion Surgery Using an Image-guided Surgical Robot System
Chung. Jae-Heon, Kim. Sung-Min, Yi. Byung-Ju, Kim. Young-Soo 제어로봇시스템학회 International Journal of Control, Automation and Systems 10 Pages
제어로봇시스템학회 International Journal of Control, Automation and Systems 2010, Vol.8 No.3 564-573 (10 pages)
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An Image-Guided Robotic Surgery System for Spinal Fusion
Chung. Goo Bong, Kim. Sungmin, Lee. Soo Gang, Yi. Byung-Ju, Kim. Wheekuk, Oh. Se Min, Kim. Young Soo, So. Byung Rok, Park. Jong Il, Oh. S 제어로봇시스템학회 International Journal of Control, Automation and Systems 12 Pages
제어로봇시스템학회 International Journal of Control, Automation and Systems 2006, Vol.4 No.1 30-41 (12 pages)
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Computer Integrated Surgical Robot System for Spinal Fusion
Kim. Sungmin, Chung. Goo Bong, Oh. Se Min, Yi. Byung-Ju, Kim. Whee Kuk, Park. Jong Il, Kim. Young Soo 대한의용생체공학회 Journal of biomedical engineering research : the official journal of the Korean Society of Medical & 6 Pages
대한의용생체공학회 Journal of biomedical engineering research : the official journal of the Korean Society of Medical & 2005, Vol.26 No.5 265-270 (6 pages)
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Effect of Dietary Calcium on Spinal Bone Fusion in an Ovariectomized Rat Model
Cho. Jae-Hoon, Cho. Dae-Chul, Yu. Song-Hee, Jeon. Young-Hoon, Sung. Joo-Kyung, Kim. Kyoung-Tae 대한신경외과학회 Journal of Korean neurosurgical society 7 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2012, Vol.52 No.4 281-287 (7 pages)
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Radiographic Analysis of Instrumented Posterolateral Fusion Mass Using Mixture of Local Autologous Bone and b-TCP (PolyBone$^{(R)}$) in a Lumbar Spinal Fusion Surgery
Park. Jin-Hoon, Choi. Chung-Gon, Jeon. Sang-Ryong, Rhim. Seung-Chul, Kim. Chang-Jin, Roh. Sung-Woo 대한신경외과학회 Journal of Korean neurosurgical society 6 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2011, Vol.49 No.5 267-272 (6 pages)
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Minimally Invasive Multi-Level Posterior Lumbar Interbody Fusion Using a Percutaneously Inserted Spinal Fixation System : Technical Tips, Surgical Outcomes
Kim. Hyeun-Sung, Park. Keun-Ho, Ju. Chag-Il, Kim. Seok-Won, Lee. Seung-Myung, Shin. Ho 대한신경외과학회 Journal of Korean neurosurgical society 5 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2011, Vol.50 No.5 441-445 (5 pages)
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The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model
Gezici. Ali Riza, Ergun. Ruchan, Gurel. Kamil, Yilmaz. Fahri, Okay. Onder, Bozdogan. Omer 대한신경외과학회 Journal of Korean neurosurgical society 7 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2009, Vol.46 No.1 45-51 (7 pages)
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Evaluation of Spinal Fusion Using Bone Marrow Derived Mesenchymal Stem Cells with or without Fibroblast Growth Factor-4
Seo. Hyun-Sung, Jung. Jong-Kwon, Lim. Mi-Hyun, Hyun. Dong-Keun, Oh. Nam-Sik, Yoon. Seung-Hwan 대한신경외과학회 Journal of Korean neurosurgical society 6 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2009, Vol.46 No.4 397-402 (6 pages)
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A Multi-center Clinical Study of Posterior Lumbar Interbody Fusion with the Expandable Stand-alone Cage($Tyche^{(R)}$ Cage) for Degenerative Lumbar Spinal Disorders
Kim. Jin-Wook, Park. Hyung-Chun, Yoon. Seung-Hwan, Oh. Seong-Hoon, Roh. Sung-Woo, Rim. Dae-Cheol, Kim. Tae-Sung 대한신경외과학회 Journal of Korean neurosurgical society 7 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2007, Vol.42 No.4 251-257 (7 pages)
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Increased phosphorylation of caveolin-1 in the spinal cord of irradiated rats
Heechul Kim, Changjong Moon, Jeongtae Kim, Meejung Ahn, Jin Won Hyun, Jae Woo Park, Sung-Ho Kim, Seungjoon Kim, Taekyun Shin* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 4호 2 323-328 (6 pages)
of activated microglia/macrophages, was matched with that of p-caveolin-1. In the irradiated spinal cords, there was a higher level of p-caveolin-1 immunoreactivity in the isolectin B4-positive microglial, ependymal, and vascular endothelial cells, in which p-caveolin-1 was weakly and constitutively expressed in the normal control spinal cords. These results suggest that total body irradiation induces activation of microglial cells in the spinal cord through the phosphorylation of caveolin-1. -
Postoperative Flat Back : Contribution of Posterior Accessed Lumbar Interbody Fusion and Spinopelvic Parameters
Kim. Jin Kwon, Moon. Byung Gwan, Kim. Deok Ryeng, Kim. Joo Seung 대한신경외과학회 Journal of Korean neurosurgical society 8 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2014, Vol.56 No.4 315-322 (8 pages)
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Vertebral Distraction during Anterior Cervical Discectomy and Fusion Causes Postoperative Neck Pain
Ha. Seung Man, Kim. Jeong Hoon, Oh. Seung Hun, Song. Ji Hwan, Kim. Hyoung Ihl, Shin. Dong Ah 대한신경외과학회 Journal of Korean neurosurgical society 5 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2013, Vol.53 No.5 288-292 (5 pages)
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Perioperative Risk Factors Related to Lumbar Spine Fusion Surgery in Korean Geriatric Patients
Lee. Jung-Hyun, Chun. Hyoung-Joon, Yi. Hyeong-Joong, Bak. Koang-Hum, Ko. Yong, Lee. Yoon-Kyoung 대한신경외과학회 Journal of Korean neurosurgical society 9 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2012, Vol.51 No.6 350-358 (9 pages)
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A Comparison of the Effect of Epidural Patient-Controlled Analgesia with Intravenous Patient-Controlled Analgesia on Pain Control after Posterior Lumbar Instrumented Fusion
Lee. Sang-Hoon, Kim. Kyung-Hyun, Cheong. Seong-Mee, Kim. Su-Mi, Kooh. Mi-Rang, Chin. Dong-Kyu 대한신경외과학회 Journal of Korean neurosurgical society 4 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2011, Vol.50 No.3 205-208 (4 pages)
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Minimum 2-Year Follow-Up Result of Degenerative Spinal Stenosis Treated with Interspinous U ($Coflex^{TM}$)
Park. Seong-Cheol, Yoon. Sang-Hoon, Hong. Yong-Pyo, Kim. Ki-Jeong, Chung. Sang-Ki, Kim. Hyun-Jib 대한신경외과학회 Journal of Korean neurosurgical society 8 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2009, Vol.46 No.4 292-299 (8 pages)
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Predictable Risk Factors for Adjacent Segment Degeneration After Lumbar Fusion
Hyun. Seung-Jae, Kim. Young-Baeg, Hong. Hyun-Jong, Kwon. Jeong-Taik, Suk. Jong-Sik, Min. Byung-Kook 대한신경외과학회 Journal of Korean neurosurgical society 7 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2007, Vol.41 No.2 88-94 (7 pages)
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Clinical Comparison of Posterolateral Fusion with Posterior Lumbar Interbody Fusion
Kim. Chang-Hyun, Gill. Seung-Bae, Jung. Myeng-Hun, Jang. Yeun-Kyu, Kim. Seong-Su 대한신경외과학회 Journal of Korean neurosurgical society 6 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2006, Vol.40 No.2 84-89 (6 pages)
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Comparable bone healing capacity of different bone graft matrices in a rabbit segmental defect model
Jong Min Kim, Myoung Hwan Kim, Seong Soo Kang, Gonhyung Kim, Seok Hwa Choi* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 16 289-295 (7 pages)
We compared the bone healing capacity of three different demineralized bone matrix (DBM) products applied using different carrier molecules (hyaluronic acid [HA] vs. carboxymethylcellulose [CMC]) or bone compositions (cortical bone vs. cortical bone and cancellous bone) in a rabbit segmental defect model. Overall, 15-mm segmental defects in the left and right radiuses were created in 36 New Zealand White rabbits and filled with HA-based demineralized cortical bone matrix (DBX), CMC-based... -
Evaluation of bone healing in canine tibial defects filled with cortical autograft, commercial-DBM, calf fetal DBM, omentum and omentum-calf fetal DBM
Amin Bigham-Sadegh, Iraj Karimi, Mahsa Alebouye, Zahra Shafie-Sarvestani, Ahmad Oryan 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 14 337-343 (7 pages)
The present study was conducted to compare the effects of xenogenic bovine fetal demineralized bone matrix (DBM), commercial DBM, omentum, omentum-calf fetal DBM, cortical autograft and xenogenic cartilage powder on the healing of tibial defects in a dog model to determine the best material for bone healing. Seven male adult mongrel dogs, weighing 26.2 ± 2.5 kg, were used in this study. Seven holes with a diameter of 4-mm were created and then filled with several biomaterials. Radiographs were... -
Diprosopus, craniorachischisis, arthrogryposis, and other associated anomalies in a stillborn lamb
Cihan Ka, Kadir Özcan, İsmet Takçı, Kutlay Gürbulak, Hasan Özen, Musa Karaman 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 4호 15 429-432 (4 pages)
than the right head. Micrencephaly, agnathia, and a rudimentary tongue, which was adherent to the palate, were present in the left head. Micrencephaly, brachygnathia superior, and cleft palate were present in the right head. Cerebellar agenesis and spinal cord hypoplasia were observed. The cerebrums and the spinal cord were covered with a tapering membranous structure. Neural and dermal tissues were noted to intervene upon microscopic examination of this structure. Disorganization of neurons was... -
Contribution of the xenograft bone plate-screw system in lumbar transpedicular stabilization of dogs: an in-vitro study
Hakan Salci*, Sani Sarigul, Seref Dogan, Huseyin Lekesiz, Resat Ozcan, O. Sacit Gorgul, Kaya Aksoy 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 2호 10 193-196 (4 pages)
(LBF) (group II, n = 5), the LBF plus TS with metal plate-screw group (group III, n = 5) and the LBF plus TS with XBPS group (group IV, n = 5). Five kinds of biomechanical tests were applied to the specimens: flexion, extension, left-right bending and rotation. The averages of the 16 stiffness values were calculated and then these were statistically analyzed. The statistical results show that the XBPS system contributes spinal stability and this system can be a good choice for achieving TS. -
Organotypic slice culture of the hypothalamic paraventricular nucleus of rat
Eun Seong Cho, So Yeong Lee, Jae-Yong Park, Seong-Geun Hong, Pan Dong Ryu 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 3 15-20 (6 pages)
Organotypic slice cultures have been developed as an alternative to acute brain slices because the neuronal viability and synaptic connectivity in these cultures can be preserved well for a prolonged period of time. This study evaluated a stationary organotypic slice culture developed for the hypothalamic paraventricular nucleus (PVN) of rat. The results showed that the slice cultures maintain the typical shape of the nucleus, the immunocytochemical signals for oxytocin, vasopressin, and... -
원저 : 실험적 자가면역성 뇌척수염을 유도한 마우스에서 Galectin-9의 과발현
조진희, 빙소진, 김아름, 유학선, 임윤규, 신태균, 최종희, 지영흔 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 4호 3 209-218 (10 pages)
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A case of canine patent ductus arteriosus showed favorable therapeutic response by surgery combined with needle-acupuncture therapy
KwangShikKim, ByungYoungKim, TaeHwaKim, WonBaeKim, JianZhuLiu, JungYeonLee, DuckHwanKim, PhilipA.M.Rogers 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 4호 17 575-579 (5 pages)
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Goldenhar Syndrome 환자의 Tessier 두개안면개열 분류 7번 측방개열의 외과적 교정: 증례보고
정필훈, 하성호 대한구순구개열학회 대한구순구개열학회지 7 Pages
대한구순구개열학회 대한구순구개열학회지 2019, 제 22권 2호 3 67-73 (7 pages)
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Antipruritic effect of curcumin on histamine-induced itching in mice
Han Kyu Lee, Seok Bum Park, Su-youne Chang, Sung Jun Jung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 8 547-554 (8 pages)
Itching is a common clinical symptom of skin disease that significantly affects a patient’s quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced... -
Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
Seon-Hui Jang, Soo-Joung Park, Chang-Jin Lee, Dong-Kuk Ahn, Seong-Kyu Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 7 539-546 (8 pages)
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action... -
Effect of etoricoxib on experimental oxidative testicular ischemia–reperfusion damage in rats induced with torsion–detorsion
TurgutYapanoglu, FatihOzkaya, AliHaydarYilmaz, RenadMammadov, FerdaKeskinCimen, ErkanHirik, DurduAltuner 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 1 457-464 (8 pages)
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG)... -
Analysis of the Baroreceptor and Vestibular Receptor Inputs in the Rostral Ventrolateral Medulla following Hypotension in Conscious Rats
YanLan, Huan-JunLu, XianJiang, Li-WeiLi, Yan-ZhaoYang, Guang-ShiJin, JooYoungPark, MinSunKim, ByungRimPark, Yuan-ZheJin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 11 159-165 (7 pages)
Input signals originating from baroreceptors and vestibular receptors are integrated in the rostral ventrolateral medulla (RVLM) to maintain blood pressure during postural movement. The contribution of baroreceptors and vestibular receptors in the maintenance of blood pressure following hypotension were quantitatively analyzed by measuring phosphorylated extracellular regulated protein kinase (pERK) expression and glutamate release in the RVLM. The expression of pERK and glutamate release in the... -
Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration
ZhenzhenHu, Eun-HyeOh, YeonBokChung, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 2 89-97 (9 pages)
The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript (CART) peptides after repeated administration of cocaine in mice. Repeated administrations of cocaine induced behavioral sensitization and CART over-expression in mice. The levels of striatal CART mRNA were significantly increased on the 3rd day. CART peptides were... -
Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
YanLan, Yan-ZhaoYang, XianJiang, Li-WeiLi, Guang-ShiJin, MinSunKim, ByungRimPark, Yuan-ZheJin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 15 367-373 (7 pages)
Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the rostral ventrolateral medulla (RVLM). Baroreflex sensitivity and c-Fos protein expression in the RVLM were measured in conscious rats that had undergone bilateral labyrinthectomy (BL) and/or baroreceptor unloading. BL attenuated baroreflex sensitivity during intravenous infusion of sodium... -
The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation
MohammadIqbalHossainBhuiyan, Hyun-BokKim, SeongYunKim, Kyung-OkCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 6 353-362 (10 pages)
In this study, cyanidin-3-glucoside (C3G) fraction extracted from the mulberry fruit (Morus alba L.) was investigated for its neuroprotective effects against oxygen-glucose deprivation (OGD) and glutamate-induced cell death in rat primary cortical neurons. Cell membrane damage and mitochondrial function were assessed by LDH release and MTT reduction assays, respectively. A time-course study of OGD-induced cell death of primary cortical neurons at 7 days in vitro (DIV) indicated that neuronal... -
The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats
YoungBaeKwon, YoungChanJeong, JungKeeKwon, JiSeonSon, KeeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 3 425-429 (5 pages)
of spinal sigma-1 receptors (Sig-1R) produces a prominent antinociceptive effect in several types of pain models. This study evaluates whether the Sig-1R antagonist (BD1047) has an antinociceptive effect on capsaicin (a potent C-fiber activator) induced headache models in rats. Intracisternal infusion of capsaicin evoked pain behavior (face grooming), which was significantly attenuated by BD1047 pretreatment. BD1047 consistently reduced capsaicin-induced Fos-like immunoreactivity (Fos-LI), a... -
Physiological, Pharmacological and Toxicological Implications of Heterodimeric Amino Acid Transporters
YoshikatsuKanaiHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 1 117-128 (12 pages)
The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT (related to b0, -amino acid transporter). Six members are associated with 4F2hc and one is linked... -
Presynaptic Mechanism Underlying Regulation of Transmitter Release by G Protein Coupled Receptors
TomoyukiTakahashi, YoshinaoKajikawa, MasahiroKimura, NaotoSaitoh, TetsuhiroTsujimoto 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 1 69-76 (8 pages)
A variety of G protein coupled receptors (GPCRs) are expressed in the presynaptic terminals of central and peripheral synapses and play regulatory roles in transmitter release. The patch-clamp whole-cell recording technique, applied to the calyx of Held presynaptic terminal in brainstem slices of rodents, has made it possible to directly examine intracellular mechanisms underlying the GPCR-mediated presynaptic inhibition. At the calyx of Held, bath-application of agonists for GPCRs such as GABAB... -
A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells
Jae-YongPark, JaeheeHan, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 13 375-379 (5 pages)
to be important for triggering myoblast fusion. It remains, however, unclear how Ca2 influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may be involved in Ca2 mobilization of muscle, and that Ca2 influx is mediated by NMDA receptors in C2C12 myoblasts. Here, we report that other types of ionotropic glutamate receptors, non-NMDA receptors (AMPA and KA receptors), are also involved in Ca2 influx in myoblasts. To explore which... -
Influence of Bradykinin on Catecholamine Release from the Rat Adrenal Medulla
Dong-YoonLim, Il-HwanKim, Gwang-MoonNa, Moo-JinKang, Ok-MinKim, Deok-HoChoi, Young-WooKi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 7 231-238 (8 pages)
The present study was undertaken to investigate the effect of bradykinin on secretion of catecholamines (CA) evoked by stimulation of cholinergic receptors and membrane depolarization from the isolated perfused model of the rat adrenal glands, and to elucidate its mechanism of action. Bradykinin (3⁓108 M) alone produced a weak secretory response of the CA. however, the perfusion with bradykinin (3⁓108 M) into an adrenal vein of the rat adrenal gland for 90 min enhanced... -
Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats
EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of rats. Channel activity was recorded from membrane patches using the patch-clamp technique. In the inside-out configuration bath-applied propofol inhibited the KATP channel activities in a dose-dependent manner. The half-maximal inhibition dose (ED50) was 48.6⁑8.4μM...
