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- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(10)
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Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves
Hwan-Goo Kang, Sang-Hee Jeong*, †, Joon-Hyoung Cho 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2010, 제 11권 제 1호 8 51-58 (8 pages)
The methanol extract from the leaves of Petasites japonicus Maxim (PJ) was studied for its (anti-)mutagenic effect with the SOS chromotest and reverse mutation assay. The (anti-)carcinogenic effects were evaluated by the cytotoxicity on human cancer line cells and by the function and the expression of gap junctions in rat liver epithelial cell. PJ extracts significantly decreased spontaneous β-galactosidase activity and β-galactosidase activity induced by a mutagen, ICR, in Salmonella (S.)... -
Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer
Jung. Minjeong, Bu. So Young, Tak. Ka-Hee, Park. Jeong-Eun, Kim. Eunjung 한국영양학회 Nutrition research and practice 7 Pages
한국영양학회 Nutrition research and practice 2013, Vol.7 No.6 439-445 (7 pages)
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Anticarcinogenic Effect and Modification of Cytochrome P450 2E1 by Dietary Garlic Powder in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis
Park. Kyung-Ae, Kweon. Sang-Hui, Choi. Hay-Mie 생화학분자생물학회 Journal of biochemistry and molecular biology 8 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2002, Vol.35 No.6 615-622 (8 pages)
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The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic Mice
Jo-HeonKim, Md.MorshedulAlam, DoekBaePark, MoonjaeCho, Seung-HongLee, You-JinJeon, Dae-YeulYu, TaeDuKim6, HaYoungKim, ChungGuCho, DaeHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 12 455-461 (7 pages)
mice. We also assessed the effect of chronic metformin treatment on HCC development in the mice. Many genes involved in hepatic retinoid physiology, including CRBP-I, were altered and the tissue levels of retinol and all-trans retinoic acid (ATRA) were elevated in the liver of HBx Tg mice compared to those of wild type (WT) control mice. CRBP-I protein expression in liver, but not in white adipose tissue, of HBx Tg mice was significantly elevated compared to WT control mice while CRBP-I protein... -
The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats
YoungSilMin, SeEunLee, SeungTaeHong, HyunSikKim, Byung-ChulChoi, SangSooSim, WanKyunWhang, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 5 295-300 (6 pages)
It was evaluated the inhibitory action of quercetin-3-O-Ղ-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by... -
Effect of Biostimulator Chlorella fusca on Improving Growth and Qualities of Chinese Chives and Spinach in Organic Farm
Min-Jeong Kim, Chang-Ki Shim, Yong-Ki Kim, Byong-Gu Ko, Jong-Ho Park, Soo-Gen Hwang, Baeg-Ho Kim 한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 6호 11 567-574 (8 pages)
This study was conducted to investigate the efficacy of freshwater alga, Chlorella fusca on the improvement of growth and qualities in organic spinach and Chinese chives farm. The average height of Chinese chives treated with the chlorella was 3.7 cm smaller than that of the untreated. The leaf width and fresh weight of Chinese chives treated with the chlorella was 0.5 mm wider and 30.3 g heavier than that of the untreated. The commercialization and yield of Chinese chives treated with the... -
Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma
Seungmo Park, Jihae Lim, Jong Rhan Kim, Seongbeom Cho 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 1 419-429 (11 pages)
this study, the anticarcinogenic effects of resveratrol against hepatitis B virus (HBV)-induced HCC were investigated by using HBV X-protein-overexpressing Huh7 (Huh7-HBx) human hepatoma cells. MTT assay showed that resveratrol decreased cell viability. Fluorescence-activated cell-sorter analysis showed that resveratrol induced G1 cell cycle arrest without increasing the sub-G1 phase cell population. Therefore, we evaluated its effect on regulation of cyclin D1, which is critically involved in... -
Chemopreventive and metabolic effects of inulin on colon cancer development
Emília Hijová, Viktória Szabadosova, Jana Štofilová, Gabriela Hrčková 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 4호 3 387-393 (7 pages)
Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4 months old) were experimentally treated with procarcinogen dimethylhydrazine to induce colon cancer development. The rats were randomly assigned to three groups: a control group (CG), a group treated with dimethylhydrazine (DMH), and a group given... -
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue, Ki Nam Lee, Jae-Hwang Jeong, Sang-Hwa Lee, Young Ho Lee, Seong-woon Jeong, Sang Yoon Nam, Young Won Yun, Beom Jun L 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 3 189-195 (7 pages)
decreased the epididymal fat weights compared with the control (p ＜ 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism. -
Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Productivity in Mice
Jin-young Kim, Byung-hyun Chung 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2003, 제 4권 제 1호 16 103-108 (6 pages)
The dietary effect of conjugated linoleic acid (CLA) on the response of the immunoglobulin (serum and tissue) production in Balb/C mice was examined at three doses: 0 %(control), 0.5% and 1.5%. The combination effects of CLA with vitamin ADE or selenium also were investigated. CLA at 0.5% increased serum immunoglobulin A, G, mesenteric lymph node (MHN) and gut luminal IgA (secretory IgA) levels. However, 1.5% CLA decreased SIgG slightly. CLA both alone and combined with vitamin ADE and selenium... -
천문동 뿌리의 자연발효에 관여하는 미생물 및 발효 후 효능 변화
김민지, 신나래, 이명종, 김호준 한방비만학회 대한한방비만학회지 10 Pages
한방비만학회 대한한방비만학회지 2018, 제 18권 제 2호 5 96-105 (10 pages)
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 8 205-213 (9 pages)
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell... -
Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts
BeomyeolBaek, SuHeeLee, KyunghoonKim, Hye-WonLim, Chang-JinLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 6 269-277 (9 pages)
Ellagic acid (EA), an antioxidant polyphenolic constituent of plant origin, has been reported to possess diverse pharmacological properties, including anti-inflammatory, anti-tumor and immunomodulatory activities. This work aimed to clarify the skin anti-photoaging properties of EA in human dermal fibroblasts. The skin anti-photoaging activity was evaluated by analyzing the reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total glutathione (GSH) and superoxide dismutase (SOD)... -
Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice
QiGuo, ZhiyangShen, HongxiaYu, GaofengLu, YongYu, XiaLiu, PengyuanZheng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 3 15-23 (9 pages)
Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase... -
Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-kB Activation
HuiSuLee, PurumKang, KaYoungKim, GeunHeeSeol 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 14 183-189 (7 pages)
Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflam-matory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7∼10). In five groups, the mice... -
Effects of Watercress Containing Rutin and Rutin Alone on the Proliferation and Osteogenic Differentiation of Human Osteoblast-like MG-63 Cells
HanbitHyun, HeajinPark, JaehoonJeong, JihyeKim, HaesungKim, HyunIlOh, HyeSeongHwang, HaHyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 10 347-352 (6 pages)
Most known osteoporosis medicines are effective for bone resorption, and so there is an increasing demand for medicines that stimulate bone formation. Watercress (N. officinale R. Br.) is widely used as a salad green and herbal remedy. This study analyzed a watercress extract using ultra-performance liquid chromatography/mass spectrometry, and identified a rutin as one of its major constituents. Osteogenic-related assays were used to compare the effects of watercress containing rutin (WCR) and... -
Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd’s Purs
WooJinChoi, SeongKeunKim, HeeKukPark, UyDongSohn, WonyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 4 33-39 (7 pages)
Shepherd’s purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd’s purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1β [IL-1β], IL-6, and IL-10), and... -
Possible Involvement of Ca2＋ Activated K＋ Channels, SK Channel, in the Quercetin-Induced Vasodilatation
SeiichiroNishida, HiroyasuSatoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 5 361-365 (5 pages)
100ՌM also had the similar effect. In the presence of both 100ՌM L-NMMA and 10ՌM indomethacin, the quercetin-induced vasodilatation was further attenuated by 100ՌM tetraethylammonium (TEA, a KCa channel inhibitor). Also TEA decreased the quercetin-induced vasodilatation in endothelium-denuded rat aorta. Used other KCa channel inhibitors, the quercetin-induced vasodilatation was attenuated by 0.3ՌM apamin (a SK channel inhibitor), but not by 30 nM charybdotoxin (a BK... -
Caffeic Acid Phenethyl Ester Inhibits the PKC-Induced IL-6 Gene Expression in the Synoviocytes of Rheumatoid Arthritis Patients
Gang-MinHur, Yin-BangHwang, Jae-HeunLee, So-HyunBae, Ji-SunPark, Choong-JaeLee, Jeong-HoSeok 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 11 363-368 (6 pages)
To gain insight on the role of pro-inflammatory cytokines in the pathogenesis and treatment of rheumatoid arthritis (RA), the phorbol 12-myristate 13-acetate (PMA)-induced IL-6 gene expression and the effect of caffeic acid phenethyl ester (CAPE) on the PMA-induced IL-6 gene expression were investigated in human fibroblast-like synoviocytes (FLSs). Synovial tissue samples were obtained from rheumatoid arthritis patients, and FLSs were isolated. The cells were stimulated with PMA (100 nM) for 6... -
Indole, Indole-3-calbinol 및 Benzofuran이 간장 microsome과 cytosol의 약물대사 효소 활성도에 미치는 영향
차영남(Young-Nam Cha), 정진호(Jin-Ho Chung), David C. Thompson, Henry S. Heine 대한약리학회 대한약리학잡지 11 Pages
대한약리학회 대한약리학잡지 1985, 제 21권 제 1호 1 1-11 (11 pages)
이물질(xenobiotics) 대사에 관여하는 간장 microsome과 cytosol 효소 활성에 indole, indole-3-carbinol 및 benzofuran이 미치는 영향을 검색하기위하여 마우스에 이들 약물을 각각 5 mmole/kg씩 10일간 투여하여 다음 몇 가지의 성적을 얻었다. Benzofuran은 microsome 효소인 aniline hydroxylase, 7-ethoxycoumarin O-deethylase, p-nitrophenol UDPGA-transferase, epoxide hydrolase와 cytosol 효소인 glutathione S-tranferase, NADH : quinone reductase, UDP-glucose dehydrogenase의 활성도를 증가시켰다. 그러나... -
Vitamin A 유도체로 인한 간의 약물대사효소 변동
이향우(H.W. Lee), 유경자(K.Z. Ryu), 노재열(J.Y. Ro), 홍사석(S.S. Hong) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1982, 제 18권 제 1호 8 65-72 (8 pages)
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석창포가 생체 해독효소 활성에 미치는 영향
소명숙, 김아린 한국보건기초의학회 한국보건기초의학회지 5 Pages
한국보건기초의학회 한국보건기초의학회지 2012, Vol.5 No.3 1 83-87 (5 pages)
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구기자추출물 섭취와 수영운동의 병행이 고지방식이 생쥐의 체중, 지방량, 지질대사 및 당대사에 미치는 영향
오기숙, 양영 한국웰니스학회 한국웰니스학회지 9 Pages
한국웰니스학회 한국웰니스학회지 2013, 제 8권 1호 11 129-137 (9 pages)
본 연구는 고지방식이 생쥐를 대상으로 구기자 섭취와 수영운동의 병행이 체중, 지방량, 지질대사 및 당대사의 변화 정도에 미 치는 영향을 분석함으로써, 비만해소에 어떠한 효과가 있는지에 대해 알아보았다. 본 연구에서는 생후 8주령 된 수컷 C57BL/6J 생쥐를 실험동물로 선정하였으며, 실험군과 대조군 모두 실험기간 동안 고지방식이를 하였다. 대조군은 구기자추출물 섭취만 하였 으며, 실험군은 구기자추출물의 섭취와 함께 수영운동을 병행하였다. 각 집단의 실험 전⦁후 체중, 지방량, 총콜레스테롤, 중성지 방, 글루코스... -
규칙적인 걷기운동이 비만 어린이의 대사관련 호르몬과 성장호르몬 그리고 자세조절 능력의 변화에 미치는 영향
김유섭, 배철웅, 정혜민 한국초등체육학회 한국초등체육학회지 12 Pages
한국초등체육학회 한국초등체육학회지 2009, 제 15권 제 1호 13 159-170 (12 pages)
최근 국민건강보험공단 건강보험연구원은 비만의 사회경제적 비용 산출 보고서를 통해 2005년 비만으로 인해 발생한 사회경제적 비용이 GDP의 0.22%규모로 1조 8천239억원에 달한다고(무등일보, 2008. 8. 15)하였고, 보건복지부 산하 질병관리본부가 대한소아과학회에 의뢰해 2005년 3월부터 11월까지 전국의 20세 이하 14만 6196명의 신체 발육을 조사한 결과 표준 체중보다 무거운 비만 소아․청소년이 전 연령에 걸쳐 크게 증가하였으며, 초등학교 고학년과 중학생의 평균체중 또한 크게 증가한 것으로 나타났다. 그리고... -
된장 숙성기간중의 항산화 및 암세포 생육 억제효과
권선화, 손미예, Kwon. Sun-Hwa, Shon. Mi-Yae 한국식품저장유통학회 한국식품저장유통학회지 7 Pages
한국식품저장유통학회 한국식품저장유통학회지 2004, Vol.11 No.4 461-467 (7 pages)
장기간 자연숙성시킨 전통된장의 항산화 효과는 숙성기간이 길어질수록 대체로 감소되었으며, 숙성기간 1년 된장에서 methanol 분획물이 가장 우수하였으며, 다음으로 hexane과 물 분획물의 순이었다. 지용성 및 수용성 추출물은 숙성기간이 길어질수록 항산화 효과가 점진적으로 오히려 증가되었으나, 분획물에 비하여 낮은 수치를 나타내었다. 전통된장의 수소공여능은 수용성 색소 추출물과 methanol 및 butanol 분획물에서 대체적으로 높은 수치였으나, chloroform과 ethylacetate 분획물은 매우 낮았다. 전통된장의 항암효과에서... -
콩 함유 이소플라본의 생리활성과 가공적성
한진숙, 하태열, 김성란, Han. Jin-Suk, Ha. Tae-Youl, Kim. Sung-Ran 한국식품영양과학회 한국식품영양과학회지 7 Pages
한국식품영양과학회 한국식품영양과학회지 2006, Vol.35 No.10 1427-1433 (7 pages)
본 연구에서는 콩 식품의 품질 및 가공적성을 최적화하기 위해 대두 이소플라본 추출물의 생리활성과 가공적성에 대한 실험을 수행하였다. 메탄을 추출 이소플라본의 free radical 소거능이 가장 우수하였고, 아질산 소거능은 메탄올, 에탄올과 열수추출물의 순으로 나타났다. ACE 저해작용은 이소플라본이 가장 많이 추출된 메탄올 추출물보다 열수추출물에서 더 큰 효과를 보였다. 또한, 한국인에게 호발하는 위암세포(SNU-1)과 대장암세포(SNU-C4)에 대한 이소플라본 및 대두 추출물의 항종양활성을 확인하였다. 대두 이소플라본이... -
모자반 분획물의 in vitro에서의 항발암효과
배송자 한국식품영양과학회 한국식품영양과학회지 7 Pages
한국식품영양과학회 한국식품영양과학회지 2004, Vol.33 No.3 480-486 (7 pages)
식용 해조류의 일종인 모자반을 추출, 분획 하여 in vitro에서의 항발암효과를 실험하였다. 모자반을 추출, 분획하여 3종의 암세포주(HepG2, HT-29, HeLa)를 이용하여 암세포 독성 효과를 본 결과, 모자반의 ethylether 분획층(SFMEE)과 ethylacetate분획층(SFMEA)에서 3종의 사용 암세포주인 HepG2, HT29 및 HeLa 모두 아주 높은 cytotoxicity를 보였으며, HT29와 HeLa에서는 mathanol 추출물(SFM)과 hexane 분획층(SFMH)에서도 유의적인 암세포 독성 효과를 나타내었다. 정상세포인 liver세포는 모자반의 모든 용매 분획층에서 암세포... -
생약(生樂) 약침액(藥鍼液)이 암예방(癌豫防) 효소계(酵素系)에 미치는 영향(影響)
임종국, 문진영, 조경희, 손윤희, 남경수, Lim. Jong-Kook, Moon. Jin-Young, Cho. Kyoung-Hee, Shon. Yun-Hee, Nam. Kyung-Soo 경락경혈학회 대한경락경혈학회지 7 Pages
경락경혈학회 대한경락경혈학회지 2000, Vol.17 No.1 11-17 (7 pages)
금은화, 당귀, 감두를 이용하여 조제한 각각의 약침액을 이용하여 암예방효과를 살펴 보았다. 발암물질을 무독화시키는 QR 생성 유도를 생쥐의 간암세포인 Hepa1c1c7과 측정하였으며, 그 결과 금은화 약침액, 당귀 약침액, 감두약침액을 처리한 Hepa1c1c7에서 QR생성이 유도되었으며 GSH 생성을 살펴본 결과 Hepa1c1c7 세포에서 실험에 이용된 모든 생약 약침액에 의한 GSH 생성이 증가하였고, GST 생성 또한 증가하였다.
