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Separation of Human Breast Cancer and Epithelial Cells by Adhesion Difference in a Microfluidic Channel
Kwon. Keon-Woo, Choi. Sung-Sik, Kim. Byung-Kyu, Lee. Se-Na, Lee. Sang-Ho, Park. Min-Cheol, Kim. Pil-Nam, Park. Suk-Ho, Kim. Young-Ho, Par 대한전자공학회 Journal of semiconductor technology and science 11 Pages
대한전자공학회 Journal of semiconductor technology and science 2007, Vol.7 No.3 140-150 (11 pages)
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Multi-channel Speech Enhancement Using Blind Source Separation and Cross-channel Wiener Filtering
Jang. Gil-Jin, Choi. Chang-Kyu, Lee. Yong-Beom, Kim. Jeong-Su, Kim. Sang-Ryong 한국음향학회 The journal of the Acoustical Society of Korea 12 Pages
한국음향학회 The journal of the Acoustical Society of Korea 2004, Vol.23 56-67 (12 pages)
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The Pathophysiologic Roles of TRPM7 Channel
HyunSooPark, ChansikHong, ByungJooKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 2 15-23 (9 pages)
channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2＋ and Ca2＋, and its channel activity is negatively regulated by free Mg2＋ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC)... -
Modulation of Large Conductance Ca2+-activated K+ Channel of Skin Fibroblast (CRL-1474) by Cyclic Nucleotides
JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 9 131-134 (4 pages)
activity, cAMP levels and absence of specific K channel. However, little is known so far about electrophysiological and pharmacological characteristics of large-conductance Ca2-activated K (BKCa) channel in human fibroblast (CRL-1474). In the present study, we found Iberiotoxin- and TEA-sensitive outward rectifying oscillatory current with whole-cell recordings. Single channel analysis showed large conductance K channels (106 pS of chord conductance at 40 mV in... -
Biocomposite membranes based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and multiwall carbon nanotubes for gas separation
Mongyoung Huh, Hye Min Lee, Young Soo Park, Seok Il Yun 한국탄소학회 Carbon Letters 6 Pages
한국탄소학회 Carbon Letters 2017, Vol.21 17 116-121 (6 pages)
gas separation membranes is currently an active research area because of the rapidly increasing interest in carbon dioxide capture and hydrogen recovery, which are two of the most important solutions for problems related to energy and the environment [1-4]. Polymer membranes show selectivity in the separation of gases due to differences in the permeability of individual gases through the polymer film [3,4]. Even though advantageous in terms of low cost, the segmental flexibility of polymers has... -
Contact resistance in graphene channel transistors
Seung Min Song, Byung Jin Cho 한국탄소학회 Carbon Letters 9 Pages
한국탄소학회 Carbon Letters 2013, Vol.14 No.3 4 162-170 (9 pages)
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동아시아 두 섬의 신화와 전통주거 공간과의 상관성: 제주도와 오키나와의 화신(火神)의 신화와 부엌의 공간을 중심으로
이석주, 김영주 한국종교교육학회 종교교육학연구 14 Pages
한국종교교육학회 종교교육학연구 2022, 제 71권 13 233-246 (14 pages)
연구 목적 본 연구의 목적은 제주도와 오키나와의 신화에 투영된 두 섬의 전통민가에서 부엌의 공간과 화신(火神)의 의미를 연계해서 분석하는 것이다. 연구 내용 본 연구에서는 두 섬사람들은 그들의 신화의 내용에 근거해서 지었던 주거공간과 화신의 의미를 섬의 자연환경에 적합한 형태로 해석했다. 이러한 사유방식은 궁극적으로 이들에게 자연과 인간이 소통할 수 있는 결정적인 계기를 제공했다. 두 섬의 신화는 섬에서 생활하는 섬사람들의 실생활의 정서와 믿음을 반영하고 있다. 이같은 문화적 요소의 특징이 ‘원망의... -
Comparative proteomic analysis of proteins expression changes in the mammary tissue of cows infected with Escherichia coli mastitis
Xiao-wei Zhao, Yong-xin Yang, Dong-wei Huang, Guang-long Cheng, Hui-ling Zhao 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 2 253-263 (11 pages)
Cows infected with Escherichia (E.) coli usually experience severe clinical symptoms, including damage to mammary tissues, reduced milk yield, and altered milk composition. In order to investigate the host response to E. coli infection and discover novel markers for mastitis treatment, mammary tissue samples were collected from healthy cows and bovines with naturally occurring severe E. coli mastitis. Changes of mammary tissue proteins were examined using two-dimensional gel... -
Neuropharmacological effects of deltamethrin in rats
S. Manna, D. Bhattacharyya, T. K. Mandal, S. Dey 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 2호 7 133-136 (4 pages)
This study examined the effect of deltamethrin on some of the neuropharmacological paradigms in a rat brain such as the motor co-ordination test using a rotarod, the pentobarbitone-induced sleeping time and pentylenetetrazole (PTZ)-induced convulsion as well as the gamma aminobutyric acid (GABA) level. Albino Wistar rats were used as the experimental animals. Different neuropharmacological paradigms such as the motor co-ordination by the rotarod, pentobarbitone-induced sleeping time and the... -
The anti-thrombotic activity of surfactins
Jong hwan Lim, Byung kwon Park, Myoung seok Kim, Mi Hyun Hwang, Man Hee Rhee, Seung Chun Park, Hyo in Yun 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 4호 15 353-355 (3 pages)
Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents. -
SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
Man-Hee Rhee and Sang-Keun Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 6 179-184 (6 pages)
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive G protein-coupled receptor signaling. Agonist activation of the G(i/o)-coupled peripheral cannabinoid receptor CB2 normally inhibits adenylyl cyclase type V and stimulates adenylyl cyclase type II. Using transfected COS cells, we show here that application of SR144528, an inverse agonist... -
Proteome analysis between diverse phenotypes of Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium)
Gee Wook Shin , In Seok Cha , Woo Won Lee , Seong Won Nho , Seong Bin Park , Ho Bin Jang , Yong Hwan Kim , Tae Sung Jung 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 11 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2010, 제 50권 제 4호 5 285-295 (11 pages)
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RhGLP-1 (7-36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD
YiFang, XiaofangLiu, LiboZhao, ZhongnaWei, DaoliJiang, HuaShao, YannanZang, JiaXu, QianWang, YangLiu, YePeng, XiaoxingYin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 3 475-485 (11 pages)
The present study aimed to explore the neuroprotective effect and possible mechanisms of rhGLP-1 (7-36) against transient ischemia/reperfusion injuries induced by middle cerebral artery occlusion (MCAO) in type 2 diabetic rats. First, diabetic rats were established by a combination of a high-fat diet and low-dose streptozotocin (STZ) (30 mg/kg, intraperitoneally). Second, they were subjected to MCAO for 2 h, then treated with rhGLP-1 (7-36) (10, 20, 40 μg/kg i.p.) at the same time of... -
Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation
GyoungWanLee, JaeHyoKim, MinSunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 8 423-428 (6 pages)
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer’s collateral commissural fibers were... -
Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent γ-schisandrin
YuranNam, HyunJongKim, Young-MiKim, Young-WonChin, YungKyuKim, HyoSangBae, JooHyunNam, WooKyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 5 309-316 (8 pages)
for the treatment of various diseases. In this study, we investigated whether SC fruit extracts and seed oil, as well as four compounds isolated from the fruit can activate the TRPV3 channel. By performing whole-cell patch clamp recording in HEK293T cells overexpressing TRPV3, we found that the methanolic extract of SC fruit has an agonistic effect on the TRPV3 channel. Furthermore, electrophysiological analysis revealed that γ-schisandrin, one of the isolated compounds, activated TRPV3 at a... -
Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein
Md.TipuSultan, Hong-MeiLi, YongZuLee, SoonSungLim, Dong-KeunSong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 6 177-183 (7 pages)
HPLC (reverse phase, size exclusion, reverse phase) steps followed by SDS-PAGE and LC-MS/MS. K49-PLA2 induced Ca2+ influx in human neutrophils without any cytotoxic effect. Two calcium channel inhibitors, 2-aminoetoxydiphenyl borate (2-APB) (30 μM) and SKF- 96365 (20 μM) significantly inhibited K49-PLA2-induced [Ca2+]i increase. These results suggest that K49-PLA2 modulates [Ca2+]i in human neutrophils via 2-APB- and SKF- 96365-sensitive calcium channels without causing membrane disruption. -
Differential Gene Expression in GPR40-Overexpressing Pancreatic β-cells Treated with Linoleic Acid
In-SuKim, So-YoungYang, Joo-HuiHan, Sang-HyukJung, Hyun-SooPark, Chang-SeonMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 9 141-149 (9 pages)
“G protein-coupled receptor 40” (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion. We examined the profiles of differential gene expression in GPR40-activated cells treated with linoleic acid, and finally predicted the integral pathways of the cellular mechanism of GPR40-mediated insulinotropic effects. After constructing a GPR40-overexpressing stable cell line (RIN-40) from the rat pancreatic β-cell line RIN-5f, we determined the... -
Effects of Fluvastatin on the Pharmacokinetics of Repaglinide: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Fluvastatin
Chong-KiLee, Jun-ShikChoi, JoonSeokBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 10 245-251 (7 pages)
The purpose of this study was to investigate the effects of fluvastatin on the pharmacokinetics of repaglinide in rats. The effect of fluvastatin on P-glycoprotein and CYP3A4 activity was evaluated. The pharmacokinetic parameters and blood glucose concentrations were also determined after oral and intravenous administration of repaglinide to rats in the presence and absence of fluvastatin. Fluvastatin inhibited CYP3A4 activity in a concentration-dependent manner with a 50% inhibition... -
Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level
Doh-YeonKim, Chang-SubJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 11 219-224 (6 pages)
Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap junctions to the ERG b-wave. Many types of retinal neurons are connected to similar and different neighboring neurons through gap junctions. The photopic (cone-dominated) ERG, stimulated by a small light beam, was recorded from goldfish (Carassius auratus) using... -
Response of IKr and hERG Currents to the Antipsychotics Tiapride and Sulpiride
Su-HyunJo, So-YoungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 9 305-310 (6 pages)
The human ether-a-go-go-related gene (hERG) channel is important for repolarization in human myocardium and is a common target for drugs that prolong the QT interval. We studied the effects of two antipsychotics, tiapride and sulpiride, on hERG channels expressed in Xenopus oocytes and also on delayed rectifier K＋ currents in guinea pig cardiomyocytes. Neither the amplitude of the hERG outward currents measured at the end of the voltage pulse, nor the amplitude of hERG tail currents, showed any... -
A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K＋ Channels in Rabbit Ventricular Myocytes
WonSunPark, YounKyoungSon, EunAKo, SeongWooChoi, NariKim, Tae-HoonChoi, HyunJooYoun, Su-HyunJo, DaHyeHong, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 1 119-125 (7 pages)
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K＋ current (IK) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC50 value of 56.1±5.5Ռg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating IK without significantly altering the resting membrane... -
The Inhibitory Effects of Hydrogen Sulfide on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine
ShankarPrasadParajuli, SeokChoi, JunLee, YoungDaeKim, ChanGukPark, ManYooKim, HyunIlKim, CheolHoYeum, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 4 83-89 (7 pages)
(500ՌM and 1 mM) it seemed to cause light tonic inward currents and then inhibited pacemaker amplitude and pacemaker frequency, and also an increase in the resting currents in the outward direction. Glibenclamide or other potassium channel blockers (TEA, BaCl2, apamin or 4-aminopydirine) did not have an effect on NaHS-induced action in ICC. The exogenous application of carbonilcyanide p-triflouromethoxyphenylhydrazone (FCCP) and thapsigargin also inhibited the pacemaker activity of ICC as... -
Electrically-evoked Neural Activities of rd1 Mice Retinal Ganglion Cells by Repetitive Pulse Stimulation
SangBaekRyu, JangHeeYe, JongSeungLee, YongSookGoo, ChiHyunKim, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 6 443-448 (6 pages)
For successful visual perception by visual prosthesis using electrical stimulation, it is essential to develop an effective stimulation strategy based on understanding of retinal ganglion cell (RGC) responses to electrical stimulation. We studied RGC responses to repetitive electrical stimulation pulses to develop a stimulation strategy using stimulation pulse frequency modulation. Retinal patches of photoreceptor-degenerated retinas from rd1 mice were attached to a planar multi-electrode array... -
Multiple Residues in the P-Region and M2 of Murine Kir 2.1 Regulate Blockage by External Ba2＋
YoungMeeLee, GarethA.Thompson, IanAshmole, MarkLeyl, InsukSo, PeterR.Stanfield 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 10 61-69 (9 pages)
We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on Ba2＋ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary (CHO) cells and used the whole cell patch-clamp technique to record K＋ currents in the absence and presence of externally applied Ba2＋. Wild type Kir2.1 was blocked by externally applied Ba2＋ in a voltage and concentration dependent manner. Mutants... -
Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome
EunHuiBae, JongUnLee, SeongKwonMa, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 1 1-8 (8 pages)
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites and positive sodium balance. The plasma and urinary ANP (atrial natriuretic peptide) immunoreactivities... -
Two Types of Voltage-activated Calcium Currents in Goldfish Horizontal Cells
Sun-SookPaik, Sun-HoBai, Chang-SubJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 3 269-274 (6 pages)
mV and peaked at 20 mV. Co2 (2 mM) suppressed both of these two components, but nifedipine (20μM), L-type Ca2 channel antagonist, blocked only the sustained current. Based on the activation voltage and the pharmacological specificity, the sustained current appears to be similar to L-type ICa and the transient type to T-type ICa. This study is the first to confirm that transient type ICa together with the sustained one is present in HCs dissociated from goldfish retina. -
Higher Expression of TRPM7 Channels in Murine Mature B Lymphocytes than Immature Cells
JinKyoungKim, JaeHongKo, JooHyunNam, Ji-EunWoo, KyeongMinMin, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 1 69-76 (8 pages)
a cation channel protein permeable to various metal ions such as Mg2, is ubiquitously expressed in variety of cells including lymphocytes. The activity of TRPM7 is tightly regulated by intracellular Mg2, thus named Mg2-inhibited cation (MIC) current, and its expression is known to be critical for the viability and proliferation of B lymphocytes. In this study, the level of MIC current was compared between immature (WEHI-231) and mature (Bal-17) B lymphocytes. In both cell... -
Mechanisms of Myotonic Dystrophies 1 and 2
TimchenkoLubov 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 1 1-8 (8 pages)
Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2) expansions. In DM1, CTG repeats are located within the 3' untranslated region of myotonin protein kinase (DMPK) gene on chromosome 19q. DM2 is caused by expansion of CCTG repeats located in the first intron of a gene coding for zinc finger factor 9 on chromosome 3q. The CTG and CCTG expansions are... -
Ca2+-activated K+ Currents of Pancreatic Duct Cells in Guinea-pig
Han-WookLee, JingchaoLi, Na-YounKoo, ZhengGenPiao, SungMinHwang, Jae-WoongHan, Han-SaemChoi, Jong-HeunLee, JoongSooKim, KyungpyoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 7 335-338 (4 pages)
There are numerous studies on transepithelial transports in duct cells including Cl and/or HCO3. However, studies on transepithelial K transport of normal duct cells in exocrine glands are scarce. In the present study, we examined the characteristics of K currents in single duct cells isolated from guinea pig pancreas, using a whole-cell patch clamp technique. Both Cl and K conductance were found with KCl rich pipette solutions. When the bath solution... -
Nitric Oxide (NO) Inhibites the Neuronal Activities in the Rat Nucleus Tractus Solitarius
MiWonKim, MunSungPark, SunYoulRyu, JiYeonJung, YeonJinJeong, Sun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 2 7-15 (9 pages)
Nitric oxide (NO) system has been implicated in a wide range of physiological functions in the nervous system. However, the roleof NO in regulating the neural activity in the gustatory zone of nucleus tractus solitarius (NTS) has not been established. The present study was aimed to investigate the role of NO in the gustatory NTS neurons. Sprague-Dawley rats, weighing about 50 g, were used. Whole cell patch recording and immunohistochemistry were done to determine the electrophysiological... -
Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney
JongUnLee, KwangjayYoo, YoonWhaOh, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 10 181-185 (5 pages)
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found... -
Developmental Changes of Gustatory Neurons in Nucleus of Solitary Tract in Rats
MiwonKim, WonjaeKim, CharlotteMistretta 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 1 169-175 (7 pages)
To learn the developmental changes in intrinsic electrophysiological properties of the second order taste neurons, whole cell recordings from the developing nucleus of the solitary tract neurons were done in brainstem slices of postnatal rats. Rats aged from postnatal 0 to 21 days (P0-P21) were used, being divided into 3 age groups: postnatal first week (P0-P7 days), second week (P8-P14 days), and third week (P15-P21 days). Slices containing gustatory NTS were cut horizontally in the thickness... -
Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats
EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)
in a dose-dependent manner. The half-maximal inhibition dose (ED50) was 48.6⁑8.4μM and the Hill coefficient was 0.73⁑0.11. Single channel conductance calculated from the slope of the relationship between single channel current and pipette potential (20∼100 mV) was not significantly altered by propofol (control: 60.0⁑2.7 pS, 0.1 mM propofol: 58.7⁑3.5 pS). However, mean closed time was surely increased. Above results indicate that propofol blocks the KATP... -
Effects of Protein Kinase C Modulation on Hepatic Hemodynamics and Glucoregulation
JoongWooLee, InDeokKong, KyuSangPark, HaeSookChung, JamesPFilkins 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 5 571-578 (8 pages)
This study evaluated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) and PKC inhibition using the isoquinoline sulfomide derivative H-7 on hemodynamics and glucoregulation in the isolated perfused rat liver. Livers were isolated from fed male Holtzman rats and perfused with Krebs Ringer bicarbonate solution under a constant flow of 50 ml/min at 35oC. Portal vein pressure, glucose and lactate concentrations in the medium and oxygen consumption rates were continuously... -
Properties of Spontaneous Activity in Gastric Smooth Muscle
H.Suzuki, Y.Yamamoto, G.D.S.Hirst 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 1 119-125 (7 pages)
or by depleting Ca2 from SR with CPA. They persisted in the presence of Ca2-sensitive Cl-channel blockers, niflumic acid and DIDS or Co2, a non selective Ca2-channel blocker. These results suggest that spontaneous activity of gastric smooth muscle results from Ca2 release from SR, followed by activation of Ca2-dependent ion channels other than Cl channels, with the release of Ca2 from SR being triggered by membrane depolarization. -
왜 다양한 항우울제가 필요한가?
윤호경, 김용구 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2008, 제 47권 제 1호 2 11-21 (11 pages)
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r -Aminobutyric acid 수용체의 다양성
백인호, 김종은 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1985, 제 24권 제 2호 2 186-193 (8 pages)
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Changes of Polyamine Metabolism and Delayed Neuronal Degeneration of Hippocampus after Transient Cerebral Ischemia in Mongolian Gerbils
신경호(Kyung-Ho Shin), 신화정(Hwa-Jung Shin), 이영재(Young-Jae Lee), 김형건(Hyung-Gun Kim), 최상현(Sang-Hyun Choi), 천연숙(Yeon-Sook Chun), 전보권(Boe-Gwun 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 4 323-334 (12 pages)
Male Mongolian gerbils (60 ~ 80g) were given DL-difluoromethylornithine (DFMO; 250mg/kg, ip) and methylglyoxal bis(guanylhydrazone) (MGBG; 50 mg/k, ip), respectively, 1 h prior to transient (7 min) occlusion of bilateral common carotid arteries (OBC7) and a daily dose of one of them for 6 days after recirculation, and the polyamine contents, activities of ornithine and S-adenosylmethionine decarboxylases (ODC and SAM-DC), and light microscopic findings of the hippocampus were evaluated. The... -
뇌허혈 손상에 있어서 해마-세포외액내 Glutamate와 Polyamine 농도의 변동에 관한 연구
신경호(Kyung-Ho Shin), 김형건(Hyung-Gun Kim), 최상현(Sang-Hyun Choi), 조소현(So-Hyun Cho), 천연숙(Yeon-Sook Chun), 전보권(Boe-Gwun Chun) 대한약리학회 대한약리학잡지 18 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 3호 2 273-290 (18 pages)
뇌-허혈후 나타나는 신경세포의 손상에 glutamate의 과다한 유리와 그의 N-methyl-D-aspartate (NMDA) 수용체: calcium 통로 활성작용 및 polyamine중 putrescine의 증가로 인한 신경세포내 [Ca2+]의 상승과 관련 있다는 보고들이 있다. 본 연구에서는 Mongolian gerbil에서 5분간 경동맥을 차단하여 뇌-허혈을 가한후 재관류시 해마의 세포외액내 polyamine, glutamate, acetylcholine농도, 해마의 [3H]MK-801 결합능의 변동 및 해마조직소견의 변동에 미치는 비가역성 ornithine decarboxylase (ODC) 억제제인 difluoromethylornithine... -
Cromakalim이 해명의 과민반응 매개체 유리에 미치는 영향
노재열(Jai Youl Ro), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 2호 12 263-274 (12 pages)
K+통로는 기도 평활근 세포에 존재하며 이들 통로가 활성화되면 평활근의 과분극의 결과 이완작용이 나타난다. K+통로의 이런 효과는 과민반응과 천식 치료에 응용될 수 있으므로 우리는 K+통로 개방제인 cromakalim (BRL34915, CK)이 IgG1 항체로 감작시킨 기도 및 폐조직으로 부터 유리되는 매개체 유리에 미치는 영향을 조사하였다. 피동적으로 감작된 두 조직은 2 × 10-6 M의 CK로 30분동안 superfusion시킨 후 CK와 항원 (Ox-HSA) 0.1 mg/ml로 자극하였다. 또한 비만세포를 이용하여 CK의 효과를 조사하였다. 해명 폐조직... -
선천성 고혈압흰쥐에서 Endothelin과 Neuropeptide Y에 의한 심혈관계 반응에 Enalapril 장기처치가 미치는 영향
김권배(Kwon-Bae Kim), 손의동(Uy-Dong Sohn), 김중영(Choong Young Kim) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1992, 제 28권 제 1호 6 49-60 (12 pages)
선천성 고혈압 흰쥐(SHR)에서 endothelin-1(ET)과 neuropeptide Y(NPY) 투여에 의한 심혈관계 반응에 미치는 enallapril 장기처치의 영향을 검토하였다. 생후 6주의 SHR에 enalapril(3 mg/kg/day)을 6주간 투여하였을 때 고혈압 발현이 현저히 억제되었다(이하 enalapril 처치군). Enalapril 처치군에서 ET 및 NPY에 의한 승압반응이 현저히 억제되었지만, ET 측뇌실투여에 의한 혈압상승 및 NPY측뇌실 투여로 야기되는 혈압하강효과에는 영향이 없었다. 뇌척수제거 흰쥐에서 전기적 자극으로 야기되는 빈맥효과는 enalapril처치나... -
β1/β2 비선택적 Radioligand (-)-[3H]-DHA를 사용한 Rat 좌심실 β-adrenoceptor에 대한 심장순환계 약물의 Binding
권광일(Kwang-Il Kwon), 이선경(Sun-Kyung Lee), 유성은(Sung-Eun Yoo) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 1991, 제 27권 제 2호 4 119-124 (6 pages)
β-수용체 효능약물 ((-)-NE), 길항약물 ((\pm)-propranolol, labetalol) 및 PDE 억제약물(imazodan, KR-30045, KR-30075 등)에 대한 β-adrenoceptor binding 실험을 β1/β2 비선택적 radioligand인 (-)-[3H]-DHA를 사용하여 실시하였다. Saturation 실험에서 β_1 및 β_2 수용체를 모두 갖고 있는 rat 좌심실의 β 수용체에 대한 (-)-[3H]-DHA의 KD 값은 1.5 ± 0.43 nM, B_{max}는 22.0 ± 0.9 fmol/mg protein이었다. ( ± )propranolol, labetalol 및 (-)NE는 단일상으로 (-)-[3H]-DHA의 결합을 억제하였으며 Ki 값은 각각 17.0 ±... -
생체의 Polyamine-분석을 위하여 FNBT-유도체를 이용하는 간편하고 특이적이며 예민한 Isocratic RP-HPLC 분석법과 재생성 흰쥐-간의 Polyamine-대사의 변동에 관한연구
최상현(Sang-Hyun Choi), 김형건(Hyung-Gun Kim), 박홍익(Hong-Ik Park), 전보권(Boe-Gwun Chun) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1988, 제 24권 제 2호 9 233-240 (8 pages)
복잡한 시료-전처리과정을 배제하여 간편하고 선택적이며 예민한 polyamine 측정방법으로써 4-fluoro-3-nitrobenzotrifluoride (FNBT)유도체 및 단일이동상을 이용하는 역상의 고속액체 크로마토 그래피 (HPLC) 방법과 아울러 이 방법을 이용한 흰쥐의 재생성간내 polyamine대사의 변동에 관한 관찰-결과를 요약하면 다음과 같다. 1. 간내-polyamine은 0.4M perchloric acid에 추출한 후 Spragg와 Hutchings의 방법에 따라서 FNBT로 N-2 -nitro-4 -trifluoromethylphenyl polyamine (NTP-polyamine) 유도체를 만들고 이를HPLC로 분석... -
Isolation and Characterization of Endosome Subpopulation in Chinese Hamster Ovarian Cells
Suh, Duk-Joon, Park, Mi-Yeon, Jung, Dong-Keun, Bae, Hae-Rahn 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 2 197-208 (12 pages)
vesicular features than early endosomes. For the purpose of determining whether ATP-dependent acidification was heterogeneous and whether the differences in acidification were attributed to differences in the activity of Na+-K+-ATPase and/or Cl- channel, endocytic compartments were fractionated into subpopulation using percoll gradient and measured ATP-dependent acidification. While all fractions exhibited ATP-dependent acidification activity, both the initial rate of acidification and extent of... -
Effects of Cd2+ on the Contractility in the Antral Circular Muscle of Guinea-pig Stomach
Kim, Eui-Yong, Han, Jin 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 4 129-136 (8 pages)
the contracture. Cd2+ suppressed the amplitude of the Na+ tee contracture dose dependently and the amplitude of Na+ free contracture almost decreased to 20% of control amplitude in the concentration of 10-4 M Cd2+. From the above results, it is suggested that Cd2+ may inhibit not only Ca2+ influx via voltage sensitive, receptor operated Ca2+ channel and Na/ca exchange but also intracellular Ca2+ release from the sarcoplasmic reticulum in the antral circular muscle of guinea pig stomach. -
Calcium Balance in the Heart -Annual Review Lecture, October 13, 1990-
Noble, Denis 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 1 1-16 (16 pages)
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고양이 회장 종주근에서 Na-Ca 교환 기전의 특성에 관한 연구
우재석(Woo, Jae-Suk), 서덕준(Suh, Duk-Joon), 김용근(Kim, Yong-Keun), 이상호(Lee, Sang-Ho) 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1989, 제 23권 제 2호 2 237-252 (16 pages)
고양이 회장 종주근에서 세포막 소포를 분리하여 Na+의 농도 경사에 의존하여 일어나는 Ca2+ 이동의 특성에 대하여 연구하였다. 막소포 내부에서 외부로 향하는 Na+의 농도 경사 존재시 Ca2+의 축적이 현저히 증가하여 Na+ 의존성 Ca2+ 축적을 보였으며, 이는 외부용액에 Na+ ionophore인 monensin을 처리시 소실되었다. 한편 이러한 Ca2+ 축적의 증가 작용은 Na+에 특이적이었으며 K+, Li+, Rb+, Cs+ 및 choline이온은 Na+의 작용을 대치하지 못하였다. Ba2+, Sr2+, Mn2+ 및 Cd2+ 등의 2가 양이온들은 0.5 mM의 농도에서 Na+ 의존성 Ca2+...
