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91.

Direct Block of Cloned K+ Channels, Kv1.5 and Kv1.3, by Cyclosporin A, Independent of Calcineurin Inhibition

BokHeeChoi, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 7 353-362 (10 pages)

BokHeeChoi, SangJuneHahn 저
...
- 3,000원
The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at ⁢50 mV in a reversible concentration- dependent manner with an apparent IC50 of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA....
92.

Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes

YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 5 103-108 (6 pages)

YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 저
...
- 3,000원
a Boltzmann equation. Voltage of half-activation (V0.5) was ⁣12⁑0.5 mV in control and ⁣11⁑1.9 mV in SS treated groups (respectively, n=5). The same values of half-inactivation were ⁣35⁑1.4 mV and ⁣35⁑1.9 mV (respectively, n=5). There was no significant difference in activation and inactivation kinetics of IBa by SS. Inhibitory effect of SS on IBa was significantly reduced by either dialysis of intracellular solution with GDPβS, a non-hydrolysableG...
93.

TASK-1 Channel Promotes Hydrogen Peroxide Induced Apoptosis

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 9 63-67 (5 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
...
- 1,500원
Hydrogen peroxide (H2O2) causes oxidative stress and is considered as an inducer of cell death in various tissues. Two-pore domain K⁢ (K2p) channels may mediate K⁢ efflux during apoptotic volume decreases (AVD) in zygotes and in mouse embryos. In the present study, we sought to elucidate linkage between K2p channels and cell death by H2O2. Thus K2p channels (TASK-1, TASK-3, TREK-1, TREK-2) were stably transfected in HEK-293 cells, and cytotoxicity assay was preformed using cell...
94.

Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 8 55-62 (8 pages)

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 저
...
- 3,000원
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the present study, 3μl of 0.1% dried crude extract or 2μl of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the [Ca2⁢]i of the cultured osteoblast cells: 3μl of 0.1% dried...
95.

Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

Yeo-MinLee, HeeJungKim, SunHwaHong, Myung-JunKim, DoSikMin, Duck-Joo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 9 57-63 (7 pages)

Yeo-MinLee, HeeJungKim, SunHwaHong, Myung-JunKim, DoSikMin, Duck-Joo 저
...
- 3,000원
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based digital calcium imaging and assay for [3H]-inositol phosphates (IPs). Treatment with ATP (100μM) for 2 min induced [Ca2⁢]i increases. The ATP-induced [Ca2⁢]i increases were significantly decreased by removal of extracellular Ca2⁢ and...
96.

Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 6 33-41 (9 pages)

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 저
...
- 3,000원
of the action potential (AP) was significantly changed by stretch in the model simulation. The duration was decreased at initial fast phase of repolarization (AP duration at 20% repolarization level from 3.7 to 2.5 ms) and increased at late slow phase of repolarization (AP duration at 90% repolarization level from 62 to 178 ms). The resting potential was depolarized from ⁣75 to ⁣61 mV. This mathematical model of SACs may quantitatively predict changes in cardiomyocytes by mechanical...
97.

Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 저
...
- 4,100원
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation...
98.

Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Il-SungJangNorioAkaike 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 1 63-70 (8 pages)

Il-SungJangNorioAkaike 저
...
- 3,000원
in the Ca2⁢-free external solution. However, the inhibitory action of muscarine on GABAergic mIPSCs was completely occluded in the presence of forskolin. The results suggest that muscarine acts presynaptically and reduces the probability of spontaneous GABA release, and that such muscarine-induced inhibitory action seems to be mediated by G-protein-coupled M2 receptors, via the reduction of cAMP production. Accordingly, M2 receptor-mediated disinhibition of nBM neurons might play one of...
99.

Forward-Mode Na+-Ca2+ Exchange during Depolarization in the Rat Ventricular Myocytes with High EGTA

Eun-GiKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 5 487-494 (8 pages)

Eun-GiKim, ChangMannKo 저
...
- 3,000원
and by omitting KCl in the external Tyrode solution. Cl⁣ current was suppressed by adding 0.1 mM DIDS in the external Tyrode solution. During stimulation roughly mimicking action potential, the initial outward current was converted into inward current, 47⁑1% of which was suppressed by 0.1 mM CdCl2. 10 mM caffeine increased the remaining inward current after CdCl2 in a cAMP-dependent manner. This caffeine-induced inward current was blocked by 1μM ryanodine, 10μM thapsigargin, 5 mM...
100.

The Inhibitory Effect of Opioid on the Hyperpolarization-Activated Cation Currents in Rat Substantia Gelatinosa Neurons

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 2 373-380 (8 pages)

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 저
...
- 3,000원
The action of opioid on the hyperpolarization-activated cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents in a subgroup of neurons. The half-maximal activation and the reversal potential of the current were compatible to neuronal Ih. DAMGO (1μM), a selective- opioid agonist, reduced the amplitude of Ih reversibly. This reduction was...

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