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Congenital LQT Syndromes From Gene to Torsade de Pointes
EdwardCarmeliet 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.1 1 1-8 (8 pages)
Congenital Long QT syndrome (LQTs) is a relatively rare pathologic disorder but results frequently in sudden cardiac death. Of the six LQTs that have been clinically described, five have been worked out for their genetic and biophysical profile. Most are generated by mutations which cause a loss of function in two delayed Kcurrents, iKs and iKr. One syndrome is generated by mutations in the Na channel which causes essentially a gain of function in the channel. Clinically the... -
Comparison of the Determinants in the Differences in Force- Frequency Relationships between Rat and Rabbit Left Atria
ChangMannKoSoon-JinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 11 417-425 (9 pages)
The underlying mechanism commonly applicable for both the positive and negative force-frequency relationships (FFR) was pursued in left atria (LA) of rat and rabbit. The species differences in the roles of Na/Ca2 exchanger and sarcoplasmic reticulum (SR), which are major intracellular Ca2 regulatory mechanisms in the heart, were examined in the amplitude accommodation to the frequency that changed from 3 Hz to the variable test frequencies for 5 minutes in the electrically... -
Renal Handling of Sodium and Potassium in Cadmium Exposed Rats
YungKyuKimYangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 12 503-510 (8 pages)
and this was due to an increased Na reabsorption both in the proximal and distal nephrons. During the late phase (third week) of cadmium treatment, filtered Na load was decreased by reduction in GFR, but the renal Na excretion returned to the control level due to impaired Na transport in the proximal tubule. Urinary excretion of K did not change during the early phase, but it rose markedly during the late phase of cadmium treatment. These results indicate that... -
Regulatory Mechanisms of Angiotensin II on the Na+/H+ Antiport System in Rabbit Renal Proximal Tubule Cells. II. Inhibitory Effects of ANG II on Na+ Uptake
HoJaeHan, SooHyunPark, HyunJuKoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 9 425-434 (10 pages)
and KN-62 blocked the ANG II-induced inhibition of Na+ uptake. Arachidonic acid reduced Na+ uptake in a dose-dependent manner. When ANG II and arachidonic acid were treated together, inhibitory effects on Na+ uptake significantly exhibited greater reduction than that of each group, respectively. When PTCs were treated by mepacrine (10-6 M) and AACOCF3 (10-5 M) for 1 hr before the addition of 10-9 M ANG II, the inhibitory effect of ANG II was reversed. In addition, econazole (10-6 M) blocked ANG... -
Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells
SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)
Cis-dichlorodiammine platinum II (Cisplatin), an effective chemotherapeutic agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin on the renal proximal tubular transport system, LLC-PK1 cell line was selected as a cell model and the sugar transport activity was evaluated during a course of cisplatin treatment. Cells grown to confluence were treated with cisplatin for 60 min, washed, and then incubated for up to 5 days. At appropriate... -
The Staging of Major Mood Disorders
Ather Muneer, Rana Mazommil 대한신경정신의학회 Psychiatry Investigation 12 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 2 747-758 (12 pages)
with the caveat that many more articles were discovered for bipolar disorder. Current evidence points to allostatic load and neuroprogression as the basis for staging of mood disorders. Conclusion_Principal affective illnesses may be characterized by distinct stages, for instance early, intermediate and late. These phases inform the management so that clinicians should incorporate the staging schema into everyday practice and implement treatment strategies according to the phase of the illness. -
정신분열병 고위험군에서의 뇌영상 연구
최정석, 권준수 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2008, 제 47권 제 5호 4 430-440 (11 pages)
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정신분열병의 비이환 형제 자매 집단에서 얼굴 정보처리 관련 뇌회로의 이상: 기능적 뇌자기공명영상 예비 연구
최경숙, 정범석, 김지웅, 최지욱 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 2009, 제 48권 제 2호 2 70-76 (7 pages)
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정신건강증진의 개념과 발전 방향
우종민, 백종우, 이주영 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 2010, 제 49권 제 2호 6 163-170 (8 pages)


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