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1151.

Dexmedetomidine inhibits vasoconstriction via activation of endothelial nitric oxide synthase

LidanNong, JueMa, GuangyanZhang, ChunyuDeng, SongsongMao, HaifengLi, JianxiuCui 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 1 441-447 (7 pages)

LidanNong, JueMa, GuangyanZhang, ChunyuDeng, SongsongMao, HaifengLi, JianxiuCui 저
...
- 3,000원
Despite the complex vascular effects of dexmedetomidine (DEX), its actions on human pulmonary resistance arteries remain unknown. The present study tested the hypothesis that DEX inhibits vascular tension in human pulmonary arteries through the endothelial nitric oxide synthase (eNOS) mediated production of nitric oxide (NO). Pulmonary artery segments were obtained from 62 patients who underwent lung resection. The direct effects of DEX on human pulmonary artery tension and changes in vascular...
1152.

Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis

Song-InKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 8 387-397 (11 pages)

Song-InKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 저
...
- 4,000원
Neurofibrillary tangles (NFTs) of microtubule-associated protein tau are a pathological hallmark of Alzheimer’s disease (AD). Endoplasmic reticulum (ER) stress has been known to be involved in the pathogenesis of AD. However, the exact role of ER stress in tau pathology has not yet been clearly elucidated. In present study, the possible relationship between tau pathology and ER stress was examined in terms of sorcin, which is a calcium binding protein and plays an important role in calcium...
1153.

Electrophysiological and Mechanical Characteristics in Human Ileal Motility: Recordings of Slow Waves Conductions and Contractions, In vitro

Seung-BumRyoo, Heung-KwonOh, SangHuiMoon, EunKyungChoe, SungAYu, Sung-HyePark, KyuJooPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 8 533-542 (10 pages)

Seung-BumRyoo, Heung-KwonOh, SangHuiMoon, EunKyungChoe, SungAYu, Sung-HyePark, KyuJooPark 저
...
- 3,000원
Little human tissue data are available for slow waves and migrating motor complexes, which are the main components of small bowel motility. We investigated the electrophysiological and mechanical characteristics of human ileal motility, in vitro. Ileum was obtained from patients undergoing bowel resection. Electrophysiological microelectrode recordings for membrane potential changes and mechanical tension recordings for contraction from smooth muscle strips and ileal segments were performed....
1154.

Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

HoaiBacNguyen, ShinYoungLee, SooHyunPark, JunHyunHan, MooYeolLee, SoonChulMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 10 257-262 (6 pages)

HoaiBacNguyen, ShinYoungLee, SooHyunPark, JunHyunHan, MooYeolLee, SoonChulMyung 저
...
- 3,000원
It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile...
1155.

NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3

SuInLee, JieunYun, Ji-YoungBaek, Yun-JiJeong, Jin-AhKim, JongSoonKang, SunHongPark, SangKyumKim, Song-KyuPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 4 105-109 (5 pages)

SuInLee, JieunYun, Ji-YoungBaek, Yun-JiJeong, Jin-AhKim, JongSoonKang, SunHongPark, SangKyumKim, Song-KyuPark 저
...
- 1,500원
NgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells using all trans-retinoic acid and the presence and/or function of cellular molecules, such as NgR1, NMDA receptors and STAT3, were examined. Neuronally differentiated P19 cells expressed the mRNA and protein of NgR1, which could stimulate the phosphorylation of STAT3 when activated...
1156.

TRPV1 in Salivary Gland Epithelial Cells Is Not Involved in Salivary Secretion via Transcellular Pathway

SeulkiChoi, Yong-HwanShin, EunNamkoong, Sung-MinHwang, XinCong, GuangyanYu, KyungpyoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 12 525-530 (6 pages)

SeulkiChoi, Yong-HwanShin, EunNamkoong, Sung-MinHwang, XinCong, GuangyanYu, KyungpyoPark 저
...
- 3,000원
Transient receptor potential vanilloid subtype 1 (TRPV1) was originally found in sensory neurons. Recently, it has been reported that TRPV1 is expressed in salivary gland epithelial cells (SGEC). However, the physiological role of TRPV1 in salivary secretion remains to be elucidated. We found that TRPV1 is expressed in mouse and human submandibular glands (SMG) and HSG cells, originated from human submandibular gland ducts at both mRNA and protein levels. However, capsaicin (CAP), TRPV1 agonist,...
1157.

Reversal of Cisplatin Resistance by Epigallocatechin Gallate Is Mediated by Downregulation of Axl and Tyro 3 Expression in Human Lung Cancer Cells

Kyung-ChanKim, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 8 61-66 (6 pages)

Kyung-ChanKim, ChuHeeLee 저
...
- 3,000원
Lung cancer is still the number one cause of death from cancer worldwide. The clinical effect of platinum-based chemotherapy for non-small cell lung cancer is constrained by the resistance to drug. To overcome chemo-resistance, various modified treatment including combination therapy has been used, but overall survival has not been improved yet. In this study, chemo-resistant lung cancer cells, A549/Cis and H460/Cis, were developed by long-term exposure of cells to cisplatin and the...
1158.

Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca2＋-Activated Potassium Channel Currents

Sun-HyeChoi, Byung-HwanLee, Hyeon-JoongKim, Sung-HeeHwang, Sang-MokLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 7 223-228 (6 pages)

Sun-HyeChoi, Byung-HwanLee, Hyeon-JoongKim, Sung-HeeHwang, Sang-MokLee, Seung-YeolNah 저
...
- 3,000원
The calcium-activated K＋ (BKCa) channel is one of the potassium-selective ion channels that are present in the nervous and vascular systems. Ca2＋ is the main regulator of BKCa channel activation. The BKCa channel contains two high affinity Ca2＋ binding sites, namely, regulators of K＋ conductance, RCK1 and the Ca2＋ bowl. Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is one of the neurolipids. LPA affects diverse cellular functions on many cell types through G protein-...
1159.

Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-α and IFNγ-stimulated Primary Cultured Astrocytes

Jin-KooLee, Jin-KyuKim, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 1 251-258 (8 pages)

Jin-KooLee, Jin-KyuKim, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Hong-WonSuh 저
...
- 3,000원
Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-Ձ and IFNՃ(CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the gene expression of ICAM-1 and VCAM-1. D-Threo-1-phenyl- 2-decanoylamino-3-morpholino-1-propanol (PDMP) and N-butyldeoxynojirimycin (NBDNJ), inhibitors of glucosylceramide synthase (GLS) and LacCer synthase (galactosyltransferase, GalT-2), inhibited the gene expression...
1160.

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 6 107-114 (8 pages)

Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 저
...
- 3,000원
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3Ղ has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate the aggregate formation of tau. The present study examined the role of GSK3Ղ-mediated phosphorylation of tau species on their autophagic degradation. We transfected wild type tau (T4), caspase-3-cleaved tau at Asp421 (T4C3), or pseudophosphorylated tau at Ser396/Ser404 (T4-2EC) in the...

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