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111.

SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation

Rosa Gagliardi, Silvia Llambí, M. Victoria Arruga 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 4 273-280 (8 pages)

Rosa Gagliardi, Silvia Llambí, M. Victoria Arruga 저
...
- 3,000원
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which animals express modified proteins or genetic sequences responsible for adverse effects associated with a drug. Among the genetic variations that have been investigated in dogs, the multidrug resistance gene (MDR) is the best studied. However, other genes such as CYP1A2 and...
112.

Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Jung Hoon Choi, Woosuk Kim, Hyo Young Jung, Moo-Ho Won, In Koo Hwang, Je Kyung Seong, 대한수의학회 Journal of Veterinary Science 7 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 1 245-251 (7 pages)

Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Jung Hoon Choi, Woosuk Kim, Hyo Young Jung, Moo-Ho Won, In Koo Hwang, Je Kyung Seong, 저
...
- 3,000원
Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor in adult neurogenesis has not been clearly demonstrated. Therefore, we performed the present study to compare the effects of pharmacological and genetic inhibition of COX-2 on adult hippocampal neurogenesis. Physiological saline or the same volume containing celecoxib was administered...
113.

The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study 

Jian Huang, Di Zhang, Fuqiang Xie, Degui Lin 대한수의학회 Journal of Veterinary Science 7 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 13 225-231 (7 pages)

Jian Huang, Di Zhang, Fuqiang Xie, Degui Lin 저
...
- 3,000원
in primary canine mammary tissues and tumorsphere models using immunohistochemistry. Patterns of COX-2, CD44, octamer-binding transcription factor (Oct)-3/4, and epidermal growth factor receptor (EGFR) expression were examined in malignant mammary tumor (MMT) samples and analyzed in terms of clinicopathological characteristics. COX-2 and Oct-3/4 expression was higher in MMTs compared to other histological samples with heterogeneous patterns. In MMTs, COX-2 expression correlated with tumor...
114.

Micro-computed tomography evaluation and pathological analyses of female rats with collagen-induced arthritis

Young Hee Kim, Jin Seok Kang 대한수의학회 Journal of Veterinary Science 7 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 5 165-171 (7 pages)

Young Hee Kim, Jin Seok Kang 저
...
- 3,000원
Imaging techniques have been introduced to assess the efficacy and toxicity of developing pharmaceuticals. The purpose of this study was to perform a comprehensive characterization of collagen-induced arthritis (CIA) in rats using micro-computed tomography (micro-CT) and to compare the results with data from conventional pathological examination. Arthritis was induced by collagen in 24 female Wistar rats. Micro-CT and pathological analyses were performed to assess arthritis progression. Micro-CT...
115.

The production and distribution of IL-6 and TNF-α in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome

Katarzyna Basinska, Krzysztof Marycz, Agnieszka ?mieszek, Jakub Nicpo? 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 15 113-120 (8 pages)

Katarzyna Basinska, Krzysztof Marycz, Agnieszka ?mieszek, Jakub Nicpo? 저
...
- 3,000원
A main symptom of equine metabolic syndrome (EMS) in ponies is pathological obesity characterized by abnormal accumulation of fat deposits and inflammation. In this study, we analyzed the expression of two pro-inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in subcutaneous adipose tissue and the correlation with serum concentrations in peripheral blood of Welsh ponies. Based on clinical examination findings, the animals were...
116.

Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats

Jong Whi Kim, Junghyun Chae , Sung Min Nam, Yo Na Kim, Dae Young Yoo, Jung Hoon Choi, Hyo Young Jung, Wook Song, In Koo Hwang, J 대한수의학회 Journal of Veterinary Science 6 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 2 11-16 (6 pages)

Jong Whi Kim, Junghyun Chae , Sung Min Nam, Yo Na Kim, Dae Young Yoo, Jung Hoon Choi, Hyo Young Jung, Wook Song, In Koo Hwang, J 저
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- 3,000원
In the present study, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean control rats (ZLC) during the onset of diabetes. At 7 weeks of age, ZLC and ZDF rats were either placed on a stationary treadmill or made to run for 1 h/day for 5 consecutive days at 16∼22 m/min for 5 weeks. At 12 weeks of age, the ZDF rats had significantly higher...
117.

β-irradiation (Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin

Joong-Sun Kim, Kyung-Jin Rhim, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Seung-Sook Lee, Sunhoo Park, Sang Moo Lim 대한수의학회 Journal of Veterinary Science 9 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 1 1-9 (9 pages)

Joong-Sun Kim, Kyung-Jin Rhim, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Seung-Sook Lee, Sunhoo Park, Sang Moo Lim 저
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- 3,000원
In the present study, the detrimental effect of β-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of β-emission delivered by Ho patches. Clinicopathological and immunohistochemical changes in exposed skin were monitored for 18 weeks after β-irradiation. Radiation induced desquamation at 2∼4 weeks and gradual repair of this damage was evident 6 weeks after irradiation. Changes in basal cell density...
118.

Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord

Ji Hyeon Ahn, Joon Ha Park, In Hye Kim, Jae-Chul Lee, Bing Chun Yan, Min Sik Yong, Choong Hyun Lee, Jung Hoon Choi, Ki-Yeon Yoo, 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 3호 1 335-342 (8 pages)

Ji Hyeon Ahn, Joon Ha Park, In Hye Kim, Jae-Chul Lee, Bing Chun Yan, Min Sik Yong, Choong Hyun Lee, Jung Hoon Choi, Ki-Yeon Yoo, 저
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- 3,000원
N-acetyltransferase (AANAT), an enzyme essential for melatonin synthesis, and melatonin receptor type 1B (MT2) in the spinal cord of young adult (2∼3 years) and aged (10∼12 years) beagle dogs using immunohistochemistry and Western blotting. AANAT-specific immunoreactivity was observed in the nuclei of spinal neurons, and was significantly increased in aged dog spinal neurons compared to young adult spinal neurons. MT2-specific immunoreactivity was found in the cytoplasm of spinal neurons, and...
119.

Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice

Zhiqiang Huang, Meng Yu, Shuang Tong, Kun Jia, Rongchang Liu, Heng Wang, Shoujun Li*, Zhangyong Ning* 대한수의학회 Journal of Veterinary Science 5 Pages

대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 1 173-177 (5 pages)

Zhiqiang Huang, Meng Yu, Shuang Tong, Kun Jia, Rongchang Liu, Heng Wang, Shoujun Li*, Zhangyong Ning* 저
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- 1,500원
Activation of the innate immune system requires recognition of pathogen-associated molecular patterns, such as NOD-like receptors. The NOD-like receptor protein 3 (NLRP3) inflammasome is involved in induction of the pro- inflammatory cytokine, IL-1β, and subsequent inflammatory responses. NLRP3 inflammasome plays important roles in the inflammatory and innate immune responses associated with autoimmune/inflammatory syndrome. However, analysis of the tissue distribution and expression profiles...
120.

Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice

Jine Yi*, Wei Xia, Jianping Wu, Liyun Yuan, Jing Wu, Di Tu, Jun Fang, Zhuliang Tan* 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 16 141-148 (8 pages)

Jine Yi*, Wei Xia, Jianping Wu, Liyun Yuan, Jing Wu, Di Tu, Jun Fang, Zhuliang Tan* 저
...
- 3,000원
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential mechanism underlying the ability of this compound to prevent liver damage induced by alcohol in vivo. Mice were given oral doses of BA (0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and induced liver injury by feeding 50% alcohol orally at the dosage of 10 ml/kg after 1 h last administration of BA. BA...

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