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1221.

Comparative Study on the Nociceptive Responses Induced by Whole Bee Venom and Melittin

HongKeeShin, KyungHeeLee, SeoEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 7 281-288 (8 pages)

HongKeeShin, KyungHeeLee, SeoEunLee 저
...
- 3,000원
The present study was undertaken to confirm whether melittin, a major constituent of whole bee venom (WBV), had the ability to produce the same nociceptive responses as those induced by WBV. In the behavioral experiment, changes in mechanical threshold, flinching behaviors and paw thickness (edema) were measured after intraplantar (i.pl.) injection of WBV (0.1 mg & 0.3 mg/paw) and melittin (0.05 mg & 0.15 mg/paw), and intrathecal (i.t.) injection of melittin (6μg). Also studied were the...
1222.

Neurotrophic and Neuritogenic Effects of Water Extracts of Rhizoma of Coptis chinensis Franch in PC12 Cells

Gee-YounKwon, Byung-KilChoe, Soo-KyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 9 175-179 (5 pages)

Gee-YounKwon, Byung-KilChoe, Soo-KyungKim 저
...
- 1,500원
Coptis chinensis (CC) is one of the traditional herbs used in Oriental medicine for the treatment of gastrointestinal disorders, anxiety, and insomnia. In this study, neurotrophic and neuritogenic effects of CC on rat pheochromocytoma (PC12) cells were evaluated. Pretreatment of PC12 cells with water extracts of CC (120μg /ml) produced considerable outgrowth of neurites that is comparable to the effect of nerve growth factor (NGF). Therefore, neurite outgrowth was quantified and expression of...
1223.

Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 저
...
- 4,100원
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation...
1224.

Effects of Kanagawa Hemolysin on Blood Pressure and Arterial Tone in Rats

YoungMoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 8 225-233 (9 pages)

YoungMoonKim 저
...
- 3,000원
Kanagawa hemolysin (KH), an exotoxin produced from Kanagawa phenomenon-positive Vibrio parahemolyticus, has been shown to possess various biological activities including hemolysis, enterotoxicity, cytotoxicity, and cardiotoxicity. The aim of this study was to investigate the effect of KH on the cardiovascular system and its mechanism, employing in vivo and in vitro experiments of the rat. Intracerebroventricular (icv) administration of 100 mHU KH produced a marked and continuous pressor effect...
1225.

Role of Calmodulin in the Generation of Reactive Oxygen Species and Apoptosis Induced by Tamoxifen in HepG2 Human Hepatoma Cells

YongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 3 187-192 (6 pages)

YongSooLee 저
...
- 3,000원
Tamoxifen, an antiestrogen, has previously been shown to induce apoptosis in HepG2 human hepatoblastoma cells through activation of the pathways independent of estrogen receptors, i.e., intracellular Ca2⁢ increase and generation of reactive oxygen species (ROS). However, the mechanism of tamoxifen to link increased intracellular Ca2⁢ to ROS generation is currently unknown. Thus, in this study we investigated the possible involvement of calmodulin, a Ca2⁢ activated protein, and...
1226.

Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 5 93-100 (8 pages)

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 저
...
- 3,000원
Effects of oxidized low-density lipoprotein (ox-LDL), l-α-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca2⁢ concentration were examined in mouse endothelial cells by measuring intracellular Ca2⁢ concentration ([Ca2⁢]i) with fura 2-AM and reverse transcription-polymerase chain reaction (RT-PCR). LPC increased [Ca2⁢]i under the condition of 1.5 mM [Ca2⁢]o but did not show any effect under the nominally Ca2⁢-free condition. Even after the store...
1227.

Lipopolysaccharide Inhibits Proliferation of the Cultured Vascular Smooth Muscle Cells by Stimulating Inducible Nitric Oxide Synthase and Subsequent Activation of Guanylate Cyclase

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 7 343-351 (9 pages)

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 저
...
- 3,000원
This study was undertaken to investigate the mechanism of lipopolysaccharide (LPS) and nitric oxide (NO) as a regulator of vascular smooth muscle cell (VSMC) proliferation. VSMC was primarily cultured from rat aorta and confirmed by the immunocytochemistry with anti-smooth muscle myosin antibody. The number of viable VSMCs were counted, and lactate dehydrogenase (LDH) activity was measured to assess the degree of cell death. Concentrations of nitrite in the culture medium were measured as an...
1228.

Tyrosine Phosphorylation of Paxillin May be Involved in Vascular Smooth Muscle Contraction

Lian-HuaFang, Kyoung-SooCho, Sang-JinLee, Hee-YulAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 5 211-217 (7 pages)

Lian-HuaFang, Kyoung-SooCho, Sang-JinLee, Hee-YulAhn 저
...
- 3,000원
Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated a possible role for the membrane-associated dense plaque protein paxillin in the regulation of contraction in rat aortic vascular smooth muscle. The tyrosine phosphorylation of paxillin, which was increased by norepinephrine, reached a peak level after 1 min stimulation and...
1229.

Selective Cytotoxicity of a Novel Platinum(II) Coordination Complex on Human Bladder Cancer Cell Lines and Normal Kidney Cells

Jee-ChangJung, Joo-HoChung, Sung-GooChang, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 11 159-167 (9 pages)

Jee-ChangJung, Joo-HoChung, Sung-GooChang, Young-SooRho 저
...
- 3,000원
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-dichloroethane (DCE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DCE)]·2NO3(PC) was evaluated for its cytotoxic activity on T-24 and J-82 human bladder carcinoma cells and normal primary cultured kidney cells. PC has demonstrated high levels of cytotoxicity against T-24 and J-82 cells. The...
1230.

Effect of Cytokines and bFGF on the Osteoclast Differentiation Induced by 1α,25-(OH)2D3 in Primary Murine Bone Marrow Cultures

Han-JungChae, , Jang-SookKang, Byung-GwanBang, Seoung-BumCho, Jo-ILHan, Joo-YoungChoi, Hyung-MinKim, Soo-WanChae, HyungRyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 1 539-546 (8 pages)

Han-JungChae, , Jang-SookKang, Byung-GwanBang, Seoung-BumCho, Jo-ILHan, Joo-YoungChoi, Hyung-MinKim, Soo-WanChae, HyungRyongKim 저
...
- 3,000원
Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly responsible for bone remodeling. Periodontal disease represents example of abnormal bone remodeling. Osteoclasts are multinucleated cells present only in bone. It is believed that osteoclast progenitors are hematopoietic origin, and they are recruited from hematopoietic tissues such...

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